JP2018535394A5 - - Google Patents
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- JP2018535394A5 JP2018535394A5 JP2018514414A JP2018514414A JP2018535394A5 JP 2018535394 A5 JP2018535394 A5 JP 2018535394A5 JP 2018514414 A JP2018514414 A JP 2018514414A JP 2018514414 A JP2018514414 A JP 2018514414A JP 2018535394 A5 JP2018535394 A5 JP 2018535394A5
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- 102100030703 Interleukin-22 Human genes 0.000 claims description 79
- 108010074109 interleukin-22 Proteins 0.000 claims description 79
- 108010065637 Interleukin-23 Proteins 0.000 claims description 59
- 102000013264 Interleukin-23 Human genes 0.000 claims description 59
- 229940124829 interleukin-23 Drugs 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 32
- 239000005557 antagonist Substances 0.000 claims description 25
- 201000010099 disease Diseases 0.000 claims description 24
- 230000001404 mediated effect Effects 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 239000012634 fragment Substances 0.000 claims description 17
- 238000003018 immunoassay Methods 0.000 claims description 12
- 208000035475 disorder Diseases 0.000 claims description 8
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 6
- 201000004624 Dermatitis Diseases 0.000 claims description 6
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
- 208000011231 Crohn disease Diseases 0.000 claims description 5
- -1 CCL22 Proteins 0.000 claims description 4
- 208000015943 Coeliac disease Diseases 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 3
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- MJZJYWCQPMNPRM-UHFFFAOYSA-N 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Chemical compound CC1(C)N=C(N)N=C(N)N1OCCCOC1=CC(Cl)=C(Cl)C=C1Cl MJZJYWCQPMNPRM-UHFFFAOYSA-N 0.000 claims description 2
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims description 2
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- 102100026887 Beta-defensin 103 Human genes 0.000 claims description 2
- 102100026886 Beta-defensin 104 Human genes 0.000 claims description 2
- 102100038326 Beta-defensin 4A Human genes 0.000 claims description 2
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- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims description 2
- 102100036848 C-C motif chemokine 20 Human genes 0.000 claims description 2
- 102100038608 Cathelicidin antimicrobial peptide Human genes 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 206010012442 Dermatitis contact Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 241000700721 Hepatitis B virus Species 0.000 claims description 2
- 101000912247 Homo sapiens Beta-defensin 103 Proteins 0.000 claims description 2
- 101000912243 Homo sapiens Beta-defensin 104 Proteins 0.000 claims description 2
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 claims description 2
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims description 2
- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims description 2
- 101000741320 Homo sapiens Cathelicidin antimicrobial peptide Proteins 0.000 claims description 2
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims description 2
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 claims description 2
- 101000852992 Homo sapiens Interleukin-12 subunit beta Proteins 0.000 claims description 2
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 claims description 2
- 101000998151 Homo sapiens Interleukin-17F Proteins 0.000 claims description 2
- 101000853012 Homo sapiens Interleukin-23 receptor Proteins 0.000 claims description 2
- 101000853000 Homo sapiens Interleukin-26 Proteins 0.000 claims description 2
- 101000642478 Homo sapiens Serpin B3 Proteins 0.000 claims description 2
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 102100020881 Interleukin-1 alpha Human genes 0.000 claims description 2
- 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 claims description 2
- 102100036701 Interleukin-12 subunit beta Human genes 0.000 claims description 2
- 102100033461 Interleukin-17A Human genes 0.000 claims description 2
- 102100033454 Interleukin-17F Human genes 0.000 claims description 2
- 102100030704 Interleukin-21 Human genes 0.000 claims description 2
- 102100036672 Interleukin-23 receptor Human genes 0.000 claims description 2
- 102100036679 Interleukin-26 Human genes 0.000 claims description 2
- 102000004889 Interleukin-6 Human genes 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 208000019693 Lung disease Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010026749 Mania Diseases 0.000 claims description 2
- 102000001691 Member 3 Group F Nuclear Receptor Subfamily 1 Human genes 0.000 claims description 2
- 108010029279 Member 3 Group F Nuclear Receptor Subfamily 1 Proteins 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 101000912227 Pan troglodytes Beta-defensin 104A Proteins 0.000 claims description 2
- 206010036790 Productive cough Diseases 0.000 claims description 2
- 102100029812 Protein S100-A12 Human genes 0.000 claims description 2
- 102100032446 Protein S100-A7 Human genes 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 2
- 206010037575 Pustular psoriasis Diseases 0.000 claims description 2
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 claims description 2
- 108010005256 S100 Calcium Binding Protein A7 Proteins 0.000 claims description 2
- 108700016890 S100A12 Proteins 0.000 claims description 2
- 101150097337 S100A12 gene Proteins 0.000 claims description 2
- 102100036383 Serpin B3 Human genes 0.000 claims description 2
- 201000002661 Spondylitis Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 206010047115 Vasculitis Diseases 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 238000011374 additional therapy Methods 0.000 claims description 2
- 208000002029 allergic contact dermatitis Diseases 0.000 claims description 2
- 231100000360 alopecia Toxicity 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 230000001363 autoimmune Effects 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- TWFZGCMQGLPBSX-UHFFFAOYSA-N carbendazim Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 210000002919 epithelial cell Anatomy 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 229950010864 guselkumab Drugs 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 108010074108 interleukin-21 Proteins 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 230000003285 pharmacodynamic effect Effects 0.000 claims description 2
- 210000004910 pleural fluid Anatomy 0.000 claims description 2
- 201000010914 pustulosis of palm and sole Diseases 0.000 claims description 2
- 208000011797 pustulosis palmaris et plantaris Diseases 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
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- 201000011549 stomach cancer Diseases 0.000 claims description 2
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- 210000001519 tissue Anatomy 0.000 claims description 2
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- 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 229960003824 ustekinumab Drugs 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 102000013519 Lipocalin-2 Human genes 0.000 description 41
- 108010051335 Lipocalin-2 Proteins 0.000 description 41
- 239000000523 sample Substances 0.000 description 9
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021110695A JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2022159196A JP2023002583A (ja) | 2015-09-17 | 2022-10-03 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220062P | 2015-09-17 | 2015-09-17 | |
| US62/220,062 | 2015-09-17 | ||
| PCT/US2016/052060 WO2017049035A1 (en) | 2015-09-17 | 2016-09-16 | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021110695A Division JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535394A JP2018535394A (ja) | 2018-11-29 |
| JP2018535394A5 true JP2018535394A5 (enExample) | 2020-11-12 |
| JP6909208B2 JP6909208B2 (ja) | 2021-07-28 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514414A Expired - Fee Related JP6909208B2 (ja) | 2015-09-17 | 2016-09-16 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2021110695A Active JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2022159196A Pending JP2023002583A (ja) | 2015-09-17 | 2022-10-03 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021110695A Active JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2022159196A Pending JP2023002583A (ja) | 2015-09-17 | 2022-10-03 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11016099B2 (enExample) |
| EP (1) | EP3349854A4 (enExample) |
| JP (3) | JP6909208B2 (enExample) |
| KR (1) | KR20180063127A (enExample) |
| CN (2) | CN108290058B (enExample) |
| AU (1) | AU2016323579A1 (enExample) |
| BR (1) | BR112018005175A2 (enExample) |
| CA (1) | CA2998349A1 (enExample) |
| HK (1) | HK1258292A1 (enExample) |
| IL (1) | IL257969A (enExample) |
| MX (1) | MX2018003376A (enExample) |
| RU (1) | RU2018113694A (enExample) |
| WO (1) | WO2017049035A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| US10370718B2 (en) | 2014-09-29 | 2019-08-06 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| CN108290058B (zh) | 2015-09-17 | 2023-05-16 | 美国安进公司 | 使用il23途径生物标志物预测il23拮抗剂的临床应答 |
| TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| WO2019113037A1 (en) * | 2017-12-04 | 2019-06-13 | Immusant, Inc. | Measurement of ccl20 after gluten exposure |
| MX2020005861A (es) * | 2017-12-07 | 2020-10-28 | Amgen Inc | Método para tratar la púrpura tombocitopénica idiopática (pti) con romiplostim. |
| CA3092551A1 (en) * | 2018-03-05 | 2019-09-12 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| WO2019220412A2 (en) * | 2018-05-18 | 2019-11-21 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
| EP3824295A4 (en) * | 2018-07-18 | 2022-04-27 | Janssen Biotech, Inc. | PREDICTORS OF PROLONGED RESPONSE AFTER TREATMENT WITH AN ANTI-IL23 SPECIFIC ANTIBODY |
| FI13575Y1 (fi) * | 2018-09-24 | 2024-03-26 | Janssen Biotech Inc | IL12/IL23-vasta-aine käytettäväksi turvallisessa ja tehokaassa menetelmässä haavaisen paksusuolitulehduksen hoitamiseksi |
| EP3884276A2 (en) * | 2018-11-23 | 2021-09-29 | Katholieke Universiteit Leuven | Predicting a treatment response in inflammatory bowel disease |
| CN109337974B (zh) * | 2018-12-14 | 2022-01-25 | 北京蛋白质组研究中心 | 一种检测银屑病的诊断标志物的试剂及其应用 |
| WO2020128864A1 (en) * | 2018-12-18 | 2020-06-25 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
| KR20210141583A (ko) * | 2019-03-18 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-il-12/il-23 항체를 사용한 소아 대상의 건선 치료 방법 |
| TW202102538A (zh) * | 2019-03-26 | 2021-01-16 | 美商阿斯特捷利康合作創業有限責任公司 | 適合il23拮抗劑療法的患者群體 |
| EP3956358A4 (en) * | 2019-04-17 | 2023-01-25 | Millennium Pharmaceuticals, Inc. | COMBINATION THERAPY WITH ALPHA4BETA7 INHIBITOR AND IL-23 INHIBITOR |
| CA3138241A1 (en) | 2019-05-23 | 2020-11-26 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| EP4017880A4 (en) * | 2019-08-21 | 2023-10-11 | Astrazeneca Collaboration Ventures, LLC | USE OF BRAZIKUMAB TO TREAT CROHN'S DISEASE |
| CN114555120A (zh) * | 2019-10-18 | 2022-05-27 | 詹森生物科技公司 | 用抗il12/il23抗体治疗溃疡性结肠炎的安全且有效的方法 |
| CN114761561B (zh) * | 2019-11-29 | 2024-04-30 | 东洋纺株式会社 | 重组c反应蛋白 |
| KR20220143005A (ko) * | 2019-12-20 | 2022-10-24 | 노바록 바이오테라퓨틱스 리미티드 | 항-인터루킨-23 p19 항체 및 이의 사용 방법 |
| MX2022009987A (es) * | 2020-02-14 | 2022-11-10 | Janssen Biotech Inc | Método seguro y efectivo para tratar la colitis ulcerosa con el anticuerpo anti-il-12/il23. |
| CN111424086A (zh) * | 2020-03-19 | 2020-07-17 | 上海交通大学 | 用于胃癌诊断及预后评估的生物标记物及应用和检测试剂盒 |
| EP4596046A3 (en) | 2020-05-21 | 2025-10-22 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| AU2021365525A1 (en) * | 2020-10-23 | 2023-06-15 | Hq Han | Bifunctional antagonists of activin and tumor necrosis factor-alpha and uses thereof |
| KR20230165746A (ko) | 2020-11-30 | 2023-12-05 | 민데라 코포레이션 | 마이크로니들 디바이스 및 방법, 및 피부 병태 어세이 |
| US20220373539A1 (en) * | 2021-05-24 | 2022-11-24 | Amgen Inc. | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
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| GB8318754D0 (en) | 1983-07-11 | 1983-08-10 | Fagerhol M K F | Human proteins anti-sera test kits |
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| DK0937259T3 (da) | 1996-11-01 | 2005-01-31 | Magne K Fagerhol | Fremgangsmåde til ekstraktion af proteiner |
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| PT1896073E (pt) | 2005-06-30 | 2013-05-28 | Janssen Biotech Inc | Composições, métodos e aplicações de anticorpos anti-il-23 |
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2016
- 2016-09-16 CN CN201680066986.XA patent/CN108290058B/zh not_active Expired - Fee Related
- 2016-09-16 BR BR112018005175A patent/BR112018005175A2/pt not_active Application Discontinuation
- 2016-09-16 HK HK19100656.4A patent/HK1258292A1/zh unknown
- 2016-09-16 KR KR1020187010308A patent/KR20180063127A/ko not_active Withdrawn
- 2016-09-16 CN CN202310427386.3A patent/CN116672446A/zh active Pending
- 2016-09-16 AU AU2016323579A patent/AU2016323579A1/en not_active Abandoned
- 2016-09-16 CA CA2998349A patent/CA2998349A1/en not_active Abandoned
- 2016-09-16 US US15/759,330 patent/US11016099B2/en active Active
- 2016-09-16 JP JP2018514414A patent/JP6909208B2/ja not_active Expired - Fee Related
- 2016-09-16 MX MX2018003376A patent/MX2018003376A/es unknown
- 2016-09-16 RU RU2018113694A patent/RU2018113694A/ru not_active Application Discontinuation
- 2016-09-16 WO PCT/US2016/052060 patent/WO2017049035A1/en not_active Ceased
- 2016-09-16 EP EP16847353.6A patent/EP3349854A4/en not_active Withdrawn
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2018
- 2018-03-08 IL IL257969A patent/IL257969A/en unknown
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2021
- 2021-07-02 JP JP2021110695A patent/JP7153775B2/ja active Active
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2022
- 2022-10-03 JP JP2022159196A patent/JP2023002583A/ja active Pending
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