JP2018530325A5 - - Google Patents
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- JP2018530325A5 JP2018530325A5 JP2018516525A JP2018516525A JP2018530325A5 JP 2018530325 A5 JP2018530325 A5 JP 2018530325A5 JP 2018516525 A JP2018516525 A JP 2018516525A JP 2018516525 A JP2018516525 A JP 2018516525A JP 2018530325 A5 JP2018530325 A5 JP 2018530325A5
- Authority
- JP
- Japan
- Prior art keywords
- modified oligonucleotide
- compound
- modified
- wing segment
- nucleoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000001875 compounds Chemical class 0.000 claims description 62
- 108091034117 Oligonucleotide Proteins 0.000 claims description 56
- 239000002777 nucleoside Substances 0.000 claims description 49
- 125000003835 nucleoside group Chemical group 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 8
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 4
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 4
- 206010020772 Hypertension Diseases 0.000 claims description 3
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims description 3
- 229930024421 Adenine Natural products 0.000 claims description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 2
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims description 2
- 229960000643 adenine Drugs 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 229940113082 thymine Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 208000019622 heart disease Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000001826 Marfan syndrome Diseases 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 208000015658 resistant hypertension Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021160831A JP2022008677A (ja) | 2015-10-08 | 2021-09-30 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562238831P | 2015-10-08 | 2015-10-08 | |
| US62/238,831 | 2015-10-08 | ||
| PCT/US2016/056068 WO2017062816A2 (en) | 2015-10-08 | 2016-10-07 | Compounds and methods for modulating angiotensinogen expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021160831A Division JP2022008677A (ja) | 2015-10-08 | 2021-09-30 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018530325A JP2018530325A (ja) | 2018-10-18 |
| JP2018530325A5 true JP2018530325A5 (https=) | 2020-11-05 |
Family
ID=58488579
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516525A Ceased JP2018530325A (ja) | 2015-10-08 | 2016-10-07 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
| JP2021160831A Ceased JP2022008677A (ja) | 2015-10-08 | 2021-09-30 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
| JP2023069869A Pending JP2023093644A (ja) | 2015-10-08 | 2023-04-21 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
| JP2024168190A Pending JP2025011138A (ja) | 2015-10-08 | 2024-09-27 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021160831A Ceased JP2022008677A (ja) | 2015-10-08 | 2021-09-30 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
| JP2023069869A Pending JP2023093644A (ja) | 2015-10-08 | 2023-04-21 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
| JP2024168190A Pending JP2025011138A (ja) | 2015-10-08 | 2024-09-27 | アンジオテンシノーゲンの発現を調節するための化合物及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10912792B2 (https=) |
| EP (3) | EP4474389A3 (https=) |
| JP (4) | JP2018530325A (https=) |
| KR (2) | KR20240033305A (https=) |
| CN (2) | CN113817735A (https=) |
| AU (3) | AU2016334114B2 (https=) |
| BR (2) | BR112018005223B1 (https=) |
| CA (1) | CA2998898A1 (https=) |
| CL (2) | CL2018000899A1 (https=) |
| CO (1) | CO2018002598A2 (https=) |
| HK (1) | HK1258275A1 (https=) |
| IL (2) | IL295971A (https=) |
| MX (2) | MX392014B (https=) |
| MY (1) | MY200263A (https=) |
| PE (1) | PE20181085A1 (https=) |
| SG (1) | SG10202003148VA (https=) |
| WO (1) | WO2017062816A2 (https=) |
| ZA (1) | ZA201801600B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015264038B2 (en) | 2014-05-22 | 2021-02-11 | Alnylam Pharmaceuticals, Inc. | Angiotensinogen (AGT) iRNA compositions and methods of use thereof |
| TWI851574B (zh) | 2018-05-14 | 2024-08-11 | 美商阿尼拉製藥公司 | 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法 |
| WO2020236755A2 (en) * | 2019-05-17 | 2020-11-26 | Ionis Pharmaceuticals, Inc. | Angiotensin ii type 1 receptor targeted oligonucleotides and uses thereof |
| BR112022009216A2 (pt) * | 2019-11-13 | 2022-08-02 | Alnylam Pharmaceuticals Inc | Métodos e composições para tratar um distúrbio associado a angiotensinogênio (agt) |
| US11649458B2 (en) | 2020-05-05 | 2023-05-16 | University Of Kentucky Research Foundation | Inhibiting angiotensinogen to attenuate aortic pathology in Marfan syndrome |
| LT4136092T (lt) * | 2020-11-18 | 2024-09-25 | Ionis Pharmaceuticals, Inc. | Junginiai ir būdai, skirti angiotenzinogeno raiškos moduliavimui |
| CN114763547A (zh) * | 2021-01-14 | 2022-07-19 | 施能康生物科技有限公司 | 靶向血管紧张素原的核酸及其用途 |
| WO2022232650A1 (en) * | 2021-04-30 | 2022-11-03 | Ionis Pharmaceuticals, Inc. | Methods for reducing agt expression |
| US20240401045A1 (en) * | 2021-10-01 | 2024-12-05 | Adarx Pharmaceuticals, Inc. | Angiotensinogen-modulating compositions and methods of use thereof |
| CN120775847A (zh) * | 2021-10-20 | 2025-10-14 | 厦门甘宝利生物医药有限公司 | Agt抑制剂及其用途 |
| IL312811A (en) | 2021-11-16 | 2024-07-01 | Shanghai Argo Biopharmaceutical Co Ltd | Composition and method for inhibiting angiotensinogen (agt) protein expression |
| US20250197853A1 (en) * | 2021-11-19 | 2025-06-19 | Tuojie Biotech (Shanghai) Co., Ltd. | Sirna targeting angiotensinogen and pharmaceutical use of sirna |
| WO2023138650A1 (zh) * | 2022-01-20 | 2023-07-27 | 上海拓界生物医药科技有限公司 | 一种dsRNA、其应用及制备方法 |
| CN117264948B (zh) * | 2022-06-14 | 2024-05-10 | 广州必贝特医药股份有限公司 | 抑制血管紧张素原基因表达的RNAi抑制剂及其应用 |
| WO2024013334A1 (en) * | 2022-07-15 | 2024-01-18 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of agt in a cell |
| WO2024031008A2 (en) * | 2022-08-03 | 2024-02-08 | Sirnaomics, Inc. | Combination sirna and peptide docking vehicle (pdov) compositions and methods of their use for improved regulation and functionality |
| EP4587573A2 (en) * | 2022-09-16 | 2025-07-23 | Sirnaomics, Inc. | Products and compositions |
| TW202430193A (zh) * | 2022-12-20 | 2024-08-01 | 美商靖因藥業（上海）有限公司 | 靶向agt之聚核酸分子及其用途 |
| CN120752336A (zh) * | 2022-12-22 | 2025-10-03 | 圣诺制药公司 | 产品和组合物 |
| CN119530218A (zh) * | 2023-08-30 | 2025-02-28 | 苏州炫景生物科技有限公司 | 双链寡核苷酸及其在抑制血管紧张素原表达中的应用 |
| WO2024234831A1 (zh) * | 2023-05-15 | 2024-11-21 | 苏州时安生物技术有限公司 | 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途 |
| EP4562158A1 (en) | 2023-06-13 | 2025-06-04 | Arnatar Therapeutics, Inc | Advanced rna targeting (arnatar) for angiotensinogen |
| WO2025097040A1 (en) * | 2023-11-03 | 2025-05-08 | Ionis Pharmaceuticals, Inc. | Methods and compositions for reducing angiotensinogen |
| CN118995714B (zh) * | 2024-09-26 | 2025-12-12 | 杭州天龙药业有限公司 | 靶向抑制AGT基因表达的siRNA及其在治疗高血压中的应用 |
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| WO2016196111A1 (en) * | 2015-06-01 | 2016-12-08 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting angiotensinogen (agt) and methods of use thereof |
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2016
- 2016-10-07 CN CN202111106191.6A patent/CN113817735A/zh active Pending
- 2016-10-07 MY MYPI2018701353A patent/MY200263A/en unknown
- 2016-10-07 CN CN201680058511.6A patent/CN108271351B/zh active Active
- 2016-10-07 JP JP2018516525A patent/JP2018530325A/ja not_active Ceased
- 2016-10-07 AU AU2016334114A patent/AU2016334114B2/en not_active Ceased
- 2016-10-07 MX MX2018004307A patent/MX392014B/es unknown
- 2016-10-07 PE PE2018000423A patent/PE20181085A1/es unknown
- 2016-10-07 EP EP24190082.8A patent/EP4474389A3/en active Pending
- 2016-10-07 EP EP16854454.2A patent/EP3359164A4/en not_active Withdrawn
- 2016-10-07 HK HK19100639.6A patent/HK1258275A1/zh unknown
- 2016-10-07 KR KR1020247007192A patent/KR20240033305A/ko active Pending
- 2016-10-07 CA CA2998898A patent/CA2998898A1/en active Pending
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- 2016-10-07 US US15/763,942 patent/US10912792B2/en active Active
- 2016-10-07 KR KR1020187012472A patent/KR20180055898A/ko not_active Abandoned
- 2016-10-07 WO PCT/US2016/056068 patent/WO2017062816A2/en not_active Ceased
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- 2016-10-07 EP EP21185493.0A patent/EP3960183A1/en not_active Withdrawn
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2018
- 2018-03-08 IL IL257989A patent/IL257989B2/en unknown
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2020
- 2020-05-29 CL CL2020001453A patent/CL2020001453A1/es unknown
- 2020-11-23 US US17/101,299 patent/US20220000901A1/en active Pending
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2021
- 2021-09-30 JP JP2021160831A patent/JP2022008677A/ja not_active Ceased
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2022
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2023
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2024
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