JP2019500030A5 - - Google Patents
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- Publication number
- JP2019500030A5 JP2019500030A5 JP2018526787A JP2018526787A JP2019500030A5 JP 2019500030 A5 JP2019500030 A5 JP 2019500030A5 JP 2018526787 A JP2018526787 A JP 2018526787A JP 2018526787 A JP2018526787 A JP 2018526787A JP 2019500030 A5 JP2019500030 A5 JP 2019500030A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid vector
- vector according
- retroviral
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 23
- 102000039446 nucleic acids Human genes 0.000 claims 23
- 230000001177 retroviral effect Effects 0.000 claims 14
- 238000000034 method Methods 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 8
- 230000010076 replication Effects 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 230000002950 deficient Effects 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 102100034353 Integrase Human genes 0.000 claims 2
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 2
- 241000713666 Lentivirus Species 0.000 claims 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 108010078428 env Gene Products Proteins 0.000 claims 2
- 239000012212 insulator Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 241001664176 Alpharetrovirus Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000713730 Equine infectious anemia virus Species 0.000 claims 1
- 101710177291 Gag polyprotein Proteins 0.000 claims 1
- 241001663880 Gammaretrovirus Species 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 241000713673 Human foamy virus Species 0.000 claims 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 1
- 101710125418 Major capsid protein Proteins 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 208000010094 Visna Diseases 0.000 claims 1
- 210000004507 artificial chromosome Anatomy 0.000 claims 1
- 210000001106 artificial yeast chromosome Anatomy 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000001638 lipofection Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108010089520 pol Gene Products Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003151 transfection method Methods 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1520764.0A GB201520764D0 (en) | 2015-11-24 | 2015-11-24 | Transient transfection method for retroviral production |
| GB1520764.0 | 2015-11-24 | ||
| GBGB1609354.4A GB201609354D0 (en) | 2016-05-26 | 2016-05-26 | Transient transfection method for retroviral production |
| GB1609354.4 | 2016-05-26 | ||
| PCT/EP2016/078334 WO2017089307A1 (en) | 2015-11-24 | 2016-11-21 | Transient transfection method for retroviral production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500030A JP2019500030A (ja) | 2019-01-10 |
| JP2019500030A5 true JP2019500030A5 (cg-RX-API-DMAC7.html) | 2020-01-09 |
| JP7110096B2 JP7110096B2 (ja) | 2022-08-01 |
Family
ID=57348703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526787A Active JP7110096B2 (ja) | 2015-11-24 | 2016-11-21 | レトロウイルス産生のための一時的トランスフェクション法 |
Country Status (15)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016185125A1 (fr) * | 2015-05-15 | 2016-11-24 | Vectalys | Particule rétrovirale comportant au moins deux arn non viraux encapsidés |
| BR112018010635A2 (pt) * | 2015-11-24 | 2018-11-27 | Glaxosmithkline Ip Dev Ltd | linhagens celulares estáveis para a produção retroviral |
| GB201706121D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Stable cell lines for retroviral production |
| GB201715052D0 (en) | 2017-09-19 | 2017-11-01 | Oxford Genetics Ltd | Vectors |
| FI3633040T3 (fi) | 2017-12-22 | 2023-08-03 | Oxford Biomedica Ltd | Retrovirusvektori |
| GB201816919D0 (en) * | 2018-10-17 | 2018-11-28 | Glaxosmithkline Ip Dev Ltd | Adeno-associated viral vector producer cell lines |
| CN110684804B (zh) * | 2019-10-15 | 2023-04-18 | 上海本导基因技术有限公司 | 递送外源rnp的慢病毒载体及其制备方法 |
| GB202004371D0 (en) | 2020-03-26 | 2020-05-13 | Glaxosmithkline Ip Dev Ltd | CAR constructs |
| GB202005096D0 (en) | 2020-04-07 | 2020-05-20 | Glaxosmithkline | Modified vectors for production of retrovirus |
| JP2023521726A (ja) * | 2020-04-10 | 2023-05-25 | サウスウエスト リサーチ インスティテュート | ウイルスベクター産生のための３次元バイオリアクター |
| TW202304960A (zh) | 2021-03-19 | 2023-02-01 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 靶向claudin-3之嵌合抗原受體及治療癌症之方法 |
| CN113373266B (zh) * | 2021-06-22 | 2022-07-01 | 内蒙古农业大学 | 一种用于检测绵羊肺腺瘤病毒的荧光rpa引物、试剂盒和检测方法 |
| WO2024218341A1 (en) | 2023-04-19 | 2024-10-24 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for car-t and car-nk cells |
| WO2024218345A1 (en) | 2023-04-21 | 2024-10-24 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for antibody-drug conjugates and bispecific antibodies |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| WO1995003400A1 (en) * | 1993-07-23 | 1995-02-02 | Johns Hopkins University School Of Medicine | Recombinationally targeted cloning in yeast artificial chromosomes |
| JP4119952B2 (ja) * | 1995-06-27 | 2008-07-16 | バヴァリアン・ノルディック・アクティーゼルスカブ | ウイルス粒子産生カプセル化細胞 |
| AU721326B2 (en) | 1996-02-13 | 2000-06-29 | Fred Hutchinson Cancer Research Center | 10A1 retroviral packaging cells and uses thereof |
| FR2751223B1 (fr) * | 1996-07-19 | 1998-12-04 | Rhone Merieux | Formule de vaccin polynucleotidique felin |
| US6277621B1 (en) * | 1998-02-26 | 2001-08-21 | Medigene, Inc. | Artificial chromosome constructs containing foreign nucleic acid sequences |
| EP1141315B1 (en) | 1998-12-31 | 2008-01-23 | Novartis Vaccines and Diagnostics, Inc. | Modified hiv env polypeptides |
| WO2000065077A1 (en) | 1999-04-22 | 2000-11-02 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
| US6677155B1 (en) | 1999-04-22 | 2004-01-13 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
| WO2000066758A1 (en) | 1999-04-29 | 2000-11-09 | Aarhus University | Expression of heterologous genes from an ires translational cassette in retroviral vectors |
| US7083971B1 (en) | 1999-06-07 | 2006-08-01 | Cell Genesys, Inc. | Hybrid yeast-bacteria cloning system and uses thereof |
| ATE351916T1 (de) | 1999-10-12 | 2007-02-15 | Pasteur Institut | Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten |
| US20060057553A1 (en) | 2000-05-30 | 2006-03-16 | Estuardo Aguilar-Cordova | Chimeric viral vectors for gene therapy |
| AU2001292711A1 (en) | 2000-09-18 | 2002-03-26 | Genetic Therapy, Inc. | Stress resistant retroviruses |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2002053576A1 (en) * | 2001-01-05 | 2002-07-11 | The General Hospital Corporation | Viral delivery system for infectious transfer of large genomic dna inserts |
| DE10111433A1 (de) | 2001-03-09 | 2002-09-19 | Bundesrepublik Deutschland Let | Replikationskompetente molekulare Klone von porcinem endogenem Retrovirus der Klasse A und Klasse B,abgeleitet von Schweine- und humanen Zellen |
| US20030119104A1 (en) | 2001-05-30 | 2003-06-26 | Edward Perkins | Chromosome-based platforms |
| US6835568B2 (en) | 2001-10-30 | 2004-12-28 | Virxsys Corporation | Regulated nucleic acid expression system |
| DK2348119T3 (en) | 2002-02-01 | 2017-08-21 | Oxford Biomedica (Uk) Ltd | Polycistronic lentiviral vector |
| EP1495125B1 (en) * | 2002-04-10 | 2010-06-16 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Vac-bac shuttle vector system |
| CA2501168A1 (en) * | 2002-11-25 | 2004-06-10 | Bavarian Nordic A/S | Recombinant poxvirus comprising at least two cowpox ati promoters |
| US20070218536A1 (en) * | 2004-04-28 | 2007-09-20 | Guangping Gao | Polyvalent Viral Vectors and a System for Production Thereof |
| US20080226677A1 (en) | 2004-05-06 | 2008-09-18 | Yasuko Mori | Recombinant virus vector for gene transfer into lymphoid cells |
| EP1652932A1 (en) | 2004-11-02 | 2006-05-03 | GBF Gesellschaft für Biotechnologische Forschung mbH | Method for the generation of virus producing cell lines and cell lines |
| WO2006057289A1 (ja) * | 2004-11-24 | 2006-06-01 | Anaeropharma Science Inc. | 新規シャトルベクター |
| CN101065492A (zh) | 2004-11-24 | 2007-10-31 | 纳诺非科特有限公司 | 病毒载体 |
| WO2008115199A2 (en) | 2006-08-18 | 2008-09-25 | The University Of North Carolina At Chapel Hill | Chimeric virus vaccines |
| GB0702695D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Production of vectors |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| US20110027313A1 (en) | 2008-04-04 | 2011-02-03 | University Of Miami | Viral recombineering and uses thereof |
| HRP20140392T1 (hr) * | 2010-09-02 | 2014-06-06 | Molmed Spa | Stabilna proizvodnja lentiviralnih vektora |
| US9273324B2 (en) | 2010-12-05 | 2016-03-01 | Andrew S. Belmont | Recombinant gene expression |
| WO2012170431A2 (en) | 2011-06-06 | 2012-12-13 | Bluebird Bio, Inc. | Improved geneswitch systems |
| GB201202516D0 (en) | 2012-02-13 | 2012-03-28 | Ucl Business Plc | Materials and methods relating to packaging cell lines |
| WO2014043131A1 (en) | 2012-09-14 | 2014-03-20 | The Regents Of The University Of California | Lentiviral vector for stem cell gene therapy of sickle cell disease |
| WO2015138852A1 (en) * | 2014-03-14 | 2015-09-17 | University Of Washington | Genomic insulator elements and uses thereof |
| GB2538324A (en) | 2015-05-15 | 2016-11-16 | Glaxosmithkline Ip Dev Ltd | Packaging cell line for retroviral production |
| GB2538321A (en) | 2015-05-15 | 2016-11-16 | Glaxosmithkline Ip Dev Ltd | Artificial chromosome for retroviral production |
| KR102058113B1 (ko) * | 2015-11-23 | 2019-12-23 | 주식회사 엘지화학 | 접착력이 개선된 리튬 이차전지용 전극 및 이의 제조방법 |
| BR112018010635A2 (pt) | 2015-11-24 | 2018-11-27 | Glaxosmithkline Ip Dev Ltd | linhagens celulares estáveis para a produção retroviral |
-
2016
- 2016-11-21 DE DE102016122317.4A patent/DE102016122317A1/de not_active Withdrawn
- 2016-11-21 IT IT102016000117287A patent/IT201600117287A1/it unknown
- 2016-11-21 WO PCT/EP2016/078334 patent/WO2017089307A1/en not_active Ceased
- 2016-11-21 AU AU2016359838A patent/AU2016359838B2/en not_active Ceased
- 2016-11-21 EP EP16798223.0A patent/EP3380605A1/en not_active Withdrawn
- 2016-11-21 BR BR112018010639A patent/BR112018010639A2/pt not_active Application Discontinuation
- 2016-11-21 CA CA3006285A patent/CA3006285A1/en active Pending
- 2016-11-21 FR FR1661254A patent/FR3044017B1/fr not_active Expired - Fee Related
- 2016-11-21 US US15/356,813 patent/US10450574B2/en active Active
- 2016-11-21 RU RU2018118964A patent/RU2749717C2/ru active
- 2016-11-21 KR KR1020187014239A patent/KR102067352B1/ko not_active Expired - Fee Related
- 2016-11-21 JP JP2018526787A patent/JP7110096B2/ja active Active
- 2016-11-21 CN CN201680068697.3A patent/CN108291211A/zh active Pending
-
2018
- 2018-05-08 IL IL259223A patent/IL259223B/en unknown
- 2018-05-15 SA SA518391585A patent/SA518391585B1/ar unknown
-
2019
- 2019-10-21 US US16/658,293 patent/US20200063144A1/en not_active Abandoned
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