JP2018536624A5 - - Google Patents
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- JP2018536624A5 JP2018536624A5 JP2018514882A JP2018514882A JP2018536624A5 JP 2018536624 A5 JP2018536624 A5 JP 2018536624A5 JP 2018514882 A JP2018514882 A JP 2018514882A JP 2018514882 A JP2018514882 A JP 2018514882A JP 2018536624 A5 JP2018536624 A5 JP 2018536624A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 143
- 239000000427 antigen Substances 0.000 claims 23
- 102000038129 antigens Human genes 0.000 claims 23
- 108091007172 antigens Proteins 0.000 claims 23
- 102000005614 monoclonal antibodies Human genes 0.000 claims 22
- 108010045030 monoclonal antibodies Proteins 0.000 claims 22
- 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 102100013078 CD47 Human genes 0.000 claims 5
- 101700033237 CD47 Proteins 0.000 claims 5
- 206010024324 Leukaemias Diseases 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 4
- 108090001123 antibodies Proteins 0.000 claims 4
- 210000004027 cells Anatomy 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 208000009285 Lymphoma, Large B-Cell, Diffuse Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010025310 Other lymphomas Diseases 0.000 claims 3
- 206010057249 Phagocytosis Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 230000000527 lymphocytic Effects 0.000 claims 3
- 230000008782 phagocytosis Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 210000004881 tumor cells Anatomy 0.000 claims 3
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 2
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 claims 2
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims 2
- 206010026798 Mantle cell lymphomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 201000006934 chronic myeloid leukemia Diseases 0.000 claims 2
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 2
- 230000001419 dependent Effects 0.000 claims 2
- 230000003325 follicular Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000003793 myelodysplastic syndrome Diseases 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 230000002441 reversible Effects 0.000 claims 2
- 208000009956 Adenocarcinoma Diseases 0.000 claims 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 206010073080 Autoinflammatory disease Diseases 0.000 claims 1
- 208000003950 B-Cell Lymphoma Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 210000003743 Erythrocytes Anatomy 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 208000005017 Glioblastoma Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 206010020243 Hodgkin's disease Diseases 0.000 claims 1
- 201000006743 Hodgkin's lymphoma Diseases 0.000 claims 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
- 206010024190 Leiomyosarcomas Diseases 0.000 claims 1
- 206010024627 Liposarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 206010027191 Meningioma Diseases 0.000 claims 1
- 206010028549 Myeloid leukaemia Diseases 0.000 claims 1
- 206010028576 Myeloproliferative disease Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 208000003359 Plasma Cell Leukemia Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 206010038038 Rectal cancer Diseases 0.000 claims 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 102100004476 SIRPA Human genes 0.000 claims 1
- 101710024246 SIRPA Proteins 0.000 claims 1
- 208000000587 Small Cell Lung Carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 206010073145 Soft tissue cancer Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 206010042863 Synovial sarcoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010046766 Uterine cancer Diseases 0.000 claims 1
- 206010047802 Waldenstrom's macroglobulinaemias Diseases 0.000 claims 1
- 230000001154 acute Effects 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 201000003076 angiosarcoma Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000001413 cellular Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000008808 fibrosarcoma Diseases 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 201000000052 gastrinoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000006866 hypopharynx cancer Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 230000003211 malignant Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000009251 multiple myeloma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 201000006958 oropharynx cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000000306 recurrent Effects 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000008736 systemic mastocytosis Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 201000011531 vascular cancer Diseases 0.000 claims 1
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562220725P | 2015-09-18 | 2015-09-18 | |
US201562220691P | 2015-09-18 | 2015-09-18 | |
US62/220,691 | 2015-09-18 | ||
US62/220,725 | 2015-09-18 | ||
US201562221852P | 2015-09-22 | 2015-09-22 | |
US62/221,852 | 2015-09-22 | ||
US201562232681P | 2015-09-25 | 2015-09-25 | |
US62/232,681 | 2015-09-25 | ||
US201562252171P | 2015-11-06 | 2015-11-06 | |
US62/252,171 | 2015-11-06 | ||
US201562263544P | 2015-12-04 | 2015-12-04 | |
US62/263,544 | 2015-12-04 | ||
US201662354592P | 2016-06-24 | 2016-06-24 | |
US62/354,592 | 2016-06-24 | ||
PCT/US2016/052383 WO2017049251A2 (en) | 2015-09-18 | 2016-09-17 | Therapeutic cd47 antibodies |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2018536624A JP2018536624A (ja) | 2018-12-13 |
JP2018536624A5 true JP2018536624A5 (US07794700-20100914-C00152.png) | 2019-12-05 |
JP6885606B2 JP6885606B2 (ja) | 2021-06-16 |
Family
ID=58289729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018514882A Active JP6885606B2 (ja) | 2015-09-18 | 2016-09-17 | 治療用cd47抗体 |
Country Status (15)
Families Citing this family (72)
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2016
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2017
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2018
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