JP2019504865A5 - - Google Patents
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- Publication number
- JP2019504865A5 JP2019504865A5 JP2018542754A JP2018542754A JP2019504865A5 JP 2019504865 A5 JP2019504865 A5 JP 2019504865A5 JP 2018542754 A JP2018542754 A JP 2018542754A JP 2018542754 A JP2018542754 A JP 2018542754A JP 2019504865 A5 JP2019504865 A5 JP 2019504865A5
- Authority
- JP
- Japan
- Prior art keywords
- ethanol
- room temperature
- solution
- dihydrophthalazine
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 238000001035 drying Methods 0.000 claims 3
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16000380 | 2016-02-16 | ||
| EP16000380.2 | 2016-02-16 | ||
| PCT/EP2017/000209 WO2017140422A1 (en) | 2016-02-16 | 2017-02-15 | Method for producing a crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504865A JP2019504865A (ja) | 2019-02-21 |
| JP2019504865A5 true JP2019504865A5 (enExample) | 2020-03-26 |
| JP6949856B2 JP6949856B2 (ja) | 2021-10-13 |
Family
ID=55361317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542754A Active JP6949856B2 (ja) | 2016-02-16 | 2017-02-15 | ５−アミノ−２，３−ジヒドロフタラジン−１，４−ジオンの結晶形の製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11203575B2 (enExample) |
| EP (1) | EP3416952B1 (enExample) |
| JP (1) | JP6949856B2 (enExample) |
| KR (1) | KR102535959B1 (enExample) |
| CN (1) | CN109071461B (enExample) |
| CA (1) | CA3011766C (enExample) |
| ES (1) | ES2796476T3 (enExample) |
| WO (1) | WO2017140422A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3511325A1 (en) | 2018-01-11 | 2019-07-17 | MetrioPharm AG | Method for solubilizing 5-amino-2,3-dihydro-1,4-phthalazinedione |
| EP3870175B1 (en) * | 2018-10-26 | 2024-08-28 | Immunopharma Plus D.O.O. | Oral aminodihydrophthalazinedione compositions and their use the treatment of non-viral hepatitis |
| EP3858328A1 (en) * | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the inhalatory treatment of inflammatory pulmonary diseases |
| BR112022019141A2 (pt) * | 2020-03-25 | 2023-01-17 | Metriopharm Ag | 5-amino-2,3-dihidro-1,4-ftalazinadiona para tratamento de lesão pulmonar aguda |
| JP2023529022A (ja) * | 2020-06-10 | 2023-07-06 | メトリオファーム アーゲー | コロナウイルス感染症の治療のための化合物 |
| CA3202852A1 (en) | 2020-12-01 | 2022-06-09 | Reverspah Llc | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis and pulmonary edema, interstitial lung disease, sarcoidosis, idiopathic pulmonary fibrosis, a cute respiratory distress syndrome, and pulmonary arterial hypertension |
| JP2024516340A (ja) * | 2020-12-02 | 2024-04-15 | メトリオファーム アーゲー | Ｓａｒｓ－ｃｏｖ－２感染の後遺症の予防と治療のためのルミノール |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743541A (en) * | 1985-07-17 | 1988-05-10 | Mast Immunosystems, Inc. | Luminescent substrate preparation and its use in specific binding assays |
| FR2839155B1 (fr) * | 2002-04-25 | 2005-02-04 | Roc Imp | Procede pour detecter et localiser des traces de sang et compose pour detecter des traces de sang |
| BRPI0307864B1 (pt) * | 2003-11-25 | 2016-01-12 | Univ Rio De Janeiro | processo para formação de hidrazidas a partir de hidrazinas e ácido dicarboxílicos |
| CN100390152C (zh) * | 2006-03-23 | 2008-05-28 | 潘健 | 一种合成3-硝基或3-氨基邻苯二甲酰肼的方法 |
| PL231885B1 (pl) * | 2009-01-16 | 2019-04-30 | Abidopharma Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wytwarzania soli 5-amino-2,3-dihydroftalazyno-1,4-di onu z metalami alkalicznymi, ich kompozycje farmaceutyczne i ich zastosowanie |
| HRP20140752T1 (hr) * | 2010-03-01 | 2014-10-24 | Metriopharm Ag | Kristalni oblici 5-amino-2,3-dihidroftalazin-1,4-dion natrijeve soli, farmaceutski pripravci koji ih sadrže i postupak za njihovu proizvodnju |
| US20110246075A1 (en) * | 2010-04-01 | 2011-10-06 | Banik Niranjan C | Providing a Transform Function to Produce a Mechanical Property of a Subterranean Structure |
| WO2011123776A2 (en) * | 2010-04-01 | 2011-10-06 | Guthery B Eugene | Method for detecting occult blood |
-
2017
- 2017-02-15 KR KR1020187026714A patent/KR102535959B1/ko active Active
- 2017-02-15 WO PCT/EP2017/000209 patent/WO2017140422A1/en not_active Ceased
- 2017-02-15 CN CN201780023173.7A patent/CN109071461B/zh active Active
- 2017-02-15 ES ES17711562T patent/ES2796476T3/es active Active
- 2017-02-15 JP JP2018542754A patent/JP6949856B2/ja active Active
- 2017-02-15 CA CA3011766A patent/CA3011766C/en active Active
- 2017-02-15 US US15/999,050 patent/US11203575B2/en active Active
- 2017-02-15 EP EP17711562.3A patent/EP3416952B1/en active Active
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