JP2019501208A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019501208A5 JP2019501208A5 JP2018541089A JP2018541089A JP2019501208A5 JP 2019501208 A5 JP2019501208 A5 JP 2019501208A5 JP 2018541089 A JP2018541089 A JP 2018541089A JP 2018541089 A JP2018541089 A JP 2018541089A JP 2019501208 A5 JP2019501208 A5 JP 2019501208A5
- Authority
- JP
- Japan
- Prior art keywords
- rsv
- vaccine
- pseudouridine
- thio
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022172576A JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245208P | 2015-10-22 | 2015-10-22 | |
| US201562245031P | 2015-10-22 | 2015-10-22 | |
| US62/245,208 | 2015-10-22 | ||
| US62/245,031 | 2015-10-22 | ||
| US201562247563P | 2015-10-28 | 2015-10-28 | |
| US62/247,563 | 2015-10-28 | ||
| US201562248250P | 2015-10-29 | 2015-10-29 | |
| US62/248,250 | 2015-10-29 | ||
| PCT/US2016/058321 WO2017070622A1 (en) | 2015-10-22 | 2016-10-21 | Respiratory syncytial virus vaccine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172576A Division JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A Division JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501208A JP2019501208A (ja) | 2019-01-17 |
| JP2019501208A5 true JP2019501208A5 (OSRAM) | 2019-12-05 |
| JP7687767B2 JP7687767B2 (ja) | 2025-06-03 |
Family
ID=58558153
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541089A Active JP7687767B2 (ja) | 2015-10-22 | 2016-10-21 | 呼吸器合胞体ウイルスワクチン |
| JP2022172576A Pending JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A Pending JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172576A Pending JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A Pending JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20180271970A1 (OSRAM) |
| EP (1) | EP3365008A4 (OSRAM) |
| JP (3) | JP7687767B2 (OSRAM) |
| KR (1) | KR20180096592A (OSRAM) |
| CN (1) | CN108472354A (OSRAM) |
| AU (1) | AU2016341311B2 (OSRAM) |
| BR (1) | BR112018008102A2 (OSRAM) |
| CA (1) | CA3002820A1 (OSRAM) |
| CL (1) | CL2018001053A1 (OSRAM) |
| CO (1) | CO2018005229A2 (OSRAM) |
| EA (1) | EA201891000A1 (OSRAM) |
| IL (1) | IL258831A (OSRAM) |
| MA (1) | MA46317A (OSRAM) |
| MX (1) | MX2018004917A (OSRAM) |
| PE (1) | PE20181530A1 (OSRAM) |
| PH (1) | PH12018500856A1 (OSRAM) |
| SG (2) | SG10201914006UA (OSRAM) |
| TN (1) | TN2018000154A1 (OSRAM) |
| TW (1) | TW201729836A (OSRAM) |
| WO (1) | WO2017070622A1 (OSRAM) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| MX369469B (es) | 2013-08-21 | 2019-11-08 | Curevac Ag | Vacuna contra el virus respiratorio sincitial. |
| SG10201912038TA (en) | 2014-04-23 | 2020-02-27 | Modernatx Inc | Nucleic acid vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| MA42502A (fr) | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
| WO2017020026A1 (en) | 2015-07-30 | 2017-02-02 | Modernatx, Inc. | Concatemeric peptide epitopes rnas |
| WO2017031232A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| EP3364982A4 (en) | 2015-10-22 | 2019-04-17 | ModernaTX, Inc. | VACCINES AGAINST SEXUALLY TRANSMITTED DISEASES |
| EP3364950A4 (en) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | VACCINES AGAINST TROPICAL DISEASES |
| WO2017070613A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| EP4349405A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| EA201891001A1 (ru) | 2015-10-22 | 2018-11-30 | МОДЕРНАТиЭкс, ИНК. | Вакцины на основе нуклеиновых кислот против вируса ветряной оспы (vzv) |
| ES2924407T3 (es) | 2015-12-10 | 2022-10-06 | Modernatx Inc | Composiciones y procedimientos para el suministro de agentes terapéuticos |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| EP4631970A2 (en) * | 2016-05-04 | 2025-10-15 | CureVac SE | Nucleic acid molecules and uses thereof |
| AU2017268394A1 (en) | 2016-05-18 | 2019-01-03 | Modernatx, Inc. | Polynucleotides encoding relaxin |
| EP3458107B1 (en) | 2016-05-18 | 2024-03-13 | ModernaTX, Inc. | Polynucleotides encoding jagged1 for the treatment of alagille syndrome |
| CN109937253B (zh) | 2016-09-14 | 2023-06-30 | 摩登纳特斯有限公司 | 高纯度rna组合物及其制备方法 |
| MA46584A (fr) | 2016-10-21 | 2019-08-28 | Modernatx Inc | Vaccin contre le cytomégalovirus humain |
| EP3538146A4 (en) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | INFLUENZA VACCINE |
| MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | VERY POWERFUL IMMUNOGENIC COMPOSITIONS |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| EP3595713A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Respiratory syncytial virus vaccine |
| US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| EP3595676A4 (en) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | RNA VACCINES AGAINST ZOONOSES |
| EP3607074A4 (en) | 2017-04-05 | 2021-07-07 | Modernatx, Inc. | REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY |
| WO2018232357A1 (en) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Rna formulations |
| EP4397757A3 (en) | 2017-08-18 | 2024-10-23 | ModernaTX, Inc. | Rna polymerase variants |
| EP3668977A4 (en) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | HPLC ANALYTICAL PROCESSES |
| EP3668979A4 (en) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | METHOD OF HPLC ANALYSIS |
| US11744801B2 (en) | 2017-08-31 | 2023-09-05 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| EP3681514A4 (en) | 2017-09-14 | 2021-07-14 | ModernaTX, Inc. | RNA VACZINE AGAINST ZIKA VIRUS |
| MA54676A (fr) | 2018-01-29 | 2021-11-17 | Modernatx Inc | Vaccins à base d'arn contre le vrs |
| EP3768834B1 (en) | 2018-03-19 | 2025-08-13 | CRISPR Therapeutics AG | Novel rna-programmable endonuclease systems and uses thereof |
| WO2019191623A1 (en) | 2018-03-30 | 2019-10-03 | Georgia State University Research Foundation, Inc. | Respiratory syncytial virus (rsv) vaccines |
| BR112020020933A2 (pt) | 2018-04-17 | 2021-04-06 | Curevac Ag | Moléculas de rna de rsv inovadoras e composições para vacinação |
| EP3833382A1 (en) * | 2018-08-07 | 2021-06-16 | GlaxoSmithKline Biologicals S.A. | Processes and vaccines |
| WO2020061284A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| JP7640452B2 (ja) | 2018-09-19 | 2025-03-05 | モデルナティエックス インコーポレイテッド | 高純度ｐｅｇ脂質及びそれらの使用 |
| WO2020061457A1 (en) * | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| KR102725189B1 (ko) * | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| CN113710799B (zh) | 2018-11-28 | 2024-11-12 | 克里斯珀医疗股份公司 | 用于在LNP中使用的编码CAS9的优化mRNA |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
| MA55037A (fr) | 2019-02-20 | 2021-12-29 | Modernatx Inc | Variants d'arn polymérase pour le coiffage co-transcriptionnel |
| EP3930750A4 (en) * | 2019-02-28 | 2023-01-18 | Novavax, Inc. | PROCEDURES TO PREVENT DISEASE OR DISORDER FROM RSV INFECTION |
| MX2021011031A (es) | 2019-03-11 | 2021-12-10 | Modernatx Inc | Proceso de transcripción in vitro en lotes alimentados. |
| WO2020186059A2 (en) | 2019-03-12 | 2020-09-17 | Crispr Therapeutics Ag | Novel high fidelity rna-programmable endonuclease systems and uses thereof |
| US12070495B2 (en) | 2019-03-15 | 2024-08-27 | Modernatx, Inc. | HIV RNA vaccines |
| WO2020205986A1 (en) * | 2019-04-02 | 2020-10-08 | Sanofi | Antigenic multimeric respiratory syncytial virus polypeptides |
| CN110638759A (zh) * | 2019-10-29 | 2020-01-03 | 珠海丽凡达生物技术有限公司 | 一种用于体外转染和体内递送mRNA的制剂 |
| EP4096683A4 (en) * | 2020-01-30 | 2024-04-10 | ModernaTX, Inc. | IMMUNIZATION COMPOSITIONS FOR RESPIRATORY VIRUSES |
| WO2021213924A1 (en) | 2020-04-22 | 2021-10-28 | BioNTech SE | Coronavirus vaccine |
| JP2023530229A (ja) | 2020-05-29 | 2023-07-14 | キュアバック エスイー | 核酸ベースの混合ワクチン |
| US12385039B2 (en) | 2020-07-02 | 2025-08-12 | Life Technologies Corporation | Trinucleotide cap analogs, preparation and uses thereof |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| CN111973563B (zh) * | 2020-09-02 | 2022-06-28 | 崔海港 | 一种鼠李糖脂冻干粉制剂及其制备方法和应用 |
| US11771652B2 (en) * | 2020-11-06 | 2023-10-03 | Sanofi | Lipid nanoparticles for delivering mRNA vaccines |
| US12329811B2 (en) | 2021-01-11 | 2025-06-17 | Modernatx, Inc. | Seasonal RNA influenza virus vaccines |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| BR112023023768A2 (pt) | 2021-06-11 | 2024-02-27 | Bayer Ag | Sistemas de endonucleases programáveis por rna tipo v |
| EP4101928A1 (en) | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
| CA3230031A1 (en) | 2021-09-03 | 2023-03-09 | Patrick Baumhof | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4144841A1 (en) | 2021-09-07 | 2023-03-08 | Bayer AG | Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof |
| US20250027108A1 (en) | 2021-10-29 | 2025-01-23 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| EP4453191A1 (en) | 2021-12-23 | 2024-10-30 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| EP4531902A1 (en) | 2022-05-25 | 2025-04-09 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| IL316824A (en) | 2022-06-10 | 2025-01-01 | Bayer Ag | Novel small, programmable endonuclease systems for type V RNA |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| TWI888970B (zh) * | 2022-10-27 | 2025-07-01 | 美商輝瑞大藥廠 | Rna分子 |
| DE202023106198U1 (de) | 2022-10-28 | 2024-03-21 | CureVac SE | Impfstoff auf Nukleinsäurebasis |
| AU2023398007A1 (en) | 2022-12-13 | 2025-06-19 | Bayer Aktiengesellschaft | Engineered type v rna programmable endonucleases and their uses |
| AU2023427858A1 (en) | 2023-02-03 | 2025-05-15 | Vernagen, LLC | Respiratory syncytial virus mrna vaccine |
| CN116286672B (zh) * | 2023-02-07 | 2025-01-28 | 金宇保灵生物药品有限公司 | 一种口蹄疫病毒及其应用 |
| CN119137160A (zh) * | 2023-03-02 | 2024-12-13 | 苏州艾博生物科技有限公司 | 呼吸道合胞病毒(rsv)的核酸疫苗 |
| DE112024001143T5 (de) | 2023-03-08 | 2025-12-18 | CureVac SE | Neue lipid-nanopartikel-formeln für die abgabe von nukleinsäuren |
| WO2024194153A1 (en) * | 2023-03-17 | 2024-09-26 | Glaxosmithkline Biologicals Sa | Rsv-f-encoding nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| CN119497628A (zh) * | 2023-06-20 | 2025-02-21 | 石药集团巨石生物制药有限公司 | 一种抵抗呼吸道合胞病毒的mRNA疫苗及其制备方法 |
| WO2024259624A1 (en) * | 2023-06-21 | 2024-12-26 | Shenzhen Genius Biotech Service Co. Ltd | A modified rsv f protein, a nanoparticle, a composition and a vaccine against respiratory syncytial virus infection |
| CN119490569A (zh) * | 2023-08-16 | 2025-02-21 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、核酸、疫苗及其应用 |
| CN117487823B (zh) * | 2023-09-28 | 2024-10-29 | 怡道生物科技(苏州)有限公司 | 呼吸道合胞体病毒mRNA疫苗及其制备方法和应用 |
| TW202521691A (zh) | 2023-10-06 | 2025-06-01 | 美商藍岩醫療公司 | 經工程化之v型rna可程式核酸內切酶及其用途 |
| CN120022355A (zh) * | 2023-11-22 | 2025-05-23 | 长春百克生物科技股份公司 | 一种mRNA疫苗及其应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| US6998115B2 (en) | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US7708915B2 (en) | 2004-05-06 | 2010-05-04 | Castor Trevor P | Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein |
| PT1857122E (pt) | 2001-06-05 | 2011-03-07 | Curevac Gmbh | Arnm estabilizado com teor de g/c aumentado, codificando para um antigénio viral |
| AU2002319668A1 (en) | 2001-07-27 | 2003-02-17 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| WO2003028657A2 (en) | 2001-10-03 | 2003-04-10 | The Johns Hopkins University | Compositions for oral gene therapy and methods of using same |
| AU2003217531A1 (en) | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| WO2005072710A2 (en) | 2004-01-28 | 2005-08-11 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
| KR20070044805A (ko) | 2004-04-15 | 2007-04-30 | 키아스마, 인코포레이티드 | 생물학적 장벽 투과를 촉진시킬 수 있는 조성물 |
| EP1856179B1 (en) | 2004-12-10 | 2013-05-15 | Kala Pharmaceuticals, Inc. | Functionalized poly (ether-anhydride) block copolymers |
| KR101288729B1 (ko) | 2005-04-01 | 2013-07-23 | 인터자인 테크놀로지스, 인코포레이티드 | 약물 전달용 중합체성 마이셀 |
| US8273339B2 (en) | 2005-04-12 | 2012-09-25 | Nektar Therapeutics | Polymer-based compositions and conjugates of antimicrobial agents |
| EP2279758B1 (en) | 2005-06-16 | 2015-02-25 | Nektar Therapeutics | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| WO2007098466A2 (en) | 2006-02-21 | 2007-08-30 | Nektar Therapeutics Al, Corporation | Segmented degradable polymers and conjugates made therefrom |
| EP2019691B1 (en) | 2006-05-15 | 2020-08-12 | Massachusetts Institute of Technology | Polymers for functional particles |
| CA2663003C (en) | 2006-09-08 | 2018-02-13 | Justin Hanes | Compositions and methods for enhancing transport through mucus |
| WO2008082563A2 (en) | 2006-12-21 | 2008-07-10 | Stryker Corporation | Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents |
| ES2647538T3 (es) | 2007-09-28 | 2017-12-22 | Pfizer Inc. | Direccionamiento a células de cáncer usando nanopartículas |
| WO2010005725A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
| US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
| DK2285350T3 (en) | 2008-06-16 | 2017-12-11 | Pfizer | PROCEDURES FOR THE PREPARATION OF DIBLOCK COPOLYMERS FUNCTIONALIZED WITH TARGETING AGENT FOR USE IN THE MANUFACTURE OF THERAPEUTIC NANOPARTICLES |
| US8206747B2 (en) | 2008-06-16 | 2012-06-26 | Bind Biosciences, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| WO2010030763A2 (en) | 2008-09-10 | 2010-03-18 | Bind Biosciences, Inc. | High throughput fabrication of nanoparticles |
| WO2010054406A1 (en) * | 2008-11-10 | 2010-05-14 | Alnylam Pharmaceuticals, Inc. | Novel lipids and compositions for the delivery of therapeutics |
| ES2776126T3 (es) | 2008-12-15 | 2020-07-29 | Pfizer | Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos |
| WO2010088537A2 (en) * | 2009-01-29 | 2010-08-05 | Alnylam Pharmaceuticals, Inc. | Improved lipid formulation |
| JP5622254B2 (ja) | 2009-03-31 | 2014-11-12 | 国立大学法人東京大学 | 二本鎖リボ核酸ポリイオンコンプレックス |
| US8287910B2 (en) | 2009-04-30 | 2012-10-16 | Intezyne Technologies, Inc. | Polymeric micelles for polynucleotide encapsulation |
| JP5823405B2 (ja) | 2009-11-04 | 2015-11-25 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 核酸含有脂質粒子および関連方法 |
| EP2512487A4 (en) | 2009-12-15 | 2013-08-07 | THERAPEUTIC POLYMERNANOPARTICLES WITH CORTICOSTEROIDS AND METHOD FOR THE PRODUCTION AND USE THEREOF | |
| JP5898627B2 (ja) | 2009-12-15 | 2016-04-06 | バインド セラピューティックス インコーポレイテッド | エポチロンを含む治療用ポリマーナノ粒子ならびにそれを製造および使用する方法 |
| JP5965844B2 (ja) | 2009-12-15 | 2016-08-10 | バインド セラピューティックス インコーポレイテッド | 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物 |
| US20130101609A1 (en) | 2010-01-24 | 2013-04-25 | Novartis Ag | Irradiated biodegradable polymer microparticles |
| US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
| EP2575895A2 (en) | 2010-05-24 | 2013-04-10 | Merck Sharp & Dohme Corp. | Novel amino alcohol cationic lipids for oligonucleotide delivery |
| WO2011163483A2 (en) | 2010-06-25 | 2011-12-29 | Massachusetts Institute Of Technology | Polymers for biomaterials and therapeutics |
| ES2586580T3 (es) * | 2010-07-06 | 2016-10-17 | Glaxosmithkline Biologicals Sa | Inmunización de mamíferos grandes con dosis bajas de ARN |
| HRP20161352T1 (hr) * | 2010-07-06 | 2016-12-02 | Glaxosmithkline Biologicals Sa | Čestice nalik na virione za unos samoreplicirajućih molekula rna |
| HUE026646T2 (en) * | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| WO2012054923A2 (en) | 2010-10-22 | 2012-04-26 | Bind Biosciences, Inc. | Therapeutic nanoparticles with high molecular weight copolymers |
| EP2635254B1 (en) | 2010-11-05 | 2019-05-15 | The John Hopkins University | Compositions and methods relating to reduced mucoadhesion |
| US20120189700A1 (en) | 2011-01-19 | 2012-07-26 | Zoraida Aguilar | Nanoparticle Based Immunological Stimulation |
| US20140066363A1 (en) | 2011-02-07 | 2014-03-06 | Arun K. Bhunia | Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide |
| CA2831469C (en) | 2011-03-31 | 2020-02-18 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
| AU2012237262A1 (en) | 2011-03-31 | 2013-11-14 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| US20140308363A1 (en) | 2011-05-31 | 2014-10-16 | Bind Therapeutics, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| CN103764121A (zh) * | 2011-07-06 | 2014-04-30 | 诺华股份有限公司 | 用于递送rna分子的具有有用n:p比的脂质体 |
| RU2649133C2 (ru) * | 2011-07-06 | 2018-03-29 | Новартис Аг | Катионные эмульсии масло-в-воде |
| CN103732211B (zh) | 2011-07-21 | 2017-03-01 | 禾大国际股份公开有限公司 | 支化的聚醚‑聚酰胺嵌段共聚物及其制造与使用方法 |
| CN104024328A (zh) | 2011-08-26 | 2014-09-03 | 箭头研究公司 | 用于体内核酸递送的聚(乙烯基酯)聚合物 |
| JP2014527071A (ja) | 2011-08-31 | 2014-10-09 | マリンクロッド エルエルシー | Ｈ−ホスホネートによるナノ粒子ｐｅｇの改変 |
| US20150017245A1 (en) | 2011-09-22 | 2015-01-15 | Bind Therapeutics, Inc. | Methods of treating cancers with therapeutic nanoparticles |
| US9375388B2 (en) | 2011-09-23 | 2016-06-28 | Indian Institute Of Technology, Bombay | Nanoparticle based cosmetic composition |
| CA2852917C (en) | 2011-10-18 | 2020-07-07 | Dicerna Pharmaceuticals, Inc. | Amine cationic lipids and uses thereof |
| PE20181541A1 (es) | 2011-10-27 | 2018-09-26 | Massachusetts Inst Technology | Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco |
| WO2013078199A2 (en) | 2011-11-23 | 2013-05-30 | Children's Medical Center Corporation | Methods for enhanced in vivo delivery of synthetic, modified rnas |
| SI2791160T1 (sl) | 2011-12-16 | 2022-07-29 | Modernatx, Inc. | Sestave modificirane MRNA |
| WO2013110028A1 (en) | 2012-01-19 | 2013-07-25 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| AU2013214799B2 (en) | 2012-02-03 | 2016-05-12 | Rutgers, The State Of University Of New Jersey | Polymeric biomaterials derived from phenolic monomers and their medical uses |
| CN104105750A (zh) | 2012-02-10 | 2014-10-15 | 纳幕尔杜邦公司 | 高-x两嵌段共聚物的制备、纯化和使用 |
| AU2013243952A1 (en) * | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| BR112014030677A2 (pt) * | 2012-06-08 | 2022-07-19 | Shire Human Genetic Therapies | distribuição pulmonar de mrna para células-alvo não-pulmonares |
| EP3628335B1 (en) * | 2012-12-07 | 2023-11-08 | Translate Bio, Inc. | Lipidic nanoparticles for mrna delivery in the lungs |
| US9738689B2 (en) * | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| WO2014160463A1 (en) * | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
| EP3932947A1 (en) * | 2013-03-14 | 2022-01-05 | Translate Bio MA, Inc. | Methods and compositions for delivering mrna coded antibodies |
| HUE071526T2 (hu) * | 2013-03-15 | 2025-09-28 | Translate Bio Inc | Nukleinsavak bejuttatásának szinergista fokozása kevert kiszerelésekkel |
| WO2014144711A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Analysis of mrna heterogeneity and stability |
| WO2014144039A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
| US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
| WO2014152027A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Manufacturing methods for production of rna transcripts |
| WO2014144767A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| WO2014152031A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Ribonucleic acid purification |
| TW201534578A (zh) * | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| EP3677279A1 (en) * | 2013-07-25 | 2020-07-08 | Calder Biosciences Inc. | Conformationally stabilized rsv pre-fusion f proteins |
| MX369469B (es) * | 2013-08-21 | 2019-11-08 | Curevac Ag | Vacuna contra el virus respiratorio sincitial. |
| MX2016005239A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Tratamiento con acido ribonucleico mensajero para la fenilcetonuria. |
-
2016
- 2016-10-21 AU AU2016341311A patent/AU2016341311B2/en not_active Expired - Fee Related
- 2016-10-21 SG SG10201914006UA patent/SG10201914006UA/en unknown
- 2016-10-21 MX MX2018004917A patent/MX2018004917A/es unknown
- 2016-10-21 CN CN201680075062.6A patent/CN108472354A/zh active Pending
- 2016-10-21 EA EA201891000A patent/EA201891000A1/ru unknown
- 2016-10-21 TW TW105134193A patent/TW201729836A/zh unknown
- 2016-10-21 US US15/767,613 patent/US20180271970A1/en not_active Abandoned
- 2016-10-21 TN TNP/2018/000154A patent/TN2018000154A1/en unknown
- 2016-10-21 KR KR1020187014339A patent/KR20180096592A/ko not_active Withdrawn
- 2016-10-21 CA CA3002820A patent/CA3002820A1/en active Pending
- 2016-10-21 WO PCT/US2016/058321 patent/WO2017070622A1/en not_active Ceased
- 2016-10-21 BR BR112018008102A patent/BR112018008102A2/pt not_active Application Discontinuation
- 2016-10-21 PE PE2018000599A patent/PE20181530A1/es unknown
- 2016-10-21 EP EP16858402.7A patent/EP3365008A4/en active Pending
- 2016-10-21 JP JP2018541089A patent/JP7687767B2/ja active Active
- 2016-10-21 SG SG11201803363YA patent/SG11201803363YA/en unknown
- 2016-10-21 MA MA046317A patent/MA46317A/fr unknown
-
2018
- 2018-04-20 PH PH12018500856A patent/PH12018500856A1/en unknown
- 2018-04-20 CL CL2018001053A patent/CL2018001053A1/es unknown
- 2018-04-22 IL IL258831A patent/IL258831A/en unknown
- 2018-05-18 CO CONC2018/0005229A patent/CO2018005229A2/es unknown
-
2022
- 2022-10-27 JP JP2022172576A patent/JP2023015151A/ja active Pending
-
2023
- 2023-05-10 US US18/314,980 patent/US20230390379A1/en active Pending
-
2024
- 2024-12-24 JP JP2024227631A patent/JP2025041835A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019501208A5 (OSRAM) | ||
| US12240873B2 (en) | Respiratory syncytial virus (RSV) vaccine | |
| JP2018536023A5 (OSRAM) | ||
| US10960070B2 (en) | Prefusion coronavirus spike proteins and their use | |
| JP2018531996A5 (OSRAM) | ||
| JP2019535665A5 (OSRAM) | ||
| JP2021504445A5 (OSRAM) | ||
| RU2018118337A (ru) | Вакцина против вируса гриппа широкого спектра действия | |
| US10751407B2 (en) | PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof | |
| RU2016145597A (ru) | Вакцины на основе нуклеиновых кислот | |
| WO2014134439A1 (en) | Immunogenic composition for mers coronavirus infection | |
| US11274282B2 (en) | Vesicular stomatitis vectors encoding Crimean-Congo hemorrhagic fever antigen | |
| US20230053555A1 (en) | Mumps and measles virus immunogens and their use | |
| EP3035960B1 (en) | Respiratory syncytial virus (rsv) vaccine | |
| CA3130956A1 (en) | Novel vaccine effective to prevent infection by sars-cov variants | |
| US20230364220A1 (en) | SAR-COV-2 DNA Vaccine and Method of Administering Thereof | |
| WO2024073552A2 (en) | Combination exosomal immunogenic compositions and methods | |
| CN120166938A (zh) | SARS-CoV-2免疫原性组合物和方法 | |
| WO2024249651A2 (en) | Sars cov-2 vaccines, associated polynucleotides, and methods of use | |
| CN119264229A (zh) | 基于SARS-CoV-2的不同奥密克戎变异型的S蛋白的疫苗和组合物 | |
| HK40057100A (en) | Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof | |
| CN120359299A (zh) | 一种广谱流感mRNA疫苗 | |
| Tachibana et al. | 666. Type-I IFN Signaling Is Required for the Induction of Antigen-Specific CD8+ T Cell Responses by Adenovirus Vector Vaccine in the Gut-Mucosal Compartment | |
| EA041575B1 (ru) | Рекомбинантные вирусные векторы, содержащие минорные белки prrsv, и способы их получения и применения |