JP2019506889A5 - - Google Patents
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- JP2019506889A5 JP2019506889A5 JP2018546429A JP2018546429A JP2019506889A5 JP 2019506889 A5 JP2019506889 A5 JP 2019506889A5 JP 2018546429 A JP2018546429 A JP 2018546429A JP 2018546429 A JP2018546429 A JP 2018546429A JP 2019506889 A5 JP2019506889 A5 JP 2019506889A5
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- JP
- Japan
- Prior art keywords
- nucleic acid
- cedna
- optionally
- stem
- rolling circle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021179896A JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303047P | 2016-03-03 | 2016-03-03 | |
| US62/303,047 | 2016-03-03 | ||
| US201662394720P | 2016-09-14 | 2016-09-14 | |
| US62/394,720 | 2016-09-14 | ||
| US201662406913P | 2016-10-11 | 2016-10-11 | |
| US62/406,913 | 2016-10-11 | ||
| PCT/US2017/020828 WO2017152149A1 (en) | 2016-03-03 | 2017-03-03 | Closed-ended linear duplex dna for non-viral gene transfer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179896A Division JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506889A JP2019506889A (ja) | 2019-03-14 |
| JP2019506889A5 true JP2019506889A5 (https=) | 2020-04-09 |
| JP6994140B2 JP6994140B2 (ja) | 2022-02-03 |
Family
ID=59743259
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546429A Active JP6994140B2 (ja) | 2016-03-03 | 2017-03-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
| JP2021179896A Active JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
| JP2022191114A Pending JP2023024489A (ja) | 2016-03-03 | 2022-11-30 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179896A Active JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
| JP2022191114A Pending JP2023024489A (ja) | 2016-03-03 | 2022-11-30 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖dna |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11066679B2 (https=) |
| EP (2) | EP3423110B1 (https=) |
| JP (3) | JP6994140B2 (https=) |
| KR (1) | KR102336362B1 (https=) |
| CN (2) | CN109195636B (https=) |
| AU (2) | AU2017228413B2 (https=) |
| CA (1) | CA3014683A1 (https=) |
| DK (1) | DK3423110T3 (https=) |
| ES (1) | ES2898337T3 (https=) |
| HR (1) | HRP20211697T1 (https=) |
| IL (2) | IL261524B2 (https=) |
| LT (1) | LT3423110T (https=) |
| MX (1) | MX2018010633A (https=) |
| PT (1) | PT3423110T (https=) |
| RU (1) | RU2752882C2 (https=) |
| SG (2) | SG11201806663TA (https=) |
| WO (1) | WO2017152149A1 (https=) |
| ZA (1) | ZA201806544B (https=) |
Families Citing this family (59)
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| RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
| WO2016077687A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| MX2018010633A (es) | 2016-03-03 | 2019-06-13 | Univ Massachusetts | Acido desoxirribonucleico (adn) lineal duplex de extremos cerrados para transferencia genica no viral. |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
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| KR102696307B1 (ko) * | 2017-09-08 | 2024-08-16 | 제너레이션 바이오 컴퍼니 | 비-바이러스성 캡시드-비함유 dna 벡터의 지질 나노입자 제형 |
| CA3075168A1 (en) * | 2017-09-08 | 2019-03-14 | Generation Bio Co. | Modified closed-ended dna (cedna) |
| ES2976559T3 (es) | 2017-09-20 | 2024-08-05 | Univ California | Terapia génica con conexina 43 para restaurar la función eléctrica y cardíaca y la estructura cardíaca, en la miocardiopatía arritmogénica del ventrículo derecho |
| US12098385B2 (en) | 2017-09-20 | 2024-09-24 | The Regents Of The University Of California | Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy |
| US11680296B2 (en) * | 2017-10-16 | 2023-06-20 | Massachusetts Institute Of Technology | Mycobacterium tuberculosis host-pathogen interaction |
| CA3084185A1 (en) * | 2017-12-06 | 2019-06-13 | Generation Bio Co. | Gene editing using a modified closed-ended dna (cedna) |
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| MA52116A (fr) * | 2018-03-02 | 2021-01-06 | Generation Bio Co | Vecteurs d'adn à extrémité fermée (cedna) pour l'insertion de transgènes au niveau de havres génomiques sécuritaires (gsh) dans des génomes humains et murins |
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| KR20210019996A (ko) | 2018-05-15 | 2021-02-23 | 보이저 테라퓨틱스, 인크. | 파킨슨병의 치료를 위한 조성물 및 방법 |
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| EP3810782A2 (en) * | 2018-06-22 | 2021-04-28 | Asklepios Biopharmaceutical, Inc. | Vectors for gene delivery that persist within cells |
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| WO2020037254A1 (en) * | 2018-08-17 | 2020-02-20 | City Of Hope | Compounds of chemically modified oligonucleotides and methods of use thereof |
| EP3856762A1 (en) | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| KR20210090619A (ko) * | 2018-11-09 | 2021-07-20 | 제너레이션 바이오 컴퍼니 | 대칭인 변형된 역말단반복을 포함하는 변형된 폐쇄형 DNA(ceDNA) |
| JP2022518504A (ja) * | 2019-01-24 | 2022-03-15 | ジェネレーション バイオ カンパニー | 閉端dna(cedna)ならびに遺伝子療法または核酸療法に関連する免疫応答を低減させる方法における使用 |
| CN113454232B (zh) * | 2019-02-15 | 2024-10-29 | 世代生物公司 | 封闭端dna(cedna)产生中对rep蛋白活性的调节 |
| EP3934700A4 (en) * | 2019-03-06 | 2022-12-14 | Generation Bio Co. | NON-ACTIVE LIPID NANOPARTICLES WITH CAPSID-FREE, NON-VIRAL DNA |
| MA55223A (fr) * | 2019-03-06 | 2022-01-12 | Generation Bio Co | Adn à extrémité fermée (cedna) et composés de modulation immunitaire |
| EP3938515A4 (en) * | 2019-03-13 | 2022-12-28 | Generation Bio Co. | NON-VIRAL DNA VECTORS AND THEIR USES FOR EXPRESSING PHENYLALANINE HYDROXYLASE (PAH) THERAPEUTIC AGENTS |
| SG11202109850SA (en) | 2019-03-13 | 2021-10-28 | Generation Bio Co | Non-viral dna vectors and uses thereof for expressing fviii therapeutics |
| JP2022527629A (ja) | 2019-04-05 | 2022-06-02 | アーリー・インコーポレイテッド | 合成バイオマーカーのための改良された方法及び組成物 |
| US12582726B1 (en) | 2019-04-05 | 2026-03-24 | Earli Inc. | Synthetic cancer-specific promoters |
| CA3147414A1 (en) | 2019-07-17 | 2021-01-21 | Generation Bio Co. | Synthetic production of single-stranded adeno associated viral dna vectors |
| KR20220128607A (ko) | 2019-09-18 | 2022-09-21 | 인터갈락틱 테라퓨틱스, 인크. | 합성 dna 벡터 및 사용 방법 |
| US20230089312A1 (en) | 2020-02-25 | 2023-03-23 | University Of Massachusetts | Inducible single aav system and uses thereof |
| US20230138409A1 (en) * | 2020-03-24 | 2023-05-04 | Generation Bio Co. | Non-viral dna vectors and uses thereof for expressing factor ix therapeutics |
| JP7746280B2 (ja) | 2020-03-27 | 2025-09-30 | ジェネレーション バイオ カンパニー | 新規脂質及びそれらのナノ粒子組成物 |
| US20210330759A1 (en) * | 2020-04-22 | 2021-10-28 | The Cleveland Clinic Foundation | Methods and compositions for treating cytokine storm, ards, and acute lung injury using beta-glucocerebrosidase |
| EP4158005A1 (en) | 2020-06-01 | 2023-04-05 | ModernaTX, Inc. | Phenylalanine hydroxylase variants and uses thereof |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Dna分子の組成物、その作製方法、及びその使用方法 |
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| KR20240005903A (ko) * | 2021-05-07 | 2024-01-12 | 제너레이션 바이오 컴퍼니 | 백신 전달을 위한 비바이러스성 dna 벡터 |
| CA3218126A1 (en) * | 2021-05-07 | 2022-11-10 | Matthew MANGANIELLO | Lyophilized non-viral dna vector compositions and uses thereof |
| US20240263195A1 (en) | 2021-05-11 | 2024-08-08 | Modernatx, Inc. | Non-viral delivery of dna for prolonged polypeptide expression in vivo |
| MX2024002333A (es) | 2021-08-23 | 2024-03-07 | Bioverativ Therapeutics Inc | Sistema de expresion de baculovirus. |
| CN118139628A (zh) * | 2021-08-23 | 2024-06-04 | 阿维麦克思生物制药公司 | 用于转基因表达的组合物和方法 |
| CN114525282A (zh) * | 2022-03-04 | 2022-05-24 | 西南大学 | 一种二价核酸适配体及其设计方法 |
| EP4665405A1 (en) * | 2023-02-17 | 2025-12-24 | Flagship Pioneering Innovations VII, LLC | Dna compositions comprising modified uracil |
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| WO2024249438A1 (en) * | 2023-05-26 | 2024-12-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Copiparvovirus genetic vector platform |
| WO2025212926A1 (en) * | 2024-04-05 | 2025-10-09 | University Of Massachusetts | Aav-mediated rhoa knockdown |
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| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
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| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
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-
2017
- 2017-03-03 MX MX2018010633A patent/MX2018010633A/es unknown
- 2017-03-03 IL IL261524A patent/IL261524B2/en unknown
- 2017-03-03 EP EP17760963.3A patent/EP3423110B1/en active Active
- 2017-03-03 KR KR1020187028000A patent/KR102336362B1/ko active Active
- 2017-03-03 RU RU2018134295A patent/RU2752882C2/ru active
- 2017-03-03 CN CN201780014840.5A patent/CN109195636B/zh active Active
- 2017-03-03 AU AU2017228413A patent/AU2017228413B2/en active Active
- 2017-03-03 US US16/081,337 patent/US11066679B2/en active Active
- 2017-03-03 IL IL302398A patent/IL302398B2/en unknown
- 2017-03-03 WO PCT/US2017/020828 patent/WO2017152149A1/en not_active Ceased
- 2017-03-03 SG SG11201806663TA patent/SG11201806663TA/en unknown
- 2017-03-03 ES ES17760963T patent/ES2898337T3/es active Active
- 2017-03-03 DK DK17760963.3T patent/DK3423110T3/da active
- 2017-03-03 HR HRP20211697TT patent/HRP20211697T1/hr unknown
- 2017-03-03 JP JP2018546429A patent/JP6994140B2/ja active Active
- 2017-03-03 CA CA3014683A patent/CA3014683A1/en active Pending
- 2017-03-03 LT LTEPPCT/US2017/020828T patent/LT3423110T/lt unknown
- 2017-03-03 CN CN202210722790.9A patent/CN115287301A/zh active Pending
- 2017-03-03 EP EP21183431.2A patent/EP3957331A1/en active Pending
- 2017-03-03 PT PT177609633T patent/PT3423110T/pt unknown
- 2017-03-03 SG SG10201913688TA patent/SG10201913688TA/en unknown
-
2018
- 2018-10-02 ZA ZA2018/06544A patent/ZA201806544B/en unknown
-
2021
- 2021-06-01 US US17/335,499 patent/US12252703B2/en active Active
- 2021-11-03 JP JP2021179896A patent/JP7193096B2/ja active Active
-
2022
- 2022-11-30 JP JP2022191114A patent/JP2023024489A/ja active Pending
-
2025
- 2025-02-13 US US19/052,351 patent/US20250290094A1/en active Pending
- 2025-04-17 AU AU2025202724A patent/AU2025202724A1/en active Pending
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