JP6908805B2 - Cnsおよび他の障害の処置のためのベンゾフラン誘導体 - Google Patents
Cnsおよび他の障害の処置のためのベンゾフラン誘導体 Download PDFInfo
- Publication number
- JP6908805B2 JP6908805B2 JP2018524421A JP2018524421A JP6908805B2 JP 6908805 B2 JP6908805 B2 JP 6908805B2 JP 2018524421 A JP2018524421 A JP 2018524421A JP 2018524421 A JP2018524421 A JP 2018524421A JP 6908805 B2 JP6908805 B2 JP 6908805B2
- Authority
- JP
- Japan
- Prior art keywords
- disease
- acid
- benzofuran
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- BGMHQBQFJYJLBP-UHFFFAOYSA-N C#Cc1ccc(C=O)cc1 Chemical compound C#Cc1ccc(C=O)cc1 BGMHQBQFJYJLBP-UHFFFAOYSA-N 0.000 description 1
- UWSVFBNNDUTQJJ-NBVRZTHBSA-N N#C/C(/C(O)=O)=C\c1cc(ccc(N(c2ccccc2)c2ccccc2)c2)c2[o]1 Chemical compound N#C/C(/C(O)=O)=C\c1cc(ccc(N(c2ccccc2)c2ccccc2)c2)c2[o]1 UWSVFBNNDUTQJJ-NBVRZTHBSA-N 0.000 description 1
- RRXIHZIUIMXWFJ-UHFFFAOYSA-N O=Cc([o]c1c2)cc1ccc2N(c1ccccc1)c1ccccc1 Chemical compound O=Cc([o]c1c2)cc1ccc2N(c1ccccc1)c1ccccc1 RRXIHZIUIMXWFJ-UHFFFAOYSA-N 0.000 description 1
- TXKMLUZHAIOPLP-UHFFFAOYSA-N O=Cc1cc([o]c(-c(cc2)ccc2N(c2ccccc2)c2ccccc2)c2)c2cc1 Chemical compound O=Cc1cc([o]c(-c(cc2)ccc2N(c2ccccc2)c2ccccc2)c2)c2cc1 TXKMLUZHAIOPLP-UHFFFAOYSA-N 0.000 description 1
- SICPTFNYPXUZGC-UHFFFAOYSA-N O=Cc1cc([o]c(-c(cc2)ccc2Oc2ccccc2)c2)c2cc1 Chemical compound O=Cc1cc([o]c(-c(cc2)ccc2Oc2ccccc2)c2)c2cc1 SICPTFNYPXUZGC-UHFFFAOYSA-N 0.000 description 1
- PUIQXFBKSHAJBE-LDADJPATSA-N OC(/C=C/c1cc([o]c(-c(cc2)ccc2N(c2ccccc2)c2ccccc2)c2)c2cc1)=O Chemical compound OC(/C=C/c1cc([o]c(-c(cc2)ccc2N(c2ccccc2)c2ccccc2)c2)c2cc1)=O PUIQXFBKSHAJBE-LDADJPATSA-N 0.000 description 1
- BOMLEQWNZHDJIH-UHFFFAOYSA-N Oc(cc(cc1)N(c2ccccc2)c2ccccc2)c1C#Cc1ccc(C=O)cc1 Chemical compound Oc(cc(cc1)N(c2ccccc2)c2ccccc2)c1C#Cc1ccc(C=O)cc1 BOMLEQWNZHDJIH-UHFFFAOYSA-N 0.000 description 1
- RIZBEUADFVKQHL-UHFFFAOYSA-N Oc(cc(cc1)N(c2ccccc2)c2ccccc2)c1I Chemical compound Oc(cc(cc1)N(c2ccccc2)c2ccccc2)c1I RIZBEUADFVKQHL-UHFFFAOYSA-N 0.000 description 1
- PLALNMFIFWIUFQ-UHFFFAOYSA-N Oc1cc(N(c2ccccc2)c2ccccc2)ccc1 Chemical compound Oc1cc(N(c2ccccc2)c2ccccc2)ccc1 PLALNMFIFWIUFQ-UHFFFAOYSA-N 0.000 description 1
- FYCFTXYOSAXZGF-UHFFFAOYSA-N Oc1cc(N(c2ccccc2)c2ccccc2)ccc1C=O Chemical compound Oc1cc(N(c2ccccc2)c2ccccc2)ccc1C=O FYCFTXYOSAXZGF-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562253903P | 2015-11-11 | 2015-11-11 | |
| US62/253,903 | 2015-11-11 | ||
| PCT/US2016/061281 WO2017083488A1 (en) | 2015-11-11 | 2016-11-10 | Benzofuran derivatives for the treatment of cns and other disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501875A JP2019501875A (ja) | 2019-01-24 |
| JP2019501875A5 JP2019501875A5 (enExample) | 2019-12-26 |
| JP6908805B2 true JP6908805B2 (ja) | 2021-07-28 |
Family
ID=58695297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524421A Active JP6908805B2 (ja) | 2015-11-11 | 2016-11-10 | Cnsおよび他の障害の処置のためのベンゾフラン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10590100B2 (enExample) |
| EP (1) | EP3374354B1 (enExample) |
| JP (1) | JP6908805B2 (enExample) |
| CN (1) | CN108699019B (enExample) |
| AU (1) | AU2016353004B2 (enExample) |
| CA (1) | CA3005212C (enExample) |
| IL (1) | IL259674B (enExample) |
| WO (1) | WO2017083488A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018208712A1 (en) | 2017-05-09 | 2018-11-15 | Warner Babcock Insitute For Green Chemistry, Llc | Stilbene and fused stilbene derivatives as solar cell dyes |
| CN108191966B (zh) * | 2018-01-11 | 2020-10-27 | 桂林医学院 | 一种含导肽可穿越血脑屏障螯合脑内铁降自由基的多肽 |
| EP3820465B1 (en) * | 2018-07-10 | 2025-09-17 | Ambient Photonics, Inc. | Solar cell dyes for copper redox based dye sensitized solar cells and combinations thereof |
| TWI824012B (zh) * | 2019-09-20 | 2023-12-01 | 美商安畢特光學公司 | 用於基於銅氧化還原的染料敏化太陽能電池的太陽能電池染料及其組合 |
| WO2026055841A1 (zh) * | 2024-09-11 | 2026-03-19 | 凯思凯迪(上海)医药科技股份有限公司 | 芳环并杂环类化合物、其制备方法和其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1349453A (en) * | 1918-01-09 | 1920-08-10 | James H Hall | Trap |
| US1348677A (en) * | 1919-10-04 | 1920-08-03 | Claude A Witter | Process of manufacturing metallic shapes |
| US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
| BE787576A (fr) * | 1971-08-13 | 1973-02-14 | Hoechst Ag | Derives de benzofuranne et leur utilisation comme azureurs optiques |
| LU85544A1 (fr) * | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5350395A (en) | 1986-04-15 | 1994-09-27 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5061273A (en) | 1989-06-01 | 1991-10-29 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
| JPS63139180A (ja) | 1986-12-02 | 1988-06-10 | Tanabe Seiyaku Co Ltd | カルボン酸誘導体 |
| US4748982A (en) | 1987-01-06 | 1988-06-07 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
| US5674278A (en) | 1989-08-24 | 1997-10-07 | Arterial Vascular Engineering, Inc. | Endovascular support device |
| US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
| US5292331A (en) | 1989-08-24 | 1994-03-08 | Applied Vascular Engineering, Inc. | Endovascular support device |
| US6774248B2 (en) * | 2001-12-18 | 2004-08-10 | Wyeth | Substituted 2-phenyl benzofurans as estrogenic agents |
| CA2549736A1 (en) | 2003-12-05 | 2005-06-23 | The University Of North Carolina At Chapel Hill | Cationic substituted benzofurans as antimicrobial agents |
| US7473786B1 (en) * | 2003-12-05 | 2009-01-06 | University Of Massachusetts | Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts |
| SE0403006D0 (sv) * | 2004-12-09 | 2004-12-09 | Biovitrum Ab | New compounds |
| GB0505725D0 (en) * | 2005-03-19 | 2005-04-27 | Merck Sharp & Dohme | Therapeutic agents |
| AU2007209981B2 (en) | 2006-02-01 | 2011-11-24 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| TW200930369A (en) * | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| US20090163586A1 (en) * | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| JP2012184224A (ja) * | 2011-02-17 | 2012-09-27 | Toho Univ Foundation | アミロイドβタンパク質凝集阻害活性を有する化合物又はその薬理学的に許容し得る塩及びその製造方法、並びに、その用途 |
| WO2013040528A1 (en) * | 2011-09-16 | 2013-03-21 | Microbiotix, Inc. | Antimicrobial compounds |
| CN102627620B (zh) * | 2012-04-10 | 2015-12-16 | 江苏先声药物研究有限公司 | 一类苯并呋喃衍生物及其医药应用 |
| AU2013323198B2 (en) * | 2012-09-28 | 2018-03-29 | Srinivasa R. Cheruku | Dihydro-6-azaphenalene derivatives for the treatment of CNS, oncological diseases and related disorders |
-
2016
- 2016-11-10 AU AU2016353004A patent/AU2016353004B2/en active Active
- 2016-11-10 WO PCT/US2016/061281 patent/WO2017083488A1/en not_active Ceased
- 2016-11-10 CN CN201680078656.2A patent/CN108699019B/zh active Active
- 2016-11-10 US US15/774,638 patent/US10590100B2/en active Active
- 2016-11-10 JP JP2018524421A patent/JP6908805B2/ja active Active
- 2016-11-10 CA CA3005212A patent/CA3005212C/en active Active
- 2016-11-10 EP EP16864979.6A patent/EP3374354B1/en active Active
-
2018
- 2018-05-29 IL IL259674A patent/IL259674B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019501875A (ja) | 2019-01-24 |
| IL259674B (en) | 2021-07-29 |
| US10590100B2 (en) | 2020-03-17 |
| EP3374354B1 (en) | 2022-09-28 |
| IL259674A (en) | 2018-07-31 |
| CN108699019A (zh) | 2018-10-23 |
| EP3374354A1 (en) | 2018-09-19 |
| CA3005212C (en) | 2024-01-23 |
| WO2017083488A1 (en) | 2017-05-18 |
| AU2016353004B2 (en) | 2020-11-05 |
| EP3374354A4 (en) | 2019-07-17 |
| AU2016353004A1 (en) | 2018-06-14 |
| CA3005212A1 (en) | 2017-05-18 |
| US20180346433A1 (en) | 2018-12-06 |
| CN108699019B (zh) | 2022-05-10 |
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