JP2018534255A5 - - Google Patents

Download PDF

Info

Publication number
JP2018534255A5
JP2018534255A5 JP2018515550A JP2018515550A JP2018534255A5 JP 2018534255 A5 JP2018534255 A5 JP 2018534255A5 JP 2018515550 A JP2018515550 A JP 2018515550A JP 2018515550 A JP2018515550 A JP 2018515550A JP 2018534255 A5 JP2018534255 A5 JP 2018534255A5
Authority
JP
Japan
Prior art keywords
item
seq
trimer
nos
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018515550A
Other languages
English (en)
Japanese (ja)
Other versions
JP6933379B2 (ja
JP2018534255A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/051966 external-priority patent/WO2017053170A1/en
Publication of JP2018534255A publication Critical patent/JP2018534255A/ja
Publication of JP2018534255A5 publication Critical patent/JP2018534255A5/ja
Priority to JP2021072064A priority Critical patent/JP2021105060A/ja
Application granted granted Critical
Publication of JP6933379B2 publication Critical patent/JP6933379B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018515550A 2015-09-24 2016-09-15 転移を低減するための方法および組成物 Expired - Fee Related JP6933379B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021072064A JP2021105060A (ja) 2015-09-24 2021-04-21 転移を低減するための方法および組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562232169P 2015-09-24 2015-09-24
US62/232,169 2015-09-24
PCT/US2016/051966 WO2017053170A1 (en) 2015-09-24 2016-09-15 Methods and compositions for reducing metastases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021072064A Division JP2021105060A (ja) 2015-09-24 2021-04-21 転移を低減するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2018534255A JP2018534255A (ja) 2018-11-22
JP2018534255A5 true JP2018534255A5 (https=) 2019-10-31
JP6933379B2 JP6933379B2 (ja) 2021-09-08

Family

ID=58386932

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018515550A Expired - Fee Related JP6933379B2 (ja) 2015-09-24 2016-09-15 転移を低減するための方法および組成物
JP2021072064A Pending JP2021105060A (ja) 2015-09-24 2021-04-21 転移を低減するための方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021072064A Pending JP2021105060A (ja) 2015-09-24 2021-04-21 転移を低減するための方法および組成物

Country Status (10)

Country Link
US (2) US11219694B2 (https=)
EP (1) EP3352800B1 (https=)
JP (2) JP6933379B2 (https=)
KR (1) KR20180063885A (https=)
CN (1) CN108289966A (https=)
AU (1) AU2016328279A1 (https=)
CA (1) CA2999756A1 (https=)
ES (1) ES2907486T3 (https=)
IL (1) IL258292A (https=)
WO (1) WO2017053170A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180063885A (ko) 2015-09-24 2018-06-12 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 전이 감소를 위한 방법 및 조성물
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
AU2016419048B2 (en) * 2016-08-11 2024-02-15 The Council Of The Queensland Institute Of Medical Research Immune-modulating compounds
WO2018071911A1 (en) 2016-10-14 2018-04-19 Emory University Nanoparticles having molecules that bind or block pd-l1 and uses in treating cancer
KR102171766B1 (ko) * 2018-02-02 2020-10-29 주식회사 뉴라클제네틱스 Pd-l1 결합력이 증대된 pd-1 변이체
CN113912697B (zh) * 2019-07-24 2023-05-30 暨南大学 靶向cd133的结合蛋白与应用
CN110669108A (zh) * 2019-09-06 2020-01-10 中国药科大学 一种多肽及其应用
US20230414660A1 (en) * 2020-11-13 2023-12-28 Ludwig Institute For Cancer Research Ltd Pd-1 decoy variants for immunotherapy
US20250051419A1 (en) * 2021-12-10 2025-02-13 Georgiamune Inc. Polypeptide modulators
CN115068496B (zh) * 2022-06-29 2023-07-07 四川大学 Dna四面体框架核酸和香蒲新苷的复合物及其制备治疗急性肾损伤的药物的用途
WO2024182318A2 (en) * 2023-02-28 2024-09-06 Kodiak Sciences Inc. Antibodies to htra1 and conjugates thereof
CN118256447A (zh) * 2024-04-26 2024-06-28 中国医学科学院北京协和医院 一种高转移能力的胰腺癌类器官及其构建方法和应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA149387A (en) 1913-05-22 1913-07-22 Andrew Jackson Coppock Means of priming explosive engines
CA151652A (en) 1913-08-23 1913-11-11 Per Erik Martin Norell Side bearing for cars
CA157738A (en) 1914-07-30 1914-09-08 John Martin Davis Aeroplane
DK100664C (da) 1960-05-11 1964-12-21 Friedrich Tonne Rørpostanlæg med automatisk styring af rørpostpatronernes bevægelse.
US5436146A (en) 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5334761A (en) 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US6133028A (en) 1993-05-28 2000-10-17 Transgene S.A. Defective adenoviruses and corresponding complementation lines
IL112920A (en) 1994-03-07 2003-04-10 Dow Chemical Co Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof
ATE336587T1 (de) 1994-06-10 2006-09-15 Genvec Inc Adenoviren-vektor systeme und zelllinien
US5908635A (en) 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
US5872005A (en) 1994-11-03 1999-02-16 Cell Genesys Inc. Packaging cell lines for adeno-associated viral vectors
US20020168342A1 (en) 1994-11-03 2002-11-14 Cell Genesys, Inc. Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
US5629184A (en) 1995-01-25 1997-05-13 Amgen Inc. Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6040183A (en) 1995-06-07 2000-03-21 University Of North Carloina At Chapel Hill Helper virus-free AAV production
US6093570A (en) 1995-06-07 2000-07-25 The University Of North Carolina At Chapel Hill Helper virus-free AAV production
CA2226299A1 (en) 1995-08-11 1997-02-27 Dendritech, Inc. Hyper comb-branched polymer conjugates
US6548286B1 (en) 1997-04-14 2003-04-15 Cell Genesys, Inc. Methods for increasing the efficiency of recombinant AAV product
US5948878A (en) 1997-04-15 1999-09-07 Burgess; Stephen W. Cationic polymers for nucleic acid transfection and bioactive agent delivery
AU1819499A (en) 1997-12-12 1999-06-28 Samyang Corporation Positively-charged poly{alpha-(omega-aminoalkyl)glycolic acid} for the delivery of a bioactive agent via tissue and cellular uptake
BR9813548A (pt) 1997-12-12 2000-10-10 Samyang Corp Micelas poliméricas misturadas biodegradáveis para distribuição de gene
US6169078B1 (en) 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
DE69939740D1 (de) 1998-05-20 2008-11-27 Expression Genetics Inc Laktose oder galaktose-polyethylen glykol-gepfropfte poly-l-lysin als genträger
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
AU2003281200A1 (en) * 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
EP1558278B1 (en) * 2002-10-11 2009-09-02 ZymoGenetics, Inc. Production of homotrimeric fusion proteins
US8512701B2 (en) * 2002-11-15 2013-08-20 Morehouse School Of Medicine Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration
WO2004045525A2 (en) * 2002-11-15 2004-06-03 Morehouse School Of Medicine Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation.
JP5136766B2 (ja) * 2004-12-15 2013-02-06 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル キメラベクター
NZ612578A (en) * 2005-08-19 2014-11-28 Abbvie Inc Dual variable domain immunoglobin and uses thereof
ES2560871T3 (es) * 2007-07-10 2016-02-23 Apogenix Gmbh Proteínas de fusión de colectina de la superfamilia de TNF
WO2010037042A2 (en) * 2008-09-26 2010-04-01 The General Hospital Corporation Methods for detecting and treating cancer
WO2010059315A1 (en) * 2008-11-18 2010-05-27 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
WO2011066342A2 (en) * 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
CN102250254A (zh) * 2010-05-19 2011-11-23 江苏先声药物研究有限公司 肿瘤坏死因子相关凋亡诱导配体融合蛋白及其制备和应用
WO2012162426A1 (en) * 2011-05-23 2012-11-29 The University Of North Carolina At Chapel Hill Methods and compositions for heptameric targeting ligands
EP2714738B1 (en) * 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
EP2765997A4 (en) * 2011-10-14 2015-06-24 Stc Unm POROUS NANOPARTICLE-SUPPORTED LIPID DOUBLE LAYERS (PROTOCOLS) FOR THE TARGETED RELEASE BY TRANSDERMAL RELEASE AND USE METHOD THEREFOR
CN104039320B (zh) * 2011-11-09 2019-10-15 百时美施贵宝公司 血液恶性肿瘤用抗-cxcr4抗体的治疗
US9200072B2 (en) * 2012-01-18 2015-12-01 Genentech Inc. Anti-LRP5 antibodies and methods of use
WO2014121085A1 (en) * 2013-01-31 2014-08-07 Thomas Jefferson University Pd-l1 and pd-l2-based fusion proteins and uses thereof
CA2920377A1 (en) * 2013-08-05 2015-02-12 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy
WO2015061209A1 (en) * 2013-10-21 2015-04-30 Genentech, Inc. ANTI-Ly6E ANTIBODIES AND METHODS OF USE
TWI681969B (zh) * 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
BR112016014952A2 (pt) * 2014-02-10 2017-09-19 Merck Patent Gmbh Inibição direcionada de tgfbeta
CN105085677B (zh) * 2014-05-05 2019-01-18 中国科学院上海药物研究所 抗vegfr2人源纳米抗体ntv1及其制备方法和用途
US20170218091A1 (en) * 2014-07-03 2017-08-03 Abbvie Inc. Monovalent binding proteins
PT3177640T (pt) * 2014-08-08 2020-08-31 Univ Leland Stanford Junior Agentes pd-1 de alta afinidade e métodos de utilização
KR20180063885A (ko) * 2015-09-24 2018-06-12 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 전이 감소를 위한 방법 및 조성물
CN108079301B (zh) * 2016-11-23 2021-03-02 四川大学 减少cxcl13蛋白活性或表达量的活性物质在制备治疗恶性肿瘤转移药物中的用途
WO2018160572A1 (en) * 2017-02-28 2018-09-07 Oncomed Pharmaceuticals, Inc. Methods for treatment of cancer comprising gitr-binding agents
CN112543643A (zh) * 2018-03-05 2021-03-23 肿瘤免疫股份有限公司 使用可溶性cd24用于治疗获得性免疫缺陷综合征(hiv/aids)的方法
CN110357960A (zh) * 2018-04-10 2019-10-22 广州爱思迈生物医药科技有限公司 抗体及抗体改造方法
CN112870362B (zh) * 2021-02-08 2023-06-27 中山大学附属第一医院 Circ-MET-1214和/或Circ-M50作为靶点在制备抗肿瘤药物中的用途
CN113234165B (zh) * 2021-05-07 2023-02-28 暨南大学 EpCAM的改造的结合蛋白及其应用
CN113402618B (zh) * 2021-06-30 2022-06-10 徐州医科大学 Ski在制备增效型CAR-T细胞中的应用
CN113512115B (zh) * 2021-08-09 2023-09-15 江苏省农业科学院 一种广谱识别小菜蛾中肠受体的抗Cry2Aa独特型单域抗体及其应用

Similar Documents

Publication Publication Date Title
JP2018534255A5 (https=)
Heidbuechel et al. Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
ES3039539T3 (en) Combined chimeric antigen receptor targeting cd19 and cd20 and applications thereof
Stuckey et al. TRAIL on trial: preclinical advances in cancer therapy
Wang et al. A bispecific protein rG7S-MICA recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma
WO2015197016A1 (zh) 时空可调性抑制病理性靶细胞的系统
CN111527109A (zh) 以抗体Fc区为骨架的融合蛋白二聚体及其应用
JP2021502810A5 (https=)
CN113717942B (zh) 一种联合嵌合抗原受体和i型干扰素的免疫治疗方法及其应用
JP2017522025A5 (https=)
Han et al. Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors
JP2018509163A5 (https=)
CN111699000A (zh) 靶沉默技术的细胞内递送
Roddy et al. Novel cellular therapies for hepatocellular carcinoma
Huang et al. The application of nanoparticles targeting cancer-associated fibroblasts
CN114437218B (zh) 靶向cd276的嵌合抗原受体以及包含其的免疫细胞
CN106117367B (zh) 一种her-3特异性嵌合抗原受体及其应用
CN110564767A (zh) 一种减毒病毒载体系统及其在制备抗恶性肿瘤的药物中的应用及药物使用方法
JP2015520172A5 (https=)
JP2020535811A5 (https=)
Jayasinghe et al. Extracellular vesicle surface display enhances the therapeutic efficacy and safety profile of cancer immunotherapy
Glitza Oliva et al. Immunotherapy for melanoma
US11485767B2 (en) Multivalent PD-L1 binding compounds for treating cancer
JP2018525347A (ja) 癌免疫療法に使用するための二重特異性抗体
Zhang et al. Trained macrophage bioreactor for penetrating delivery of fused antitumor protein