CA3011004A1 - Oncolytic virus comprising a fusogenic protein-encoding gene and immune stimulatory protein-encoding gene - Google Patents

Oncolytic virus comprising a fusogenic protein-encoding gene and immune stimulatory protein-encoding gene Download PDF

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Publication number
CA3011004A1
CA3011004A1 CA3011004A CA3011004A CA3011004A1 CA 3011004 A1 CA3011004 A1 CA 3011004A1 CA 3011004 A CA3011004 A CA 3011004A CA 3011004 A CA3011004 A CA 3011004A CA 3011004 A1 CA3011004 A1 CA 3011004A1
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Prior art keywords
virus
immune
inhibitor
tumor
promoter
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CA3011004A
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English (en)
French (fr)
Inventor
Robert Coffin
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Replimune Ltd
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Replimune Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57796748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3011004(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1600382.4A external-priority patent/GB201600382D0/en
Priority claimed from GBGB1600381.6A external-priority patent/GB201600381D0/en
Priority claimed from GBGB1600380.8A external-priority patent/GB201600380D0/en
Application filed by Replimune Ltd filed Critical Replimune Ltd
Publication of CA3011004A1 publication Critical patent/CA3011004A1/en
Pending legal-status Critical Current

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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K35/763Herpes virus
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C12N2710/16011Herpesviridae
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    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
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    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
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    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
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    • C12N2740/13011Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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CA3011004A 2016-01-08 2017-01-09 Oncolytic virus comprising a fusogenic protein-encoding gene and immune stimulatory protein-encoding gene Pending CA3011004A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1600382.4A GB201600382D0 (en) 2016-01-08 2016-01-08 Engineered virus
GBGB1600381.6A GB201600381D0 (en) 2016-01-08 2016-01-08 Virus strain
GBGB1600380.8A GB201600380D0 (en) 2016-01-08 2016-01-08 Modified virus
GB1600382.4 2016-01-08
GB1600381.6 2016-01-08
GB1600380.8 2016-01-08
PCT/GB2017/050036 WO2017118864A1 (en) 2016-01-08 2017-01-09 Modified oncolytic viurs

Publications (1)

Publication Number Publication Date
CA3011004A1 true CA3011004A1 (en) 2017-07-13

Family

ID=57796748

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3011009A Pending CA3011009A1 (en) 2016-01-08 2017-01-09 Oncolytic virus comprising a gm-csf-encoding gene and an immune co-stimulatory pathway activating molecule-encoding gene
CA3010987A Pending CA3010987A1 (en) 2016-01-08 2017-01-09 Oncolytic herpes simplex virus type 1 strain
CA3011004A Pending CA3011004A1 (en) 2016-01-08 2017-01-09 Oncolytic virus comprising a fusogenic protein-encoding gene and immune stimulatory protein-encoding gene

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA3011009A Pending CA3011009A1 (en) 2016-01-08 2017-01-09 Oncolytic virus comprising a gm-csf-encoding gene and an immune co-stimulatory pathway activating molecule-encoding gene
CA3010987A Pending CA3010987A1 (en) 2016-01-08 2017-01-09 Oncolytic herpes simplex virus type 1 strain

Country Status (13)

Country Link
US (13) US10626377B2 (cg-RX-API-DMAC7.html)
EP (8) EP3400293B2 (cg-RX-API-DMAC7.html)
JP (8) JP6959258B2 (cg-RX-API-DMAC7.html)
KR (2) KR20250026348A (cg-RX-API-DMAC7.html)
CN (3) CN109415703B (cg-RX-API-DMAC7.html)
AU (2) AU2017205216B2 (cg-RX-API-DMAC7.html)
CA (3) CA3011009A1 (cg-RX-API-DMAC7.html)
DK (4) DK3400290T5 (cg-RX-API-DMAC7.html)
ES (4) ES2831080T5 (cg-RX-API-DMAC7.html)
IL (2) IL260480B (cg-RX-API-DMAC7.html)
MX (1) MX2018008413A (cg-RX-API-DMAC7.html)
SG (2) SG11201805835WA (cg-RX-API-DMAC7.html)
WO (4) WO2017118864A1 (cg-RX-API-DMAC7.html)

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