JP2013536194A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013536194A5 JP2013536194A5 JP2013524250A JP2013524250A JP2013536194A5 JP 2013536194 A5 JP2013536194 A5 JP 2013536194A5 JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013536194 A5 JP2013536194 A5 JP 2013536194A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- carboxylic acid
- quinazolin
- amino
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *N[C@](C1=CC=N)NC([n]2ncc(C(O)=O)c2)=NC1=CC=C Chemical compound *N[C@](C1=CC=N)NC([n]2ncc(C(O)=O)c2)=NC1=CC=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37366410P | 2010-08-13 | 2010-08-13 | |
| US61/373,664 | 2010-08-13 | ||
| PCT/US2011/047626 WO2012021830A1 (en) | 2010-08-13 | 2011-08-12 | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536194A JP2013536194A (ja) | 2013-09-19 |
| JP2013536194A5 true JP2013536194A5 (https=) | 2014-09-25 |
| JP5755741B2 JP5755741B2 (ja) | 2015-07-29 |
Family
ID=44533176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524250A Expired - Fee Related JP5755741B2 (ja) | 2010-08-13 | 2011-08-12 | プロリルヒドロキシラーゼインヒビタとしての４−アミノキナゾリン−２−イル−１−ピラゾール−４−カルボン酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8796263B2 (https=) |
| EP (1) | EP2603502B1 (https=) |
| JP (1) | JP5755741B2 (https=) |
| CN (1) | CN103068821B (https=) |
| AU (1) | AU2011289230B2 (https=) |
| WO (1) | WO2012021830A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916574B2 (en) | 2009-09-28 | 2014-12-23 | Qilu Pharmaceutical Co., Ltd. | 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors |
| AU2011289230B2 (en) * | 2010-08-13 | 2014-09-04 | Janssen Pharmaceutica Nv | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
| US9273034B2 (en) | 2011-10-25 | 2016-03-01 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
| JP6506390B2 (ja) | 2014-09-02 | 2019-04-24 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | キノリノン系化合物及びその薬物への使用 |
| CA3006300C (en) * | 2015-11-25 | 2024-02-27 | Convergene Llc | Bicyclic bet bromodomain inhibitors and uses thereof |
| EP4048261A4 (en) * | 2019-10-25 | 2023-11-22 | Merck Sharp & Dohme LLC | N-(HETEROARYL)-QUINAZOLINE-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| TW202206065A (zh) * | 2020-04-29 | 2022-02-16 | 美商百愛及生物醫藥公司 | 用以治療老化相關病況之缺氧誘導因子脯胺醯羥化酶抑制劑 |
| CN115943144B (zh) * | 2020-08-14 | 2025-05-13 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| CN114075175A (zh) * | 2020-08-14 | 2022-02-22 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| TWI896831B (zh) * | 2020-12-31 | 2025-09-11 | 大陸商成都海博為藥業有限公司 | 一種作為ｐａｋ４激酶抑制劑的化合物及其製備方法和應用 |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| CN117999069A (zh) | 2021-05-27 | 2024-05-07 | 凯克斯生物制药公司 | 柠檬酸铁的儿科调配物 |
| US20240415878A1 (en) * | 2021-10-13 | 2024-12-19 | Board Of Regents, The University Of Texas System | Compositions and Methods for Modulating Mitochondrial Function |
| US20230183356A1 (en) * | 2021-12-14 | 2023-06-15 | Brown University | HIF-1a MODULATORS AND USES THEREOF |
| WO2026015819A1 (en) * | 2024-07-12 | 2026-01-15 | The General Hospital Corporation | Trdmt1 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US20060276477A1 (en) | 2005-06-06 | 2006-12-07 | Fibrogen, Inc. | Treatment method for anemia |
| JP5202327B2 (ja) | 2005-12-09 | 2013-06-05 | アムジエン・インコーポレーテツド | プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用 |
| AR059733A1 (es) | 2006-03-07 | 2008-04-23 | Smithkline Beecham Corp | Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| BRPI0713350B1 (pt) | 2006-06-26 | 2022-04-12 | Akebia Therapeutics Inc | Composto, e, composição |
| DE102006050513A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substitiuierte Dihydropyrazolone und ihre Verwendung |
| JP5557832B2 (ja) * | 2008-03-18 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 置換４−ヒドロキシピリジン−５−カルボキサミド |
| CN102171481B (zh) * | 2008-08-22 | 2015-04-08 | 因文图斯工程有限公司 | 运动阻尼装置 |
| EP2396316B1 (en) | 2009-02-10 | 2015-07-01 | Janssen Pharmaceutica, N.V. | Quinazolinones as prolyl hydroxylase inhibitors |
| AU2011289230B2 (en) * | 2010-08-13 | 2014-09-04 | Janssen Pharmaceutica Nv | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
-
2011
- 2011-08-12 AU AU2011289230A patent/AU2011289230B2/en not_active Ceased
- 2011-08-12 EP EP11749643.0A patent/EP2603502B1/en active Active
- 2011-08-12 JP JP2013524250A patent/JP5755741B2/ja not_active Expired - Fee Related
- 2011-08-12 CN CN201180039665.8A patent/CN103068821B/zh active Active
- 2011-08-12 US US13/816,747 patent/US8796263B2/en active Active
- 2011-08-12 WO PCT/US2011/047626 patent/WO2012021830A1/en not_active Ceased
-
2014
- 2014-06-24 US US14/313,892 patent/US9006251B2/en active Active - Reinstated
-
2015
- 2015-03-26 US US14/670,352 patent/US9573940B2/en active Active
-
2017
- 2017-02-17 US US15/436,596 patent/US10246442B2/en active Active - Reinstated
-
2019
- 2019-04-01 US US16/371,400 patent/US10975062B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013536194A5 (https=) | ||
| US20040192701A1 (en) | Phenlypyridine carbonyl piperazine derivative | |
| JP2019077725A5 (https=) | ||
| JP2016519156A5 (https=) | ||
| JP4075064B2 (ja) | ４，４−ジフルオロ−１，２，３，４−テトラヒドロ−５ｈ−１−ベンゾアゼピン誘導体又はその塩 | |
| JP2017525757A5 (https=) | ||
| JP7158393B2 (ja) | 環状構造を有する化合物 | |
| JP2005526723A5 (https=) | ||
| ME02648B (me) | Jedinjenje pirazin karboksamida | |
| JP2016504378A5 (https=) | ||
| WO2008030836A2 (en) | Bcl inhibitors treating platelet excess | |
| EP1302463A1 (en) | Medicine comprising dicyanopyridine derivative | |
| RU2008116313A (ru) | Диарилминсодержащие соединения, композиции и их примеение в качестве модуляторов рецепторов с-кit | |
| JP2014501732A5 (https=) | ||
| TW200400958A (en) | Nitrogenous heterocyclic compound and pharmaceuticals thereof | |
| JP2011515462A5 (https=) | ||
| JP2019505595A5 (https=) | ||
| JP2012503018A5 (https=) | ||
| JPWO2000047558A1 (ja) | アミド化合物およびその医薬としての用途 | |
| JP2015533782A (ja) | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 | |
| JP2015500307A5 (https=) | ||
| JPWO2021170109A5 (https=) | ||
| HRP20140252T1 (hr) | Derivati imidazola kao inhibitori kazeinske kinaze | |
| WO2012036278A1 (ja) | グリシントランスポーター阻害物質 | |
| JP2013532709A5 (https=) |