CN116672446A - 使用il23途径生物标志物预测il23拮抗剂的临床应答 - Google Patents

使用il23途径生物标志物预测il23拮抗剂的临床应答 Download PDF

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Publication number
CN116672446A
CN116672446A CN202310427386.3A CN202310427386A CN116672446A CN 116672446 A CN116672446 A CN 116672446A CN 202310427386 A CN202310427386 A CN 202310427386A CN 116672446 A CN116672446 A CN 116672446A
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lcn2
patient
level
antibody
aspects
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CN202310427386.3A
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Chinese (zh)
Inventor
R.W.乔甘塔斯三世
C.摩尔豪斯
B.希格斯
K.拉纳德
K.斯特雷彻尔
W.里斯
M.梁
R.法焦尼
J.李
I.维因什泰因
Y-W.李
J.陈
R.A.小加塞尔
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Amgen Inc
MedImmune LLC
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Amgen Inc
MedImmune LLC
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Publication of CN116672446A publication Critical patent/CN116672446A/zh
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]
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    • G01N2800/00Detection or diagnosis of diseases
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    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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CN202310427386.3A 2015-09-17 2016-09-16 使用il23途径生物标志物预测il23拮抗剂的临床应答 Pending CN116672446A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562220062P 2015-09-17 2015-09-17
US62/220062 2015-09-17
PCT/US2016/052060 WO2017049035A1 (en) 2015-09-17 2016-09-16 Prediction of clinical response to il23-antagonists using il23 pathway biomarkers
CN201680066986.XA CN108290058B (zh) 2015-09-17 2016-09-16 使用il23途径生物标志物预测il23拮抗剂的临床应答

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CN201680066986.XA Expired - Fee Related CN108290058B (zh) 2015-09-17 2016-09-16 使用il23途径生物标志物预测il23拮抗剂的临床应答
CN202310427386.3A Pending CN116672446A (zh) 2015-09-17 2016-09-16 使用il23途径生物标志物预测il23拮抗剂的临床应答

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US (1) US11016099B2 (enExample)
EP (1) EP3349854A4 (enExample)
JP (3) JP6909208B2 (enExample)
KR (1) KR20180063127A (enExample)
CN (2) CN108290058B (enExample)
AU (1) AU2016323579A1 (enExample)
BR (1) BR112018005175A2 (enExample)
CA (1) CA2998349A1 (enExample)
HK (1) HK1258292A1 (enExample)
IL (1) IL257969A (enExample)
MX (1) MX2018003376A (enExample)
RU (1) RU2018113694A (enExample)
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