JP2012505162A5 - - Google Patents
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- Publication number
- JP2012505162A5 JP2012505162A5 JP2011530339A JP2011530339A JP2012505162A5 JP 2012505162 A5 JP2012505162 A5 JP 2012505162A5 JP 2011530339 A JP2011530339 A JP 2011530339A JP 2011530339 A JP2011530339 A JP 2011530339A JP 2012505162 A5 JP2012505162 A5 JP 2012505162A5
- Authority
- JP
- Japan
- Prior art keywords
- macular degeneration
- therapy
- subject
- alkyl
- vegf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002780 macular degeneration Diseases 0.000 claims description 23
- 238000002560 therapeutic procedure Methods 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 208000035475 disorder Diseases 0.000 claims description 12
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 10
- 229940127557 pharmaceutical product Drugs 0.000 claims description 10
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 9
- 238000012014 optical coherence tomography Methods 0.000 claims description 8
- -1 scyllo-inositol compound Chemical class 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000002252 acyl group Chemical group 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 239000003981 vehicle Substances 0.000 claims description 6
- 108010041308 Endothelial Growth Factors Proteins 0.000 claims description 5
- 230000002137 anti-vascular effect Effects 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 230000000649 photocoagulation Effects 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 238000002428 photodynamic therapy Methods 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 3
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 3
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical group COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 claims description 2
- 201000004569 Blindness Diseases 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 230000000740 bleeding effect Effects 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 229940076783 lucentis Drugs 0.000 claims description 2
- 229940092110 macugen Drugs 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims description 2
- 230000002207 retinal effect Effects 0.000 claims description 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 2
- 230000004393 visual impairment Effects 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 150000002431 hydrogen Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 210000003161 choroid Anatomy 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10409408P | 2008-10-09 | 2008-10-09 | |
| US61/104,094 | 2008-10-09 | ||
| PCT/CA2009/001448 WO2010040232A1 (en) | 2008-10-09 | 2009-10-09 | Use of scyllo-inositols for the treatment of macular degeneration-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012505162A JP2012505162A (ja) | 2012-03-01 |
| JP2012505162A5 true JP2012505162A5 (enExample) | 2012-11-22 |
Family
ID=42099427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530339A Pending JP2012505162A (ja) | 2008-10-09 | 2009-10-09 | 黄斑変性症関連障害を処置するためのｓｃｙｌｌｏ−イノシトールの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100093648A1 (enExample) |
| EP (1) | EP2349233A4 (enExample) |
| JP (1) | JP2012505162A (enExample) |
| AU (1) | AU2009301603A1 (enExample) |
| CA (1) | CA2740124A1 (enExample) |
| WO (1) | WO2010040232A1 (enExample) |
| ZA (1) | ZA201102640B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| EP2044951A1 (en) | 2007-10-02 | 2009-04-08 | Merz Pharma GmbH & Co. KGaA | The use of substances for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases |
| US20210121430A1 (en) | 2011-07-18 | 2021-04-29 | Prn Physician Recommended Nutriceuticals, Llc | Omega-3 fatty acid supplementation for use in treating dry eye |
| US9115078B2 (en) | 2011-07-18 | 2015-08-25 | Physicians Recommended Nutriceuticals, Llc | Compositions for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands |
| US9381183B2 (en) | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US10709680B2 (en) | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
| PT3858405T (pt) | 2012-06-01 | 2023-06-26 | Novartis Ag | Seringa |
| TW201412325A (zh) | 2012-06-20 | 2014-04-01 | 梅茲製藥有限兩合公司 | 用於治療患有青光眼及其他退化性眼疾之人類視力喪失的間隔醫療 |
| CN103070992B (zh) * | 2013-01-11 | 2014-07-02 | 管学刚 | 一种治疗高度近视黄斑出血药物 |
| CA2939121C (en) | 2014-01-28 | 2020-11-24 | Mayo Foundation For Medical Education And Research | Effective treatment of osteoarthritis, pulmonary disease, ophthalmic disease, and atherosclerosis by removing senescent cells at the site of the disease |
| WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US9173915B1 (en) | 2014-10-10 | 2015-11-03 | Peter F. Kador | Antioxidant eye drops |
| EP3233174B1 (en) | 2014-12-19 | 2021-03-31 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
| RU2718065C2 (ru) * | 2016-02-15 | 2020-03-30 | Кемин Индастриз, Инк. | Положительно заряженные липосомы в качестве липофильных молекул-носителей |
| WO2019213462A1 (en) * | 2018-05-03 | 2019-11-07 | Normoxys, Inc. | Inositol-based immunotherapies |
| WO2022155242A1 (en) * | 2021-01-12 | 2022-07-21 | The Regents Of The University Of Michigan | Treatment and prevention of dry macular degeneration |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4515722A (en) * | 1982-03-30 | 1985-05-07 | Merck & Co., Inc. | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents |
| US4474806A (en) * | 1982-05-10 | 1984-10-02 | Merck & Co., Inc. | Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents |
| US4952396A (en) * | 1986-11-19 | 1990-08-28 | Linus Pauling Institute Of Science & Medicine | Method of using phytic acid for inhibiting tumor growth |
| US4758430A (en) * | 1987-01-21 | 1988-07-19 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| SE8904355D0 (sv) * | 1989-12-21 | 1989-12-21 | Perstorp Ab | Medicament |
| US5217959A (en) * | 1990-09-06 | 1993-06-08 | Robert Sabin | Method of treating multiple sclerosis with phytic acid |
| US5112814A (en) * | 1990-10-24 | 1992-05-12 | Robert Sabin | Method of treatment of Parkinson's disease using phytic acid |
| KR0185215B1 (ko) * | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| SE9102068L (sv) * | 1991-07-03 | 1993-01-04 | Perstorp Ab | Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav |
| SE469260B (sv) * | 1992-02-25 | 1993-06-14 | Perstorp Ab | En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat |
| NZ256610A (en) * | 1992-10-05 | 1997-03-24 | Virginia Tech Intell Prop | Synthesis of epoxydiol intermediates in the preparation of inositols and inosose; epoxydiols |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| DK0619369T3 (da) * | 1993-04-05 | 2003-10-06 | Aveve Nv | Phytathydrolyse og enzymsammensætning til hydrolyse af phytat |
| ATE176779T1 (de) * | 1993-08-11 | 1999-03-15 | Hokko Chem Ind Co | Verfahren zur herstellung von d-chiro inositol |
| SE502574C2 (sv) * | 1994-01-25 | 1995-11-13 | Perstorp Ab | En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat |
| US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| US6232486B1 (en) * | 1996-06-11 | 2001-05-15 | Nutrimed Biotech | Molecular probes and modulators for PI-PLC and PI 3-kinase |
| US5977078A (en) * | 1996-09-20 | 1999-11-02 | The Regents Of The Univesity Of California | Inositol polyphosphate derivatives and methods of using same |
| US5880099A (en) * | 1996-09-20 | 1999-03-09 | The Regents Of The University Of California | Inositol polyphosphates and methods of using same |
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| US6153603A (en) * | 1997-06-27 | 2000-11-28 | Perstorp Ab | Method of treating angiogenesis in tumor tissue |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| US6818430B1 (en) * | 1999-06-07 | 2004-11-16 | Hokko Chemical Industry Co., Ltd. | Process for producing L-epi-2-inosose and novel process for producing epi-inositol |
| US6329256B1 (en) * | 1999-09-24 | 2001-12-11 | Advanced Micro Devices, Inc. | Self-aligned damascene gate formation with low gate resistance |
| JP2003511094A (ja) * | 1999-10-18 | 2003-03-25 | マッスルテク リサーチ アンド ディヴェロプメント インコーポレーション | 無脂肪体重及び体力を増強するための食物補充物質 |
| US6887898B1 (en) * | 1999-10-22 | 2005-05-03 | Darrick S. H. L. Kim | Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease |
| US7728043B2 (en) * | 1999-10-22 | 2010-06-01 | Kim Darrick S H L | Methods for treatment of beta-amyloid protein-induced ocular disease |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| DE10031955A1 (de) * | 2000-06-30 | 2002-01-17 | Deutsches Krebsforsch | Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel |
| US7060695B2 (en) * | 2001-02-06 | 2006-06-13 | Qlt, Inc. | Method to prevent vision loss |
| CA2437563C (en) * | 2001-02-06 | 2010-03-23 | Qlt Inc. | Photodynamic therapy of occult age-related macular degeneration |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| US6599891B2 (en) * | 2001-07-20 | 2003-07-29 | Qlt Inc. | Treatment of macular edema |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| DK2058390T3 (da) * | 2003-10-14 | 2013-05-06 | Hokko Chem Ind Co | Fremgangsmåde til fremstilling af scyllo-inositol |
| JP2008504372A (ja) * | 2004-06-18 | 2008-02-14 | ニューロケム （インターナショナル） リミティッド | β−アミロイド関連疾患の治療のための治療用製剤 |
| ZA200704872B (en) * | 2004-11-17 | 2008-12-31 | Mclaurin Joanne | Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation |
| EP2656839A1 (en) * | 2007-04-12 | 2013-10-30 | Waratah Pharmaceuticals, Inc. | Use of Cyclohexanehexol Derivatives in the Treatment of Ocular Diseases |
-
2009
- 2009-10-09 CA CA2740124A patent/CA2740124A1/en not_active Abandoned
- 2009-10-09 AU AU2009301603A patent/AU2009301603A1/en not_active Abandoned
- 2009-10-09 US US12/576,957 patent/US20100093648A1/en not_active Abandoned
- 2009-10-09 JP JP2011530339A patent/JP2012505162A/ja active Pending
- 2009-10-09 EP EP09818730A patent/EP2349233A4/en not_active Withdrawn
- 2009-10-09 WO PCT/CA2009/001448 patent/WO2010040232A1/en not_active Ceased
-
2011
- 2011-04-08 ZA ZA2011/02640A patent/ZA201102640B/en unknown
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