AR062373A1 - Sales maleato, tosilato, fumarato y oxalato de la 5-(1(s)-amino-2-hidroxietil)-n-[(2,4-difluorofenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazol carboxamida y procesos de preparacion para las mismas - Google Patents
Sales maleato, tosilato, fumarato y oxalato de la 5-(1(s)-amino-2-hidroxietil)-n-[(2,4-difluorofenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazol carboxamida y procesos de preparacion para las mismasInfo
- Publication number
- AR062373A1 AR062373A1 ARP070103601A ARP070103601A AR062373A1 AR 062373 A1 AR062373 A1 AR 062373A1 AR P070103601 A ARP070103601 A AR P070103601A AR P070103601 A ARP070103601 A AR P070103601A AR 062373 A1 AR062373 A1 AR 062373A1
- Authority
- AR
- Argentina
- Prior art keywords
- fumarate
- maleate
- oxalate
- quinolin
- hydroxyethyl
- Prior art date
Links
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title abstract 5
- -1 (S) -AMINO-2-HYDROXYETHYL Chemical class 0.000 title abstract 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 title abstract 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 title 1
- 229950004288 tosilate Drugs 0.000 title 1
- 150000003839 salts Chemical group 0.000 abstract 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 abstract 1
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical group C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se revelan sales maleato, tosilato, fumarato y oxalato del compuesto 5-(1-(S)-amino-2-hidroxietil)-N-[(2,4-difluoro-fenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazolcarbonamida. Procesos de preparacion de las formas salinas mencionadas. Reivindicacion 1: Una forma salina cristalina del compuesto (1) seleccionada de una sal cristalina maleato monohidrato, forma l, sal cristalina tosilato hidrato, forma l, forma salina cristalina fumarato, y forma salina cristalina oxalato.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83766106P | 2006-08-14 | 2006-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR062373A1 true AR062373A1 (es) | 2008-11-05 |
Family
ID=38895795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103601A AR062373A1 (es) | 2006-08-14 | 2007-08-14 | Sales maleato, tosilato, fumarato y oxalato de la 5-(1(s)-amino-2-hidroxietil)-n-[(2,4-difluorofenil)-metil]-2-[8-metoxi-2-(trifluorometil)-5-quinolin]-4-oxazol carboxamida y procesos de preparacion para las mismas |
Country Status (11)
Country | Link |
---|---|
US (1) | US7956189B2 (es) |
EP (1) | EP2069337A1 (es) |
JP (3) | JP2010500406A (es) |
CN (1) | CN101522671A (es) |
AR (1) | AR062373A1 (es) |
CA (1) | CA2660703A1 (es) |
CL (1) | CL2007002366A1 (es) |
MX (1) | MX2009001770A (es) |
PE (1) | PE20080424A1 (es) |
TW (1) | TW200819446A (es) |
WO (1) | WO2008021271A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1888548B1 (en) | 2005-05-26 | 2012-08-22 | Neuron Systems, Inc | Quinoline derivative for the treatment of retinal diseases |
WO2014012859A1 (en) * | 2012-07-19 | 2014-01-23 | Boehringer Ingelheim International Gmbh | Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as medicament and the preparation thereof |
MX2020003425A (es) | 2017-10-10 | 2020-07-29 | Aldeyra Therapeutics Inc | Tratamiento de trastornos inflamatorios. |
JP2021533154A (ja) * | 2018-08-06 | 2021-12-02 | アルデイラ セラピューティクス, インコーポレイテッド | 多形化合物およびその使用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1984901B (zh) | 2004-05-18 | 2011-02-09 | 先灵公司 | 用作pde4抑制剂的取代的2-喹啉基-*唑 |
-
2007
- 2007-08-10 JP JP2009524638A patent/JP2010500406A/ja not_active Withdrawn
- 2007-08-10 EP EP07811264A patent/EP2069337A1/en not_active Withdrawn
- 2007-08-10 CN CNA2007800382818A patent/CN101522671A/zh active Pending
- 2007-08-10 WO PCT/US2007/017848 patent/WO2008021271A1/en active Application Filing
- 2007-08-10 CA CA002660703A patent/CA2660703A1/en not_active Abandoned
- 2007-08-10 MX MX2009001770A patent/MX2009001770A/es active IP Right Grant
- 2007-08-10 US US11/891,351 patent/US7956189B2/en not_active Expired - Fee Related
- 2007-08-14 CL CL200702366A patent/CL2007002366A1/es unknown
- 2007-08-14 AR ARP070103601A patent/AR062373A1/es not_active Application Discontinuation
- 2007-08-14 PE PE2007001088A patent/PE20080424A1/es not_active Application Discontinuation
- 2007-08-14 TW TW096130026A patent/TW200819446A/zh unknown
-
2012
- 2012-06-19 JP JP2012137788A patent/JP2012176989A/ja not_active Withdrawn
- 2012-11-09 JP JP2012247215A patent/JP2013032394A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TW200819446A (en) | 2008-05-01 |
WO2008021271A1 (en) | 2008-02-21 |
MX2009001770A (es) | 2009-02-25 |
CA2660703A1 (en) | 2008-02-21 |
US20080108818A1 (en) | 2008-05-08 |
CN101522671A (zh) | 2009-09-02 |
EP2069337A1 (en) | 2009-06-17 |
PE20080424A1 (es) | 2008-04-28 |
CL2007002366A1 (es) | 2008-03-14 |
US7956189B2 (en) | 2011-06-07 |
JP2012176989A (ja) | 2012-09-13 |
JP2013032394A (ja) | 2013-02-14 |
JP2010500406A (ja) | 2010-01-07 |
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Legal Events
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FA | Abandonment or withdrawal |