JP2013536194A5 - - Google Patents
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- Publication number
- JP2013536194A5 JP2013536194A5 JP2013524250A JP2013524250A JP2013536194A5 JP 2013536194 A5 JP2013536194 A5 JP 2013536194A5 JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013536194 A5 JP2013536194 A5 JP 2013536194A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- carboxylic acid
- quinazolin
- amino
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *N[C@](C1=CC=N)NC([n]2ncc(C(O)=O)c2)=NC1=CC=C Chemical compound *N[C@](C1=CC=N)NC([n]2ncc(C(O)=O)c2)=NC1=CC=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37366410P | 2010-08-13 | 2010-08-13 | |
| US61/373,664 | 2010-08-13 | ||
| PCT/US2011/047626 WO2012021830A1 (en) | 2010-08-13 | 2011-08-12 | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536194A JP2013536194A (ja) | 2013-09-19 |
| JP2013536194A5 true JP2013536194A5 (https=) | 2014-09-25 |
| JP5755741B2 JP5755741B2 (ja) | 2015-07-29 |
Family
ID=44533176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524250A Expired - Fee Related JP5755741B2 (ja) | 2010-08-13 | 2011-08-12 | プロリルヒドロキシラーゼインヒビタとしての４−アミノキナゾリン−２−イル−１−ピラゾール−４−カルボン酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8796263B2 (https=) |
| EP (1) | EP2603502B1 (https=) |
| JP (1) | JP5755741B2 (https=) |
| CN (1) | CN103068821B (https=) |
| AU (1) | AU2011289230B2 (https=) |
| WO (1) | WO2012021830A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011035540A1 (zh) | 2009-09-28 | 2011-03-31 | 齐鲁制药有限公司 | 作为酪氨酸激酶抑制剂的4-（取代苯胺基）喹唑啉衍生物 |
| AU2011289230B2 (en) * | 2010-08-13 | 2014-09-04 | Janssen Pharmaceutica Nv | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
| WO2013063221A1 (en) | 2011-10-25 | 2013-05-02 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1h-benzo[d]imidazol-2-yl)-1h-pyrazole-4-carboxylic acid |
| WO2016034108A1 (zh) | 2014-09-02 | 2016-03-10 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其应用 |
| JP6882289B2 (ja) * | 2015-11-25 | 2021-06-02 | コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ | 二環式ｂｅｔブロモドメイン阻害剤及びその使用 |
| BR112022007680A2 (pt) * | 2019-10-25 | 2022-08-09 | Merck Sharp & Dohme | Derivados de n-(heteroaril)quinazolin-2-amina como inibidores de lrrk2, composições farmacêuticas, e usos dos mesmos |
| WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| EP4142721A1 (en) * | 2020-04-29 | 2023-03-08 | Bioage Labs, Inc. | Hypoxia-inducible factor prolyl hydroxylase inhibitors for treating aging-related conditions |
| CN114075175A (zh) * | 2020-08-14 | 2022-02-22 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| CN115943144B (zh) * | 2020-08-14 | 2025-05-13 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| TWI896831B (zh) * | 2020-12-31 | 2025-09-11 | 大陸商成都海博為藥業有限公司 | 一種作為ｐａｋ４激酶抑制劑的化合物及其製備方法和應用 |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| EP4347022A1 (en) | 2021-05-27 | 2024-04-10 | Keryx Biopharmaceuticals, Inc. | Pediatric formulations of ferric citrate |
| US20240415878A1 (en) * | 2021-10-13 | 2024-12-19 | Board Of Regents, The University Of Texas System | Compositions and Methods for Modulating Mitochondrial Function |
| US20230183356A1 (en) * | 2021-12-14 | 2023-06-15 | Brown University | HIF-1a MODULATORS AND USES THEREOF |
| WO2026015819A1 (en) * | 2024-07-12 | 2026-01-15 | The General Hospital Corporation | Trdmt1 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| AU2006254897A1 (en) | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a HIF-alpha stabilising agent |
| EP1960363B1 (en) | 2005-12-09 | 2014-01-22 | Amgen, Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions and uses thereof |
| AR059733A1 (es) | 2006-03-07 | 2008-04-23 | Smithkline Beecham Corp | Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| PL3357911T3 (pl) | 2006-06-26 | 2022-09-05 | Akebia Therapeutics Inc. | Inhibitory prolilohydroksylazy i sposoby ich użycia |
| DE102006050513A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substitiuierte Dihydropyrazolone und ihre Verwendung |
| ES2524883T3 (es) | 2008-03-18 | 2014-12-15 | Merck Sharp & Dohme Corp. | 4-Hidroxipirimidina-5-carboxamidas sustituidas |
| CN102171481B (zh) * | 2008-08-22 | 2015-04-08 | 因文图斯工程有限公司 | 运动阻尼装置 |
| RU2528412C2 (ru) | 2009-02-10 | 2014-09-20 | Янссен Фармацевтика Нв | Хиназолиноны как ингибиторы пролилгидроксилазы |
| AU2011289230B2 (en) * | 2010-08-13 | 2014-09-04 | Janssen Pharmaceutica Nv | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
-
2011
- 2011-08-12 AU AU2011289230A patent/AU2011289230B2/en not_active Ceased
- 2011-08-12 CN CN201180039665.8A patent/CN103068821B/zh active Active
- 2011-08-12 US US13/816,747 patent/US8796263B2/en active Active
- 2011-08-12 EP EP11749643.0A patent/EP2603502B1/en active Active
- 2011-08-12 WO PCT/US2011/047626 patent/WO2012021830A1/en not_active Ceased
- 2011-08-12 JP JP2013524250A patent/JP5755741B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-24 US US14/313,892 patent/US9006251B2/en active Active - Reinstated
-
2015
- 2015-03-26 US US14/670,352 patent/US9573940B2/en active Active
-
2017
- 2017-02-17 US US15/436,596 patent/US10246442B2/en active Active - Reinstated
-
2019
- 2019-04-01 US US16/371,400 patent/US10975062B2/en active Active
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