AR062373A1 - Sales maleato, tosilato, fumarato y oxalato de la 5-(1(s)-amino-2-hidroxietil)-n-[(2,4-difluorofenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazol carboxamida y procesos de preparacion para las mismas - Google Patents
Sales maleato, tosilato, fumarato y oxalato de la 5-(1(s)-amino-2-hidroxietil)-n-[(2,4-difluorofenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazol carboxamida y procesos de preparacion para las mismasInfo
- Publication number
- AR062373A1 AR062373A1 ARP070103601A ARP070103601A AR062373A1 AR 062373 A1 AR062373 A1 AR 062373A1 AR P070103601 A ARP070103601 A AR P070103601A AR P070103601 A ARP070103601 A AR P070103601A AR 062373 A1 AR062373 A1 AR 062373A1
- Authority
- AR
- Argentina
- Prior art keywords
- fumarate
- maleate
- oxalate
- quinolin
- hydroxyethyl
- Prior art date
Links
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title abstract 5
- -1 (S) -AMINO-2-HYDROXYETHYL Chemical class 0.000 title abstract 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 title abstract 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 title 1
- 229950004288 tosilate Drugs 0.000 title 1
- 150000003839 salts Chemical group 0.000 abstract 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 abstract 1
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical group C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83766106P | 2006-08-14 | 2006-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062373A1 true AR062373A1 (es) | 2008-11-05 |
Family
ID=38895795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103601A AR062373A1 (es) | 2006-08-14 | 2007-08-14 | Sales maleato, tosilato, fumarato y oxalato de la 5-(1(s)-amino-2-hidroxietil)-n-[(2,4-difluorofenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazol carboxamida y procesos de preparacion para las mismas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7956189B2 (enExample) |
| EP (1) | EP2069337A1 (enExample) |
| JP (3) | JP2010500406A (enExample) |
| CN (1) | CN101522671A (enExample) |
| AR (1) | AR062373A1 (enExample) |
| CA (1) | CA2660703A1 (enExample) |
| CL (1) | CL2007002366A1 (enExample) |
| MX (1) | MX2009001770A (enExample) |
| PE (1) | PE20080424A1 (enExample) |
| TW (1) | TW200819446A (enExample) |
| WO (1) | WO2008021271A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2419610C2 (ru) | 2005-05-26 | 2011-05-27 | Ньюрон Системз, Инк. | Композиции и способы лечения заболевания сетчатки |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| WO2014012859A1 (en) * | 2012-07-19 | 2014-01-23 | Boehringer Ingelheim International Gmbh | Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as medicament and the preparation thereof |
| US9687481B2 (en) | 2013-01-23 | 2017-06-27 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| EP4400106A1 (en) | 2015-08-21 | 2024-07-17 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
| US12006298B2 (en) | 2018-08-06 | 2024-06-11 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CN113784954A (zh) | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100907354B1 (ko) | 2004-05-18 | 2009-07-10 | 쉐링 코포레이션 | Pde4 억제제로서 유용한 치환된 2-퀴놀릴-옥사졸 |
-
2007
- 2007-08-10 EP EP07811264A patent/EP2069337A1/en not_active Withdrawn
- 2007-08-10 MX MX2009001770A patent/MX2009001770A/es active IP Right Grant
- 2007-08-10 WO PCT/US2007/017848 patent/WO2008021271A1/en not_active Ceased
- 2007-08-10 JP JP2009524638A patent/JP2010500406A/ja not_active Withdrawn
- 2007-08-10 CN CNA2007800382818A patent/CN101522671A/zh active Pending
- 2007-08-10 US US11/891,351 patent/US7956189B2/en not_active Expired - Fee Related
- 2007-08-10 CA CA002660703A patent/CA2660703A1/en not_active Abandoned
- 2007-08-14 TW TW096130026A patent/TW200819446A/zh unknown
- 2007-08-14 PE PE2007001088A patent/PE20080424A1/es not_active Application Discontinuation
- 2007-08-14 CL CL200702366A patent/CL2007002366A1/es unknown
- 2007-08-14 AR ARP070103601A patent/AR062373A1/es not_active Application Discontinuation
-
2012
- 2012-06-19 JP JP2012137788A patent/JP2012176989A/ja not_active Withdrawn
- 2012-11-09 JP JP2012247215A patent/JP2013032394A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010500406A (ja) | 2010-01-07 |
| EP2069337A1 (en) | 2009-06-17 |
| JP2013032394A (ja) | 2013-02-14 |
| PE20080424A1 (es) | 2008-04-28 |
| US7956189B2 (en) | 2011-06-07 |
| MX2009001770A (es) | 2009-02-25 |
| CN101522671A (zh) | 2009-09-02 |
| TW200819446A (en) | 2008-05-01 |
| CA2660703A1 (en) | 2008-02-21 |
| CL2007002366A1 (es) | 2008-03-14 |
| WO2008021271A1 (en) | 2008-02-21 |
| JP2012176989A (ja) | 2012-09-13 |
| US20080108818A1 (en) | 2008-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |