JP2018538266A5 - - Google Patents
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- JP2018538266A5 JP2018538266A5 JP2018526119A JP2018526119A JP2018538266A5 JP 2018538266 A5 JP2018538266 A5 JP 2018538266A5 JP 2018526119 A JP2018526119 A JP 2018526119A JP 2018526119 A JP2018526119 A JP 2018526119A JP 2018538266 A5 JP2018538266 A5 JP 2018538266A5
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- Prior art keywords
- alkyl
- group
- pharmaceutically acceptable
- antagonist
- haloalkyl
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 27
- 150000003839 salts Chemical class 0.000 claims 23
- 239000012453 solvate Substances 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000005557 antagonist Substances 0.000 claims 17
- 150000001204 N-oxides Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 239000003112 inhibitor Substances 0.000 claims 15
- -1 hydrate Chemical class 0.000 claims 14
- 239000003446 ligand Substances 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 9
- 150000004677 hydrates Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 6
- 102000013691 Interleukin-17 Human genes 0.000 claims 6
- 108050003558 Interleukin-17 Proteins 0.000 claims 6
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 6
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 6
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 6
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 claims 5
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
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- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 4
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- 239000003814 drug Substances 0.000 claims 4
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- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
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- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 3
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- 101710136122 Tryptophan 2,3-dioxygenase Proteins 0.000 claims 3
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- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
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- 239000001257 hydrogen Substances 0.000 claims 3
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- 102100022464 5'-nucleotidase Human genes 0.000 claims 2
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- 101710093674 Cyclic nucleotide-gated cation channel beta-1 Proteins 0.000 claims 2
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- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 2
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- 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 claims 2
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 2
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 2
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- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
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- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 229940075993 receptor modulator Drugs 0.000 claims 2
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- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
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- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 1
- 108010082808 4-1BB Ligand Proteins 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000036764 Adenocarcinoma of the esophagus Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
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- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims 1
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- 208000016778 CD4+/CD56+ hematodermic neoplasm Diseases 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
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- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims 1
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- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
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- 229940122209 Sphingosine 1-phosphate receptor 1 antagonist Drugs 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 claims 1
- 101100289792 Squirrel monkey polyomavirus large T gene Proteins 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
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- 125000004432 carbon atom Chemical group C* 0.000 claims 1
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- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257389P | 2015-11-19 | 2015-11-19 | |
| US62/257,389 | 2015-11-19 | ||
| US201662277711P | 2016-01-12 | 2016-01-12 | |
| US62/277,711 | 2016-01-12 | ||
| PCT/US2016/062417 WO2017087607A1 (en) | 2015-11-19 | 2016-11-17 | Modulators of chemokine receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538266A JP2018538266A (ja) | 2018-12-27 |
| JP2018538266A5 true JP2018538266A5 (cg-RX-API-DMAC10.html) | 2019-12-26 |
| JP6923522B2 JP6923522B2 (ja) | 2021-08-18 |
Family
ID=58717803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526119A Active JP6923522B2 (ja) | 2015-11-19 | 2016-11-17 | ケモカイン受容体のモジュレーター |
Country Status (15)
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| AU2018219226B2 (en) | 2017-02-07 | 2024-12-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| CN110582288B (zh) | 2017-02-28 | 2024-09-20 | 恩多塞特公司 | 用于car t细胞疗法的组合物和方法 |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
| CN107271592B (zh) * | 2017-06-07 | 2023-12-01 | 江苏悦兴医药技术有限公司 | 一种盐酸替吡拉西与其相关杂质完全分离的液相色谱纯度检测方法 |
| KR20200037857A (ko) | 2017-08-14 | 2020-04-09 | 알러간, 인코포레이티드 | 3,4-이치환된 3-시클로부텐-1,2-디온 및 그의 용도 |
| ES3067325T3 (en) * | 2018-01-08 | 2026-05-21 | Chemocentryx Inc | Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2 |
| WO2019144095A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| AU2019218729B2 (en) | 2018-02-06 | 2025-12-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| JP7568224B2 (ja) | 2018-02-23 | 2024-10-16 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための配列決定法 |
| FR3079232A1 (fr) * | 2018-03-26 | 2019-09-27 | Galderma Research & Development | Nouveaux composes squaramides inhibiteurs de hdac et leurs utilisations pour le traitement des lymphomes cutanes a cellules t (ctcl) |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| WO2019195135A1 (en) * | 2018-04-01 | 2019-10-10 | The Wistar Institute | Substituted chromenones, ire1 inhibitors, and methods of using same |
| PE20211070A1 (es) | 2018-09-21 | 2021-06-09 | Pfizer | Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas utiles como inhibidores de ccr6 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN113950486A (zh) | 2019-01-28 | 2022-01-18 | 罗德岛大学理事会 | pHLIP®-介导的免疫刺激化合物的细胞内递送 |
| CN117018202A (zh) * | 2019-07-08 | 2023-11-10 | 上海交通大学医学院附属瑞金医院 | 趋化因子受体ccr6抑制剂在预防银屑病复发中的新应用 |
| KR102890201B1 (ko) | 2019-07-10 | 2025-11-24 | 케모센트릭스, 인크. | Pd-l1 억제제로서의 인단 |
| ES3068390T3 (en) | 2019-10-16 | 2026-05-29 | Chemocentryx Inc | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases |
| AU2020368392B2 (en) | 2019-10-16 | 2026-01-08 | Chemocentryx, Inc. | Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases |
| WO2021092593A1 (en) * | 2019-11-08 | 2021-05-14 | The University Of North Carolina At Chapel Hill | Use of agonists to augment car t function in solid tumors |
| EP4061371B1 (en) | 2019-11-22 | 2025-02-19 | AB Science | Masitinib for the treatment of sickle cell disease |
| CN113018438B (zh) * | 2019-12-24 | 2022-06-17 | 四川大学 | Cxcr2抑制剂在制备治疗鼻咽癌的药物中的用途 |
| IL295063A (en) | 2020-02-04 | 2022-09-01 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Chimeric antigen receptors (car) against dinitrophenol |
| TWI904157B (zh) | 2020-04-30 | 2025-11-11 | 瑞士商愛杜西亞製藥有限公司 | Ccr6受體調節劑 |
| GB202103640D0 (en) * | 2021-03-16 | 2021-04-28 | C4X Discovery Ltd | Therapeutic compounds |
| US11896593B2 (en) * | 2020-09-10 | 2024-02-13 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compounds for use in treating or alleviating a psychiatric disorder |
| CN113713092A (zh) * | 2021-08-05 | 2021-11-30 | 齐鲁工业大学 | 趋化因子受体ccr6在制备抗肿瘤药物中的应用 |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| JP2024539987A (ja) | 2021-10-26 | 2024-10-31 | イドルシア・ファーマシューティカルズ・リミテッド | Ｃｃｒ６受容体調節剤 |
| ES3073199T3 (en) | 2021-10-28 | 2026-07-09 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| CN117924147B (zh) * | 2024-01-17 | 2026-08-11 | 首都医科大学 | 一种异吲哚啉联氯苯类衍生物及其制备方法和应用 |
| WO2025255109A1 (en) * | 2024-06-03 | 2025-12-11 | Artax Biopharma Inc. | Combination of a chromene derivative tcr inhibitor and a pde4 inhibitor |
Family Cites Families (59)
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