JP2021525084A5 - - Google Patents
Info
- Publication number
- JP2021525084A5 JP2021525084A5 JP2020565431A JP2020565431A JP2021525084A5 JP 2021525084 A5 JP2021525084 A5 JP 2021525084A5 JP 2020565431 A JP2020565431 A JP 2020565431A JP 2020565431 A JP2020565431 A JP 2020565431A JP 2021525084 A5 JP2021525084 A5 JP 2021525084A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- nephropathy
- pharmaceutically acceptable
- compound
- pharmaceutical composition
- Prior art date
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023040313A JP7645301B2 (ja) | 2018-05-22 | 2023-03-15 | Ａｐｏｌ１発現のモジュレーター |
| JP2024194079A JP2025013513A (ja) | 2018-05-22 | 2024-11-06 | Ａｐｏｌ１発現のモジュレーター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862674865P | 2018-05-22 | 2018-05-22 | |
| US62/674,865 | 2018-05-22 | ||
| PCT/US2019/033244 WO2019226611A1 (en) | 2018-05-22 | 2019-05-21 | Modulators of apol1 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023040313A Division JP7645301B2 (ja) | 2018-05-22 | 2023-03-15 | Ａｐｏｌ１発現のモジュレーター |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021525084A JP2021525084A (ja) | 2021-09-24 |
| JPWO2019226611A5 JPWO2019226611A5 (https=) | 2022-03-24 |
| JP2021525084A5 true JP2021525084A5 (https=) | 2022-03-24 |
| JP7247227B2 JP7247227B2 (ja) | 2023-03-28 |
Family
ID=68613945
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020565431A Active JP7247227B2 (ja) | 2018-05-22 | 2019-05-21 | Ａｐｏｌ１発現のモジュレーター |
| JP2023040313A Active JP7645301B2 (ja) | 2018-05-22 | 2023-03-15 | Ａｐｏｌ１発現のモジュレーター |
| JP2024194079A Pending JP2025013513A (ja) | 2018-05-22 | 2024-11-06 | Ａｐｏｌ１発現のモジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023040313A Active JP7645301B2 (ja) | 2018-05-22 | 2023-03-15 | Ａｐｏｌ１発現のモジュレーター |
| JP2024194079A Pending JP2025013513A (ja) | 2018-05-22 | 2024-11-06 | Ａｐｏｌ１発現のモジュレーター |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US10927377B2 (https=) |
| EP (1) | EP3799570A4 (https=) |
| JP (3) | JP7247227B2 (https=) |
| KR (2) | KR20250153881A (https=) |
| CN (3) | CN118127020A (https=) |
| AR (1) | AR115416A1 (https=) |
| AU (2) | AU2019274461B2 (https=) |
| BR (1) | BR112020023436A2 (https=) |
| CA (1) | CA3099750A1 (https=) |
| CL (1) | CL2020003010A1 (https=) |
| CO (1) | CO2020015377A2 (https=) |
| CR (1) | CR20200631A (https=) |
| EA (1) | EA202092748A1 (https=) |
| EC (1) | ECSP20082339A (https=) |
| IL (2) | IL278785B2 (https=) |
| JO (1) | JOP20200291A1 (https=) |
| MA (1) | MA53924A (https=) |
| MX (2) | MX2020012497A (https=) |
| MY (1) | MY200352A (https=) |
| NI (1) | NI202000085A (https=) |
| PE (1) | PE20211397A1 (https=) |
| PH (1) | PH12020551995A1 (https=) |
| SG (1) | SG11202011397QA (https=) |
| TW (2) | TWI841564B (https=) |
| UA (1) | UA128819C2 (https=) |
| WO (1) | WO2019226611A1 (https=) |
| ZA (1) | ZA202007537B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE49076E1 (en) | 2010-04-18 | 2022-05-17 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for treating renal disease |
| MA53924A (fr) | 2018-05-22 | 2021-08-25 | Ionis Pharmaceuticals Inc | Modulateurs de l'expression d'apol1 |
| TWI848031B (zh) | 2018-12-17 | 2024-07-11 | 美商維泰克斯製藥公司 | Apol1抑制劑及其使用方法 |
| WO2021154997A1 (en) | 2020-01-29 | 2021-08-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| CA3185604A1 (en) | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and use of the same |
| WO2021252863A1 (en) | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Solid forms of apol1 inhibitor and using the same |
| IL314330A (en) | 2022-01-18 | 2024-09-01 | Maze Therapeutics Inc | Apol1 inhibitors and methods of use |
| US20260055083A1 (en) * | 2022-08-19 | 2026-02-26 | Maze Therapeutics, Inc. | Apol1 inhibitors and methods of use |
| TW202545540A (zh) | 2024-05-21 | 2025-12-01 | 瑞典商阿斯特捷利康公司 | 用於治療ａｐｏｌ１介導之腎病之方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020082401A1 (en) | 1994-12-15 | 2002-06-27 | Yeda Research And Development Company | Modulators of the function of FAS/APO1 receptors |
| US6833361B2 (en) * | 1998-05-26 | 2004-12-21 | Ribapharm, Inc. | Nucleosides having bicyclic sugar moiety |
| WO2002028999A2 (en) | 2000-10-03 | 2002-04-11 | Gene Logic, Inc. | Gene expression profiles in granulocytic cells |
| USH2191H1 (en) | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| US20070054278A1 (en) | 2003-11-18 | 2007-03-08 | Applera Corporation | Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof |
| US20050171044A1 (en) | 2003-12-24 | 2005-08-04 | Stein David A. | Oligonucleotide compound and method for treating nidovirus infections |
| EP2397563A3 (en) | 2004-09-17 | 2012-07-18 | Isis Pharmaceuticals, Inc. | Enhanced antisense oligonucleotides |
| EP1867338A1 (en) | 2006-05-30 | 2007-12-19 | Université Libre De Bruxelles | Pharmaceutical composition comprising apolipoproteins for the treatment of human diseases |
| JP2010507387A (ja) * | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のｓｉＲＮＡおよびその使用方法 |
| WO2010040112A2 (en) | 2008-10-03 | 2010-04-08 | Curna, Inc. | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| EP2370580B1 (en) | 2008-12-04 | 2019-09-11 | CuRNA, Inc. | Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirtuin 1 |
| WO2011020865A1 (en) | 2009-08-18 | 2011-02-24 | Universite Libre De Bruxelles | Apolipoprotein l- i variants and their use |
| AU2010319314C1 (en) | 2009-11-13 | 2016-09-01 | Sarepta Therapeutics, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
| RU2619185C2 (ru) | 2009-12-23 | 2017-05-12 | Курна, Инк. | Лечение заболеваний, связанных с разобщающим белком 2 (ucp2), путем ингибирования природного антисмыслового транскрипта к ucp2 |
| US9023355B2 (en) | 2010-04-13 | 2015-05-05 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for treating renal disease |
| US20120003644A1 (en) | 2010-06-07 | 2012-01-05 | Rappaport Family Institute For Research In The Medical Sciences | Methods and kits for determining predisposition to develop kidney diseases |
| HK1205189A1 (en) | 2012-02-08 | 2015-12-11 | Isis Pharmaceuticals, Inc. | Methods and compositions for modulating factor vii expression |
| RU2748495C2 (ru) | 2012-05-24 | 2021-05-26 | Ионис Фармасьютикалз, Инк. | Способы и композиции для модулирования экспрессии аполипопротеина (а) |
| EP2920206A4 (en) | 2012-11-16 | 2016-07-06 | Merck Sharp & Dohme | MODIFIED APOL1 POLYPEPTIDE |
| US10130632B2 (en) * | 2012-11-27 | 2018-11-20 | Beth Israel Deaconess Medical Center, Inc. | Methods for treating renal disease |
| EP2972381A2 (en) | 2013-03-14 | 2016-01-20 | Galapagos NV | Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition |
| GB201311057D0 (en) | 2013-06-21 | 2013-08-07 | Univ Greenwich | Antisense oligonucleotide compositions |
| TWI772856B (zh) * | 2013-07-19 | 2022-08-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| WO2015136509A2 (en) | 2014-03-14 | 2015-09-17 | Genesis Theranostix Korlatolt Felelossegu Tarsasag | Diagnostic and therapeutic targets for preeclampsia and closely related complications of pregnancy |
| CN106103717A (zh) | 2014-03-19 | 2016-11-09 | Ionis制药公司 | 用于调节共济失调蛋白2表达的组合物 |
| EP3020813A1 (en) | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
| TW201718010A (zh) | 2015-06-19 | 2017-06-01 | 健臻公司 | 治療原發性局部節段性腎小球硬化症之方法 |
| CA2991045A1 (en) | 2015-06-29 | 2017-01-05 | Caris Science, Inc. | Therapeutic oligonucleotides binding c1q |
| JP6877414B2 (ja) | 2015-09-24 | 2021-05-26 | アイオニス・ファーマシューティカルズ・インコーポレイテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｋｒａｓ発現のモジュレーター |
| MA53924A (fr) | 2018-05-22 | 2021-08-25 | Ionis Pharmaceuticals Inc | Modulateurs de l'expression d'apol1 |
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2019
- 2019-05-21 MA MA053924A patent/MA53924A/fr unknown
- 2019-05-21 IL IL278785A patent/IL278785B2/en unknown
- 2019-05-21 IL IL316397A patent/IL316397A/en unknown
- 2019-05-21 JP JP2020565431A patent/JP7247227B2/ja active Active
- 2019-05-21 KR KR1020257034730A patent/KR20250153881A/ko active Pending
- 2019-05-21 CN CN202410386621.1A patent/CN118127020A/zh active Pending
- 2019-05-21 WO PCT/US2019/033244 patent/WO2019226611A1/en not_active Ceased
- 2019-05-21 CA CA3099750A patent/CA3099750A1/en active Pending
- 2019-05-21 UA UAA202007818A patent/UA128819C2/uk unknown
- 2019-05-21 SG SG11202011397QA patent/SG11202011397QA/en unknown
- 2019-05-21 MX MX2020012497A patent/MX2020012497A/es unknown
- 2019-05-21 EP EP19807789.3A patent/EP3799570A4/en active Pending
- 2019-05-21 US US16/418,060 patent/US10927377B2/en active Active
- 2019-05-21 AU AU2019274461A patent/AU2019274461B2/en active Active
- 2019-05-21 TW TW108117504A patent/TWI841564B/zh active
- 2019-05-21 CR CR20200631A patent/CR20200631A/es unknown
- 2019-05-21 EA EA202092748A patent/EA202092748A1/ru unknown
- 2019-05-21 JO JOP/2020/0291A patent/JOP20200291A1/ar unknown
- 2019-05-21 BR BR112020023436-2A patent/BR112020023436A2/pt unknown
- 2019-05-21 CN CN202410386618.XA patent/CN118127019A/zh active Pending
- 2019-05-21 KR KR1020207036583A patent/KR102874776B1/ko active Active
- 2019-05-21 MY MYPI2020006084A patent/MY200352A/en unknown
- 2019-05-21 CN CN201980033544.9A patent/CN112423792B/zh active Active
- 2019-05-21 TW TW113114934A patent/TW202430638A/zh unknown
- 2019-05-21 PE PE2020001880A patent/PE20211397A1/es unknown
- 2019-05-22 AR ARP190101365A patent/AR115416A1/es unknown
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2020
- 2020-09-18 US US17/025,239 patent/US11525136B2/en active Active
- 2020-11-18 PH PH12020551995A patent/PH12020551995A1/en unknown
- 2020-11-19 CL CL2020003010A patent/CL2020003010A1/es unknown
- 2020-11-20 MX MX2025003294A patent/MX2025003294A/es unknown
- 2020-11-20 NI NI202000085A patent/NI202000085A/es unknown
- 2020-12-03 ZA ZA2020/07537A patent/ZA202007537B/en unknown
- 2020-12-09 CO CONC2020/0015377A patent/CO2020015377A2/es unknown
- 2020-12-18 EC ECSENADI202082339A patent/ECSP20082339A/es unknown
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2022
- 2022-11-08 US US18/053,447 patent/US12168766B2/en active Active
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2023
- 2023-03-15 JP JP2023040313A patent/JP7645301B2/ja active Active
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2024
- 2024-11-06 JP JP2024194079A patent/JP2025013513A/ja active Pending
- 2024-11-07 US US18/939,901 patent/US20250066785A1/en active Pending
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2025
- 2025-10-31 AU AU2025259982A patent/AU2025259982A1/en active Pending