JP2019011261A - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
- Publication number
- JP2019011261A JP2019011261A JP2017127542A JP2017127542A JP2019011261A JP 2019011261 A JP2019011261 A JP 2019011261A JP 2017127542 A JP2017127542 A JP 2017127542A JP 2017127542 A JP2017127542 A JP 2017127542A JP 2019011261 A JP2019011261 A JP 2019011261A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- composition
- aloe
- weight
- aloe vera
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 104
- 235000014104 aloe vera supplement Nutrition 0.000 claims abstract description 60
- 239000002244 precipitate Substances 0.000 claims abstract description 46
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000011732 tocopherol Substances 0.000 claims abstract description 23
- 229930003799 tocopherol Natural products 0.000 claims abstract description 23
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 21
- 229960001295 tocopherol Drugs 0.000 claims abstract description 21
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 21
- 229940069521 aloe extract Drugs 0.000 claims description 63
- 239000007788 liquid Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 8
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
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- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 2
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Abstract
Description
項1. キダチアロエエキス及び/又はアロエベラエキス、並びにトコフェロール及び/又はその誘導体を含有する、外用組成物。
項2. キダチアロエエキス及び/又はアロエベラエキスの総量が、乾燥重量換算で0.000005〜1重量%である、項1に記載の外用組成物。
項3. キダチアロエエキス及びアロエベラエキスを含有する、項1又は2に記載の外用組成物。
項4. キダチアロエエキスが乾燥重量換算で0.03重量%以上である、項3に記載の外用組成物。
項5. 前記トコフェロール及び/又はその誘導体として、酢酸トコフェロールを含む、項1〜4のいずれかに記載の外用組成物。
項6. 液剤である、項1〜5のいずれかに記載の外用組成物。
項7. 育毛剤である、項1〜6のいずれかに記載の外用組成物。
項8. キダチアロエエキス及び/又はアロエベラエキスを含む外用組成物における析出物の発生を抑制する方法であって、
外用組成物に、キダチアロエエキス及び/又はアロエベラエキスと共に、トコフェロール及び/又はその誘導体を配合する、抑制方法。
本発明の外用医薬組成物は、キダチアロエエキス及び/又はアロエベラエキス、並びにトコフェロール及び/又はその誘導体を含有することを特徴とする。以下、本発明の外用組成物について詳述する。
キダチアロエエキスとは、キダチアロエ(Aloe arborescens)を原料として抽出処理することにより得られる抽出物である。
本発明の外用組成物では、トコフェロール及び/又はその誘導体を含有することによって、キダチアロエエキス及び/又はアロエベラエキスに起因する析出の発生を抑制し、優れた製剤安定性を備えさせることが可能になっている。
本発明の外用組成物には、必要に応じて、析出物の発生の抑制効果の向上等を目的として、1価の低級アルコールが含まれていてもよい。
本発明の外用組成物には、必要に応じて、析出物の発生の抑制効果の向上等を目的として、多価アルコールが含まれていてもよい。
本発明の外用組成物には、必要に応じて、析出物の発生の抑制効果の向上等を目的として、界面活性剤が含まれていてもよい。
本発明の外用組成物は、所望の製剤形態への調製等のために、水が含まれる。従来技術では、キダチアロエエキス及び/又はアロエベラエキスを含む外用組成物において、水が含まれる場合には、析出物が発生するが、本発明の外用組成物では、水共存下で生じる析出物の発生を抑制することができる。
本発明の外用組成物には、前述する成分以外に、所望の製剤形態にするために、外用組成物に通常使用される他の添加剤が含まれていてもよい。このような添加剤としては、例えば、油性基剤、増粘剤、pH調節剤、乳化剤、可溶化剤、防腐剤、保存剤、酸化防止剤、安定化剤、キレート剤、香料、着色料等が挙げられる。
本発明の外用組成物の剤型については、経皮適用が可能であることを限度として特に制限されず、液状又は半固形状(ゲル状、軟膏状、ペースト状等)のいずれであってもよい。
更に、本発明は、キダチアロエエキス及び/又はアロエベラエキスを含む外用組成物における析出物の発生を抑制する方法であって、外用組成物に、キダチアロエエキス及び/又はアロエベラエキスと共に、トコフェロール及び/又はその誘導体を配合する、析出抑制方法を提供する。
表1に示す組成の液剤(育毛用化粧料)を調製した。調製した液剤200mlをガラス製スクリュー管瓶(容量225mL)に充填し、遮光条件下で、5℃で1か月間静置して保管した。1か月間保管後の各液剤の外観を観察し、以下に示す判定基準に従って、析出物の生成の程度を評点化した。なお、調製直後の液剤は、いずれも析出物が認められず、良好な外観であった。
<析出物の生成の程度の判定基準>
1:析出物は全く認められない。
2:顕微鏡で観察されるレベルの僅かな析出物が生成しているが、全体的に良好な外観性状が維持できている。
3:目視上確認できる微量の析出物が生成しており、外観性状の悪化が認められる。
4:析出物が凝集し、1mm程度の塊になっている。
5:析出物が凝集し、1mm超3mm以下程度の塊になっている。
6:析出物が凝集し、5mm以上程度の塊になっている。
Claims (8)
- キダチアロエエキス及び/又はアロエベラエキス、並びにトコフェロール及び/又はその誘導体を含有する、外用組成物。
- キダチアロエエキス及び/又はアロエベラエキスの総量が、乾燥重量換算で0.000005〜1重量%である、請求項1に記載の外用組成物。
- キダチアロエエキス及びアロエベラエキスを含有する、請求項1又は2に記載の外用組成物。
- キダチアロエエキスが乾燥重量換算で0.03重量%以上である、請求項3に記載の外用組成物。
- 前記トコフェロール及び/又はその誘導体として、酢酸トコフェロールを含む、請求項1〜4のいずれかに記載の外用組成物。
- 液剤である、請求項1〜5のいずれかに記載の外用組成物。
- 育毛剤である、請求項1〜6のいずれかに記載の外用組成物。
- キダチアロエエキス及び/又はアロエベラエキスを含む外用組成物における析出物の発生を抑制する方法であって、
外用組成物に、キダチアロエエキス及び/又はアロエベラエキスと共に、トコフェロール及び/又はその誘導体を配合する、抑制方法。
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006347959A (ja) * | 2005-06-16 | 2006-12-28 | Pias Arise Kk | 養毛剤 |
JP2007022923A (ja) * | 2005-07-12 | 2007-02-01 | Lion Corp | 毛包アポトーシス反応阻害剤および毛髪化粧料組成物 |
JP2010184916A (ja) * | 2009-02-13 | 2010-08-26 | Pias Arise Kk | 育毛剤 |
JP2013144650A (ja) * | 2012-01-13 | 2013-07-25 | Kobayashi Pharmaceutical Co Ltd | Vegf産生促進剤 |
JP2015131771A (ja) * | 2014-01-09 | 2015-07-23 | 小林製薬株式会社 | 皮膚用洗浄剤組成物 |
JP2015196655A (ja) * | 2014-03-31 | 2015-11-09 | 小林製薬株式会社 | ビタミンb6含有組成物 |
-
2017
- 2017-06-29 JP JP2017127542A patent/JP2019011261A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006347959A (ja) * | 2005-06-16 | 2006-12-28 | Pias Arise Kk | 養毛剤 |
JP2007022923A (ja) * | 2005-07-12 | 2007-02-01 | Lion Corp | 毛包アポトーシス反応阻害剤および毛髪化粧料組成物 |
JP2010184916A (ja) * | 2009-02-13 | 2010-08-26 | Pias Arise Kk | 育毛剤 |
JP2013144650A (ja) * | 2012-01-13 | 2013-07-25 | Kobayashi Pharmaceutical Co Ltd | Vegf産生促進剤 |
JP2015131771A (ja) * | 2014-01-09 | 2015-07-23 | 小林製薬株式会社 | 皮膚用洗浄剤組成物 |
JP2015196655A (ja) * | 2014-03-31 | 2015-11-09 | 小林製薬株式会社 | ビタミンb6含有組成物 |
Non-Patent Citations (1)
Title |
---|
NOEVIR, JAPAN: "Cleansing Massage Cream", MINTEL GNPD [ONLINE], JPN6021012266, September 2016 (2016-09-01), ISSN: 0004791577 * |
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