CN109071467B - 无环抗病毒药 - Google Patents

无环抗病毒药 Download PDF

Info

Publication number
CN109071467B
CN109071467B CN201780028902.8A CN201780028902A CN109071467B CN 109071467 B CN109071467 B CN 109071467B CN 201780028902 A CN201780028902 A CN 201780028902A CN 109071467 B CN109071467 B CN 109071467B
Authority
CN
China
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780028902.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN109071467A (zh
Inventor
L.贝格曼
王广义
M.钟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biopharma Inc
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of CN109071467A publication Critical patent/CN109071467A/zh
Application granted granted Critical
Publication of CN109071467B publication Critical patent/CN109071467B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/51—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads
    • A61F13/511—Topsheet, i.e. the permeable cover or layer facing the skin
    • A61F13/51113—Topsheet, i.e. the permeable cover or layer facing the skin comprising an additive, e.g. lotion or odour control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/51—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads
    • A61F13/511—Topsheet, i.e. the permeable cover or layer facing the skin
    • A61F13/512—Topsheet, i.e. the permeable cover or layer facing the skin characterised by its apertures, e.g. perforations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/51—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads
    • A61F13/511—Topsheet, i.e. the permeable cover or layer facing the skin
    • A61F13/513—Topsheet, i.e. the permeable cover or layer facing the skin characterised by its function or properties, e.g. stretchability, breathability, rewet, visual effect; having areas of different permeability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/51—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads
    • A61F13/514—Backsheet, i.e. the impermeable cover or layer furthest from the skin
    • A61F13/51401—Backsheet, i.e. the impermeable cover or layer furthest from the skin characterised by the material
    • A61F13/51405—Backsheet, i.e. the impermeable cover or layer furthest from the skin characterised by the material treated or coated, e.g. with moisture repellent agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/51—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads
    • A61F2013/51002—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads with special fibres
    • A61F2013/51023—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads with special fibres being polymeric fibres
    • A61F2013/51026—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the outer layers of the pads with special fibres being polymeric fibres being in thermoplastic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780028902.8A 2016-03-09 2017-03-09 无环抗病毒药 Active CN109071467B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662305723P 2016-03-09 2016-03-09
US62/305723 2016-03-09
PCT/US2017/021559 WO2017156262A1 (en) 2016-03-09 2017-03-09 Acyclic antivirals

Publications (2)

Publication Number Publication Date
CN109071467A CN109071467A (zh) 2018-12-21
CN109071467B true CN109071467B (zh) 2023-04-04

Family

ID=58361178

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780028902.8A Active CN109071467B (zh) 2016-03-09 2017-03-09 无环抗病毒药

Country Status (7)

Country Link
US (2) US10745427B2 (enExample)
EP (1) EP3426642A4 (enExample)
JP (1) JP6860585B2 (enExample)
CN (1) CN109071467B (enExample)
AU (1) AU2017231824B2 (enExample)
TW (1) TWI740910B (enExample)
WO (1) WO2017156262A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6284547B2 (ja) 2012-12-21 2018-02-28 アリオス バイオファーマ インク． 置換ヌクレオシド、置換ヌクレオチドおよびそれらの類似体
CN109071467B (zh) 2016-03-09 2023-04-04 艾丽奥斯生物制药有限公司 无环抗病毒药
CN108137630A (zh) * 2016-09-23 2018-06-08 鲁汶天主教大学 氟化无环核苷膦酸酯的前药
KR102497051B1 (ko) * 2018-01-19 2023-02-09 길리애드 사이언시즈, 인코포레이티드 빅테그라비르의 대사물
JP2022512397A (ja) 2018-12-12 2022-02-03 ヤンセン バイオファーマ インク． 抗ウイルス薬としてのシクロペンチルヌクレオシド類似体
WO2020121122A1 (en) 2018-12-12 2020-06-18 Janssen Biopharma, Inc. Cyclobutyl nucleoside analogs as anti-virals
SG11202107145SA (en) 2019-01-25 2021-08-30 Univ Brown Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
EP4045504A1 (en) 2019-10-17 2022-08-24 Ai-biopharma Anti-viral and hepatic-targeted drugs
AR121356A1 (es) 2020-02-18 2022-05-11 Gilead Sciences Inc Compuestos antivirales
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
CN111909153B (zh) * 2020-04-16 2021-11-19 山东鲁西药业有限公司 7-碘吡咯并[2,1-f][1,2,4]三嗪-4-胺的合成工艺
US20220296676A1 (en) * 2020-06-04 2022-09-22 Waterstone Pharmaceuticals(Wuhan) Co., Ltd. Treatment or prevention of coronaviridae infection
WO2022081823A1 (en) * 2020-10-14 2022-04-21 Temple University -Of The Commonwealth System Of Higher Education Pharmacologic approach for suppression of coronaviruses
ES3028915T3 (en) 2021-04-16 2025-06-20 Gilead Sciences Inc Methods of preparing carbanucleosides using amides
EP4387977A1 (en) 2021-08-18 2024-06-26 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039344A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US5869467A (en) * 1986-07-18 1999-02-09 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic 9-(2-phosphonylmethoxyethyl) guanine
CN1921867A (zh) * 2004-02-17 2007-02-28 株式会社Lg生命科学 用于治疗hiv感染的膦酸核苷衍生物
CN101027062A (zh) * 2004-07-27 2007-08-29 吉里德科学公司 Hiv抑制剂化合物的膦酸酯类似物
CN101066981A (zh) * 2007-05-25 2007-11-07 中国科学院上海药物研究所 非环核苷膦酸酯类化合物及其组合物、制备方法和用途
US7368437B1 (en) * 1999-03-20 2008-05-06 Bayer Cropscience Ag Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents
CN101381379A (zh) * 2003-04-25 2009-03-11 吉里德科学公司 激酶抑制性膦酸酯类似物
US20090105261A1 (en) * 2002-07-26 2009-04-23 Greenpharma Novel substituted pyrazolo[1,5<I>A</I>]-1,3,5-Triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same
CN101611046A (zh) * 2007-01-12 2009-12-23 拜奥克里斯特制药公司 抗病毒的核苷类似物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273169A3 (en) * 1983-05-24 1990-08-29 Sri International Novel antiviral agents
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5532225A (en) * 1992-07-31 1996-07-02 Sri International Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
HUP0400726A3 (en) 2001-01-22 2007-05-29 Merck & Co Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
EA200400690A1 (ru) * 2001-11-14 2005-06-30 Байокрист Фармасьютикалз, Инк. Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз
FR2850653A1 (fr) * 2003-02-04 2004-08-06 Univ Pasteur Derives de pyrazolotriazine, procede de preparation et utilisations
EP1620109A2 (en) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
US20050080053A1 (en) * 2003-08-29 2005-04-14 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
WO2007056170A2 (en) 2005-11-02 2007-05-18 Bayer Healthcare Ag Pyrrolo[2,1-f] [1,2,4] triazin-4-ylamines igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
MX2008007103A (es) 2005-12-02 2008-09-12 Bayer Healthcare Llc Derivados 4-amino-pirrolotriazina sustituidos, útiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis.
MX2010010151A (es) 2008-03-20 2010-10-25 Amgen Inc Moduladores de cinasa aurora y metodo de uso.
AR071395A1 (es) 2008-04-23 2010-06-16 Gilead Sciences Inc Analogos carba-nucleosidos 1'-sustituidos para tratamiento antiviral
EP2313102A2 (en) 2008-07-03 2011-04-27 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
ES2730805T3 (es) * 2009-09-21 2019-11-12 Gilead Sciences Inc Análogos de carba-nucleósido sustituido por 2'-fluoro para el tratamiento antiviral
CA2865021C (en) 2012-02-23 2020-06-30 Bayer Intellectual Property Gmbh Substituted benzothienyl-pyrrolotriazines and uses thereof
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
JP6338402B2 (ja) 2014-03-07 2018-06-06 日東電工株式会社 樹脂フィルム
CN109071467B (zh) 2016-03-09 2023-04-04 艾丽奥斯生物制药有限公司 无环抗病毒药

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869467A (en) * 1986-07-18 1999-02-09 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic 9-(2-phosphonylmethoxyethyl) guanine
WO1998039344A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US7368437B1 (en) * 1999-03-20 2008-05-06 Bayer Cropscience Ag Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents
US20090105261A1 (en) * 2002-07-26 2009-04-23 Greenpharma Novel substituted pyrazolo[1,5<I>A</I>]-1,3,5-Triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same
CN101381379A (zh) * 2003-04-25 2009-03-11 吉里德科学公司 激酶抑制性膦酸酯类似物
CN1921867A (zh) * 2004-02-17 2007-02-28 株式会社Lg生命科学 用于治疗hiv感染的膦酸核苷衍生物
CN101027062A (zh) * 2004-07-27 2007-08-29 吉里德科学公司 Hiv抑制剂化合物的膦酸酯类似物
CN101611046A (zh) * 2007-01-12 2009-12-23 拜奥克里斯特制药公司 抗病毒的核苷类似物
CN101066981A (zh) * 2007-05-25 2007-11-07 中国科学院上海药物研究所 非环核苷膦酸酯类化合物及其组合物、制备方法和用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine Bis(2,2,2-trifluoroethyl) Esters as Novel HBV-Specific Antiviral Reagents;Kouichi Sekiya et al.;《J. Med. Chem.》;20020604;第45卷;第3138-3142页 *
Fructose-1,6-bisphosphatase Inhibitors. 1. Purine Phosphonic Acids as Novel AMP Mimics;Qun Dang et al.;《Journal of Medicinal Chemistry》;20090406;第52卷(第9期);第2880-2898页 *
STN检索报告1;来源于Aurora Fine Chemicals等提供的产品目录;《数据库REGISTRY（在线）》;20091221;第1-3页 *
Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity;Mark D. Erion et al.;《J. AM. CHEM. SOC.》;20071128;第129卷(第50期);第15480-15490页 *

Also Published As

Publication number Publication date
JP6860585B2 (ja) 2021-04-14
AU2017231824A1 (en) 2018-09-27
EP3426642A1 (en) 2019-01-16
US20200392169A1 (en) 2020-12-17
TWI740910B (zh) 2021-10-01
US20190055273A1 (en) 2019-02-21
JP2019509288A (ja) 2019-04-04
WO2017156262A1 (en) 2017-09-14
AU2017231824B2 (en) 2021-07-01
TW201741314A (zh) 2017-12-01
US11472826B2 (en) 2022-10-18
EP3426642A4 (en) 2019-10-09
CN109071467A (zh) 2018-12-21
US10745427B2 (en) 2020-08-18

Similar Documents

Publication Publication Date Title
CN109071467B (zh) 无环抗病毒药
US8093380B2 (en) Compounds with the bicyclo[4.2.1]nonane system for the treatment of Flaviviridae infections
KR101508018B1 (ko) 바이러스 감염의 치료를 위한 화합물 및 제약 조성물
CN107427530B (zh) 用于HCV治疗的β-D-2’-脱氧-2’α-氟-2’-β-C-取代的-2-改性的-N6-取代的嘌呤核苷酸
US8673926B2 (en) Spiro[2.4]heptanes for treatment of flaviviridae infections
TW201429983A (zh) 經取代之核苷、核苷酸及其類似物
US20220033406A1 (en) Cyclopentyl nucleoside analogs as anti-virals
US20220048912A1 (en) Cyclobutyl nucleoside analogs as anti-virals
CN114901657A (zh) 抗病毒和肝靶向药物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant