JP2012176989A5 - - Google Patents
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- Publication number
- JP2012176989A5 JP2012176989A5 JP2012137788A JP2012137788A JP2012176989A5 JP 2012176989 A5 JP2012176989 A5 JP 2012176989A5 JP 2012137788 A JP2012137788 A JP 2012137788A JP 2012137788 A JP2012137788 A JP 2012137788A JP 2012176989 A5 JP2012176989 A5 JP 2012176989A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- temperature
- heating
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- -1 (S) -amino-2-hydroxyethyl Chemical group 0.000 claims 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83766106P | 2006-08-14 | 2006-08-14 | |
| US60/837,661 | 2006-08-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524638A Division JP2010500406A (ja) | 2006-08-14 | 2007-08-10 | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012176989A JP2012176989A (ja) | 2012-09-13 |
| JP2012176989A5 true JP2012176989A5 (enExample) | 2012-12-27 |
Family
ID=38895795
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524638A Withdrawn JP2010500406A (ja) | 2006-08-14 | 2007-08-10 | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
| JP2012137788A Withdrawn JP2012176989A (ja) | 2006-08-14 | 2012-06-19 | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
| JP2012247215A Pending JP2013032394A (ja) | 2006-08-14 | 2012-11-09 | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524638A Withdrawn JP2010500406A (ja) | 2006-08-14 | 2007-08-10 | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012247215A Pending JP2013032394A (ja) | 2006-08-14 | 2012-11-09 | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7956189B2 (enExample) |
| EP (1) | EP2069337A1 (enExample) |
| JP (3) | JP2010500406A (enExample) |
| CN (1) | CN101522671A (enExample) |
| AR (1) | AR062373A1 (enExample) |
| CA (1) | CA2660703A1 (enExample) |
| CL (1) | CL2007002366A1 (enExample) |
| MX (1) | MX2009001770A (enExample) |
| PE (1) | PE20080424A1 (enExample) |
| TW (1) | TW200819446A (enExample) |
| WO (1) | WO2008021271A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2393768T3 (es) | 2005-05-26 | 2012-12-27 | Neuron Systems, Inc | Derivado de quinolina para el tratamiento de enfermedades retinianas |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| JP2015524400A (ja) * | 2012-07-19 | 2015-08-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製 |
| HK1217439A1 (zh) | 2013-01-23 | 2017-01-13 | Aldeyra Therapeutics, Inc. | 与毒性醛相关的疾病和治疗 |
| CN118724806A (zh) | 2015-08-21 | 2024-10-01 | 奥尔德拉医疗公司 | 氘化化合物和其用途 |
| AU2018348174A1 (en) | 2017-10-10 | 2020-04-23 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
| AU2019319740A1 (en) | 2018-08-06 | 2021-03-25 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| CA3137301A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CA3175856A1 (en) | 2020-05-13 | 2021-11-18 | Todd Brady | Pharmaceutical formulations and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20060241A1 (es) | 2004-05-18 | 2006-04-01 | Schering Corp | 2-quinolil-oxazoles sustituidos como inhibidores de pde4 |
-
2007
- 2007-08-10 MX MX2009001770A patent/MX2009001770A/es active IP Right Grant
- 2007-08-10 WO PCT/US2007/017848 patent/WO2008021271A1/en not_active Ceased
- 2007-08-10 CN CNA2007800382818A patent/CN101522671A/zh active Pending
- 2007-08-10 CA CA002660703A patent/CA2660703A1/en not_active Abandoned
- 2007-08-10 JP JP2009524638A patent/JP2010500406A/ja not_active Withdrawn
- 2007-08-10 US US11/891,351 patent/US7956189B2/en not_active Expired - Fee Related
- 2007-08-10 EP EP07811264A patent/EP2069337A1/en not_active Withdrawn
- 2007-08-14 TW TW096130026A patent/TW200819446A/zh unknown
- 2007-08-14 AR ARP070103601A patent/AR062373A1/es not_active Application Discontinuation
- 2007-08-14 CL CL200702366A patent/CL2007002366A1/es unknown
- 2007-08-14 PE PE2007001088A patent/PE20080424A1/es not_active Application Discontinuation
-
2012
- 2012-06-19 JP JP2012137788A patent/JP2012176989A/ja not_active Withdrawn
- 2012-11-09 JP JP2012247215A patent/JP2013032394A/ja active Pending