AU2009301603A1 - Use of scyllo-inositols for the treatment of macular degeneration-related disorders - Google Patents
Use of scyllo-inositols for the treatment of macular degeneration-related disorders Download PDFInfo
- Publication number
- AU2009301603A1 AU2009301603A1 AU2009301603A AU2009301603A AU2009301603A1 AU 2009301603 A1 AU2009301603 A1 AU 2009301603A1 AU 2009301603 A AU2009301603 A AU 2009301603A AU 2009301603 A AU2009301603 A AU 2009301603A AU 2009301603 A1 AU2009301603 A1 AU 2009301603A1
- Authority
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- Australia
- Prior art keywords
- scyllo
- macular degeneration
- subject
- inositol
- inositol compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229960003895 verteporfin Drugs 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 229940061392 visudyne Drugs 0.000 description 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 description 1
- 208000020938 vitelliform macular dystrophy 2 Diseases 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 208000000318 vitreous detachment Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
- 150000003735 xanthophylls Chemical class 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10409408P | 2008-10-09 | 2008-10-09 | |
| US61/104,094 | 2008-10-09 | ||
| PCT/CA2009/001448 WO2010040232A1 (en) | 2008-10-09 | 2009-10-09 | Use of scyllo-inositols for the treatment of macular degeneration-related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2009301603A1 true AU2009301603A1 (en) | 2010-04-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009301603A Abandoned AU2009301603A1 (en) | 2008-10-09 | 2009-10-09 | Use of scyllo-inositols for the treatment of macular degeneration-related disorders |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100093648A1 (enExample) |
| EP (1) | EP2349233A4 (enExample) |
| JP (1) | JP2012505162A (enExample) |
| AU (1) | AU2009301603A1 (enExample) |
| CA (1) | CA2740124A1 (enExample) |
| WO (1) | WO2010040232A1 (enExample) |
| ZA (1) | ZA201102640B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| EP2044951A1 (en) | 2007-10-02 | 2009-04-08 | Merz Pharma GmbH & Co. KGaA | The use of substances for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases |
| US20210121430A1 (en) | 2011-07-18 | 2021-04-29 | Prn Physician Recommended Nutriceuticals, Llc | Omega-3 fatty acid supplementation for use in treating dry eye |
| US9115078B2 (en) | 2011-07-18 | 2015-08-25 | Physicians Recommended Nutriceuticals, Llc | Compositions for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands |
| US9381183B2 (en) | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US10709680B2 (en) | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
| PT3858405T (pt) | 2012-06-01 | 2023-06-26 | Novartis Ag | Seringa |
| TW201412325A (zh) | 2012-06-20 | 2014-04-01 | 梅茲製藥有限兩合公司 | 用於治療患有青光眼及其他退化性眼疾之人類視力喪失的間隔醫療 |
| CN103070992B (zh) * | 2013-01-11 | 2014-07-02 | 管学刚 | 一种治疗高度近视黄斑出血药物 |
| CA2939121C (en) | 2014-01-28 | 2020-11-24 | Mayo Foundation For Medical Education And Research | Effective treatment of osteoarthritis, pulmonary disease, ophthalmic disease, and atherosclerosis by removing senescent cells at the site of the disease |
| WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US9173915B1 (en) | 2014-10-10 | 2015-11-03 | Peter F. Kador | Antioxidant eye drops |
| EP3233174B1 (en) | 2014-12-19 | 2021-03-31 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
| RU2718065C2 (ru) * | 2016-02-15 | 2020-03-30 | Кемин Индастриз, Инк. | Положительно заряженные липосомы в качестве липофильных молекул-носителей |
| WO2019213462A1 (en) * | 2018-05-03 | 2019-11-07 | Normoxys, Inc. | Inositol-based immunotherapies |
| WO2022155242A1 (en) * | 2021-01-12 | 2022-07-21 | The Regents Of The University Of Michigan | Treatment and prevention of dry macular degeneration |
Family Cites Families (45)
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| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4515722A (en) * | 1982-03-30 | 1985-05-07 | Merck & Co., Inc. | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents |
| US4474806A (en) * | 1982-05-10 | 1984-10-02 | Merck & Co., Inc. | Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents |
| US4952396A (en) * | 1986-11-19 | 1990-08-28 | Linus Pauling Institute Of Science & Medicine | Method of using phytic acid for inhibiting tumor growth |
| US4758430A (en) * | 1987-01-21 | 1988-07-19 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| SE8904355D0 (sv) * | 1989-12-21 | 1989-12-21 | Perstorp Ab | Medicament |
| US5217959A (en) * | 1990-09-06 | 1993-06-08 | Robert Sabin | Method of treating multiple sclerosis with phytic acid |
| US5112814A (en) * | 1990-10-24 | 1992-05-12 | Robert Sabin | Method of treatment of Parkinson's disease using phytic acid |
| KR0185215B1 (ko) * | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| SE9102068L (sv) * | 1991-07-03 | 1993-01-04 | Perstorp Ab | Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav |
| SE469260B (sv) * | 1992-02-25 | 1993-06-14 | Perstorp Ab | En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat |
| NZ256610A (en) * | 1992-10-05 | 1997-03-24 | Virginia Tech Intell Prop | Synthesis of epoxydiol intermediates in the preparation of inositols and inosose; epoxydiols |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| DK0619369T3 (da) * | 1993-04-05 | 2003-10-06 | Aveve Nv | Phytathydrolyse og enzymsammensætning til hydrolyse af phytat |
| ATE176779T1 (de) * | 1993-08-11 | 1999-03-15 | Hokko Chem Ind Co | Verfahren zur herstellung von d-chiro inositol |
| SE502574C2 (sv) * | 1994-01-25 | 1995-11-13 | Perstorp Ab | En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat |
| US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| US6232486B1 (en) * | 1996-06-11 | 2001-05-15 | Nutrimed Biotech | Molecular probes and modulators for PI-PLC and PI 3-kinase |
| US5977078A (en) * | 1996-09-20 | 1999-11-02 | The Regents Of The Univesity Of California | Inositol polyphosphate derivatives and methods of using same |
| US5880099A (en) * | 1996-09-20 | 1999-03-09 | The Regents Of The University Of California | Inositol polyphosphates and methods of using same |
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| US6153603A (en) * | 1997-06-27 | 2000-11-28 | Perstorp Ab | Method of treating angiogenesis in tumor tissue |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| US6818430B1 (en) * | 1999-06-07 | 2004-11-16 | Hokko Chemical Industry Co., Ltd. | Process for producing L-epi-2-inosose and novel process for producing epi-inositol |
| US6329256B1 (en) * | 1999-09-24 | 2001-12-11 | Advanced Micro Devices, Inc. | Self-aligned damascene gate formation with low gate resistance |
| JP2003511094A (ja) * | 1999-10-18 | 2003-03-25 | マッスルテク リサーチ アンド ディヴェロプメント インコーポレーション | 無脂肪体重及び体力を増強するための食物補充物質 |
| US6887898B1 (en) * | 1999-10-22 | 2005-05-03 | Darrick S. H. L. Kim | Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease |
| US7728043B2 (en) * | 1999-10-22 | 2010-06-01 | Kim Darrick S H L | Methods for treatment of beta-amyloid protein-induced ocular disease |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| DE10031955A1 (de) * | 2000-06-30 | 2002-01-17 | Deutsches Krebsforsch | Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel |
| US7060695B2 (en) * | 2001-02-06 | 2006-06-13 | Qlt, Inc. | Method to prevent vision loss |
| CA2437563C (en) * | 2001-02-06 | 2010-03-23 | Qlt Inc. | Photodynamic therapy of occult age-related macular degeneration |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| US6599891B2 (en) * | 2001-07-20 | 2003-07-29 | Qlt Inc. | Treatment of macular edema |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| DK2058390T3 (da) * | 2003-10-14 | 2013-05-06 | Hokko Chem Ind Co | Fremgangsmåde til fremstilling af scyllo-inositol |
| JP2008504372A (ja) * | 2004-06-18 | 2008-02-14 | ニューロケム （インターナショナル） リミティッド | β−アミロイド関連疾患の治療のための治療用製剤 |
| ZA200704872B (en) * | 2004-11-17 | 2008-12-31 | Mclaurin Joanne | Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation |
| EP2656839A1 (en) * | 2007-04-12 | 2013-10-30 | Waratah Pharmaceuticals, Inc. | Use of Cyclohexanehexol Derivatives in the Treatment of Ocular Diseases |
-
2009
- 2009-10-09 CA CA2740124A patent/CA2740124A1/en not_active Abandoned
- 2009-10-09 AU AU2009301603A patent/AU2009301603A1/en not_active Abandoned
- 2009-10-09 US US12/576,957 patent/US20100093648A1/en not_active Abandoned
- 2009-10-09 JP JP2011530339A patent/JP2012505162A/ja active Pending
- 2009-10-09 EP EP09818730A patent/EP2349233A4/en not_active Withdrawn
- 2009-10-09 WO PCT/CA2009/001448 patent/WO2010040232A1/en not_active Ceased
-
2011
- 2011-04-08 ZA ZA2011/02640A patent/ZA201102640B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010040232A1 (en) | 2010-04-15 |
| EP2349233A4 (en) | 2012-04-18 |
| US20100093648A1 (en) | 2010-04-15 |
| ZA201102640B (en) | 2012-09-26 |
| CA2740124A1 (en) | 2010-04-15 |
| JP2012505162A (ja) | 2012-03-01 |
| EP2349233A1 (en) | 2011-08-03 |
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Legal Events
| Date | Code | Title | Description |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |