AU2016369523B2 - Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds - Google Patents

Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds Download PDF

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Publication number
AU2016369523B2
AU2016369523B2 AU2016369523A AU2016369523A AU2016369523B2 AU 2016369523 B2 AU2016369523 B2 AU 2016369523B2 AU 2016369523 A AU2016369523 A AU 2016369523A AU 2016369523 A AU2016369523 A AU 2016369523A AU 2016369523 B2 AU2016369523 B2 AU 2016369523B2
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Australia
Prior art keywords
approximately
polymorph
cancer
compound
ray powder
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Ceased
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AU2016369523A
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AU2016369523A1 (en
Inventor
Craig Bates
David P. Reed
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Arqule Inc
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Arqule Inc
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Publication of AU2016369523A1 publication Critical patent/AU2016369523A1/en
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Priority to AU2022201947A priority Critical patent/AU2022201947B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016369523A 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds Ceased AU2016369523B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022201947A AU2022201947B2 (en) 2015-12-17 2022-03-21 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17
US62/268,747 2015-12-17
PCT/US2016/067164 WO2017106642A1 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022201947A Division AU2022201947B2 (en) 2015-12-17 2022-03-21 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Publications (2)

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AU2016369523A1 AU2016369523A1 (en) 2018-06-07
AU2016369523B2 true AU2016369523B2 (en) 2021-12-23

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AU2016369523A Ceased AU2016369523B2 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
AU2022201947A Expired - Fee Related AU2022201947B2 (en) 2015-12-17 2022-03-21 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

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Country Status (19)

Country Link
US (3) US9981921B2 (enExample)
EP (2) EP3390369B1 (enExample)
JP (2) JP2018537499A (enExample)
KR (1) KR20180086508A (enExample)
CN (1) CN108368061A (enExample)
AU (2) AU2016369523B2 (enExample)
BR (1) BR112018012095A2 (enExample)
CA (1) CA3006081A1 (enExample)
EA (2) EA036295B1 (enExample)
ES (1) ES2935818T3 (enExample)
HK (1) HK1256825A1 (enExample)
IL (1) IL259556B2 (enExample)
MX (2) MX394320B (enExample)
NZ (1) NZ742695A (enExample)
PH (2) PH12018501246A1 (enExample)
SA (1) SA518391805B1 (enExample)
SG (1) SG11201804670PA (enExample)
TW (2) TWI771280B (enExample)
WO (1) WO2017106642A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017106639A1 (en) 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
TWI771280B (zh) 2015-12-17 2022-07-21 美商亞闊股份有限公司 經取代之5,6-二氫-6-苯基苯并[f]異喹啉-2-胺化合物之固體形式
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma
JP7641247B2 (ja) 2022-03-02 2025-03-06 日立建機株式会社 機械の性能診断装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010078421A1 (en) * 2008-12-30 2010-07-08 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds

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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
WO1998028281A1 (en) 1996-12-23 1998-07-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
EP1638937B1 (en) * 2003-06-18 2008-12-17 Teva Pharmaceutical Industries Limited Fluvastatin sodium crystal form xiv, processes for preparing it, compositions containing it and methods of using it
EP2079736B1 (en) * 2006-12-29 2017-10-18 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
KR20130105675A (ko) * 2010-11-25 2013-09-25 라티오팜 게엠베하 아파티닙의 신규 염 및 다형
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
EP2760859A1 (en) * 2011-09-30 2014-08-06 Sunshine Lake Pharma Co., Ltd Crystalline forms of azilsartan and preparation and uses thereof
TWI771280B (zh) * 2015-12-17 2022-07-21 美商亞闊股份有限公司 經取代之5,6-二氫-6-苯基苯并[f]異喹啉-2-胺化合物之固體形式
WO2017106639A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010078421A1 (en) * 2008-12-30 2010-07-08 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds

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Publication number Publication date
PH12018501246A1 (en) 2019-02-04
JP2018537499A (ja) 2018-12-20
EA202091691A1 (ru) 2021-01-29
US10227311B2 (en) 2019-03-12
AU2022201947B2 (en) 2023-07-27
SA518391805B1 (ar) 2022-12-21
WO2017106642A1 (en) 2017-06-22
MX394320B (es) 2025-03-24
TWI771280B (zh) 2022-07-21
HK1256825A1 (zh) 2019-10-04
EP3390369B1 (en) 2022-11-02
EP3390369A4 (en) 2019-08-14
US20200002293A1 (en) 2020-01-02
TWI796250B (zh) 2023-03-11
EA036295B1 (ru) 2020-10-22
US9981921B2 (en) 2018-05-29
PH12020551465A1 (en) 2021-07-26
TW202241854A (zh) 2022-11-01
KR20180086508A (ko) 2018-07-31
US20170174636A1 (en) 2017-06-22
EP4019499A1 (en) 2022-06-29
EA201891430A1 (ru) 2018-11-30
US10717710B2 (en) 2020-07-21
ES2935818T3 (es) 2023-03-10
NZ742695A (en) 2022-10-28
CN108368061A (zh) 2018-08-03
JP2022031797A (ja) 2022-02-22
AU2016369523A1 (en) 2018-06-07
MX2018007414A (es) 2018-11-09
MX2021000432A (es) 2022-07-28
US20180258055A1 (en) 2018-09-13
BR112018012095A2 (pt) 2018-11-27
AU2022201947A1 (en) 2022-04-14
SG11201804670PA (en) 2018-07-30
CA3006081A1 (en) 2017-06-22
IL259556A (en) 2018-07-31
MX385671B (es) 2025-03-18
IL259556B1 (en) 2023-05-01
EP3390369A1 (en) 2018-10-24
IL259556B2 (en) 2023-09-01
TW201736352A (zh) 2017-10-16

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