JP2018535394A5 - - Google Patents
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- JP2018535394A5 JP2018535394A5 JP2018514414A JP2018514414A JP2018535394A5 JP 2018535394 A5 JP2018535394 A5 JP 2018535394A5 JP 2018514414 A JP2018514414 A JP 2018514414A JP 2018514414 A JP2018514414 A JP 2018514414A JP 2018535394 A5 JP2018535394 A5 JP 2018535394A5
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- 102100030703 Interleukin-22 Human genes 0.000 claims description 79
- 108010074109 interleukin-22 Proteins 0.000 claims description 79
- 108010065637 Interleukin-23 Proteins 0.000 claims description 59
- 102000013264 Interleukin-23 Human genes 0.000 claims description 59
- 229940124829 interleukin-23 Drugs 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 32
- 239000005557 antagonist Substances 0.000 claims description 25
- 201000010099 disease Diseases 0.000 claims description 24
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- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 239000012634 fragment Substances 0.000 claims description 17
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- 208000035475 disorder Diseases 0.000 claims description 8
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- 201000004624 Dermatitis Diseases 0.000 claims description 6
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
- 208000011231 Crohn disease Diseases 0.000 claims description 5
- -1 CCL22 Proteins 0.000 claims description 4
- 208000015943 Coeliac disease Diseases 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 3
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- MJZJYWCQPMNPRM-UHFFFAOYSA-N 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Chemical compound CC1(C)N=C(N)N=C(N)N1OCCCOC1=CC(Cl)=C(Cl)C=C1Cl MJZJYWCQPMNPRM-UHFFFAOYSA-N 0.000 claims description 2
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims description 2
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- 102100026887 Beta-defensin 103 Human genes 0.000 claims description 2
- 102100026886 Beta-defensin 104 Human genes 0.000 claims description 2
- 102100038326 Beta-defensin 4A Human genes 0.000 claims description 2
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- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims description 2
- 102100036848 C-C motif chemokine 20 Human genes 0.000 claims description 2
- 102100038608 Cathelicidin antimicrobial peptide Human genes 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 2
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- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 241000700721 Hepatitis B virus Species 0.000 claims description 2
- 101000912247 Homo sapiens Beta-defensin 103 Proteins 0.000 claims description 2
- 101000912243 Homo sapiens Beta-defensin 104 Proteins 0.000 claims description 2
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 claims description 2
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims description 2
- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims description 2
- 101000741320 Homo sapiens Cathelicidin antimicrobial peptide Proteins 0.000 claims description 2
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims description 2
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 claims description 2
- 101000852992 Homo sapiens Interleukin-12 subunit beta Proteins 0.000 claims description 2
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 claims description 2
- 101000998151 Homo sapiens Interleukin-17F Proteins 0.000 claims description 2
- 101000853012 Homo sapiens Interleukin-23 receptor Proteins 0.000 claims description 2
- 101000853000 Homo sapiens Interleukin-26 Proteins 0.000 claims description 2
- 101000642478 Homo sapiens Serpin B3 Proteins 0.000 claims description 2
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 102100020881 Interleukin-1 alpha Human genes 0.000 claims description 2
- 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 claims description 2
- 102100036701 Interleukin-12 subunit beta Human genes 0.000 claims description 2
- 102100033461 Interleukin-17A Human genes 0.000 claims description 2
- 102100033454 Interleukin-17F Human genes 0.000 claims description 2
- 102100030704 Interleukin-21 Human genes 0.000 claims description 2
- 102100036672 Interleukin-23 receptor Human genes 0.000 claims description 2
- 102100036679 Interleukin-26 Human genes 0.000 claims description 2
- 102000004889 Interleukin-6 Human genes 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 208000019693 Lung disease Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010026749 Mania Diseases 0.000 claims description 2
- 102000001691 Member 3 Group F Nuclear Receptor Subfamily 1 Human genes 0.000 claims description 2
- 108010029279 Member 3 Group F Nuclear Receptor Subfamily 1 Proteins 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 101000912227 Pan troglodytes Beta-defensin 104A Proteins 0.000 claims description 2
- 206010036790 Productive cough Diseases 0.000 claims description 2
- 102100029812 Protein S100-A12 Human genes 0.000 claims description 2
- 102100032446 Protein S100-A7 Human genes 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 2
- 206010037575 Pustular psoriasis Diseases 0.000 claims description 2
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 claims description 2
- 108010005256 S100 Calcium Binding Protein A7 Proteins 0.000 claims description 2
- 108700016890 S100A12 Proteins 0.000 claims description 2
- 101150097337 S100A12 gene Proteins 0.000 claims description 2
- 102100036383 Serpin B3 Human genes 0.000 claims description 2
- 201000002661 Spondylitis Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 206010047115 Vasculitis Diseases 0.000 claims description 2
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- 238000011374 additional therapy Methods 0.000 claims description 2
- 208000002029 allergic contact dermatitis Diseases 0.000 claims description 2
- 231100000360 alopecia Toxicity 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 230000001363 autoimmune Effects 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- TWFZGCMQGLPBSX-UHFFFAOYSA-N carbendazim Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 210000002919 epithelial cell Anatomy 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 229950010864 guselkumab Drugs 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 108010074108 interleukin-21 Proteins 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 230000003285 pharmacodynamic effect Effects 0.000 claims description 2
- 210000004910 pleural fluid Anatomy 0.000 claims description 2
- 201000010914 pustulosis of palm and sole Diseases 0.000 claims description 2
- 208000011797 pustulosis palmaris et plantaris Diseases 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
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- 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims description 2
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- 229960003824 ustekinumab Drugs 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 102000013519 Lipocalin-2 Human genes 0.000 description 41
- 108010051335 Lipocalin-2 Proteins 0.000 description 41
- 239000000523 sample Substances 0.000 description 9
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021110695A JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2022159196A JP2023002583A (ja) | 2015-09-17 | 2022-10-03 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220062P | 2015-09-17 | 2015-09-17 | |
| US62/220,062 | 2015-09-17 | ||
| PCT/US2016/052060 WO2017049035A1 (en) | 2015-09-17 | 2016-09-16 | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021110695A Division JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535394A JP2018535394A (ja) | 2018-11-29 |
| JP2018535394A5 true JP2018535394A5 (enExample) | 2020-11-12 |
| JP6909208B2 JP6909208B2 (ja) | 2021-07-28 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514414A Expired - Fee Related JP6909208B2 (ja) | 2015-09-17 | 2016-09-16 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2021110695A Active JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2022159196A Pending JP2023002583A (ja) | 2015-09-17 | 2022-10-03 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021110695A Active JP7153775B2 (ja) | 2015-09-17 | 2021-07-02 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| JP2022159196A Pending JP2023002583A (ja) | 2015-09-17 | 2022-10-03 | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11016099B2 (enExample) |
| EP (1) | EP3349854A4 (enExample) |
| JP (3) | JP6909208B2 (enExample) |
| KR (1) | KR20180063127A (enExample) |
| CN (2) | CN108290058B (enExample) |
| AU (1) | AU2016323579A1 (enExample) |
| BR (1) | BR112018005175A2 (enExample) |
| CA (1) | CA2998349A1 (enExample) |
| HK (1) | HK1258292A1 (enExample) |
| IL (1) | IL257969A (enExample) |
| MX (1) | MX2018003376A (enExample) |
| RU (1) | RU2018113694A (enExample) |
| WO (1) | WO2017049035A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| US10370718B2 (en) | 2014-09-29 | 2019-08-06 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| CA2998349A1 (en) | 2015-09-17 | 2017-03-23 | Amgen Inc. | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
| TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| WO2019113037A1 (en) * | 2017-12-04 | 2019-06-13 | Immusant, Inc. | Measurement of ccl20 after gluten exposure |
| KR20200097286A (ko) * | 2017-12-07 | 2020-08-18 | 암젠 인크 | 로미플로스팀을 사용한 특발성 혈소판 감소 자반병(itp)의 치료 방법 |
| US20190269757A1 (en) | 2018-03-05 | 2019-09-05 | Janssen Biotech, Inc. | Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody |
| EP3793521A4 (en) | 2018-05-18 | 2022-02-23 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY |
| EP3824295A4 (en) * | 2018-07-18 | 2022-04-27 | Janssen Biotech, Inc. | PREDICTORS WITH DELAYED ACTION AFTER TREATMENT WITH ANTI-IL23 SPECIFIC ANTIBODIES |
| KR20210064315A (ko) * | 2018-09-24 | 2021-06-02 | 얀센 바이오테크 인코포레이티드 | 항-il12/il23 항체로 궤양성 결장염을 치료하는 안전하고 효과적인 방법 |
| WO2020104705A2 (en) * | 2018-11-23 | 2020-05-28 | Katholieke Universiteit Leuven | Predicting a treatment response in inflammatory bowel disease |
| CN109337974B (zh) * | 2018-12-14 | 2022-01-25 | 北京蛋白质组研究中心 | 一种检测银屑病的诊断标志物的试剂及其应用 |
| EP3897722A4 (en) * | 2018-12-18 | 2022-09-14 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE METHOD OF TREATMENT OF LUPUS WITH ANTI-IL12/IL23 ANTIBODIES |
| CN113853385A (zh) * | 2019-03-18 | 2021-12-28 | 詹森生物科技公司 | 用抗il12/il23抗体治疗儿科受试者的银屑病的方法 |
| CN113710316A (zh) * | 2019-03-26 | 2021-11-26 | 阿斯特捷利康合作创业有限责任公司 | 适合于il23拮抗剂疗法的患者群体 |
| JP7778567B2 (ja) * | 2019-04-17 | 2025-12-02 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | α４β７阻害薬及びＩＬ－２３阻害薬の併用療法 |
| BR112021023295A2 (pt) | 2019-05-23 | 2022-02-08 | Janssen Biotech Inc | Método de tratamento de doença inflamatória intestinal com uma terapia de combinação de anticorpos para il-23 e tnf-alfa |
| CN114641493A (zh) * | 2019-08-21 | 2022-06-17 | 阿斯特捷利康合作创业有限责任公司 | 使用布雷库单抗治疗克罗恩病 |
| EP4424381A3 (en) * | 2019-10-18 | 2024-11-13 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
| EP4067372A4 (en) * | 2019-11-29 | 2023-11-08 | Toyobo Co., Ltd. | RECOMBINANT C-REACTIVE PROTEIN |
| US11396541B2 (en) | 2019-12-20 | 2022-07-26 | Novarock Biotherapeutics, Ltd. | Anti-interleukin-23 P19 antibodies and methods of use thereof |
| JP2023514567A (ja) * | 2020-02-14 | 2023-04-06 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ１２／ｉｌ２３抗体で潰瘍性大腸炎を治療する安全かつ有効な方法 |
| CN111424086A (zh) * | 2020-03-19 | 2020-07-17 | 上海交通大学 | 用于胃癌诊断及预后评估的生物标记物及应用和检测试剂盒 |
| JP2023528265A (ja) | 2020-05-21 | 2023-07-04 | ヤンセン バイオテツク，インコーポレーテツド | Ｉｌ－２３に対する抗体及びｔｎｆアルファに対する抗体の組み合わせ療法を用いた炎症性腸疾患の治療方法 |
| CA3196112A1 (en) * | 2020-10-23 | 2022-04-28 | Hq Han | Bifunctional antagonists of activin and tumor necrosis factor-alpha and uses thereof |
| AU2021385427A1 (en) | 2020-11-30 | 2023-06-29 | Mindera Corporation | Microneedle devices and methods, and skin condition assays |
| US20220373539A1 (en) * | 2021-05-24 | 2022-11-24 | Amgen Inc. | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
| WO2025170982A2 (en) | 2024-02-06 | 2025-08-14 | Paragon Therapeutics, Inc. | Il-23 antibody compositions and methods of use |
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| DK0937259T3 (da) | 1996-11-01 | 2005-01-31 | Magne K Fagerhol | Fremgangsmåde til ekstraktion af proteiner |
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2016
- 2016-09-16 CA CA2998349A patent/CA2998349A1/en not_active Abandoned
- 2016-09-16 WO PCT/US2016/052060 patent/WO2017049035A1/en not_active Ceased
- 2016-09-16 BR BR112018005175A patent/BR112018005175A2/pt not_active Application Discontinuation
- 2016-09-16 AU AU2016323579A patent/AU2016323579A1/en not_active Abandoned
- 2016-09-16 CN CN201680066986.XA patent/CN108290058B/zh not_active Expired - Fee Related
- 2016-09-16 HK HK19100656.4A patent/HK1258292A1/zh unknown
- 2016-09-16 MX MX2018003376A patent/MX2018003376A/es unknown
- 2016-09-16 US US15/759,330 patent/US11016099B2/en active Active
- 2016-09-16 JP JP2018514414A patent/JP6909208B2/ja not_active Expired - Fee Related
- 2016-09-16 CN CN202310427386.3A patent/CN116672446A/zh active Pending
- 2016-09-16 EP EP16847353.6A patent/EP3349854A4/en not_active Withdrawn
- 2016-09-16 RU RU2018113694A patent/RU2018113694A/ru not_active Application Discontinuation
- 2016-09-16 KR KR1020187010308A patent/KR20180063127A/ko not_active Withdrawn
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2018
- 2018-03-08 IL IL257969A patent/IL257969A/en unknown
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2021
- 2021-07-02 JP JP2021110695A patent/JP7153775B2/ja active Active
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2022
- 2022-10-03 JP JP2022159196A patent/JP2023002583A/ja active Pending
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