JP2019509294A5 - - Google Patents
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- Publication number
- JP2019509294A5 JP2019509294A5 JP2018547928A JP2018547928A JP2019509294A5 JP 2019509294 A5 JP2019509294 A5 JP 2019509294A5 JP 2018547928 A JP2018547928 A JP 2018547928A JP 2018547928 A JP2018547928 A JP 2018547928A JP 2019509294 A5 JP2019509294 A5 JP 2019509294A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- methyl
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 COC(C(C=C([C@@](C1)C2=C(c3ccccc3)Nc3ccc(*)c(*)c3)NC2=O)=C1I)=O Chemical compound COC(C(C=C([C@@](C1)C2=C(c3ccccc3)Nc3ccc(*)c(*)c3)NC2=O)=C1I)=O 0.000 description 28
- WRFFGTGNLDIMTO-WUKNDPDISA-N CC(N(c(c(/C1=C(/c2ccccc2)\I)c2)cc(C(OC)=O)c2I)C1=O)=O Chemical compound CC(N(c(c(/C1=C(/c2ccccc2)\I)c2)cc(C(OC)=O)c2I)C1=O)=O WRFFGTGNLDIMTO-WUKNDPDISA-N 0.000 description 5
- SOOYHJXKDJIECQ-UHFFFAOYSA-N COC(Cc(c([N+]([O-])=O)c1)cc(I)c1C(OC)=O)=O Chemical compound COC(Cc(c([N+]([O-])=O)c1)cc(I)c1C(OC)=O)=O SOOYHJXKDJIECQ-UHFFFAOYSA-N 0.000 description 2
- UDEOEHAYSKOZAQ-UHFFFAOYSA-N COC(c(cc(c(C1)c2)NC1=O)c2I)=O Chemical compound COC(c(cc(c(C1)c2)NC1=O)c2I)=O UDEOEHAYSKOZAQ-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16159231 | 2016-03-08 | ||
| EP16159231.6 | 2016-03-08 | ||
| PCT/GB2017/050619 WO2017153748A1 (en) | 2016-03-08 | 2017-03-08 | Indole derivatives and their use as protein kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509294A JP2019509294A (ja) | 2019-04-04 |
| JP2019509294A5 true JP2019509294A5 (https=) | 2020-04-16 |
| JP7039480B2 JP7039480B2 (ja) | 2022-03-22 |
Family
ID=55521584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547928A Expired - Fee Related JP7039480B2 (ja) | 2016-03-08 | 2017-03-08 | プロテインキナーゼ阻害剤としてのインドール誘導体およびそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10669235B2 (https=) |
| EP (1) | EP3426649B1 (https=) |
| JP (1) | JP7039480B2 (https=) |
| CN (1) | CN109153666B (https=) |
| AU (1) | AU2017231860C1 (https=) |
| BR (1) | BR112018068213A2 (https=) |
| CA (1) | CA3017308A1 (https=) |
| EA (1) | EA038773B1 (https=) |
| ES (1) | ES2836255T3 (https=) |
| WO (1) | WO2017153748A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3722291T3 (pl) | 2015-12-24 | 2023-11-27 | Respivert Limited | Związki indolinonowe i ich zastosowanie w leczeniu chorób zwłóknieniowych |
| CN109153666B (zh) | 2016-03-08 | 2021-07-16 | 莱斯彼维特有限公司 | 吲哚衍生物及其作为蛋白激酶抑制剂的用途 |
| KR102460040B1 (ko) | 2016-04-27 | 2022-11-01 | 애브비 인코포레이티드 | 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법 |
| CN112574094B (zh) * | 2020-12-14 | 2022-07-01 | 成都大学 | 吲哚酮衍生物及其制药用途 |
| WO2023043473A1 (en) * | 2021-09-14 | 2023-03-23 | R-Pharm Overseas, Inc. | TGF-β INHIBITOR COMPOSITION AND USE THEREOF |
| CN117624014A (zh) * | 2022-11-02 | 2024-03-01 | 徐诺药业(南京)有限公司 | 3-(吲哚氨基)亚甲基吲哚啉类衍生物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| JP2004182726A (ja) | 2002-11-22 | 2004-07-02 | Yamanouchi Pharmaceut Co Ltd | ２−オキソインドリン誘導体 |
| JP2005145928A (ja) * | 2003-11-19 | 2005-06-09 | Yamanouchi Pharmaceut Co Ltd | ３−キノリン−２（１ｈ）−イリデンインドリン−２−オン誘導体を有効成分とする医薬組成物 |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
| EP1902025A1 (en) | 2005-07-13 | 2008-03-26 | Allergan, Inc. | Kinase inhibitors |
| WO2010009166A1 (en) * | 2008-07-14 | 2010-01-21 | Gilead Colorado, Inc. | Oxindolyl inhibitor compounds |
| JP6152389B2 (ja) * | 2012-01-26 | 2017-06-21 | アンジオン バイオメディカ コーポレーション | 抗線維化化合物及びその使用 |
| WO2015179436A1 (en) * | 2014-05-19 | 2015-11-26 | Sanford-Burnham Medical Research Institute | Inflammation therapy using mekk3 inhibitors or blocking peptides |
| PL3722291T3 (pl) | 2015-12-24 | 2023-11-27 | Respivert Limited | Związki indolinonowe i ich zastosowanie w leczeniu chorób zwłóknieniowych |
| CN109153666B (zh) | 2016-03-08 | 2021-07-16 | 莱斯彼维特有限公司 | 吲哚衍生物及其作为蛋白激酶抑制剂的用途 |
-
2017
- 2017-03-08 CN CN201780023315.XA patent/CN109153666B/zh not_active Expired - Fee Related
- 2017-03-08 JP JP2018547928A patent/JP7039480B2/ja not_active Expired - Fee Related
- 2017-03-08 ES ES17711736T patent/ES2836255T3/es active Active
- 2017-03-08 EP EP17711736.3A patent/EP3426649B1/en not_active Not-in-force
- 2017-03-08 BR BR112018068213A patent/BR112018068213A2/pt not_active IP Right Cessation
- 2017-03-08 AU AU2017231860A patent/AU2017231860C1/en not_active Ceased
- 2017-03-08 EA EA201892020A patent/EA038773B1/ru unknown
- 2017-03-08 US US16/083,886 patent/US10669235B2/en active Active
- 2017-03-08 WO PCT/GB2017/050619 patent/WO2017153748A1/en not_active Ceased
- 2017-03-08 CA CA3017308A patent/CA3017308A1/en not_active Abandoned
-
2020
- 2020-06-01 US US16/889,780 patent/US11208381B2/en not_active Expired - Fee Related
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