JP2021518844A5 - - Google Patents

Info

Publication number
JP2021518844A5
JP2021518844A5 JP2020551340A JP2020551340A JP2021518844A5 JP 2021518844 A5 JP2021518844 A5 JP 2021518844A5 JP 2020551340 A JP2020551340 A JP 2020551340A JP 2020551340 A JP2020551340 A JP 2020551340A JP 2021518844 A5 JP2021518844 A5 JP 2021518844A5
Authority
JP
Japan
Prior art keywords
optionally substituted
pharmaceutically acceptable
acceptable salt
seizures
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020551340A
Other languages
English (en)
Japanese (ja)
Other versions
JP7757036B2 (ja
JP2021518844A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/023039 external-priority patent/WO2019183148A1/en
Publication of JP2021518844A publication Critical patent/JP2021518844A/ja
Publication of JP2021518844A5 publication Critical patent/JP2021518844A5/ja
Priority to JP2023195267A priority Critical patent/JP2024026104A/ja
Application granted granted Critical
Publication of JP7757036B2 publication Critical patent/JP7757036B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020551340A 2018-03-19 2019-03-19 Ｋｖ７チャネル活性化剤の構成および使用方法 Active JP7757036B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023195267A JP2024026104A (ja) 2018-03-19 2023-11-16 Ｋｖ７チャネル活性化剤の構成および使用方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862644932P 2018-03-19 2018-03-19
US201862644902P 2018-03-19 2018-03-19
US62/644,932 2018-03-19
US62/644,902 2018-03-19
US201862663438P 2018-04-27 2018-04-27
US62/663,438 2018-04-27
US201862697198P 2018-07-12 2018-07-12
US62/697,198 2018-07-12
PCT/US2019/023039 WO2019183148A1 (en) 2018-03-19 2019-03-19 Kv7 channel activators compositions and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023195267A Division JP2024026104A (ja) 2018-03-19 2023-11-16 Ｋｖ７チャネル活性化剤の構成および使用方法

Publications (3)

Publication Number Publication Date
JP2021518844A JP2021518844A (ja) 2021-08-05
JP2021518844A5 true JP2021518844A5 (enExample) 2023-01-06
JP7757036B2 JP7757036B2 (ja) 2025-10-21

Family

ID=67905138

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020551340A Active JP7757036B2 (ja) 2018-03-19 2019-03-19 Ｋｖ７チャネル活性化剤の構成および使用方法
JP2023195267A Pending JP2024026104A (ja) 2018-03-19 2023-11-16 Ｋｖ７チャネル活性化剤の構成および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023195267A Pending JP2024026104A (ja) 2018-03-19 2023-11-16 Ｋｖ７チャネル活性化剤の構成および使用方法

Country Status (13)

Country Link
US (5) US10851067B2 (enExample)
EP (1) EP3768677A4 (enExample)
JP (2) JP7757036B2 (enExample)
KR (3) KR20250150168A (enExample)
CN (6) CN119118926A (enExample)
AU (3) AU2019239955B2 (enExample)
BR (1) BR112020018933A2 (enExample)
CA (1) CA3093976A1 (enExample)
IL (2) IL277419B2 (enExample)
MX (2) MX2020009693A (enExample)
SG (1) SG11202008030WA (enExample)
WO (1) WO2019183148A1 (enExample)
ZA (1) ZA202308070B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2749103T3 (es) * 2014-09-12 2020-03-19 Knopp Biosciences Llc Benzoimidazol-1,2-ilamidas como activadores del canal Kv7
CN119118926A (zh) * 2018-03-19 2024-12-13 诺普生物科学有限责任公司 Kv7通道激活剂组合物和使用方法
IL328371A (en) * 2019-09-17 2026-07-01 Knopp Biosciences Llc Usage methods for KV7 channel operators
WO2023133256A1 (en) * 2022-01-07 2023-07-13 Biohaven Therapeutics Ltd. Pyrazolo[1,5-a]pyridin-2,3-yl amides as kv7 channel activators
WO2024050389A1 (en) * 2022-08-30 2024-03-07 Biohaven Therapeutics Ltd. Combination therapies including metal channel activators and nmda receptor antagonists
EP4584250A4 (en) * 2022-09-06 2026-02-25 Biohaven Therapeutics Ltd POLYTHERAPIES INCLUDING METAL CHANNEL ACTIVATORS
KR20260049605A (ko) * 2023-08-10 2026-04-14 바이오하벤 테라퓨틱스 리미티드 Kv7.2/7.3 칼륨 채널 활성제의 서방형 제형
KR20260074334A (ko) * 2023-09-15 2026-05-22 바이오하벤 테라퓨틱스 리미티드 강력하고 선택적인 칼륨 채널 활성제를 이용한 뇌전증 및 관련 질환의 치료 방법
KR20260114565A (ko) * 2023-11-15 2026-07-22 씨엠에스 리서치 앤드 디벨롭먼트 피티이. 리미티드 6,5-융합 헤테로아릴 유도체 및 이의 용도
CN122421958A (zh) * 2023-12-22 2026-07-17 拜奥海芬治疗学有限公司 神经性障碍的组合治疗
WO2025198930A1 (en) * 2024-03-18 2025-09-25 Humanwell Pharmacuetical Us, Inc. Small molecules as kcnq2/3 (kv7.2/3) channel activators and their medical use thereof
WO2026042005A1 (en) 2024-08-18 2026-02-26 Biohaven Therapeutics Ltd. Prodrugs of benzimidazol-1,2-yl amide compounds
WO2026046157A1 (zh) * 2024-08-27 2026-03-05 上海汇伦医药股份有限公司 苯并杂芳环类化合物、含其的组合物及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0772181B2 (ja) 1989-06-26 1995-08-02 株式会社大塚製薬工場 ベンズイミダゾール誘導体
JPH0772181A (ja) 1993-09-03 1995-03-17 Advantest Corp 電位波形測定方法および装置
GB9413724D0 (en) 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
US6855714B2 (en) 2001-07-06 2005-02-15 Schering Aktiengesellschaft 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
SE0301701D0 (sv) 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
CA2607219A1 (en) 2005-05-18 2007-02-15 Neuraxon, Inc. Substituted benzimidazole compounds with dual nos inhibitory activity and mu opioid agonist activity
CN101516873A (zh) * 2006-10-03 2009-08-26 神经研究公司 用作钾通道调节剂的吲唑基衍生物
US8288393B2 (en) 2007-08-10 2012-10-16 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
EP2218718A1 (en) 2007-11-22 2010-08-18 Zenyaku Kogyo Kabushikikaisha Amorphous form of heterocyclic compound, solid dispersion and medicinal preparation each comprising the same, and process for production of the same
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
US7820665B2 (en) 2007-12-19 2010-10-26 Amgen Inc. Imidazopyridazine inhibitors of PI3 kinase for cancer treatment
US20110269783A1 (en) 2008-11-10 2011-11-03 Neurosearch A/S Novel 2,3-diamino-quinazolinone derivatives and their medical use
KR101685718B1 (ko) 2008-12-19 2016-12-12 제넨테크, 인크. 헤테로시클릭 화합물 및 사용 방법
US8883812B2 (en) 2010-07-08 2014-11-11 Pfizer Inc. Piperidinyl pyrimidine amides as Kv7 potassium channel openers
SG10201505997TA (en) 2010-08-05 2015-09-29 Amgen Inc Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase
WO2014145852A2 (en) * 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
US10471139B2 (en) * 2013-08-15 2019-11-12 The University Of Kansas Toll-like receptor agonists
ES2749103T3 (es) * 2014-09-12 2020-03-19 Knopp Biosciences Llc Benzoimidazol-1,2-ilamidas como activadores del canal Kv7
CN119118926A (zh) * 2018-03-19 2024-12-13 诺普生物科学有限责任公司 Kv7通道激活剂组合物和使用方法
IL328371A (en) * 2019-09-17 2026-07-01 Knopp Biosciences Llc Usage methods for KV7 channel operators

Similar Documents

Publication Publication Date Title
JP2024026104A5 (enExample)
CA2440037A1 (en) Benzimidazole derivatives for modulating the rage receptor
JP2019520417A5 (enExample)
JP2009526831A5 (enExample)
JP2013536833A5 (enExample)
JP2013502431A5 (enExample)
JP2009538897A5 (enExample)
JP2007505933A5 (enExample)
JP2012507566A5 (enExample)
JP2008512348A5 (enExample)
RU2006141416A (ru) Пролекарства леводопа, композиции на их основе и их применения
JP2016506387A5 (enExample)
JP2018505898A5 (enExample)
JP2011500623A5 (enExample)
RU2009147708A (ru) Производные оксадиазола и их применение в качестве потенцирующих средств метаботропных глутаматных рецепторов-842
CA2551178A1 (en) Polycyclic agents for the treatment of respiratory syncytial virus infections
RU2017121044A (ru) Производные амидотиадиазола в качестве ингибиторов надфн-оксидазы
JP2004527508A5 (enExample)
CA2642465A1 (en) Novel pyrone-indole derivatives and process for their preparation
CA2441565A1 (en) Bisarylamines as potassium channel openers
RU2009103307A (ru) ПРОИЗВОДНЫЕ ИМИДАЗО[1, 2-a]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ
JP2017525737A (ja) キノリノン系化合物及びその薬物への使用
JP2012526107A5 (enExample)
JP2010536842A5 (enExample)
RU2013142364A (ru) Замещенные производные 6,7-диалкокси-3-изохинолинола в качестве ингибиторов фосфодиэстеразы 10 (фдэ10а)