JP2018537499A - 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 - Google Patents

置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 Download PDF

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JP2018537499A
JP2018537499A JP2018531388A JP2018531388A JP2018537499A JP 2018537499 A JP2018537499 A JP 2018537499A JP 2018531388 A JP2018531388 A JP 2018531388A JP 2018531388 A JP2018531388 A JP 2018531388A JP 2018537499 A JP2018537499 A JP 2018537499A
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ray powder
powder diffraction
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compound
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JP2018537499A5 (enExample
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クレイグ ベイツ
クレイグ ベイツ
デイビッド ピー． リード
デイビッド ピー． リード
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アークル インコーポレイテッド
アークル インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018531388A 2015-12-17 2016-12-16 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 Pending JP2018537499A (ja)

Priority Applications (1)

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JP2021191696A JP2022031797A (ja) 2015-12-17 2021-11-26 置換５，６－ジヒドロ－６－フェニルベンゾ［ｆ］イソキノリン－２－アミン化合物の固体形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17
US62/268,747 2015-12-17
PCT/US2016/067164 WO2017106642A1 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

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JP2021191696A Division JP2022031797A (ja) 2015-12-17 2021-11-26 置換５，６－ジヒドロ－６－フェニルベンゾ［ｆ］イソキノリン－２－アミン化合物の固体形態

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JP2018537499A true JP2018537499A (ja) 2018-12-20
JP2018537499A5 JP2018537499A5 (enExample) 2020-01-16

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JP2018531388A Pending JP2018537499A (ja) 2015-12-17 2016-12-16 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態
JP2021191696A Pending JP2022031797A (ja) 2015-12-17 2021-11-26 置換５，６－ジヒドロ－６－フェニルベンゾ［ｆ］イソキノリン－２－アミン化合物の固体形態

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EP (2) EP3390369B1 (enExample)
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AU (2) AU2016369523B2 (enExample)
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Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
WO2017106639A1 (en) 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
TWI771280B (zh) 2015-12-17 2022-07-21 美商亞闊股份有限公司 經取代之5,6-二氫-6-苯基苯并[f]異喹啉-2-胺化合物之固體形式
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma
JP7641247B2 (ja) 2022-03-02 2025-03-06 日立建機株式会社 機械の性能診断装置

Citations (5)

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JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
JP2002504926A (ja) * 1997-06-20 2002-02-12 セルテック セラピューティックス リミテッド プロテインキナーゼ阻害剤としての縮合多環式２−アミノピリミジン誘導体
JP2010514810A (ja) * 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
JP2012514045A (ja) * 2008-12-30 2012-06-21 アークル インコーポレイテッド 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds

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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP1638937B1 (en) * 2003-06-18 2008-12-17 Teva Pharmaceutical Industries Limited Fluvastatin sodium crystal form xiv, processes for preparing it, compositions containing it and methods of using it
KR20130105675A (ko) * 2010-11-25 2013-09-25 라티오팜 게엠베하 아파티닙의 신규 염 및 다형
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
EP2760859A1 (en) * 2011-09-30 2014-08-06 Sunshine Lake Pharma Co., Ltd Crystalline forms of azilsartan and preparation and uses thereof
TWI771280B (zh) * 2015-12-17 2022-07-21 美商亞闊股份有限公司 經取代之5,6-二氫-6-苯基苯并[f]異喹啉-2-胺化合物之固體形式
WO2017106639A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Patent Citations (5)

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JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
JP2002504926A (ja) * 1997-06-20 2002-02-12 セルテック セラピューティックス リミテッド プロテインキナーゼ阻害剤としての縮合多環式２−アミノピリミジン誘導体
JP2010514810A (ja) * 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
JP2012514045A (ja) * 2008-12-30 2012-06-21 アークル インコーポレイテッド 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds

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DATABASE REGISTRY [ONLINE], vol. [retrieved on 2020.10.19], JPN7020003673, 25 November 2015 (2015-11-25), pages Retrieved from: STN, ISSN: 0004710496 *
平山令明編, 有機化合物結晶作製ハンドブック −原理とノウハウ−, JPN6011053065, 25 July 2008 (2008-07-25), pages 57 - 84, ISSN: 0004710494 *
緒方章, 化学実験操作法 上巻, JPN6009048171, 20 November 1963 (1963-11-20), ISSN: 0004710495 *
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0004710493 *

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PH12018501246A1 (en) 2019-02-04
EA202091691A1 (ru) 2021-01-29
US10227311B2 (en) 2019-03-12
AU2022201947B2 (en) 2023-07-27
SA518391805B1 (ar) 2022-12-21
WO2017106642A1 (en) 2017-06-22
MX394320B (es) 2025-03-24
TWI771280B (zh) 2022-07-21
HK1256825A1 (zh) 2019-10-04
EP3390369B1 (en) 2022-11-02
EP3390369A4 (en) 2019-08-14
US20200002293A1 (en) 2020-01-02
TWI796250B (zh) 2023-03-11
EA036295B1 (ru) 2020-10-22
US9981921B2 (en) 2018-05-29
PH12020551465A1 (en) 2021-07-26
TW202241854A (zh) 2022-11-01
KR20180086508A (ko) 2018-07-31
US20170174636A1 (en) 2017-06-22
AU2016369523B2 (en) 2021-12-23
EP4019499A1 (en) 2022-06-29
EA201891430A1 (ru) 2018-11-30
US10717710B2 (en) 2020-07-21
ES2935818T3 (es) 2023-03-10
NZ742695A (en) 2022-10-28
CN108368061A (zh) 2018-08-03
JP2022031797A (ja) 2022-02-22
AU2016369523A1 (en) 2018-06-07
MX2018007414A (es) 2018-11-09
MX2021000432A (es) 2022-07-28
US20180258055A1 (en) 2018-09-13
BR112018012095A2 (pt) 2018-11-27
AU2022201947A1 (en) 2022-04-14
SG11201804670PA (en) 2018-07-30
CA3006081A1 (en) 2017-06-22
IL259556A (en) 2018-07-31
MX385671B (es) 2025-03-18
IL259556B1 (en) 2023-05-01
EP3390369A1 (en) 2018-10-24
IL259556B2 (en) 2023-09-01
TW201736352A (zh) 2017-10-16

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