JP2018505199A5 - - Google Patents
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- JP2018505199A5 JP2018505199A5 JP2017542048A JP2017542048A JP2018505199A5 JP 2018505199 A5 JP2018505199 A5 JP 2018505199A5 JP 2017542048 A JP2017542048 A JP 2017542048A JP 2017542048 A JP2017542048 A JP 2017542048A JP 2018505199 A5 JP2018505199 A5 JP 2018505199A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- crystalline
- accordance
- data substantially
- diffraction data
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000012453 solvate Substances 0.000 claims 21
- 238000002447 crystallographic data Methods 0.000 claims 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 239000013078 crystal Substances 0.000 claims 6
- YKYONYBAUNKHLG-UHFFFAOYSA-N propyl acetate Chemical compound CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 2
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 claims 2
- SKTCDJAMAYNROS-UHFFFAOYSA-N methoxycyclopentane Chemical compound COC1CCCC1 SKTCDJAMAYNROS-UHFFFAOYSA-N 0.000 claims 2
- 229940043265 methyl isobutyl ketone Drugs 0.000 claims 2
- 150000004682 monohydrates Chemical group 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 1
- 229940011051 isopropyl acetate Drugs 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical group CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562115674P | 2015-02-13 | 2015-02-13 | |
| US62/115,674 | 2015-02-13 | ||
| PCT/IB2016/050755 WO2016128936A1 (en) | 2015-02-13 | 2016-02-12 | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018505199A JP2018505199A (ja) | 2018-02-22 |
| JP2018505199A5 true JP2018505199A5 (enExample) | 2019-03-22 |
Family
ID=55359562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542048A Pending JP2018505199A (ja) | 2015-02-13 | 2016-02-12 | （Ｓ）−５−ベンジル−Ｎ−（５−メチル−４−オキソ−２，３，４，５テトラヒドロベンゾ［ｂ］［１，４］オキサゼピン−３−イル）−４Ｈ−１，２，４−トリアゾール−３−カルボキサミドの結晶形 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10287280B2 (enExample) |
| EP (1) | EP3256467A1 (enExample) |
| JP (1) | JP2018505199A (enExample) |
| KR (1) | KR20170117472A (enExample) |
| CN (1) | CN107207485A (enExample) |
| AU (1) | AU2016217496B2 (enExample) |
| BR (1) | BR112017017411A2 (enExample) |
| CA (1) | CA2976172A1 (enExample) |
| IL (1) | IL253731A0 (enExample) |
| RU (1) | RU2017131862A (enExample) |
| WO (1) | WO2016128936A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3002542C (en) | 2015-10-23 | 2023-11-28 | Takeda Pharmaceutical Company Limited | Substituted azepin heterocyclic derivatives and compositions thereof useful as rip1 kinase inhibitor |
| MX2018009448A (es) | 2016-02-05 | 2018-11-21 | Denali Therapeutics Inc | Inhibidores de proteina quinasa 1 de interaccion con receptores. |
| ES2912295T3 (es) | 2016-12-09 | 2022-05-25 | Denali Therapeutics Inc | Compuestos útiles como inhibidores de RIPK1 |
| WO2019123219A1 (en) * | 2017-12-20 | 2019-06-27 | Glaxosmithkline Intellectual Property Development Limited | Crystalline salt form of (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide |
| JOP20200278A1 (ar) | 2018-05-03 | 2020-11-03 | Rigel Pharmaceuticals Inc | مركبات تثبيط rip1 وطرق لتحضير واستخدامها |
| MX2020011622A (es) | 2018-05-03 | 2021-02-17 | Rigel Pharmaceuticals Inc | Compuestos inhibidores de rip1 y métodos para preparar y usar los mismos. |
| US20220218719A1 (en) * | 2019-05-17 | 2022-07-14 | Glaxosmithkline Intellectual Property Development Limited | Matrix composition comprising (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide |
| WO2021046437A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Rip1 inhibitory compounds and methods for making and using the same |
| KR102785137B1 (ko) | 2019-09-06 | 2025-03-25 | 리겔 파마슈티칼스, 인크. | Rip1 억제 화합물 및 그를 제조 및 사용하는 방법 |
| EP4055021B1 (en) | 2019-11-07 | 2025-10-08 | Rigel Pharmaceuticals, Inc. | Heterocyclic rip1 inhibitory compounds |
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| TWI824259B (zh) | 2020-07-01 | 2023-12-01 | 美商雷傑製藥公司 | Rip1k抑制劑 |
| AR125587A1 (es) | 2021-03-11 | 2023-08-02 | Rigel Pharmaceuticals Inc | Inhibidores heterocíclicos de la quinasa de rip1 |
| US11999750B2 (en) | 2022-01-12 | 2024-06-04 | Denali Therapeutics Inc. | Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI638815B (zh) * | 2013-02-15 | 2018-10-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類（一） |
-
2016
- 2016-02-12 AU AU2016217496A patent/AU2016217496B2/en not_active Ceased
- 2016-02-12 WO PCT/IB2016/050755 patent/WO2016128936A1/en not_active Ceased
- 2016-02-12 RU RU2017131862A patent/RU2017131862A/ru not_active Application Discontinuation
- 2016-02-12 CA CA2976172A patent/CA2976172A1/en not_active Abandoned
- 2016-02-12 CN CN201680010191.7A patent/CN107207485A/zh active Pending
- 2016-02-12 EP EP16704713.3A patent/EP3256467A1/en not_active Withdrawn
- 2016-02-12 KR KR1020177025358A patent/KR20170117472A/ko not_active Withdrawn
- 2016-02-12 US US15/548,500 patent/US10287280B2/en active Active
- 2016-02-12 BR BR112017017411A patent/BR112017017411A2/pt not_active Application Discontinuation
- 2016-02-12 JP JP2017542048A patent/JP2018505199A/ja active Pending
-
2017
- 2017-07-30 IL IL253731A patent/IL253731A0/en unknown
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