JP2019513701A5 - - Google Patents

Info

Publication number

JP2019513701A5

JP2019513701A5 JP2018548416A JP2018548416A JP2019513701A5 JP 2019513701 A5 JP2019513701 A5 JP 2019513701A5 JP 2018548416 A JP2018548416 A JP 2018548416A JP 2018548416 A JP2018548416 A JP 2018548416A JP 2019513701 A5 JP2019513701 A5 JP 2019513701A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

hvr

cancer

Prior art date

2017-03-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 84
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 41
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 41
• 108020001507 fusion proteins Proteins 0.000 claims description 31
• 102000037865 fusion proteins Human genes 0.000 claims description 31
• 239000012634 fragment Substances 0.000 claims description 29
• 239000000427 antigen Substances 0.000 claims description 23
• 102000036639 antigens Human genes 0.000 claims description 23
• 108091007433 antigens Proteins 0.000 claims description 23
• 229920001184 polypeptide Polymers 0.000 claims description 14
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
• 206010028980 Neoplasm Diseases 0.000 claims description 13
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• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 9
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 9
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 239000003862 glucocorticoid Substances 0.000 claims description 4
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• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 2
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