JP2018534937A5 - - Google Patents
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- Publication number
- JP2018534937A5 JP2018534937A5 JP2018526799A JP2018526799A JP2018534937A5 JP 2018534937 A5 JP2018534937 A5 JP 2018534937A5 JP 2018526799 A JP2018526799 A JP 2018526799A JP 2018526799 A JP2018526799 A JP 2018526799A JP 2018534937 A5 JP2018534937 A5 JP 2018534937A5
- Authority
- JP
- Japan
- Prior art keywords
- retrovirus
- nucleic acid
- vector
- producing cell
- retroviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 28
- 150000007523 nucleic acids Chemical group 0.000 claims 21
- 241001430294 unidentified retrovirus Species 0.000 claims 19
- 230000001177 retroviral effect Effects 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 230000010076 replication Effects 0.000 claims 5
- 230000002950 deficient Effects 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102100034353 Integrase Human genes 0.000 claims 3
- 108010078428 env Gene Products Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 2
- 101710177291 Gag polyprotein Proteins 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 241000713666 Lentivirus Species 0.000 claims 2
- 101710125418 Major capsid protein Proteins 0.000 claims 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 239000012212 insulator Substances 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000004806 packaging method and process Methods 0.000 claims 2
- 108010089520 pol Gene Products Proteins 0.000 claims 2
- 241001664176 Alpharetrovirus Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000713730 Equine infectious anemia virus Species 0.000 claims 1
- 241001663880 Gammaretrovirus Species 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 241000713673 Human foamy virus Species 0.000 claims 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 1
- 108010034634 Repressor Proteins Proteins 0.000 claims 1
- 102000009661 Repressor Proteins Human genes 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 208000010094 Visna Diseases 0.000 claims 1
- 210000004507 artificial chromosome Anatomy 0.000 claims 1
- 210000001106 artificial yeast chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1520761.6A GB201520761D0 (en) | 2015-11-24 | 2015-11-24 | Stable cell lines for retroviral production |
| GB1520761.6 | 2015-11-24 | ||
| GB1609303.1 | 2016-05-26 | ||
| GBGB1609303.1A GB201609303D0 (en) | 2016-05-26 | 2016-05-26 | Stable cell lines for retroviral production |
| PCT/EP2016/078336 WO2017089308A1 (en) | 2015-11-24 | 2016-11-21 | Stable cell lines for retroviral production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534937A JP2018534937A (ja) | 2018-11-29 |
| JP2018534937A5 true JP2018534937A5 (cg-RX-API-DMAC7.html) | 2020-01-09 |
| JP7098521B2 JP7098521B2 (ja) | 2022-07-11 |
Family
ID=57354376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526799A Active JP7098521B2 (ja) | 2015-11-24 | 2016-11-21 | レトロウイルス産生のための安定な細胞株 |
Country Status (17)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7816612B2 (en) * | 2005-12-21 | 2010-10-19 | Ishida Co., Ltd. | Rotary measuring device |
| DE102016122317A1 (de) | 2015-11-24 | 2017-05-24 | Glaxosmithkline Intellectual Property Development Limited | Transientes transfektionsverfahren für retrovirale produktion |
| GB201706121D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Stable cell lines for retroviral production |
| GB201715052D0 (en) | 2017-09-19 | 2017-11-01 | Oxford Genetics Ltd | Vectors |
| FI3633040T3 (fi) | 2017-12-22 | 2023-08-03 | Oxford Biomedica Ltd | Retrovirusvektori |
| CA3123449A1 (en) * | 2018-12-21 | 2020-06-25 | Lonza Walkersville, Inc. | Automated production of viral vectors |
| KR20220047635A (ko) * | 2019-08-23 | 2022-04-18 | 론자 워커스빌 아이엔씨. | 렌티바이러스 벡터의 생산을 위한 방법 및 작제물 |
| CN114829588A (zh) * | 2019-12-18 | 2022-07-29 | 隆萨沃克斯维尔股份有限公司 | 用于慢病毒载体的瞬时产生的方法和构建体 |
| GB202004371D0 (en) | 2020-03-26 | 2020-05-13 | Glaxosmithkline Ip Dev Ltd | CAR constructs |
| GB202005096D0 (en) | 2020-04-07 | 2020-05-20 | Glaxosmithkline | Modified vectors for production of retrovirus |
| CN113528515B (zh) * | 2020-04-22 | 2023-05-05 | 中国科学院分子植物科学卓越创新中心 | 基于CRISPR-Cas13a干预阻断病毒逆转录转座的技术 |
| JP2023526348A (ja) * | 2020-05-15 | 2023-06-21 | アイヴェックスソル インコーポレイテッド | 細胞療法及び遺伝子療法のための安定したウイルスベクター産生細胞を産生するための組成物及び方法 |
| CN112430582B (zh) * | 2020-12-04 | 2022-05-03 | 北京艺妙神州医药科技有限公司 | 一种慢病毒稳定包装细胞系及其制备方法 |
| TW202304960A (zh) | 2021-03-19 | 2023-02-01 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 靶向claudin-3之嵌合抗原受體及治療癌症之方法 |
| WO2022225973A1 (en) * | 2021-04-20 | 2022-10-27 | The Regents Of The University Of California | Packaging cells with targeted gene knockouts that improve retroviral vector titers |
| EP4649162A1 (en) * | 2023-01-10 | 2025-11-19 | Legend Biotech Ireland Limited | Regulatory sequences and uses thereof |
| WO2024218341A1 (en) | 2023-04-19 | 2024-10-24 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for car-t and car-nk cells |
| WO2024218345A1 (en) | 2023-04-21 | 2024-10-24 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for antibody-drug conjugates and bispecific antibodies |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| WO1995003400A1 (en) * | 1993-07-23 | 1995-02-02 | Johns Hopkins University School Of Medicine | Recombinationally targeted cloning in yeast artificial chromosomes |
| JP4119952B2 (ja) * | 1995-06-27 | 2008-07-16 | バヴァリアン・ノルディック・アクティーゼルスカブ | ウイルス粒子産生カプセル化細胞 |
| FR2751223B1 (fr) * | 1996-07-19 | 1998-12-04 | Rhone Merieux | Formule de vaccin polynucleotidique felin |
| WO2000065077A1 (en) * | 1999-04-22 | 2000-11-02 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
| US6677155B1 (en) * | 1999-04-22 | 2004-01-13 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
| WO2000066758A1 (en) * | 1999-04-29 | 2000-11-09 | Aarhus University | Expression of heterologous genes from an ires translational cassette in retroviral vectors |
| US20060057553A1 (en) * | 2000-05-30 | 2006-03-16 | Estuardo Aguilar-Cordova | Chimeric viral vectors for gene therapy |
| US6689601B2 (en) | 2000-09-01 | 2004-02-10 | E. I. Du Pont De Nemours And Company | High growth methanotropic bacterial strain |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| DE10111433A1 (de) * | 2001-03-09 | 2002-09-19 | Bundesrepublik Deutschland Let | Replikationskompetente molekulare Klone von porcinem endogenem Retrovirus der Klasse A und Klasse B,abgeleitet von Schweine- und humanen Zellen |
| US20030119104A1 (en) | 2001-05-30 | 2003-06-26 | Edward Perkins | Chromosome-based platforms |
| US6835568B2 (en) * | 2001-10-30 | 2004-12-28 | Virxsys Corporation | Regulated nucleic acid expression system |
| DK2348119T3 (en) * | 2002-02-01 | 2017-08-21 | Oxford Biomedica (Uk) Ltd | Polycistronic lentiviral vector |
| CA2501168A1 (en) * | 2002-11-25 | 2004-06-10 | Bavarian Nordic A/S | Recombinant poxvirus comprising at least two cowpox ati promoters |
| US20070218536A1 (en) * | 2004-04-28 | 2007-09-20 | Guangping Gao | Polyvalent Viral Vectors and a System for Production Thereof |
| EP1652932A1 (en) * | 2004-11-02 | 2006-05-03 | GBF Gesellschaft für Biotechnologische Forschung mbH | Method for the generation of virus producing cell lines and cell lines |
| WO2006057289A1 (ja) * | 2004-11-24 | 2006-06-01 | Anaeropharma Science Inc. | 新規シャトルベクター |
| GB0702695D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Production of vectors |
| WO2010131747A1 (ja) * | 2009-05-15 | 2010-11-18 | 国立大学法人 東京大学 | ウイルス産生細胞 |
| HRP20140392T1 (hr) * | 2010-09-02 | 2014-06-06 | Molmed Spa | Stabilna proizvodnja lentiviralnih vektora |
| US9273324B2 (en) * | 2010-12-05 | 2016-03-01 | Andrew S. Belmont | Recombinant gene expression |
| WO2012170431A2 (en) * | 2011-06-06 | 2012-12-13 | Bluebird Bio, Inc. | Improved geneswitch systems |
| FR2979919B1 (fr) * | 2011-09-12 | 2015-12-11 | Centre Nat Rech Scient | Genomes lentiviraux chimeriques non-integratifs comme vaccins innovants contre vih-1 |
| GB201202516D0 (en) * | 2012-02-13 | 2012-03-28 | Ucl Business Plc | Materials and methods relating to packaging cell lines |
| WO2014043131A1 (en) * | 2012-09-14 | 2014-03-20 | The Regents Of The University Of California | Lentiviral vector for stem cell gene therapy of sickle cell disease |
| EP3623478A1 (en) * | 2012-10-25 | 2020-03-18 | Tocagen Inc. | Retroviral vector with mini-promoter cassette |
| WO2015031686A1 (en) * | 2013-08-30 | 2015-03-05 | Amgen Inc. | High titer recombinant aav vector production in adherent and suspension cells |
| GB2538324A (en) * | 2015-05-15 | 2016-11-16 | Glaxosmithkline Ip Dev Ltd | Packaging cell line for retroviral production |
| GB2538321A (en) * | 2015-05-15 | 2016-11-16 | Glaxosmithkline Ip Dev Ltd | Artificial chromosome for retroviral production |
| DK3351851T3 (da) * | 2015-09-01 | 2020-01-06 | Signify Holding Bv | Belysningsindretning med en trådløs kommunikationsantenne |
| DE102016122317A1 (de) * | 2015-11-24 | 2017-05-24 | Glaxosmithkline Intellectual Property Development Limited | Transientes transfektionsverfahren für retrovirale produktion |
-
2016
- 2016-11-21 BR BR112018010635A patent/BR112018010635A2/pt not_active Application Discontinuation
- 2016-11-21 EP EP19151187.2A patent/EP3489353B8/en active Active
- 2016-11-21 KR KR1020187014237A patent/KR102091957B1/ko not_active Expired - Fee Related
- 2016-11-21 JP JP2018526799A patent/JP7098521B2/ja active Active
- 2016-11-21 WO PCT/EP2016/078336 patent/WO2017089308A1/en not_active Ceased
- 2016-11-21 DE DE102016122316.6A patent/DE102016122316A1/de not_active Withdrawn
- 2016-11-21 EP EP16798512.6A patent/EP3380604B1/en active Active
- 2016-11-21 CN CN201680068650.7A patent/CN108291208A/zh active Pending
- 2016-11-21 ES ES16798512T patent/ES2939617T3/es active Active
- 2016-11-21 AU AU2016360763A patent/AU2016360763B2/en not_active Ceased
- 2016-11-21 ES ES19151187T patent/ES2959326T3/es active Active
- 2016-11-21 IT IT102016000117326A patent/IT201600117326A1/it unknown
- 2016-11-21 GB GB1619643.8A patent/GB2544892B/en not_active Expired - Fee Related
- 2016-11-21 RU RU2018122636A patent/RU2752498C2/ru active
- 2016-11-21 FR FR1661255A patent/FR3044016A1/fr not_active Withdrawn
- 2016-11-21 CA CA3006288A patent/CA3006288A1/en active Pending
- 2016-11-21 US US15/356,830 patent/US20170145388A1/en not_active Abandoned
-
2018
- 2018-05-09 IL IL259254A patent/IL259254A/en unknown
- 2018-05-20 SA SA518391623A patent/SA518391623B1/ar unknown
- 2018-07-13 US US16/034,517 patent/US20180320147A1/en not_active Abandoned
-
2019
- 2019-12-18 US US16/718,791 patent/US20200123505A1/en not_active Abandoned
-
2021
- 2021-04-23 IL IL282603A patent/IL282603B/en unknown
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