JP2019500909A5 - - Google Patents
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- JP2019500909A5 JP2019500909A5 JP2018555310A JP2018555310A JP2019500909A5 JP 2019500909 A5 JP2019500909 A5 JP 2019500909A5 JP 2018555310 A JP2018555310 A JP 2018555310A JP 2018555310 A JP2018555310 A JP 2018555310A JP 2019500909 A5 JP2019500909 A5 JP 2019500909A5
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- Prior art keywords
- virus
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1600382.4A GB201600382D0 (en) | 2016-01-08 | 2016-01-08 | Engineered virus |
| GBGB1600381.6A GB201600381D0 (en) | 2016-01-08 | 2016-01-08 | Virus strain |
| GBGB1600380.8A GB201600380D0 (en) | 2016-01-08 | 2016-01-08 | Modified virus |
| GB1600382.4 | 2016-01-08 | ||
| GB1600381.6 | 2016-01-08 | ||
| GB1600380.8 | 2016-01-08 | ||
| PCT/GB2017/050037 WO2017118865A1 (en) | 2016-01-08 | 2017-01-09 | Oncolytic virus strain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500909A JP2019500909A (ja) | 2019-01-17 |
| JP2019500909A5 true JP2019500909A5 (cg-RX-API-DMAC7.html) | 2020-01-30 |
| JP7038065B2 JP7038065B2 (ja) | 2022-03-17 |
Family
ID=57796748
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555309A Active JP6959258B2 (ja) | 2016-01-08 | 2017-01-09 | 改変された腫瘍溶解性ウイルス |
| JP2018555310A Active JP7038065B2 (ja) | 2016-01-08 | 2017-01-09 | 腫瘍溶解性ウイルス株 |
| JP2018555311A Active JP7038664B2 (ja) | 2016-01-08 | 2017-01-09 | 操作された腫瘍溶解性ウイルス |
| JP2021163811A Active JP7295192B2 (ja) | 2016-01-08 | 2021-10-05 | 改変された腫瘍溶解性ウイルス |
| JP2022034569A Pending JP2022078225A (ja) | 2016-01-08 | 2022-03-07 | 操作された腫瘍溶解性ウイルス |
| JP2023094818A Pending JP2023113885A (ja) | 2016-01-08 | 2023-06-08 | 改変された腫瘍溶解性ウイルス |
| JP2024119344A Pending JP2024153748A (ja) | 2016-01-08 | 2024-07-25 | 操作された腫瘍溶解性ウイルス |
| JP2025128636A Pending JP2025163138A (ja) | 2016-01-08 | 2025-07-31 | 改変された腫瘍溶解性ウイルス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555309A Active JP6959258B2 (ja) | 2016-01-08 | 2017-01-09 | 改変された腫瘍溶解性ウイルス |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555311A Active JP7038664B2 (ja) | 2016-01-08 | 2017-01-09 | 操作された腫瘍溶解性ウイルス |
| JP2021163811A Active JP7295192B2 (ja) | 2016-01-08 | 2021-10-05 | 改変された腫瘍溶解性ウイルス |
| JP2022034569A Pending JP2022078225A (ja) | 2016-01-08 | 2022-03-07 | 操作された腫瘍溶解性ウイルス |
| JP2023094818A Pending JP2023113885A (ja) | 2016-01-08 | 2023-06-08 | 改変された腫瘍溶解性ウイルス |
| JP2024119344A Pending JP2024153748A (ja) | 2016-01-08 | 2024-07-25 | 操作された腫瘍溶解性ウイルス |
| JP2025128636A Pending JP2025163138A (ja) | 2016-01-08 | 2025-07-31 | 改変された腫瘍溶解性ウイルス |
Country Status (13)
| Country | Link |
|---|---|
| US (13) | US10626377B2 (cg-RX-API-DMAC7.html) |
| EP (8) | EP3400293B2 (cg-RX-API-DMAC7.html) |
| JP (8) | JP6959258B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20250026348A (cg-RX-API-DMAC7.html) |
| CN (3) | CN109415703B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2017205216B2 (cg-RX-API-DMAC7.html) |
| CA (3) | CA3011009A1 (cg-RX-API-DMAC7.html) |
| DK (4) | DK3400290T5 (cg-RX-API-DMAC7.html) |
| ES (4) | ES2831080T5 (cg-RX-API-DMAC7.html) |
| IL (2) | IL260480B (cg-RX-API-DMAC7.html) |
| MX (1) | MX2018008413A (cg-RX-API-DMAC7.html) |
| SG (2) | SG11201805835WA (cg-RX-API-DMAC7.html) |
| WO (4) | WO2017118864A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0107736B8 (pt) * | 2000-01-21 | 2021-05-25 | Biovex Ltd | cepa hsv1 js1, composição farmacêutica, e, uso de uma cepa hsv1 js1 |
| NZ595736A (en) | 2005-12-02 | 2013-05-31 | Sinai School Medicine | Chimeric viruses presenting non-native surface proteins and uses thereof |
| US8901798B2 (en) | 2007-05-31 | 2014-12-02 | Regal Beloit America, Inc. | Switched reluctance machines with minimum stator core |
| KR102222157B1 (ko) | 2013-03-14 | 2021-03-03 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 뉴캐슬병 바이러스 및 이의 용도 |
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| MA42459A (fr) | 2015-07-16 | 2018-05-23 | Bioxcel Therapeutics Inc | Nouvelle approche pour le traitement du cancer par immunomodulation |
| EP3400293B2 (en) * | 2016-01-08 | 2023-07-12 | Replimune Limited | Modified oncolytic virus |
| AU2017212713B2 (en) | 2016-01-27 | 2023-01-19 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| HUE066998T2 (hu) | 2016-03-16 | 2024-09-28 | Amal Therapeutics Sa | Egy immunellenõrzõpont-modulátor és egy sejtpenetráló peptidet, kargót és TLR peptidagonistát tartalmazó komplex kombinációja gyógyászatban történõ alkalmazásra |
| AU2016403583B2 (en) * | 2016-04-22 | 2020-05-28 | Immvira Co., Limited | Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US10888594B2 (en) | 2016-05-30 | 2021-01-12 | National University Corporation Tottori University | Genetically engineered vaccinia viruses |
| US20190336552A1 (en) | 2016-05-30 | 2019-11-07 | Astellas Pharma Inc. | Genetically engineered vaccinia viruses |
| RU2021127872A (ru) * | 2016-06-30 | 2021-11-09 | Онкорус, Инк. | Доставка терапевтических полипептидов посредством псевдотипированных онколитических вирусов |
| WO2018055060A1 (en) | 2016-09-21 | 2018-03-29 | Amal Therapeutics Sa | Fusion comprising a cell penetrating peptide, a multi epitope and a tlr peptide agonist for treatment of cancer |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| GB201700350D0 (en) * | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| EA201992575A1 (ru) | 2017-04-28 | 2020-04-13 | Мерк Шарп И Доум Корп. | Биомаркеры для терапии рака |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| RU2771110C2 (ru) | 2017-07-26 | 2022-04-26 | Онкорус, Инк. | Онколитические вирусные векторы и их применение |
| PE20200867A1 (es) | 2017-08-03 | 2020-08-31 | Amgen Inc | Conjugados que comprende una muteina de interleucina 21 y un anticuerpo anti-pd-1 |
| JP7150823B2 (ja) | 2017-09-08 | 2022-10-11 | アムジエン・インコーポレーテツド | ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法 |
| CN109554353B (zh) * | 2017-09-26 | 2021-08-06 | 杭州康万达医药科技有限公司 | 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途 |
| US11896635B2 (en) * | 2017-11-08 | 2024-02-13 | Kagoshima University | Oncolytic virus (oncolytic immunotherapy) capable of effectively treating even metastatic cancer while ensuring safety, with expression control system providing optimal expression level of mounted immunogenic gene |
| BR112020009363A2 (pt) * | 2017-11-13 | 2020-10-27 | Bioxcel Therapeutics, Inc. | métodos e composições para tratar câncer por modificação de múltiplos braços do sistema imunológico |
| EP3731850A4 (en) * | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| CA3087273A1 (en) | 2018-01-12 | 2019-07-18 | Amgen Inc. | Anti-pd-1 antibodies and methods of treatment |
| WO2019147982A1 (en) * | 2018-01-26 | 2019-08-01 | Celldex Therapeutics, Inc. | Methods of treating cancer with dendritic cell mobilizing agents |
| GB201804473D0 (en) * | 2018-03-21 | 2018-05-02 | Valo Therapeutics Oy | Modified oncolytic adenoviruses |
| CN108635380A (zh) * | 2018-04-13 | 2018-10-12 | 北京唯源立康生物科技有限公司 | 重组溶瘤病毒组合物及其在制备用于治疗肿瘤的药物中的应用 |
| WO2019243847A1 (en) * | 2018-06-21 | 2019-12-26 | Replimune Limited | Treatment using oncolytic virus |
| WO2020006486A1 (en) * | 2018-06-29 | 2020-01-02 | Krystal Biotech, Inc. | Compositions and methods for antibody delivery |
| CN109161561A (zh) * | 2018-08-09 | 2019-01-08 | 湖北科技学院 | 一种选择性杀灭前列腺癌细胞的新型溶瘤病毒及其构建方法 |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| CN113164538B (zh) * | 2018-09-10 | 2025-03-04 | 上海锦斯生物技术有限公司 | 修饰的溶瘤病毒、其组合物和用途 |
| EP3858369A4 (en) * | 2018-09-26 | 2022-07-20 | Astellas Pharma Inc. | Cancer therapy where oncolytic vaccinia virus and immune checkpoint inhibitor are used in combination, and pharmaceutical composition and combination drug used therein |
| AU2019414450B2 (en) | 2018-12-27 | 2025-07-03 | Amgen Inc. | Lyophilized virus formulations |
| CN111606999B (zh) * | 2019-02-26 | 2022-09-06 | 南京惟亚德生物医药有限公司 | 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用 |
| CA3131529A1 (en) * | 2019-03-05 | 2020-09-10 | Amgen Inc. | Use of oncolytic viruses for the treatment of cancer |
| TW202102543A (zh) | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
| CN110054678B (zh) * | 2019-05-16 | 2023-04-18 | 中国医学科学院血液病医院（血液学研究所） | 一种膜结合型mFLT3LG蛋白及其应用 |
| CN110218707B (zh) * | 2019-05-29 | 2021-10-22 | 上海市公共卫生临床中心 | 一种新型溶瘤病毒及其制备方法和应用 |
| JPWO2021024897A1 (cg-RX-API-DMAC7.html) * | 2019-08-05 | 2021-02-11 | ||
| US11951141B2 (en) * | 2019-11-06 | 2024-04-09 | Memgen, Inc. | Replication-enhanced oncolytic adenoviruses |
| CN110982794B (zh) * | 2020-03-05 | 2020-06-16 | 北京唯源立康生物科技有限公司 | 一种修饰的单纯疱疹病毒 |
| US20240216533A1 (en) * | 2020-03-05 | 2024-07-04 | Beijing Wellgene Company Ltd. | Herpes simplex virus and use thereof |
| CN110982795B (zh) * | 2020-03-05 | 2020-06-16 | 北京唯源立康生物科技有限公司 | 一种单纯疱疹病毒及其用途 |
| JPWO2021193081A1 (cg-RX-API-DMAC7.html) * | 2020-03-23 | 2021-09-30 | ||
| CN116096906A (zh) | 2020-06-29 | 2023-05-09 | 旗舰创业创新五公司 | 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途 |
| US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
| CN112941039A (zh) * | 2021-02-01 | 2021-06-11 | 南京大学 | 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用 |
| DE102022104146A1 (de) | 2021-03-19 | 2022-09-22 | Yamada Manufacturing Co., Ltd. | Lenkvorrichtung |
| AU2022255538A1 (en) * | 2021-04-08 | 2023-09-28 | Immvira Biopharmaceuticals Co., Limited | Genetically modified oncolytic herpes simplex virus delivering chemokine and tumor associated/specific antigen |
| WO2022245808A1 (en) * | 2021-05-18 | 2022-11-24 | The Penn State Research Foundation | Oncolytic virus based cancer therapy |
| CN113583979B (zh) * | 2021-08-03 | 2022-11-22 | 杭州荣谷生物科技有限公司 | 一种重组溶瘤痘苗病毒、制备方法及其用途 |
| EP4464441A4 (en) | 2022-01-11 | 2025-12-03 | Mitsubishi Materials Corp | CUTTING TOOL WITH A SURFACE COATING |
| WO2024055022A2 (en) * | 2022-09-08 | 2024-03-14 | Virogin Biotech Canada Ltd | Oncolytic virus expressing an immune cell engager for tumor targeting |
| WO2025248110A1 (en) * | 2024-05-31 | 2025-12-04 | Replimune Limited | An oncolytic herpes simplex virus (hsv) and an anti-pd-1 antibody for use in treating braf mutant melanoma |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU594014B2 (en) | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
| CA1282721C (en) | 1984-06-04 | 1991-04-09 | Bernard Roizman | Herpes simplex virus as a vector |
| US5288641A (en) | 1984-06-04 | 1994-02-22 | Arch Development Corporation | Herpes Simplex virus as a vector |
| DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5698531A (en) | 1989-03-31 | 1997-12-16 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5328688A (en) | 1990-09-10 | 1994-07-12 | Arch Development Corporation | Recombinant herpes simplex viruses vaccines and methods |
| US6770274B1 (en) | 1990-09-14 | 2004-08-03 | The General Hospital Corporation | Viral mutant HSV mediated destruction of neoplastic cells |
| US6040169A (en) | 1991-01-31 | 2000-03-21 | Medical Research Council | Herpes simplex virus-1 deletion variants and vaccines thereof |
| DE69332525T2 (de) | 1992-03-31 | 2003-04-17 | Arch Development Corp., Chicago | Behandlung von Tumorerkrankungen mit modifiziertem HSV |
| US6699468B1 (en) | 1994-06-23 | 2004-03-02 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| WO1997012623A1 (en) | 1995-10-06 | 1997-04-10 | Arch Development Corporation | Methods and compositions for viral enhancement of cell killing |
| US5824318A (en) | 1996-07-24 | 1998-10-20 | American Cyanamid Company | Avirulent herpetic viruses useful as tumoricidal agents and vaccines |
| GB9700411D0 (en) | 1997-01-10 | 1997-02-26 | Univ London | Eukaryotic gene expression cassette and uses thereof |
| US6379674B1 (en) | 1997-08-12 | 2002-04-30 | Georgetown University | Use of herpes vectors for tumor therapy |
| US7300774B1 (en) | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
| US6428968B1 (en) | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| EP1227828A1 (en) | 1999-11-12 | 2002-08-07 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
| BRPI0107736B8 (pt) | 2000-01-21 | 2021-05-25 | Biovex Ltd | cepa hsv1 js1, composição farmacêutica, e, uso de uma cepa hsv1 js1 |
| ES2366608T3 (es) | 2001-03-27 | 2011-10-21 | The General Hospital Corporation | Vectores víricos y su uso en métodos terapéuticos. |
| GB0317511D0 (en) | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| WO2006002394A2 (en) * | 2004-06-24 | 2006-01-05 | New York University | Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response |
| RU2007114111A (ru) | 2004-11-04 | 2008-12-10 | Пфайзер Продактс Инк. (Us) | Лечение рака молочной железы с помощью комбинации антитела против ctla4 и ингибитора ароматазы |
| US9866961B2 (en) | 2004-12-01 | 2018-01-09 | Todd Beauchamp | Multi-channel loudspeaker enclosure with laterally projecting wings and method for orienting and driving multiple loudspeakers |
| DK2620450T3 (en) | 2005-03-08 | 2019-02-04 | Pfizer Prod Inc | Antibody Compositions against CTLA-4 |
| LT2650020T (lt) | 2005-05-06 | 2016-12-12 | Providence Health & Services - Oregon | Trimerinio ox40-immunoglobulino sulietas baltymas ir naudojimo būdai |
| CN101495126B (zh) | 2005-06-23 | 2016-01-06 | 休斯顿大学 | Ⅱ型单纯疱疹病毒突变体在治疗癌症中的用途 |
| GB0522476D0 (en) * | 2005-11-03 | 2005-12-14 | Biovex Ltd | Oncolytic herpes virus vectors |
| JP6092497B2 (ja) | 2006-03-30 | 2017-03-08 | ユニバーシティー オブ カリフォルニア | 抗ｃｔｌａ−４抗体の限局性分泌のための方法および組成物 |
| US8313896B2 (en) * | 2008-04-04 | 2012-11-20 | The General Hospital Corporation | Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer |
| WO2009148488A2 (en) | 2008-05-29 | 2009-12-10 | The General Hospital Corporation | Use of oncolytic herpes viruses for killing cancer stem cells |
| RU2573912C2 (ru) | 2008-10-08 | 2016-01-27 | Интрексон Корпорейшн | Сконструированные клетки, экспрессирующие множественные иммуномодуляторы, и их применения |
| US20100297072A1 (en) | 2009-05-19 | 2010-11-25 | Depinho Ronald A | Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy |
| EP2502078A1 (en) | 2009-11-20 | 2012-09-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
| WO2011119925A2 (en) * | 2010-03-25 | 2011-09-29 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses for treatment of cancers |
| WO2011118866A1 (ko) | 2010-03-26 | 2011-09-29 | 연세대학교 산학협력단 | 네트워크를 통한 심사요청 방법 |
| CA2812093A1 (en) * | 2010-09-24 | 2012-03-29 | Oncos Therapeutics Oy | Oncolytic adenoviral vectors coding for monoclonal anti - ctla - 4 antibodies |
| RS58146B1 (sr) * | 2011-09-08 | 2019-02-28 | Univ New York | Onkolitički herpes simpleks virus i njegova terapeutska upotreba |
| FI20115914L (fi) | 2011-09-16 | 2013-03-17 | Oncos Therapeutics Ltd | Muunnettu onkolyyttinen virus |
| US10238698B2 (en) | 2012-01-25 | 2019-03-26 | Dnatrix, Inc. | Biomarkers and combination therapies using oncolytic virus and immunomodulation |
| KR20150038066A (ko) | 2012-07-30 | 2015-04-08 | 알렉스 와 힌 영 | 종양 세포, 암세포파괴 바이러스 벡터 및 면역 체크포인트 조절인자를 갖는 암 백신 시스템 |
| CN114984062A (zh) | 2012-08-30 | 2022-09-02 | 安姆根有限公司 | 使用单纯疱疹病毒和免疫检查点抑制剂治疗黑色素瘤的方法 |
| WO2014066532A1 (en) | 2012-10-23 | 2014-05-01 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-ctla-4 antibodies to treat cancer |
| WO2014128235A1 (en) | 2013-02-22 | 2014-08-28 | F. Hoffmann-La Roche Ag | Methods of treating cancer and preventing drug resistance |
| KR102222157B1 (ko) | 2013-03-14 | 2021-03-03 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 뉴캐슬병 바이러스 및 이의 용도 |
| JP6557234B2 (ja) | 2013-09-03 | 2019-08-07 | メディミューン リミテッド | 弱毒化ニューカッスル病ウイルスを特徴とする組成物並びに新生物を治療するための使用方法 |
| SI3021859T1 (en) | 2013-10-25 | 2018-04-30 | Psioxus Therapeutics Limited | Oncolytic adenoviruses equipped with heterologous genes |
| PT3184641T (pt) | 2013-10-28 | 2020-08-21 | Univ Pittsburgh Commonwealth Sys Higher Education | Vetor de hsv oncolítico |
| JP2016540505A (ja) | 2013-11-22 | 2016-12-28 | ディーエヌエートリックス インコーポレイテッド | アデノウイルス発現免疫細胞刺激受容体アゴニスト |
| US10933106B2 (en) | 2014-02-25 | 2021-03-02 | Deutsches Krebsforschungszentrum | RNA viruses for immunovirotherapy |
| MA39818A (fr) * | 2014-03-30 | 2017-02-08 | Benevir Biopharm Inc | Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques |
| JP6843736B2 (ja) | 2014-07-16 | 2021-03-17 | トランジェーヌＴｒａｎｓｇｅｎｅ | 腫瘍溶解性ウイルスと免疫チェックポイントモジュレーターとの組合せ |
| CA3190510A1 (en) | 2014-07-16 | 2016-01-21 | Transgene Sa | Oncolytic virus for expression of immune checkpoint modulators |
| US20160040186A1 (en) | 2014-08-07 | 2016-02-11 | Xiaoyun Liu | Dna construct and method for transgene expression |
| GB201419579D0 (en) | 2014-11-03 | 2014-12-17 | Iomet Pharma Ltd | Pharmaceutical compound |
| CA2974529C (en) | 2015-01-23 | 2023-08-15 | Dreamwell, Ltd. | Automated mattress manufacturing process and apparatus |
| EP3400293B2 (en) * | 2016-01-08 | 2023-07-12 | Replimune Limited | Modified oncolytic virus |
| AU2016403583B2 (en) | 2016-04-22 | 2020-05-28 | Immvira Co., Limited | Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| US12029647B2 (en) * | 2017-03-07 | 2024-07-09 | 4C Medical Technologies, Inc. | Systems, methods and devices for prosthetic heart valve with single valve leaflet |
| WO2019243847A1 (en) | 2018-06-21 | 2019-12-26 | Replimune Limited | Treatment using oncolytic virus |
| AU2019410148A1 (en) | 2018-12-21 | 2021-08-12 | Ottawa Hospital Research Institute | Modified orthopoxvirus vectors |
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