JP2019196365A5 - - Google Patents
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- JP2019196365A5 JP2019196365A5 JP2019117073A JP2019117073A JP2019196365A5 JP 2019196365 A5 JP2019196365 A5 JP 2019196365A5 JP 2019117073 A JP2019117073 A JP 2019117073A JP 2019117073 A JP2019117073 A JP 2019117073A JP 2019196365 A5 JP2019196365 A5 JP 2019196365A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- bispecific fusion
- tissue
- protein according
- bispecific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108020001507 fusion proteins Proteins 0.000 claims 15
- 102000037865 fusion proteins Human genes 0.000 claims 15
- 210000001519 tissue Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 210000005084 renal tissue Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000000451 tissue damage Effects 0.000 claims 2
- 231100000827 tissue damage Toxicity 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 1
- 108090000672 Annexin A5 Proteins 0.000 claims 1
- 102000004121 Annexin A5 Human genes 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 102000007584 Prealbumin Human genes 0.000 claims 1
- 108010071690 Prealbumin Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims 1
- 101710179590 Vitamin D-binding protein Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000006041 cell recruitment Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000001503 joint Anatomy 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34704010P | 2010-05-21 | 2010-05-21 | |
| US61/347,040 | 2010-05-21 | ||
| US13/068,808 US9238080B2 (en) | 2010-05-21 | 2011-05-20 | Bi-specific fusion proteins |
| US13/068,808 | 2011-05-20 | ||
| US13/112,907 | 2011-05-20 | ||
| US13/112,907 US8691771B2 (en) | 2010-05-21 | 2011-05-20 | Bi-specific fusion proteins for tissue repair |
| JP2017132859A JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017132859A Division JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019196365A JP2019196365A (ja) | 2019-11-14 |
| JP2019196365A5 true JP2019196365A5 (https=) | 2020-02-13 |
| JP6965311B2 JP6965311B2 (ja) | 2021-11-10 |
Family
ID=44972647
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511403A Active JP6200806B2 (ja) | 2010-05-21 | 2011-05-20 | 二重特異的融合タンパク質 |
| JP2016130526A Active JP6174763B2 (ja) | 2010-05-21 | 2016-06-30 | 二重特異的融合タンパク質 |
| JP2017132859A Active JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
| JP2019117073A Active JP6965311B2 (ja) | 2010-05-21 | 2019-06-25 | 二重特異的融合タンパク質 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511403A Active JP6200806B2 (ja) | 2010-05-21 | 2011-05-20 | 二重特異的融合タンパク質 |
| JP2016130526A Active JP6174763B2 (ja) | 2010-05-21 | 2016-06-30 | 二重特異的融合タンパク質 |
| JP2017132859A Active JP6822911B2 (ja) | 2010-05-21 | 2017-07-06 | 二重特異的融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (11) | US9238080B2 (https=) |
| EP (1) | EP2571992B1 (https=) |
| JP (4) | JP6200806B2 (https=) |
| CN (1) | CN103124788B (https=) |
| AU (1) | AU2011255238B2 (https=) |
| BR (1) | BR112012029611A2 (https=) |
| CA (1) | CA2800173C (https=) |
| ES (1) | ES2674567T3 (https=) |
| WO (1) | WO2011146902A1 (https=) |
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| US10233228B2 (en) | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| BR112012029611A2 (pt) | 2010-05-21 | 2017-07-25 | Merrimack Pharmaceuticals Inc | proteína de fusão biespecífica, composição farmacêutica, método de tratamento de dano ao tecido em um indivíduo, método de promoção da regeração ou sobrevivência do tecido em um indivíduo e molécula de ácido nucleico |
| US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
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