JP2019505502A5 - - Google Patents
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- Publication number
- JP2019505502A5 JP2019505502A5 JP2018533169A JP2018533169A JP2019505502A5 JP 2019505502 A5 JP2019505502 A5 JP 2019505502A5 JP 2018533169 A JP2018533169 A JP 2018533169A JP 2018533169 A JP2018533169 A JP 2018533169A JP 2019505502 A5 JP2019505502 A5 JP 2019505502A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- alkyl
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 **c1nc(N(*)c2c(*)c(*)c(*)c(*)c2*)nc(N(*)*)n1 Chemical compound **c1nc(N(*)c2c(*)c(*)c(*)c(*)c2*)nc(N(*)*)n1 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021140812A JP7297827B2 (ja) | 2015-12-24 | 2021-08-31 | Ｃｆｔｒ制御因子及びこの使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387590P | 2015-12-24 | 2015-12-24 | |
| US62/387,590 | 2015-12-24 | ||
| PCT/US2016/068569 WO2017112951A1 (en) | 2015-12-24 | 2016-12-23 | Cftr regulators and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021140812A Division JP7297827B2 (ja) | 2015-12-24 | 2021-08-31 | Ｃｆｔｒ制御因子及びこの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505502A JP2019505502A (ja) | 2019-02-28 |
| JP2019505502A5 true JP2019505502A5 (enExample) | 2020-02-06 |
| JP6938510B2 JP6938510B2 (ja) | 2021-09-22 |
Family
ID=59091271
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018533169A Active JP6938510B2 (ja) | 2015-12-24 | 2016-12-23 | Ｃｆｔｒ制御因子及びこの使用方法 |
| JP2021140812A Active JP7297827B2 (ja) | 2015-12-24 | 2021-08-31 | Ｃｆｔｒ制御因子及びこの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021140812A Active JP7297827B2 (ja) | 2015-12-24 | 2021-08-31 | Ｃｆｔｒ制御因子及びこの使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US10604492B2 (enExample) |
| EP (2) | EP4019501B1 (enExample) |
| JP (2) | JP6938510B2 (enExample) |
| KR (1) | KR102733897B1 (enExample) |
| CN (2) | CN108848668B (enExample) |
| AU (1) | AU2016379444B2 (enExample) |
| BR (1) | BR112018012949B1 (enExample) |
| CL (1) | CL2018001715A1 (enExample) |
| CO (1) | CO2018007237A2 (enExample) |
| DK (1) | DK3394040T3 (enExample) |
| ES (2) | ES2909316T3 (enExample) |
| IL (1) | IL260208B2 (enExample) |
| MX (2) | MX383072B (enExample) |
| PL (1) | PL3394040T3 (enExample) |
| PT (1) | PT3394040T (enExample) |
| RU (1) | RU2749834C2 (enExample) |
| WO (1) | WO2017112951A1 (enExample) |
| ZA (1) | ZA201804230B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2909316T3 (es) * | 2015-12-24 | 2022-05-06 | Univ California | Reguladores de CFTR y métodos de uso de los mismos |
| KR20200044873A (ko) * | 2017-08-24 | 2020-04-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구 제약학적 조성물 |
| FR3096890B1 (fr) * | 2019-06-07 | 2021-05-14 | H4 Orphan Pharma | Utilisation d’une molécule opioïde pour traiter l’œil sec et l’œil allergique. |
| TWI845795B (zh) | 2019-12-05 | 2024-06-21 | 美商汎達製藥公司 | 眼用醫藥組合物 |
| US20220071549A1 (en) * | 2020-09-08 | 2022-03-10 | The Regents Of The University Of California | Apparatus, systems and methods of use for ocular surface potential difference measurement |
| CN116507336B (zh) | 2020-09-10 | 2026-01-02 | Vanda制药公司 | 治疗pde iv介导的疾病或病症的方法 |
| AU2025224045A1 (en) | 2024-02-22 | 2026-08-06 | Vanda Pharmaceuticals, Inc. | Treatment of dry eye disease |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK35124C (da) | 1924-03-19 | 1925-10-12 | Niels Christian Carl S Nielsen | Anordning ved Ægisolatorer og lignende. |
| DK72517C (da) | 1948-04-08 | 1951-05-15 | Hans Dr Ing Wolf | Kobling til paralleldrift af vekselstrømsmotorer. |
| DK101373C (da) | 1962-03-16 | 1965-03-29 | Hoechst Ag | Fremgangsmåde til fremstilling af vandopløselige monoazofarvestoffer. |
| ZA794209B (en) | 1978-08-15 | 1980-07-30 | Fisons Ltd | Pharmaceutically active heterocyclic compounds |
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JPS62126178A (ja) * | 1985-11-26 | 1987-06-08 | Mitsubishi Petrochem Co Ltd | 新規トリアジン誘導体及びこれを含む除草剤 |
| US5236952A (en) | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| AU5433594A (en) | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| IL137128A0 (en) | 1998-01-30 | 2001-07-24 | R Tech Ueno Ltd | Ophthalmic compositions containing tetrahydroquinazoline derivatives |
| EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| GB9806739D0 (en) | 1998-03-28 | 1998-05-27 | Univ Newcastle Ventures Ltd | Cyclin dependent kinase inhibitors |
| BR9815785A (pt) | 1998-03-31 | 2000-12-05 | Warner Lambert Co | Quinoxalinonas como inibidores de protease de serina tal como fator xa e trombina |
| CA2396693A1 (en) * | 1999-12-28 | 2001-07-05 | Stephen T. Wrobleski | Cytokine, especially tnf-alpha, inhibitors |
| PL369600A1 (en) * | 2001-09-21 | 2005-05-02 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7163943B2 (en) * | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| WO2004031184A1 (en) * | 2002-10-01 | 2004-04-15 | Johnson & Johnson Pharmaceutical Research & Development, Inc. | 4,6-diaminosubstituted-2-[oxy or aminoxy]-[1,3,5]triazines as protein tyrosine kinase inhibitors |
| WO2005009980A1 (en) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| BRPI0507278A (pt) | 2004-01-30 | 2007-06-26 | Vertex Pharma | moduladores dos transportadores do cassete de ligação ao atp |
| US7335770B2 (en) * | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| CA2600869A1 (en) * | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | Compounds having activity in correcting mutant-cftr processing and uses thereof |
| WO2007095812A1 (en) | 2006-02-27 | 2007-08-30 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof |
| US8080563B2 (en) | 2006-07-07 | 2011-12-20 | Kalypsys | Bicyclic heteroaryl inhibitors of PDE4 |
| US8263607B2 (en) * | 2007-05-22 | 2012-09-11 | Astellas Pharma Inc. | 1-substituted tetrahydroisoquinoline compound |
| US20090105240A1 (en) | 2007-10-17 | 2009-04-23 | Tomas Mustelin | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same |
| WO2009091388A2 (en) * | 2007-12-21 | 2009-07-23 | Progenics Pharmaceuticals, Inc. | Triazines and related compounds having antiviral activity, compositions and methods thereof |
| ES2548583T3 (es) | 2008-03-05 | 2015-10-19 | Merck Patent Gmbh | Derivados de quinoxalinona como estimuladores de la secreción de insulina, métodos para su obtención y su uso para el tratamiento de la diabetes |
| US8314239B2 (en) | 2008-10-23 | 2012-11-20 | Vertex Pharmaceutical Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| WO2010073011A2 (en) | 2008-12-23 | 2010-07-01 | Betagenon Ab | Compounds useful as medicaments |
| SI3330255T1 (sl) * | 2009-03-20 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi |
| FR2958645B1 (fr) | 2010-04-09 | 2012-08-31 | Commissariat Energie Atomique | Hemi-anticorps a auto-assemblage |
| RU2569678C2 (ru) * | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| TWI450891B (zh) | 2010-12-29 | 2014-09-01 | Dev Center Biotechnology | 新穎微管蛋白抑制劑 |
| CA2895656A1 (en) | 2012-12-19 | 2014-06-26 | Novartis Ag | Tricyclic compounds as cftr inhibitors |
| AU2014304562B8 (en) | 2013-08-08 | 2018-07-05 | Galapagos Nv | Thieno[2,3-c]pyrans as CFTR modulators |
| WO2015168079A1 (en) * | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| US10354851B2 (en) | 2015-09-11 | 2019-07-16 | Iontof Technologies Gmbh | Secondary ion mass spectrometer and secondary ion mass spectrometric method |
| RU2730855C2 (ru) | 2015-12-24 | 2020-08-26 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа | Кфтр регуляторы и способы их применения |
| ES2956820T3 (es) | 2015-12-24 | 2023-12-28 | Respivert Ltd | Compuestos de indolinonas y su uso en el tratamiento de enfermedades fibróticas |
| RU2742934C2 (ru) | 2015-12-24 | 2021-02-11 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа | Кфтр регуляторы и способы их применения |
| ES2909316T3 (es) | 2015-12-24 | 2022-05-06 | Univ California | Reguladores de CFTR y métodos de uso de los mismos |
| KR20200044873A (ko) | 2017-08-24 | 2020-04-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구 제약학적 조성물 |
| JP7256631B2 (ja) | 2018-11-01 | 2023-04-12 | 株式会社豊田中央研究所 | 距離測定装置 |
-
2016
- 2016-12-23 ES ES16880160T patent/ES2909316T3/es active Active
- 2016-12-23 EP EP21207338.1A patent/EP4019501B1/en active Active
- 2016-12-23 PT PT168801603T patent/PT3394040T/pt unknown
- 2016-12-23 RU RU2018126958A patent/RU2749834C2/ru active
- 2016-12-23 JP JP2018533169A patent/JP6938510B2/ja active Active
- 2016-12-23 MX MX2018007767A patent/MX383072B/es unknown
- 2016-12-23 CN CN201680082483.1A patent/CN108848668B/zh active Active
- 2016-12-23 PL PL16880160T patent/PL3394040T3/pl unknown
- 2016-12-23 KR KR1020187021208A patent/KR102733897B1/ko active Active
- 2016-12-23 CN CN202210373667.0A patent/CN115710233A/zh active Pending
- 2016-12-23 DK DK16880160.3T patent/DK3394040T3/da active
- 2016-12-23 BR BR112018012949-6A patent/BR112018012949B1/pt active IP Right Grant
- 2016-12-23 AU AU2016379444A patent/AU2016379444B2/en active Active
- 2016-12-23 EP EP16880160.3A patent/EP3394040B1/en active Active
- 2016-12-23 US US16/016,290 patent/US10604492B2/en active Active
- 2016-12-23 ES ES21207338T patent/ES3066112T3/es active Active
- 2016-12-23 WO PCT/US2016/068569 patent/WO2017112951A1/en not_active Ceased
- 2016-12-23 IL IL260208A patent/IL260208B2/en unknown
-
2018
- 2018-06-21 CL CL2018001715A patent/CL2018001715A1/es unknown
- 2018-06-22 ZA ZA201804230A patent/ZA201804230B/en unknown
- 2018-06-22 MX MX2021006439A patent/MX2021006439A/es unknown
- 2018-07-11 CO CONC2018/0007237A patent/CO2018007237A2/es unknown
-
2020
- 2020-02-07 US US16/785,417 patent/US11230535B2/en active Active
-
2021
- 2021-08-31 JP JP2021140812A patent/JP7297827B2/ja active Active
- 2021-11-23 US US17/456,368 patent/US20220081402A1/en not_active Abandoned
-
2023
- 2023-05-11 US US18/316,183 patent/US12065412B2/en active Active
-
2024
- 2024-05-31 US US18/731,154 patent/US12391654B2/en active Active
-
2025
- 2025-07-14 US US19/269,026 patent/US20260103446A1/en active Pending
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