JP2018530606A5 - - Google Patents
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- Publication number
- JP2018530606A5 JP2018530606A5 JP2018536071A JP2018536071A JP2018530606A5 JP 2018530606 A5 JP2018530606 A5 JP 2018530606A5 JP 2018536071 A JP2018536071 A JP 2018536071A JP 2018536071 A JP2018536071 A JP 2018536071A JP 2018530606 A5 JP2018530606 A5 JP 2018530606A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- polysaccharide
- activity
- biological function
- micelle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011782 vitamin Substances 0.000 claims 40
- 229940088594 vitamin Drugs 0.000 claims 40
- 229930003231 vitamin Natural products 0.000 claims 38
- 235000013343 vitamin Nutrition 0.000 claims 38
- 150000003722 vitamin derivatives Chemical class 0.000 claims 29
- 239000008187 granular material Substances 0.000 claims 28
- 150000004676 glycans Chemical class 0.000 claims 18
- 229920001282 polysaccharide Polymers 0.000 claims 18
- 239000005017 polysaccharide Substances 0.000 claims 18
- 230000008827 biological function Effects 0.000 claims 17
- 230000000694 effects Effects 0.000 claims 16
- 239000000693 micelle Substances 0.000 claims 16
- 239000013543 active substance Substances 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- -1 cyclic anhydride Chemical class 0.000 claims 3
- 230000004614 tumor growth Effects 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 125000003636 chemical group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002224 folic acids Chemical class 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- NCYVXEGFNDZQCU-UHFFFAOYSA-N nikethamide Chemical compound CCN(CC)C(=O)C1=CC=CN=C1 NCYVXEGFNDZQCU-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562233112P | 2015-09-25 | 2015-09-25 | |
| US62/233,112 | 2015-09-25 | ||
| PCT/US2016/053626 WO2017053920A1 (en) | 2015-09-25 | 2016-09-25 | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530606A JP2018530606A (ja) | 2018-10-18 |
| JP2018530606A5 true JP2018530606A5 (https=) | 2019-12-12 |
| JP6877049B2 JP6877049B2 (ja) | 2021-05-26 |
Family
ID=58387558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536071A Active JP6877049B2 (ja) | 2015-09-25 | 2016-09-25 | 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10517961B2 (https=) |
| EP (1) | EP3352796B1 (https=) |
| JP (1) | JP6877049B2 (https=) |
| KR (1) | KR20180058759A (https=) |
| CN (1) | CN108135917B (https=) |
| AU (1) | AU2016326747A1 (https=) |
| CA (1) | CA2995029C (https=) |
| IL (1) | IL257652A (https=) |
| WO (1) | WO2017053920A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3302423B1 (en) | 2015-06-04 | 2022-05-25 | Crititech, Inc. | Particle production system and particle collection device |
| BR112018069628A2 (pt) | 2016-04-04 | 2019-02-12 | Crititech, Inc. | métodos para tratamento de tumor sólido |
| EP3615145B1 (en) | 2017-06-09 | 2024-05-15 | Crititech, Inc. | Compositions for use in the treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| WO2018231908A1 (en) | 2017-06-14 | 2018-12-20 | Crititech, Inc. | Methods for treating lung disorders |
| KR20250057947A (ko) | 2017-10-03 | 2025-04-29 | 크리티테크, 인크. | 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달 |
| CN113382643A (zh) * | 2018-11-20 | 2021-09-10 | 斯菲拉封装有限责任公司 | 多层颗粒 |
| CN111956806B (zh) * | 2020-09-03 | 2023-04-07 | 四川大学 | 一种药物载体、胶束、药剂及其制备方法和应用 |
| KR102619293B1 (ko) * | 2021-01-14 | 2023-12-29 | 주식회사 엔바이오스 | Sp-fa 접합체를 유효성분으로 함유하는 항암용 조성물 |
| CN113082219B (zh) * | 2021-04-07 | 2023-02-17 | 中国科学院大学温州研究院(温州生物材料与工程研究所) | 一种基于π-π作用的疏水药物的增溶方法 |
| CN118477122B (zh) * | 2024-07-16 | 2024-09-24 | 中科创导(山东)生物科技有限公司 | 一种混合酶发酵生产治疗眼疾的中药制剂及其制备方法 |
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| CN103992417A (zh) * | 2012-12-14 | 2014-08-20 | 苏州友林生物科技有限公司 | 用于包裹药物化合物的辅料的制备方法及该辅料 |
| CN103120794B (zh) * | 2012-12-14 | 2014-04-30 | 苏州友林生物科技有限公司 | 协同起效的药用辅料及其抗肿瘤应用 |
| CN104434792B (zh) * | 2013-09-12 | 2018-03-23 | 中国科学院深圳先进技术研究院 | 聚合物胶束及其制备方法和抗肿瘤药物组合物、制剂及其制备方法 |
| WO2015126841A1 (en) * | 2014-02-18 | 2015-08-27 | Plasmatech Biopharmaceuticals, Inc. | Nutritional and therapeutic mucoadhesive formulations |
-
2016
- 2016-09-25 US US15/745,066 patent/US10517961B2/en active Active
- 2016-09-25 JP JP2018536071A patent/JP6877049B2/ja active Active
- 2016-09-25 WO PCT/US2016/053626 patent/WO2017053920A1/en not_active Ceased
- 2016-09-25 CN CN201680055476.2A patent/CN108135917B/zh active Active
- 2016-09-25 AU AU2016326747A patent/AU2016326747A1/en not_active Abandoned
- 2016-09-25 EP EP16849831.9A patent/EP3352796B1/en active Active
- 2016-09-25 CA CA2995029A patent/CA2995029C/en active Active
- 2016-09-25 KR KR1020187011217A patent/KR20180058759A/ko not_active Withdrawn
-
2018
- 2018-02-21 IL IL257652A patent/IL257652A/en unknown
-
2019
- 2019-11-08 US US16/678,908 patent/US10994024B2/en active Active
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