JP2019077725A5 - - Google Patents
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- Publication number
- JP2019077725A5 JP2019077725A5 JP2019017086A JP2019017086A JP2019077725A5 JP 2019077725 A5 JP2019077725 A5 JP 2019077725A5 JP 2019017086 A JP2019017086 A JP 2019017086A JP 2019017086 A JP2019017086 A JP 2019017086A JP 2019077725 A5 JP2019077725 A5 JP 2019077725A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- ethyl
- azaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 14
- 239000011780 sodium chloride Substances 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 208000005298 Acute Pain Diseases 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- IKKKUWUFDRRBSC-AFJQURTJSA-N C(C)[C@@H]1N(C(CC1)=O)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC Chemical compound C(C)[C@@H]1N(C(CC1)=O)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC IKKKUWUFDRRBSC-AFJQURTJSA-N 0.000 claims 1
- HEJAEKBVOZHTRA-UHFFFAOYSA-N CN1N=CC=C1C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC Chemical compound CN1N=CC=C1C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC HEJAEKBVOZHTRA-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010057668 Cognitive disease Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- QKTXQEYKBXLLNQ-TVRKMHQQSA-N FC1(C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)CO)F Chemical compound FC1(C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)CO)F QKTXQEYKBXLLNQ-TVRKMHQQSA-N 0.000 claims 1
- BOEACPBYTRPLBC-UORCXSCMSA-N F[C@@H]1C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)CO Chemical compound F[C@@H]1C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)CO BOEACPBYTRPLBC-UORCXSCMSA-N 0.000 claims 1
- XBYWKKNGSJNKJG-JJXOGSGTSA-N F[C@H]1C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)C(=O)OC Chemical compound F[C@H]1C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)C(=O)OC XBYWKKNGSJNKJG-JJXOGSGTSA-N 0.000 claims 1
- BOEACPBYTRPLBC-JQZVFVSYSA-N F[C@H]1C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)CO Chemical compound F[C@H]1C[C@@H](N(C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC)CO BOEACPBYTRPLBC-JQZVFVSYSA-N 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- HZMNRFTWMDFPNO-UHFFFAOYSA-N N1(N=CC=C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC Chemical compound N1(N=CC=C1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC HZMNRFTWMDFPNO-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 Neuralgia Diseases 0.000 claims 1
- QZVYLGBTRSXKIE-UHFFFAOYSA-N O=C1N(CCC1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC Chemical compound O=C1N(CCC1)C1CCN(CC1)C1CC2(C1)CN(CC2)C(=O)OCC QZVYLGBTRSXKIE-UHFFFAOYSA-N 0.000 claims 1
- 206010061920 Psychotic disease Diseases 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- -1 hydroxy, methoxy, methyl Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000009457 movement disease Diseases 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 0 C*(C)C(CCC1)N1C(C(F)(F)F)=O Chemical compound C*(C)C(CCC1)N1C(C(F)(F)F)=O 0.000 description 17
- ZAVNAIXXOHWBDG-UHFFFAOYSA-N CC(CCC1)N1C(CC(F)(F)F)=O Chemical compound CC(CCC1)N1C(CC(F)(F)F)=O ZAVNAIXXOHWBDG-UHFFFAOYSA-N 0.000 description 1
- YQSRKFAOUYPUAC-UHFFFAOYSA-N CC(CCC1)N1C(CCN)=O Chemical compound CC(CCC1)N1C(CCN)=O YQSRKFAOUYPUAC-UHFFFAOYSA-N 0.000 description 1
- FMOMSFCVAGTHGO-UHFFFAOYSA-N CC(CCC1)N1C(COC)=O Chemical compound CC(CCC1)N1C(COC)=O FMOMSFCVAGTHGO-UHFFFAOYSA-N 0.000 description 1
- VXQOOMPIHVLABQ-UHFFFAOYSA-N CC(CCC1)N1C(NC1CCC1)=O Chemical compound CC(CCC1)N1C(NC1CCC1)=O VXQOOMPIHVLABQ-UHFFFAOYSA-N 0.000 description 1
- PJVFUINVNVDZBV-UHFFFAOYSA-N CC(CCC1)N1C(OC1CCC1)=O Chemical compound CC(CCC1)N1C(OC1CCC1)=O PJVFUINVNVDZBV-UHFFFAOYSA-N 0.000 description 1
- GBKJBXGCDXMHPY-UHFFFAOYSA-N CC1N(COCCN(C)C)CCC1 Chemical compound CC1N(COCCN(C)C)CCC1 GBKJBXGCDXMHPY-UHFFFAOYSA-N 0.000 description 1
- LCXFKHBYVGVYGH-UHFFFAOYSA-N CCC(CCC1)N1C(C1CC1)=O Chemical compound CCC(CCC1)N1C(C1CC1)=O LCXFKHBYVGVYGH-UHFFFAOYSA-N 0.000 description 1
- UZOZSUUBKDDEPD-MLWJPKLSSA-N CCC(N(C1)C(C)C[C@@H]1F)=O Chemical compound CCC(N(C1)C(C)C[C@@H]1F)=O UZOZSUUBKDDEPD-MLWJPKLSSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1402013.5 | 2014-02-06 | ||
| GBGB1402013.5A GB201402013D0 (en) | 2014-02-06 | 2014-02-06 | Pharmaceutical compounds |
| GBGB1416622.7A GB201416622D0 (en) | 2014-09-19 | 2014-09-19 | Pharmaceutical compounds |
| GB1416622.7 | 2014-09-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550483A Division JP6479029B2 (ja) | 2014-02-06 | 2015-02-06 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168341A Division JP2021006571A (ja) | 2014-02-06 | 2020-10-05 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019077725A JP2019077725A (ja) | 2019-05-23 |
| JP2019077725A5 true JP2019077725A5 (US06653308-20031125-C00057.png) | 2019-09-26 |
| JP6774513B2 JP6774513B2 (ja) | 2020-10-28 |
Family
ID=52465550
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550483A Active JP6479029B2 (ja) | 2014-02-06 | 2015-02-06 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2019017086A Active JP6774513B2 (ja) | 2014-02-06 | 2019-02-01 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2020168341A Withdrawn JP2021006571A (ja) | 2014-02-06 | 2020-10-05 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2023060030A Pending JP2023073504A (ja) | 2014-02-06 | 2023-04-03 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2023076024A Pending JP2023087045A (ja) | 2014-02-06 | 2023-05-02 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2023076025A Pending JP2023087046A (ja) | 2014-02-06 | 2023-05-02 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550483A Active JP6479029B2 (ja) | 2014-02-06 | 2015-02-06 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168341A Withdrawn JP2021006571A (ja) | 2014-02-06 | 2020-10-05 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2023060030A Pending JP2023073504A (ja) | 2014-02-06 | 2023-04-03 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2023076024A Pending JP2023087045A (ja) | 2014-02-06 | 2023-05-02 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
| JP2023076025A Pending JP2023087046A (ja) | 2014-02-06 | 2023-05-02 | ムスカリンｍ１受容体アゴニストとしての二環式アザ化合物 |
Country Status (29)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9187451B2 (en) | 2011-11-18 | 2015-11-17 | Heptares Therapeutics Limited | Muscarinic M1 receptor agonists |
| RU2019101889A (ru) | 2013-03-15 | 2019-03-28 | Версеон Корпорейшн | Полизамещенные ароматические соединения в качестве ингибиторов сериновых протеаз |
| RS65894B1 (sr) | 2014-02-06 | 2024-09-30 | Nxera Pharma Uk Ltd | Biciklična aza jedinjenja kao agonisti muskarinskog receptora |
| GB201404922D0 (en) * | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| WO2016044662A1 (en) | 2014-09-17 | 2016-03-24 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| EP3261639B1 (en) * | 2015-02-27 | 2022-08-24 | Verseon International Corporation | Substituted pyrazole compounds as serine protease inhibitors |
| GB201504675D0 (en) | 2015-03-19 | 2015-05-06 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201513742D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201513743D0 (en) * | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201513740D0 (en) * | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonist |
| GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| ES2789756T3 (es) | 2015-12-23 | 2020-10-26 | Merck Sharp & Dohme | Moduladores alostéricos de 6,7-dihidro-5H-pirrolo[3,4-b]piridin-5-ona del receptor de acetilcolina muscarínico M4 |
| AU2017286868B2 (en) | 2016-07-01 | 2021-11-11 | Pfizer Inc. | 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| GB201709652D0 (en) * | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| US11274100B2 (en) | 2017-06-21 | 2022-03-15 | Daiichi Sankyo Company, Limited | EP300/CREBBP inhibitor |
| WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000237A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000236A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| JP7166331B2 (ja) * | 2017-08-01 | 2022-11-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中間体化合物及び方法 |
| US10501483B2 (en) | 2017-10-24 | 2019-12-10 | Allergan, Inc. | Enamines and diastereo-selective reduction of enamines |
| WO2019126559A1 (en) | 2017-12-20 | 2019-06-27 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| TWI801540B (zh) * | 2018-03-23 | 2023-05-11 | 美商輝瑞大藥廠 | 哌嗪氮雜螺衍生物 |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201810245D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| AU2020361735B2 (en) * | 2019-10-09 | 2024-04-18 | Novartis Ag | 2-azaspiro(3.4)octane derivatives as M4 agonists |
| CN114555606B (zh) * | 2019-10-09 | 2024-10-01 | 诺华股份有限公司 | 作为m4激动剂的5-氧杂-2-氮杂螺[3.4]辛烷衍生物 |
| US11912705B2 (en) * | 2020-08-20 | 2024-02-27 | The Corporation Of Mercer University | Cathinone derivatives, pharmaceutical formulations, and methods |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| TW202416955A (zh) | 2022-08-04 | 2024-05-01 | 英商海普泰爾思治療公司 | 毒蕈鹼受體激動劑 |
| WO2024059249A1 (en) * | 2022-09-16 | 2024-03-21 | Cerevel Therapeutics, Llc | M4 activators/modulators and uses thereof |
| WO2024151833A1 (en) * | 2023-01-12 | 2024-07-18 | Cerevel Therapeutics, Llc | Spiro derivatives as m4 activators/modulators and uses thereof |
| WO2024158645A1 (en) | 2023-01-24 | 2024-08-02 | Neurocrine Biosciences, Inc. | Deuterated compounds |
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| WO1999032489A1 (en) | 1997-12-23 | 1999-07-01 | Alcon Laboratories, Inc. | Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions |
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| EP1753429A1 (en) * | 2004-05-28 | 2007-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
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| AU2006330866A1 (en) | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
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| KR20080095895A (ko) * | 2006-03-03 | 2008-10-29 | 노파르티스 아게 | Ｎ―포르밀 히드록실아민 화합물 |
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| MX2011004340A (es) | 2008-10-29 | 2011-05-23 | Gruenenthal Gmbh | Espiroaminas sustituidas. |
| FR2945531A1 (fr) | 2009-05-12 | 2010-11-19 | Sanofi Aventis | Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique |
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| US9187451B2 (en) * | 2011-11-18 | 2015-11-17 | Heptares Therapeutics Limited | Muscarinic M1 receptor agonists |
| WO2014045031A1 (en) * | 2012-09-18 | 2014-03-27 | Heptares Therapeutics Limited | Bicyclic aza compounds as muscarinic m1 receptor agonists |
| EA030196B1 (ru) | 2013-04-30 | 2018-07-31 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Ингибиторы энхансера zeste гомолога 2 |
| CN105979951B (zh) | 2014-02-06 | 2020-12-25 | 里博科学有限责任公司 | 作为流感rna复制的抑制剂的4’-二氟甲基取代的核苷衍生物 |
| EA035848B1 (ru) | 2014-02-06 | 2020-08-20 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b |
| RS65894B1 (sr) | 2014-02-06 | 2024-09-30 | Nxera Pharma Uk Ltd | Biciklična aza jedinjenja kao agonisti muskarinskog receptora |
| CN106687456B (zh) | 2014-09-19 | 2019-12-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 可溶性鸟苷酸环化酶活化剂及它们的用途 |
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2015
- 2015-02-06 RS RS20240960A patent/RS65894B1/sr unknown
- 2015-02-06 EP EP18179258.1A patent/EP3406609B1/en active Active
- 2015-02-06 PT PT181792581T patent/PT3406609T/pt unknown
- 2015-02-06 PT PT15703826T patent/PT3102568T/pt unknown
- 2015-02-06 EP EP24177415.7A patent/EP4413985A3/en active Pending
- 2015-02-06 SG SG11201606269WA patent/SG11201606269WA/en unknown
- 2015-02-06 MX MX2020001236A patent/MX2020001236A/es unknown
- 2015-02-06 KR KR1020167024572A patent/KR102352388B1/ko active IP Right Grant
- 2015-02-06 WO PCT/GB2015/050331 patent/WO2015118342A1/en active Application Filing
- 2015-02-06 SI SI201530399T patent/SI3102568T1/sl unknown
- 2015-02-06 RS RS20181127A patent/RS57843B1/sr unknown
- 2015-02-06 CA CA2938169A patent/CA2938169C/en active Active
- 2015-02-06 EP EP15703826.6A patent/EP3102568B1/en active Active
- 2015-02-06 LT LTEP18179258.1T patent/LT3406609T/lt unknown
- 2015-02-06 LT LTEP15703826.6T patent/LT3102568T/lt unknown
- 2015-02-06 DK DK18179258.1T patent/DK3406609T3/da active
- 2015-02-06 ES ES15703826.6T patent/ES2688548T3/es active Active
- 2015-02-06 MX MX2016010322A patent/MX371529B/es active IP Right Grant
- 2015-02-06 JP JP2016550483A patent/JP6479029B2/ja active Active
- 2015-02-06 AU AU2015213900A patent/AU2015213900B2/en active Active
- 2015-02-06 CN CN201580017993.6A patent/CN106458986B/zh active Active
- 2015-02-06 NZ NZ723103A patent/NZ723103A/en unknown
- 2015-02-06 DK DK15703826.6T patent/DK3102568T3/en active
- 2015-02-06 CN CN201910003375.6A patent/CN109851610B/zh active Active
- 2015-02-06 US US15/117,018 patent/US9670183B2/en active Active
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2016
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2017
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2018
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2019
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