JP2018531238A - 抗腫瘍性組成物 - Google Patents
抗腫瘍性組成物 Download PDFInfo
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- JP2018531238A JP2018531238A JP2018515877A JP2018515877A JP2018531238A JP 2018531238 A JP2018531238 A JP 2018531238A JP 2018515877 A JP2018515877 A JP 2018515877A JP 2018515877 A JP2018515877 A JP 2018515877A JP 2018531238 A JP2018531238 A JP 2018531238A
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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- General Engineering & Computer Science (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (13)
- 癌細胞の少なくとも1つの特異新生抗原をコードする少なくとも1つの核酸配列、少なくとも1つのポックスウイルス型ウイルス粒子、および、抗CTLA4抗体を有することを特徴とする、医薬組成物。
- 前記核酸配列がさらに、真核生物細胞において癌細胞の特異新生抗原の発現を提供する調節要素を有することを特徴とする、請求項1に記載の組成物。
- 前記核酸配列が、プラスミド、閉鎖線状DNAベクターおよびRNA分子を含む群から選択されることを特徴とする、請求項1または2に記載の組成物。
- 前記核酸配列が閉鎖線状核酸配列であることを特徴とする、請求項1〜3のいずれか一つに記載の組成物。
- 真核生物細胞において癌細胞に関連する新生抗原の発現を提供する調節要素が、宿主細胞の遺伝子転写プロモーターおよび翻訳開始領域を含むことを特徴とする、請求項2〜4のいずれか一つに記載の組成物。
- 前記ポックスウイルスが非組み換え型であるか、または少なくとも癌細胞に関連する抗原の必須領域をコードする異種DNA配列を有することを特徴とする、請求項1〜5のいずれか一つに記載の組成物。
- ポックスウイルスが生きている、または死んでいることを特徴とする、請求項1〜6のいずれか一つに記載の組成物。
- 少なくとも癌細胞に関連する抗原の必須領域をコードする前記DNA配列が、使用したポックスウイルスの遺伝子のプロモーターの制御下にあることを特徴とする、請求項6または7に記載の組成物。
- ポックスウイルス粒子が、ワクシニアウイルス、カナリア痘または鶏痘由来であることを特徴とする、請求項1〜8のいずれか一つに記載の組成物。
- ヒトまたは動物に注射により投与を可能にする薬学的に許容される基剤を有することを特徴とする、請求項1〜9のいずれか一つに記載の組成物。
- 前記薬学的に許容される基剤が、無針注射器による前記組成物の注入を可能にするものであることを特徴とする、請求項10に記載の組成物。
- 癌または腫瘍の治療に使用することを意図した、請求項1〜11のいずれか一つに記載の組成物。
- 子宮頸部癌、HPVウイルスにより誘導されたENT球または他の腫瘍、慢性B型肝炎またはC型肝炎ウイルスが関与する肝癌、またはMUC1タンパク質を発現する癌の治療に使用することを意図した、請求項12に記載の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1559589A FR3042121A1 (fr) | 2015-10-08 | 2015-10-08 | Composition anti-tumorale |
FR1559589 | 2015-10-08 | ||
FR1659450 | 2016-09-30 | ||
FR1659450A FR3042122B1 (fr) | 2015-10-08 | 2016-09-30 | Composition anti-tumorale |
PCT/FR2016/052598 WO2017060650A1 (fr) | 2015-10-08 | 2016-10-07 | Composition anti-tumorale |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2018531238A true JP2018531238A (ja) | 2018-10-25 |
JP2018531238A6 JP2018531238A6 (ja) | 2018-12-13 |
JP7211815B2 JP7211815B2 (ja) | 2023-01-24 |
Family
ID=55178130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018515877A Active JP7211815B2 (ja) | 2015-10-08 | 2016-10-07 | 抗腫瘍性組成物 |
Country Status (14)
Country | Link |
---|---|
US (2) | US20180296653A1 (ja) |
EP (1) | EP3359185B1 (ja) |
JP (1) | JP7211815B2 (ja) |
KR (1) | KR20180059547A (ja) |
CN (1) | CN108348587A (ja) |
CA (1) | CA2999948C (ja) |
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CA2974651A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
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US20180296653A1 (en) | 2018-10-18 |
JP7211815B2 (ja) | 2023-01-24 |
DK3359185T3 (da) | 2022-07-04 |
WO2017060650A1 (fr) | 2017-04-13 |
HK1253315A1 (zh) | 2019-06-14 |
FR3042121A1 (fr) | 2017-04-14 |
KR20180059547A (ko) | 2018-06-04 |
RU2728748C2 (ru) | 2020-07-31 |
CA2999948C (fr) | 2024-04-23 |
LT3359185T (lt) | 2022-06-27 |
FR3042122B1 (fr) | 2020-01-17 |
EP3359185A1 (fr) | 2018-08-15 |
IL258430B (en) | 2022-03-01 |
ES2919134T3 (es) | 2022-07-22 |
FR3042122A1 (fr) | 2017-04-14 |
US20210138053A1 (en) | 2021-05-13 |
RU2018115534A (ru) | 2019-11-08 |
RU2018115534A3 (ja) | 2020-02-26 |
CN108348587A (zh) | 2018-07-31 |
IL258430A (en) | 2018-06-28 |
EP3359185B1 (fr) | 2022-04-06 |
CA2999948A1 (fr) | 2017-04-13 |
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