JP2019065009A5 - - Google Patents
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- Publication number
- JP2019065009A5 JP2019065009A5 JP2018188038A JP2018188038A JP2019065009A5 JP 2019065009 A5 JP2019065009 A5 JP 2019065009A5 JP 2018188038 A JP2018188038 A JP 2018188038A JP 2018188038 A JP2018188038 A JP 2018188038A JP 2019065009 A5 JP2019065009 A5 JP 2019065009A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 201000005569 Gout Diseases 0.000 claims 5
- 201000001431 Hyperuricemia Diseases 0.000 claims 5
- 108091006303 SLC2A9 Proteins 0.000 claims 5
- 102100022720 Solute carrier family 2, facilitated glucose transporter member 6 Human genes 0.000 claims 5
- 208000020832 chronic kidney disease Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 150000001924 cycloalkanes Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017194005 | 2017-10-04 | ||
| JP2017194005 | 2017-10-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019065009A JP2019065009A (ja) | 2019-04-25 |
| JP2019065009A5 true JP2019065009A5 (enExample) | 2021-11-11 |
| JP7125882B2 JP7125882B2 (ja) | 2022-08-25 |
Family
ID=65994698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018188038A Active JP7125882B2 (ja) | 2017-10-04 | 2018-10-03 | 含窒素ヘテロアリール化合物およびその医薬用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10752596B2 (enExample) |
| EP (1) | EP3693358B1 (enExample) |
| JP (1) | JP7125882B2 (enExample) |
| KR (1) | KR20200064101A (enExample) |
| CN (1) | CN111148735B (enExample) |
| AR (1) | AR113270A1 (enExample) |
| AU (1) | AU2018345221A1 (enExample) |
| BR (1) | BR112020004857A2 (enExample) |
| CA (1) | CA3074989A1 (enExample) |
| CL (1) | CL2020000898A1 (enExample) |
| CO (1) | CO2020003977A2 (enExample) |
| IL (1) | IL273573A (enExample) |
| MX (1) | MX2020003816A (enExample) |
| PE (1) | PE20200846A1 (enExample) |
| PH (1) | PH12020550403A1 (enExample) |
| RU (1) | RU2020115045A (enExample) |
| SG (1) | SG11202003005PA (enExample) |
| TW (1) | TW201922706A (enExample) |
| WO (1) | WO2019069973A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110156698B (zh) * | 2019-06-06 | 2020-10-13 | 沈阳海诺威医药科技有限公司 | 2-苯基-1，6-二氢嘧啶-5-甲酸衍生物的制备方法和用途 |
| CN113181206B (zh) * | 2021-04-30 | 2023-07-14 | 青岛大学 | 与高尿酸血症伴高血脂、高血糖治疗相关基因SLC2A9的siRNA及其应用 |
| US20250179032A1 (en) * | 2022-01-07 | 2025-06-05 | Horizon Therapeutics Ireland Dac | Heterocyclic inhibitors of glut9 for treatment of disease |
| CN114805192B (zh) * | 2022-03-30 | 2023-05-23 | 华南理工大学 | 一种含2-羟基苯甲酸的三环类xor/urat1双重抑制剂及其制备方法与应用 |
| WO2024167952A1 (en) * | 2023-02-08 | 2024-08-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Oxidatively cleavable organophosphate drugs |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| SI0912518T1 (en) * | 1996-07-18 | 2003-12-31 | Merck Frosst Canada & Co. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| KR100416111B1 (ko) * | 1998-04-10 | 2004-01-31 | 니뽄 다바코 산교 가부시키가이샤 | 아미딘 화합물 |
| US7300932B2 (en) * | 2003-08-07 | 2007-11-27 | Japan Tobacco Inc. | Pyrrolo[1,2-b]pyridazine derivatives |
| JP2008536950A (ja) | 2005-04-18 | 2008-09-11 | ニューロジェン・コーポレーション | 置換ヘテロアリールのｃｂ１拮抗薬 |
| JP2007176933A (ja) * | 2005-11-29 | 2007-07-12 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP5162827B2 (ja) | 2005-12-27 | 2013-03-13 | ぺんてる株式会社 | 鉛筆芯の製造方法 |
| WO2008126901A1 (ja) | 2007-04-11 | 2008-10-23 | Kissei Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびそれを含有する医薬組成物 |
| JP2009016193A (ja) * | 2007-07-05 | 2009-01-22 | Daihen Corp | 電気機器用樹脂ブッシング |
| SG178049A1 (en) * | 2009-07-17 | 2012-03-29 | Japan Tobacco Inc | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| CN103037690B (zh) | 2010-03-24 | 2016-04-27 | 俄亥俄州立大学 | 用于葡萄糖转运抑制的组合物和方法 |
| AR081930A1 (es) | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | Compuestos de tioacetato |
| CN105439946B (zh) | 2014-08-13 | 2018-02-02 | 益方生物科技（上海）有限公司 | 羧酸化合物及其制备方法和用途 |
| CN104306363B (zh) * | 2014-10-31 | 2017-06-06 | 南京葆赫生物技术有限公司 | 芪类衍生物及其药学可接受的盐在制备治疗高尿酸血症药物中的应用 |
-
2018
- 2018-10-03 CN CN201880064738.0A patent/CN111148735B/zh active Active
- 2018-10-03 KR KR1020207012149A patent/KR20200064101A/ko not_active Withdrawn
- 2018-10-03 CA CA3074989A patent/CA3074989A1/en not_active Abandoned
- 2018-10-03 SG SG11202003005PA patent/SG11202003005PA/en unknown
- 2018-10-03 PE PE2020000529A patent/PE20200846A1/es unknown
- 2018-10-03 RU RU2020115045A patent/RU2020115045A/ru unknown
- 2018-10-03 EP EP18864398.5A patent/EP3693358B1/en active Active
- 2018-10-03 US US16/150,989 patent/US10752596B2/en active Active
- 2018-10-03 JP JP2018188038A patent/JP7125882B2/ja active Active
- 2018-10-03 AU AU2018345221A patent/AU2018345221A1/en not_active Abandoned
- 2018-10-03 BR BR112020004857-7A patent/BR112020004857A2/pt not_active Application Discontinuation
- 2018-10-03 TW TW107134941A patent/TW201922706A/zh unknown
- 2018-10-03 WO PCT/JP2018/037007 patent/WO2019069973A1/ja not_active Ceased
- 2018-10-03 MX MX2020003816A patent/MX2020003816A/es unknown
- 2018-10-03 AR ARP180102853A patent/AR113270A1/es unknown
-
2020
- 2020-03-24 IL IL273573A patent/IL273573A/en unknown
- 2020-03-31 CO CONC2020/0003977A patent/CO2020003977A2/es unknown
- 2020-04-02 CL CL2020000898A patent/CL2020000898A1/es unknown
- 2020-04-06 PH PH12020550403A patent/PH12020550403A1/en unknown
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