JP2019501875A5 - - Google Patents
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- JP2019501875A5 JP2019501875A5 JP2018524421A JP2018524421A JP2019501875A5 JP 2019501875 A5 JP2019501875 A5 JP 2019501875A5 JP 2018524421 A JP2018524421 A JP 2018524421A JP 2018524421 A JP2018524421 A JP 2018524421A JP 2019501875 A5 JP2019501875 A5 JP 2019501875A5
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- 150000001875 compounds Chemical class 0.000 claims description 32
- 208000024827 Alzheimer disease Diseases 0.000 claims description 12
- 208000012902 Nervous system disease Diseases 0.000 claims description 12
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 10
- 208000025966 Neurological disease Diseases 0.000 claims description 7
- -1 diethylamino, diphenylamino, methyl (phenyl) amino, cyclohexyl (methyl) amino, bis (4-methoxyphenyl) amino, bis (4- (tert-butyl) phenyl) amino Chemical group 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 206010002022 amyloidosis Diseases 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 208000023105 Huntington disease Diseases 0.000 claims description 5
- 208000026072 Motor neurone disease Diseases 0.000 claims description 5
- 208000018737 Parkinson disease Diseases 0.000 claims description 5
- 208000024777 Prion disease Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000005264 motor neuron disease Diseases 0.000 claims description 5
- 206010065040 AIDS dementia complex Diseases 0.000 claims description 4
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims description 4
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 208000030533 eye disease Diseases 0.000 claims description 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 230000000472 traumatic effect Effects 0.000 claims description 4
- 208000023769 AA amyloidosis Diseases 0.000 claims description 3
- 208000023761 AL amyloidosis Diseases 0.000 claims description 3
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims description 3
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 3
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 3
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 3
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 claims description 3
- 201000004176 Gelatinous drop-like corneal dystrophy Diseases 0.000 claims description 3
- 206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims description 3
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims description 3
- 208000002537 Neuronal Ceroid-Lipofuscinoses Diseases 0.000 claims description 3
- 201000007902 Primary cutaneous amyloidosis Diseases 0.000 claims description 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 3
- 201000007891 familial visceral amyloidosis Diseases 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 201000008051 neuronal ceroid lipofuscinosis Diseases 0.000 claims description 3
- 230000004845 protein aggregation Effects 0.000 claims description 3
- 201000007905 transthyretin amyloidosis Diseases 0.000 claims description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 208000031277 Amaurotic familial idiocy Diseases 0.000 claims description 2
- 201000006474 Brain Ischemia Diseases 0.000 claims description 2
- 208000014644 Brain disease Diseases 0.000 claims description 2
- 208000002177 Cataract Diseases 0.000 claims description 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 2
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims description 2
- 201000010374 Down Syndrome Diseases 0.000 claims description 2
- 208000032274 Encephalopathy Diseases 0.000 claims description 2
- 208000024412 Friedreich ataxia Diseases 0.000 claims description 2
- 208000010412 Glaucoma Diseases 0.000 claims description 2
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims description 2
- 208000032382 Ischaemic stroke Diseases 0.000 claims description 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 2
- 201000002832 Lewy body dementia Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000014060 Niemann-Pick disease Diseases 0.000 claims description 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 2
- 208000017442 Retinal disease Diseases 0.000 claims description 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims description 2
- 206010038923 Retinopathy Diseases 0.000 claims description 2
- 206010039966 Senile dementia Diseases 0.000 claims description 2
- 208000002667 Subdural Hematoma Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 208000029028 brain injury Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 206010008118 cerebral infarction Diseases 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 208000017004 dementia pugilistica Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 208000017476 juvenile neuronal ceroid lipofuscinosis Diseases 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 201000007601 neurodegeneration with brain iron accumulation Diseases 0.000 claims description 2
- 201000007607 neuronal ceroid lipofuscinosis 3 Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 210000001685 thyroid gland Anatomy 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 208000019553 vascular disease Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 230000001123 neurodevelopmental effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 208000037196 Medullary thyroid carcinoma Diseases 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 201000000083 maturity-onset diabetes of the young type 1 Diseases 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 208000013818 thyroid gland medullary carcinoma Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562253903P | 2015-11-11 | 2015-11-11 | |
| US62/253,903 | 2015-11-11 | ||
| PCT/US2016/061281 WO2017083488A1 (en) | 2015-11-11 | 2016-11-10 | Benzofuran derivatives for the treatment of cns and other disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501875A JP2019501875A (ja) | 2019-01-24 |
| JP2019501875A5 true JP2019501875A5 (enExample) | 2019-12-26 |
| JP6908805B2 JP6908805B2 (ja) | 2021-07-28 |
Family
ID=58695297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524421A Active JP6908805B2 (ja) | 2015-11-11 | 2016-11-10 | Ｃｎｓおよび他の障害の処置のためのベンゾフラン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10590100B2 (enExample) |
| EP (1) | EP3374354B1 (enExample) |
| JP (1) | JP6908805B2 (enExample) |
| CN (1) | CN108699019B (enExample) |
| AU (1) | AU2016353004B2 (enExample) |
| CA (1) | CA3005212C (enExample) |
| IL (1) | IL259674B (enExample) |
| WO (1) | WO2017083488A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018208712A1 (en) | 2017-05-09 | 2018-11-15 | Warner Babcock Insitute For Green Chemistry, Llc | Stilbene and fused stilbene derivatives as solar cell dyes |
| CN108191966B (zh) * | 2018-01-11 | 2020-10-27 | 桂林医学院 | 一种含导肽可穿越血脑屏障螯合脑内铁降自由基的多肽 |
| EP3820465B1 (en) * | 2018-07-10 | 2025-09-17 | Ambient Photonics, Inc. | Solar cell dyes for copper redox based dye sensitized solar cells and combinations thereof |
| TWI824012B (zh) * | 2019-09-20 | 2023-12-01 | 美商安畢特光學公司 | 用於基於銅氧化還原的染料敏化太陽能電池的太陽能電池染料及其組合 |
| WO2026055841A1 (zh) * | 2024-09-11 | 2026-03-19 | 凯思凯迪(上海)医药科技股份有限公司 | 芳环并杂环类化合物、其制备方法和其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1349453A (en) * | 1918-01-09 | 1920-08-10 | James H Hall | Trap |
| US1348677A (en) * | 1919-10-04 | 1920-08-03 | Claude A Witter | Process of manufacturing metallic shapes |
| US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
| BE787576A (fr) * | 1971-08-13 | 1973-02-14 | Hoechst Ag | Derives de benzofuranne et leur utilisation comme azureurs optiques |
| LU85544A1 (fr) * | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5350395A (en) | 1986-04-15 | 1994-09-27 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5061273A (en) | 1989-06-01 | 1991-10-29 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
| JPS63139180A (ja) | 1986-12-02 | 1988-06-10 | Tanabe Seiyaku Co Ltd | カルボン酸誘導体 |
| US4748982A (en) | 1987-01-06 | 1988-06-07 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
| US5674278A (en) | 1989-08-24 | 1997-10-07 | Arterial Vascular Engineering, Inc. | Endovascular support device |
| US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
| US5292331A (en) | 1989-08-24 | 1994-03-08 | Applied Vascular Engineering, Inc. | Endovascular support device |
| US6774248B2 (en) * | 2001-12-18 | 2004-08-10 | Wyeth | Substituted 2-phenyl benzofurans as estrogenic agents |
| CA2549736A1 (en) | 2003-12-05 | 2005-06-23 | The University Of North Carolina At Chapel Hill | Cationic substituted benzofurans as antimicrobial agents |
| US7473786B1 (en) * | 2003-12-05 | 2009-01-06 | University Of Massachusetts | Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts |
| SE0403006D0 (sv) * | 2004-12-09 | 2004-12-09 | Biovitrum Ab | New compounds |
| GB0505725D0 (en) * | 2005-03-19 | 2005-04-27 | Merck Sharp & Dohme | Therapeutic agents |
| AU2007209981B2 (en) | 2006-02-01 | 2011-11-24 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| TW200930369A (en) * | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| US20090163586A1 (en) * | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| JP2012184224A (ja) * | 2011-02-17 | 2012-09-27 | Toho Univ Foundation | アミロイドβタンパク質凝集阻害活性を有する化合物又はその薬理学的に許容し得る塩及びその製造方法、並びに、その用途 |
| WO2013040528A1 (en) * | 2011-09-16 | 2013-03-21 | Microbiotix, Inc. | Antimicrobial compounds |
| CN102627620B (zh) * | 2012-04-10 | 2015-12-16 | 江苏先声药物研究有限公司 | 一类苯并呋喃衍生物及其医药应用 |
| AU2013323198B2 (en) * | 2012-09-28 | 2018-03-29 | Srinivasa R. Cheruku | Dihydro-6-azaphenalene derivatives for the treatment of CNS, oncological diseases and related disorders |
-
2016
- 2016-11-10 AU AU2016353004A patent/AU2016353004B2/en active Active
- 2016-11-10 WO PCT/US2016/061281 patent/WO2017083488A1/en not_active Ceased
- 2016-11-10 CN CN201680078656.2A patent/CN108699019B/zh active Active
- 2016-11-10 US US15/774,638 patent/US10590100B2/en active Active
- 2016-11-10 JP JP2018524421A patent/JP6908805B2/ja active Active
- 2016-11-10 CA CA3005212A patent/CA3005212C/en active Active
- 2016-11-10 EP EP16864979.6A patent/EP3374354B1/en active Active
-
2018
- 2018-05-29 IL IL259674A patent/IL259674B/en unknown