JP2018538253A5 - - Google Patents
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- Publication number
- JP2018538253A5 JP2018538253A5 JP2018522572A JP2018522572A JP2018538253A5 JP 2018538253 A5 JP2018538253 A5 JP 2018538253A5 JP 2018522572 A JP2018522572 A JP 2018522572A JP 2018522572 A JP2018522572 A JP 2018522572A JP 2018538253 A5 JP2018538253 A5 JP 2018538253A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl
- methylpyrimidin
- indoline
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(c(c(N1*(*)N*)c2)ccc2-c2cnc(C)nc2)C1=O Chemical compound CC(C)(c(c(N1*(*)N*)c2)ccc2-c2cnc(C)nc2)C1=O 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15193355 | 2015-11-06 | ||
| EP15193355.3 | 2015-11-06 | ||
| PCT/EP2016/076315 WO2017076842A1 (en) | 2015-11-06 | 2016-11-02 | Indolin-2-one derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538253A JP2018538253A (ja) | 2018-12-27 |
| JP2018538253A5 true JP2018538253A5 (https=) | 2019-11-28 |
| JP6839184B2 JP6839184B2 (ja) | 2021-03-03 |
Family
ID=54476823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522572A Active JP6839184B2 (ja) | 2015-11-06 | 2016-11-02 | インドリン−２−オン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10519140B2 (https=) |
| EP (1) | EP3371174B1 (https=) |
| JP (1) | JP6839184B2 (https=) |
| CN (1) | CN108137561B (https=) |
| AR (1) | AR106589A1 (https=) |
| TW (1) | TWI614244B (https=) |
| WO (1) | WO2017076842A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| PH12018500978B1 (en) | 2015-11-06 | 2023-05-05 | Hoffmann La Roche | Indolin-2-one derivatives |
| EP3371170B1 (en) | 2015-11-06 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives useful in the treatment of cns diseases |
| CN108137561B (zh) | 2015-11-06 | 2021-03-26 | 豪夫迈·罗氏有限公司 | 二氢吲哚-2-酮衍生物 |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CA3152752A1 (en) | 2019-10-01 | 2021-04-08 | Thomas Henley | Genetic engineering of fungi to modulate tryptamine expression |
| WO2021231933A1 (en) * | 2020-05-15 | 2021-11-18 | Neucyte Pharmaceuticals | Anti-epileptic pharmaceutical compositions and use thereof |
| CN118984868A (zh) | 2021-12-31 | 2024-11-19 | 恩派瑞安神经科学公司 | 用于产生精神药物生物碱的遗传修饰的生物体 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3935514A1 (de) | 1989-10-25 | 1991-05-02 | Boehringer Mannheim Gmbh | Neue bicyclo-imidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW251284B (https=) | 1992-11-02 | 1995-07-11 | Pfizer | |
| DE4427648A1 (de) | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung |
| FR2757157B1 (fr) | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
| AU2494300A (en) | 1999-01-07 | 2000-07-24 | American Home Products Corporation | 3,4-dihydro-2h-benzo(1,4)oxazine derivatives |
| MXPA03000032A (es) | 2000-06-29 | 2003-08-19 | Neurosearch As | Uso de derivados de oxindol 3-sustituidos como moduladores de los canales de potasio kcnq. |
| WO2004060902A2 (en) | 2002-12-31 | 2004-07-22 | John K Buolamwini | Novel nucleoside transport inhibitors |
| CZ2006769A3 (cs) | 2004-05-11 | 2007-03-14 | Egis Gyogyszergyár Nyrt. | Pyridinové deriváty alkyloxindolu jako aktivní látka vuci 5-HT7 receptoru |
| US20060253263A1 (en) | 2005-04-11 | 2006-11-09 | Meshkin Brian J | Method to optimize drug selection, dosing and evaluation and to help predict therapeutic response and toxicity from immunosuppressant therapy |
| AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| AR056317A1 (es) | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| WO2008002946A2 (en) | 2006-06-26 | 2008-01-03 | Helicon Therapeutics, Inc. | Method of modulating neurite outgrowth by the use of a galanin-3 receptor antagonist |
| WO2008046083A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of oxindole compounds as therapeutic agents |
| EP2114921B1 (en) | 2006-12-30 | 2012-12-26 | Abbott GmbH & Co. KG | Substituted oxindole derivative and its use as a vasopressin receptor ligand |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| JO3126B1 (ar) * | 2007-11-14 | 2017-09-20 | Janssen Pharmaceutica Nv | مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1 |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| KR101706877B1 (ko) | 2012-09-13 | 2017-02-15 | 에프. 호프만-라 로슈 아게 | Cns 장애의 치료를 위한 2-옥소-2,3-다이하이드로-인돌 |
| KR101811549B1 (ko) * | 2013-06-19 | 2017-12-26 | 에프. 호프만-라 로슈 아게 | 인돌린-2-온 또는 피롤로-피리딘/피리미딘-2-온 유도체 |
| FR3017867A1 (fr) * | 2014-02-21 | 2015-08-28 | Inventiva | Nouveaux composes de type phenylazetidine carboxylate ou carboxamide |
| AU2015279377B2 (en) * | 2014-06-26 | 2019-09-12 | F. Hoffmann-La Roche Ag | Indolin-2-one or pyrrolo-pyridin-2-one derivatives |
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| PH12018500978B1 (en) | 2015-11-06 | 2023-05-05 | Hoffmann La Roche | Indolin-2-one derivatives |
| CN108137561B (zh) | 2015-11-06 | 2021-03-26 | 豪夫迈·罗氏有限公司 | 二氢吲哚-2-酮衍生物 |
| EP3371170B1 (en) | 2015-11-06 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives useful in the treatment of cns diseases |
-
2016
- 2016-11-02 CN CN201680056575.2A patent/CN108137561B/zh active Active
- 2016-11-02 EP EP16790588.4A patent/EP3371174B1/en active Active
- 2016-11-02 WO PCT/EP2016/076315 patent/WO2017076842A1/en not_active Ceased
- 2016-11-02 JP JP2018522572A patent/JP6839184B2/ja active Active
- 2016-11-04 TW TW105135829A patent/TWI614244B/zh not_active IP Right Cessation
- 2016-11-04 AR ARP160103364A patent/AR106589A1/es unknown
-
2018
- 2018-05-04 US US15/971,368 patent/US10519140B2/en active Active
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