JP2018529747A - 多発性硬化症を治療するための方法 - Google Patents

多発性硬化症を治療するための方法 Download PDF

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Publication number
JP2018529747A
JP2018529747A JP2018517617A JP2018517617A JP2018529747A JP 2018529747 A JP2018529747 A JP 2018529747A JP 2018517617 A JP2018517617 A JP 2018517617A JP 2018517617 A JP2018517617 A JP 2018517617A JP 2018529747 A JP2018529747 A JP 2018529747A
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Japan
Prior art keywords
antibody
exposure
weeks
patient
seq
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Pending
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JP2018517617A
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Japanese (ja)
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JP2018529747A5 (enExample
Inventor
ダーヴィト レペット，
ダーヴィト レペット，
アンヌ−マリー リー−カイ−チャン，
アンヌ−マリー リー−カイ−チャン，
ミシェル リボナティ，
ミシェル リボナティ，
ドナ マスターマン，
ドナ マスターマン，
ジャン−ポール プフェフェン，
ジャン−ポール プフェフェン，
クレイグ スミス，
クレイグ スミス，
アルギルダス ヨーナス カカリエカ ヴァイスコップ，
アルギルダス ヨーナス カカリエカ ヴァイスコップ，
チアモン チャン，
チアモン チャン，
ピーター エス． チン，
ピーター エス． チン，
ヒデキ ガレン，
ヒデキ ガレン，
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Genentech Inc
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2018529747A publication Critical patent/JP2018529747A/ja
Publication of JP2018529747A5 publication Critical patent/JP2018529747A5/ja
Priority to JP2021090543A priority Critical patent/JP2021152026A/ja
Priority to JP2023093742A priority patent/JP2023123521A/ja
Priority to JP2025134905A priority patent/JP2025170299A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Preliminary Treatment Of Fibers (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Treatment Of Fiber Materials (AREA)
JP2018517617A 2015-10-06 2016-10-06 多発性硬化症を治療するための方法 Pending JP2018529747A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021090543A JP2021152026A (ja) 2015-10-06 2021-05-28 多発性硬化症を治療するための方法
JP2023093742A JP2023123521A (ja) 2015-10-06 2023-06-07 多発性硬化症を治療するための方法
JP2025134905A JP2025170299A (ja) 2015-10-06 2025-08-13 多発性硬化症を治療するための方法

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201562238103P 2015-10-06 2015-10-06
US62/238,103 2015-10-06
US201562238674P 2015-10-07 2015-10-07
US62/238,674 2015-10-07
US201562271985P 2015-12-28 2015-12-28
US62/271,985 2015-12-28
US201662296049P 2016-02-16 2016-02-16
US62/296,049 2016-02-16
US201662322734P 2016-04-14 2016-04-14
US62/322,734 2016-04-14
US201662342633P 2016-05-27 2016-05-27
US62/342,633 2016-05-27
US201662355299P 2016-06-27 2016-06-27
US62/355,299 2016-06-27
PCT/US2016/055841 WO2017062682A2 (en) 2015-10-06 2016-10-06 Method for treating multiple sclerosis

Related Child Applications (1)

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JP2021090543A Division JP2021152026A (ja) 2015-10-06 2021-05-28 多発性硬化症を治療するための方法

Publications (2)

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JP2018529747A true JP2018529747A (ja) 2018-10-11
JP2018529747A5 JP2018529747A5 (enExample) 2019-11-14

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018517617A Pending JP2018529747A (ja) 2015-10-06 2016-10-06 多発性硬化症を治療するための方法
JP2021090543A Withdrawn JP2021152026A (ja) 2015-10-06 2021-05-28 多発性硬化症を治療するための方法
JP2023093742A Pending JP2023123521A (ja) 2015-10-06 2023-06-07 多発性硬化症を治療するための方法
JP2025134905A Pending JP2025170299A (ja) 2015-10-06 2025-08-13 多発性硬化症を治療するための方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021090543A Withdrawn JP2021152026A (ja) 2015-10-06 2021-05-28 多発性硬化症を治療するための方法
JP2023093742A Pending JP2023123521A (ja) 2015-10-06 2023-06-07 多発性硬化症を治療するための方法
JP2025134905A Pending JP2025170299A (ja) 2015-10-06 2025-08-13 多発性硬化症を治療するための方法

Country Status (18)

Country Link
US (3) US20180327505A1 (enExample)
EP (2) EP3359572B1 (enExample)
JP (4) JP2018529747A (enExample)
KR (2) KR20240107346A (enExample)
CN (1) CN108431038A (enExample)
DK (1) DK3359572T3 (enExample)
ES (1) ES3007182T3 (enExample)
FI (1) FI3359572T3 (enExample)
HK (1) HK1257072A1 (enExample)
HR (1) HRP20250052T1 (enExample)
HU (1) HUE069935T2 (enExample)
IL (2) IL258506A (enExample)
LT (1) LT3359572T (enExample)
PL (1) PL3359572T3 (enExample)
PT (1) PT3359572T (enExample)
RS (1) RS66408B1 (enExample)
SI (1) SI3359572T1 (enExample)
WO (1) WO2017062682A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023515528A (ja) * 2020-02-28 2023-04-13 ジェネンテック， インコーポレイテッド ブルトン型チロシンキナーゼの阻害剤を使用する一次性進行型多発性硬化症の治療方法
JP2023537751A (ja) * 2020-08-14 2023-09-05 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト オクレリズマブで多発性硬化症を治療するための方法

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