JP2019510826A5 - - Google Patents
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- Publication number
- JP2019510826A5 JP2019510826A5 JP2019502544A JP2019502544A JP2019510826A5 JP 2019510826 A5 JP2019510826 A5 JP 2019510826A5 JP 2019502544 A JP2019502544 A JP 2019502544A JP 2019502544 A JP2019502544 A JP 2019502544A JP 2019510826 A5 JP2019510826 A5 JP 2019510826A5
- Authority
- JP
- Japan
- Prior art keywords
- trapidil
- composition
- compound
- levodopa
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 trapidil compound Chemical class 0.000 claims 15
- 229960000363 trapidil Drugs 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 12
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 12
- 229960004502 levodopa Drugs 0.000 claims 12
- GSNOZLZNQMLSKJ-UHFFFAOYSA-N Trapidil Chemical class CCN(CC)C1=CC(C)=NC2=NC=NN12 GSNOZLZNQMLSKJ-UHFFFAOYSA-N 0.000 claims 4
- 208000016285 Movement disease Diseases 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- 206010061623 Adverse drug reaction Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 229940071870 hydroiodic acid Drugs 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022044284A JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
| JP2024041690A JP2024095682A (ja) | 2016-04-04 | 2024-03-15 | トラピジルを使用する錐体外路症候群の処置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317983P | 2016-04-04 | 2016-04-04 | |
| US62/317,983 | 2016-04-04 | ||
| PCT/US2017/025788 WO2017176652A2 (en) | 2016-04-04 | 2017-04-03 | Treating extrapyramidal syndrome using trapidil |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022044284A Division JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510826A JP2019510826A (ja) | 2019-04-18 |
| JP2019510826A5 true JP2019510826A5 (enExample) | 2020-05-14 |
| JP7049683B2 JP7049683B2 (ja) | 2022-04-07 |
Family
ID=60001402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502544A Active JP7049683B2 (ja) | 2016-04-04 | 2017-04-03 | トラピジルを使用する錐体外路症候群の処置 |
| JP2022044284A Active JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
| JP2024041690A Pending JP2024095682A (ja) | 2016-04-04 | 2024-03-15 | トラピジルを使用する錐体外路症候群の処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022044284A Active JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
| JP2024041690A Pending JP2024095682A (ja) | 2016-04-04 | 2024-03-15 | トラピジルを使用する錐体外路症候群の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10350212B2 (enExample) |
| EP (1) | EP3442538B1 (enExample) |
| JP (3) | JP7049683B2 (enExample) |
| CN (2) | CN109310700A (enExample) |
| AU (1) | AU2017246334C1 (enExample) |
| CA (1) | CA3054674A1 (enExample) |
| DK (1) | DK3442538T3 (enExample) |
| ES (1) | ES3039958T3 (enExample) |
| FI (1) | FI3442538T3 (enExample) |
| WO (1) | WO2017176652A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3054674A1 (en) | 2016-04-04 | 2017-12-10 | Sinopia Biosciences, Inc. | Treating extrapyramidal syndrome using trapidil |
| JP2021532098A (ja) | 2018-07-19 | 2021-11-25 | インペル ニューロファーマ インコーポレイテッド | パーキンソン病の治療のためのレボドパおよびドーパデカルボキシラーゼ阻害剤の呼吸管路送達 |
| EP4069239A4 (en) * | 2019-12-02 | 2023-11-29 | Sinopia Biosciences, Inc. | Treating cognitive disorders using trapidil |
| IL296788A (en) * | 2020-03-26 | 2022-11-01 | Sinopia Biosciences Inc | Isotopically labeled trepidil histories |
| WO2024053728A1 (ja) * | 2022-09-09 | 2024-03-14 | 住友ファーマ株式会社 | 対象の状態の予測およびその応用 |
| CN116754348B (zh) * | 2023-06-06 | 2024-03-08 | 华北理工大学 | 基于zif-8-90材料的泡腾片、其制备方法及其应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4624848A (en) | 1984-05-10 | 1986-11-25 | Ciba-Geigy Corporation | Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4739044A (en) | 1985-06-13 | 1988-04-19 | Amgen | Method for derivitization of polynucleotides |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| US4968509A (en) | 1987-07-27 | 1990-11-06 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
| IT1222414B (it) | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Composizioni farmaceutiche contenenti trapidil,loro procedimento di preparazione e relaticvo impiego terapeutico |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| IL92966A (en) | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| JPH02268185A (ja) * | 1989-04-04 | 1990-11-01 | Biogal Gyogyszergyar | ５―メチル―７―（ジエチルアミノ）―Ｓ―トリアゾロ（１，５―ａ）ピリミジン及びその酸付加塩の製造方法 |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| ES2111065T5 (es) | 1991-04-16 | 2005-06-16 | Nippon Shinyaku Company, Limited | Procedimiento para producir una dispersion solida. |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| EP0604552B1 (en) | 1991-09-18 | 1997-02-12 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
| JP3195391B2 (ja) | 1991-11-14 | 2001-08-06 | エスエス製薬株式会社 | 徐放性トラピジル錠 |
| CZ282760B6 (cs) | 1991-11-22 | 1997-09-17 | Procter And Gamble Pharmaceuticals, Inc. | Risedronátové prostředky se zpožděným uvolňováním |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| DE69233087T2 (de) | 1991-11-22 | 2003-12-24 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verfahren zur Herstellung von Polymerarrays |
| US5348853A (en) | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
| US5567583A (en) | 1991-12-16 | 1996-10-22 | Biotronics Corporation | Methods for reducing non-specific priming in DNA detection |
| US6033854A (en) | 1991-12-16 | 2000-03-07 | Biotronics Corporation | Quantitative PCR using blocking oligonucleotides |
| US5461140A (en) | 1992-04-30 | 1995-10-24 | Pharmaceutical Delivery Systems | Bioerodible polymers for solid controlled release pharmaceutical compositions |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| WO1994008568A1 (fr) | 1992-10-16 | 1994-04-28 | Nippon Shinyaku Co., Ltd. | Procede pour fabriquer des matrices de cire |
| US5686105A (en) | 1993-10-19 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| DE19514048A1 (de) * | 1995-04-13 | 1996-10-17 | Rentschler Arzneimittel | Trapidil zur Verwendung in der Therapie von immunmodulatorisch beeinflußbaren Krankheitsbildern |
| KR19990014865A (ko) | 1995-05-17 | 1999-02-25 | 피터 이. 브래이브맨 | 소장에서의 소화 및 흡수를 증진시키기 위한, 지방산을 함유한조성물들 |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US5869717A (en) | 1997-09-17 | 1999-02-09 | Uop Llc | Process for inhibiting the polymerization of vinyl aromatics |
| JP2001521753A (ja) | 1997-10-31 | 2001-11-13 | アフィメトリックス インコーポレイテッド | 成人臓器及び胎児臓器中の発現プロフィール |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| JP2001322933A (ja) | 2000-05-15 | 2001-11-20 | Ucb Sa | Ｃｄ４０シグナル遮断剤 |
| US6465014B1 (en) | 2001-03-21 | 2002-10-15 | Isp Investments Inc. | pH-dependent sustained release, drug-delivery composition |
| US6960563B2 (en) | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
| US20060166972A1 (en) | 2003-07-11 | 2006-07-27 | Conn P J | Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator |
| US20080242657A1 (en) | 2004-03-26 | 2008-10-02 | Marino Michael J | Treatment of Tremor with Histamine H3 Inverse Agonists or Hist Amine H3 Antagonists |
| WO2007061798A2 (en) * | 2005-11-18 | 2007-05-31 | Cornell Research Foundation, Inc. | Nicotinoyl riboside compositions and methods of use |
| WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| CA2721797C (en) | 2008-04-18 | 2018-02-27 | Gary Zabow | Magnetic microstructures for magnetic resonance imaging |
| EP3225697A3 (en) | 2010-12-30 | 2017-11-22 | Foundation Medicine, Inc. | Optimization of multigene analysis of tumor samples |
| US20140045856A1 (en) * | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| KR101534395B1 (ko) | 2013-08-01 | 2015-07-09 | 서울대학교산학협력단 | 트라피딜을 유효성분으로 포함하는 골 관련 질환의 예방 또는 치료용 조성물 |
| WO2017059118A1 (en) * | 2015-09-29 | 2017-04-06 | Duke University | Compositions and methods for identifying and treating dystonia disorders |
| WO2017117240A1 (en) | 2015-12-29 | 2017-07-06 | JONES AND MALTERER TECHNOLOGY INNOVATIONS INCORPORATED, d/b/a JAMTek | Multi-point synchronizable and scalable lighting control systems |
| CA3054674A1 (en) * | 2016-04-04 | 2017-12-10 | Sinopia Biosciences, Inc. | Treating extrapyramidal syndrome using trapidil |
| IL296788A (en) | 2020-03-26 | 2022-11-01 | Sinopia Biosciences Inc | Isotopically labeled trepidil histories |
-
2017
- 2017-04-03 CA CA3054674A patent/CA3054674A1/en active Pending
- 2017-04-03 DK DK17779608.3T patent/DK3442538T3/da active
- 2017-04-03 JP JP2019502544A patent/JP7049683B2/ja active Active
- 2017-04-03 ES ES17779608T patent/ES3039958T3/es active Active
- 2017-04-03 WO PCT/US2017/025788 patent/WO2017176652A2/en not_active Ceased
- 2017-04-03 CN CN201780034722.0A patent/CN109310700A/zh active Pending
- 2017-04-03 FI FIEP17779608.3T patent/FI3442538T3/fi active
- 2017-04-03 CN CN202310643240.2A patent/CN116509869A/zh active Pending
- 2017-04-03 AU AU2017246334A patent/AU2017246334C1/en active Active
- 2017-04-03 EP EP17779608.3A patent/EP3442538B1/en active Active
-
2018
- 2018-04-25 US US15/962,999 patent/US10350212B2/en active Active
-
2019
- 2019-07-03 US US16/503,128 patent/US11628170B2/en active Active
-
2022
- 2022-03-18 JP JP2022044284A patent/JP7794668B2/ja active Active
-
2023
- 2023-03-01 US US18/176,962 patent/US12268691B2/en active Active
-
2024
- 2024-03-15 JP JP2024041690A patent/JP2024095682A/ja active Pending
-
2025
- 2025-01-16 US US19/025,296 patent/US20250387396A1/en active Pending
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