JP2019509288A5 - - Google Patents
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- JP2019509288A5 JP2019509288A5 JP2018547294A JP2018547294A JP2019509288A5 JP 2019509288 A5 JP2019509288 A5 JP 2019509288A5 JP 2018547294 A JP2018547294 A JP 2018547294A JP 2018547294 A JP2018547294 A JP 2018547294A JP 2019509288 A5 JP2019509288 A5 JP 2019509288A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- aryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- BGNUVVYDMAUNTM-UHFFFAOYSA-N Cc1ccc2[n]1nc(N)nc2N Chemical compound Cc1ccc2[n]1nc(N)nc2N BGNUVVYDMAUNTM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305723P | 2016-03-09 | 2016-03-09 | |
| US62/305,723 | 2016-03-09 | ||
| PCT/US2017/021559 WO2017156262A1 (en) | 2016-03-09 | 2017-03-09 | Acyclic antivirals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509288A JP2019509288A (ja) | 2019-04-04 |
| JP2019509288A5 true JP2019509288A5 (enExample) | 2020-04-16 |
| JP6860585B2 JP6860585B2 (ja) | 2021-04-14 |
Family
ID=58361178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547294A Expired - Fee Related JP6860585B2 (ja) | 2016-03-09 | 2017-03-09 | 非環状抗ウイルス 優先出願の参照による組み込み |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10745427B2 (enExample) |
| EP (1) | EP3426642A4 (enExample) |
| JP (1) | JP6860585B2 (enExample) |
| CN (1) | CN109071467B (enExample) |
| AU (1) | AU2017231824B2 (enExample) |
| TW (1) | TWI740910B (enExample) |
| WO (1) | WO2017156262A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9243022B2 (en) | 2012-12-21 | 2016-01-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US10745427B2 (en) | 2016-03-09 | 2020-08-18 | Janssen Biopharma, Inc. | Acyclic antivirals |
| EP3515923A1 (en) * | 2016-09-23 | 2019-07-31 | Katholieke Universiteit Leuven | Prodrugs of fluorinated acyclic nucleoside phosphonates |
| CN111615391B (zh) * | 2018-01-19 | 2023-05-30 | 吉利德科学公司 | 比卡格韦的代谢物 |
| BR112021010351A2 (pt) | 2018-12-12 | 2021-08-31 | Janssen Biopharma, Inc. | Análogos de ciclopentil nucleosídeos como antivirais |
| MX2021006992A (es) | 2018-12-12 | 2021-11-17 | Janssen Biopharma Inc | Análogos de nucleósidos de ciclobutilo como antivirales. |
| MX2021008751A (es) | 2019-01-25 | 2021-11-12 | Univ Brown | Composiciones y metodos para tratar, prevenir o revertir la inflamacion y los trastornos asociados a la edad. |
| JP2023500794A (ja) | 2019-10-17 | 2023-01-11 | エーアイ‐バイオファーマ | 抗ウイルス薬および肝臓標的薬 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| KR20250133471A (ko) | 2020-02-18 | 2025-09-05 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 화합물 |
| CN111909153B (zh) * | 2020-04-16 | 2021-11-19 | 山东鲁西药业有限公司 | 7-碘吡咯并[2,1-f][1,2,4]三嗪-4-胺的合成工艺 |
| EP4161557B1 (en) * | 2020-06-04 | 2026-03-11 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Ws-635 for use in the treatment or prevention of sars-cov-2 infection |
| WO2022081823A1 (en) * | 2020-10-14 | 2022-04-21 | Temple University -Of The Commonwealth System Of Higher Education | Pharmacologic approach for suppression of coronaviruses |
| AU2022256476B2 (en) | 2021-04-16 | 2025-06-05 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| CA3228162A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US5532225A (en) * | 1992-07-31 | 1996-07-02 | Sri International | Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods |
| US5877166A (en) * | 1996-04-29 | 1999-03-02 | Sri International | Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents |
| WO1998039344A1 (en) * | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| DE19912636A1 (de) * | 1999-03-20 | 2000-09-21 | Aventis Cropscience Gmbh | Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel |
| MXPA03006514A (es) | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
| EA200400690A1 (ru) * | 2001-11-14 | 2005-06-30 | Байокрист Фармасьютикалз, Инк. | Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз |
| FR2842809A1 (fr) | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
| EP1620109A2 (en) | 2003-04-25 | 2006-02-01 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| CN1819832A (zh) * | 2003-04-25 | 2006-08-16 | 吉里德科学公司 | 激酶抑制性膦酸酯类似物 |
| US20050080053A1 (en) * | 2003-08-29 | 2005-04-14 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| TW200533358A (en) * | 2004-02-17 | 2005-10-16 | Anadys Pharmaceuticals Inc | Nucleoside phosphonate derivatives useful in the treatment of hiv infections |
| PT2258376T (pt) * | 2004-07-27 | 2019-05-31 | Gilead Sciences Inc | Análogos fosfonatados de compostos inibidores do vih |
| EP1945222B1 (en) | 2005-11-02 | 2012-12-26 | Bayer Pharma Aktiengesellschaft | Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
| BRPI0619146A2 (pt) | 2005-12-02 | 2011-09-13 | Bayer Pharmaceuticals Corp | derivados de 4-amino-pirroltriazina substituìda úteis no tratamento de disordens e doenças hiperproliferativas associadas com angiogênesis |
| NZ598927A (en) * | 2007-01-12 | 2013-09-27 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
| CN101066981B (zh) * | 2007-05-25 | 2011-10-05 | 中国科学院上海药物研究所 | 非环核苷膦酸酯类化合物及其组合物、制备方法和用途 |
| AU2009226024B2 (en) | 2008-03-20 | 2012-07-12 | Amgen Inc. | Aurora kinase modulators and method of use |
| PL2280973T3 (pl) | 2008-04-23 | 2013-05-31 | Gilead Sciences Inc | Analogi karba-nukleozydowe do leczenia przeciwwirusowego |
| EP2313102A2 (en) | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| DK2480552T3 (en) * | 2009-09-21 | 2017-02-20 | Gilead Sciences Inc | 2 'FLUOROUS-SUBSTITUTED CARBA NUCLEOSIDE ANALYSIS FOR ANTIVIRAL TREATMENT |
| CA2865021C (en) | 2012-02-23 | 2020-06-30 | Bayer Intellectual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| JP6338402B2 (ja) | 2014-03-07 | 2018-06-06 | 日東電工株式会社 | 樹脂フィルム |
| US10745427B2 (en) | 2016-03-09 | 2020-08-18 | Janssen Biopharma, Inc. | Acyclic antivirals |
-
2017
- 2017-03-09 US US16/090,715 patent/US10745427B2/en active Active
- 2017-03-09 EP EP17764089.3A patent/EP3426642A4/en not_active Withdrawn
- 2017-03-09 TW TW106107827A patent/TWI740910B/zh not_active IP Right Cessation
- 2017-03-09 CN CN201780028902.8A patent/CN109071467B/zh not_active Expired - Fee Related
- 2017-03-09 AU AU2017231824A patent/AU2017231824B2/en not_active Ceased
- 2017-03-09 WO PCT/US2017/021559 patent/WO2017156262A1/en not_active Ceased
- 2017-03-09 JP JP2018547294A patent/JP6860585B2/ja not_active Expired - Fee Related
-
2020
- 2020-06-30 US US16/916,618 patent/US11472826B2/en active Active