JP2018538315A - 骨関節炎治療のための親水化されたスルファサラジンおよびヒアルロン酸を含む組成物およびその製造方法 - Google Patents
骨関節炎治療のための親水化されたスルファサラジンおよびヒアルロン酸を含む組成物およびその製造方法 Download PDFInfo
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- JP2018538315A JP2018538315A JP2018532096A JP2018532096A JP2018538315A JP 2018538315 A JP2018538315 A JP 2018538315A JP 2018532096 A JP2018532096 A JP 2018532096A JP 2018532096 A JP2018532096 A JP 2018532096A JP 2018538315 A JP2018538315 A JP 2018538315A
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- osteoarthritis
- sulfasalazine
- hyaluronic acid
- treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Abstract
【選択図】 図5
Description
[化学式1]
Claims (13)
- 有効成分として2〜10mMの親水化されたスルファサラジンを含む、関節腔および局所投与可能な骨関節炎治療用組成物。
- 前記親水化されたスルファサラジンと共に、全体組成物に対して1〜2(w/v)%のヒアルロン酸、その塩または誘導体をさらに含む、請求項1に記載の関節腔および局所投与可能な骨関節炎治療用組成物。
- 前記ヒアルロン酸の誘導体は、交差結合、硫化、エステル化またはアミノ酸結合によって化学的に変形されたヒアルロン酸であることを特徴とする、請求項2に記載の骨関節炎治療用組成物。
- 前記組成物が液状製剤である、請求項1に記載の骨関節炎治療用組成物。
- 前記組成物が注射剤である、請求項1に記載の骨関節炎治療用組成物。
- a)塩基性添加物を水に溶解させてpH11以上14以下の水溶液を製造し、これにスルファサラジンを溶解させる段階;および
b)段階a)の反応物にヒアルロン酸、その塩または誘導体を溶解させる段階;
c)段階b)で製造された反応物を酸性添加物で中和させる段階
を含む、関節腔および局所投与可能な骨関節炎治療用組成物の製造方法。 - 前記塩基性添加物は、0.01〜1(w/v)%の水酸化ナトリウム、水酸化カリウムおよびアンモニアからなる群より選択された一つ以上である、請求項6に記載の製造方法。
- 前記水溶液はPEGをさらに含む、請求項6に記載の製造方法。
- 前記PEGは400〜20000の重量平均分子量を有する、請求項8に記載の製造方法。
- 前記PEGは全体組成物に対して、1〜40(w/v)%である、請求項8に記載の製造方法。
- 請求項6〜10のうちのいずれか一項の方法によって製造された、関節腔および局所投与可能な骨関節炎治療用組成物。
- 有効成分として2〜10mMの親水化されたスルファサラジンを含む組成物を投与する段階を含む、骨関節炎の改善または治療方法。
- 前記関節腔または局所投与することを特徴とする、請求項12に記載の骨関節炎の改善または治療方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2015-0182260 | 2015-12-18 | ||
KR1020150182260A KR101895950B1 (ko) | 2015-12-18 | 2015-12-18 | 골관절염 치료를 위한 친수화된 설파살라진 및 히알루론산을 포함하는 조성물 및 이의제조방법 |
PCT/KR2016/014822 WO2017105139A1 (ko) | 2015-12-18 | 2016-12-16 | 골관절염 치료를 위한 친수화된 설파살라진 및 히알루론산을 포함하는 조성물 및 이의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018538315A true JP2018538315A (ja) | 2018-12-27 |
JP6595717B2 JP6595717B2 (ja) | 2019-10-23 |
Family
ID=59057108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2018532096A Active JP6595717B2 (ja) | 2015-12-18 | 2016-12-16 | 骨関節炎治療のための親水化されたスルファサラジンおよびヒアルロン酸を含む組成物およびその製造方法 |
Country Status (7)
Country | Link |
---|---|
US (3) | US20180344750A1 (ja) |
EP (1) | EP3391889A4 (ja) |
JP (1) | JP6595717B2 (ja) |
KR (1) | KR101895950B1 (ja) |
CN (1) | CN108430478B (ja) |
RU (1) | RU2712168C1 (ja) |
WO (1) | WO2017105139A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11406612B2 (en) | 2018-02-26 | 2022-08-09 | Rensselaer Polytechnic Institute | Method of treatment via intra-articular application of potassium |
KR102647997B1 (ko) | 2021-06-15 | 2024-03-18 | 주식회사 제넨셀 | 증숙생강 추출물 또는 이로부터 분리된 1-데하이드로-6-진저다이온을 유효성분으로 포함하는 퇴행성 관절염 예방, 개선, 또는 치료용 조성물 |
KR20230024004A (ko) | 2021-08-11 | 2023-02-20 | 주식회사 제넨셀 | 담팔수 추출물 또는 담팔수 추출물과 설파살라진의 혼합물을 유효성분으로 포함하는 관절염 예방, 치료, 또는 개선용 조성물 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008517927A (ja) * | 2004-10-21 | 2008-05-29 | ユニバーシティー オブ アイオワ リサーチ ファンデーション | insitu制御放出薬剤送達システム |
JP2010511596A (ja) * | 2006-12-06 | 2010-04-15 | 生化学工業株式会社 | 関節疾患に対する持続的治療効果を有する薬剤 |
JP2011507912A (ja) * | 2008-04-18 | 2011-03-10 | ウォーソー・オーソペディック・インコーポレーテッド | 生分解性ポリマー担体中のスルファサラジン製剤 |
WO2014200211A1 (en) * | 2013-06-13 | 2014-12-18 | Dong-A St Co., Ltd | Liquid pharmaceutical composition containing piroxicam and hyaluronic acid for the treatment of osteoarthritis |
JP2015500334A (ja) * | 2011-12-12 | 2015-01-05 | ビーエムアイ コリア カンパニー リミテッド | 後発性白内障抑制用組成物およびその製造方法 |
Family Cites Families (6)
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---|---|---|---|---|
KR100490286B1 (ko) * | 2001-09-12 | 2005-05-17 | 주식회사 뉴로테크 | 설파살라진을 활성성분으로 함유하는 것을 특징으로 하는망막손상 치료용 안약 조성물과 그 제조방법 |
MXPA01011542A (es) * | 2001-11-13 | 2003-05-22 | Alcon Inc | Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel. |
ITPD20060219A1 (it) * | 2006-05-31 | 2007-12-01 | Fidia Farmaceutici | Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi |
KR100894042B1 (ko) * | 2007-04-13 | 2009-04-20 | 가톨릭대학교 산학협력단 | 설파살라진-히알루론산 혼합물의 제조방법 및 이로부터얻어진 혼합물을 포함하는 후발성 백내장 억제용 조성물 |
TWI589299B (zh) * | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
KR101412776B1 (ko) * | 2013-03-11 | 2014-07-01 | 가톨릭대학교 산학협력단 | 각결막염 치료용 점안제 조성물 및 이의 제조 방법 |
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2015
- 2015-12-18 KR KR1020150182260A patent/KR101895950B1/ko active IP Right Grant
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2016
- 2016-12-16 JP JP2018532096A patent/JP6595717B2/ja active Active
- 2016-12-16 RU RU2018124278A patent/RU2712168C1/ru active
- 2016-12-16 CN CN201680074216.XA patent/CN108430478B/zh active Active
- 2016-12-16 WO PCT/KR2016/014822 patent/WO2017105139A1/ko active Application Filing
- 2016-12-16 EP EP16876081.7A patent/EP3391889A4/en active Pending
- 2016-12-16 US US15/780,684 patent/US20180344750A1/en not_active Abandoned
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2019
- 2019-12-19 US US16/720,372 patent/US20200138834A1/en not_active Abandoned
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- 2021-01-26 US US17/158,177 patent/US20210145850A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008517927A (ja) * | 2004-10-21 | 2008-05-29 | ユニバーシティー オブ アイオワ リサーチ ファンデーション | insitu制御放出薬剤送達システム |
JP2010511596A (ja) * | 2006-12-06 | 2010-04-15 | 生化学工業株式会社 | 関節疾患に対する持続的治療効果を有する薬剤 |
JP2011507912A (ja) * | 2008-04-18 | 2011-03-10 | ウォーソー・オーソペディック・インコーポレーテッド | 生分解性ポリマー担体中のスルファサラジン製剤 |
JP2015500334A (ja) * | 2011-12-12 | 2015-01-05 | ビーエムアイ コリア カンパニー リミテッド | 後発性白内障抑制用組成物およびその製造方法 |
WO2014200211A1 (en) * | 2013-06-13 | 2014-12-18 | Dong-A St Co., Ltd | Liquid pharmaceutical composition containing piroxicam and hyaluronic acid for the treatment of osteoarthritis |
Also Published As
Publication number | Publication date |
---|---|
EP3391889A4 (en) | 2019-08-21 |
US20180344750A1 (en) | 2018-12-06 |
JP6595717B2 (ja) | 2019-10-23 |
US20210145850A1 (en) | 2021-05-20 |
WO2017105139A1 (ko) | 2017-06-22 |
CN108430478A (zh) | 2018-08-21 |
KR101895950B1 (ko) | 2018-09-06 |
KR20170073388A (ko) | 2017-06-28 |
CN108430478B (zh) | 2021-04-20 |
RU2712168C1 (ru) | 2020-01-24 |
EP3391889A1 (en) | 2018-10-24 |
US20200138834A1 (en) | 2020-05-07 |
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