JP2018529735A - ナイアシンアミドとピコリンアミドとを含む組成物 - Google Patents
ナイアシンアミドとピコリンアミドとを含む組成物 Download PDFInfo
- Publication number
- JP2018529735A JP2018529735A JP2018517293A JP2018517293A JP2018529735A JP 2018529735 A JP2018529735 A JP 2018529735A JP 2018517293 A JP2018517293 A JP 2018517293A JP 2018517293 A JP2018517293 A JP 2018517293A JP 2018529735 A JP2018529735 A JP 2018529735A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- niacinamide
- picolinamide
- present
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
皮膚軟化剤、例えば、ステアリルアルコール、モノリシノール酸グリセリル、ミンク油、セチルアルコール、イソステアリン酸イソプロピル、ステアリン酸、パルミチン酸イソブチル、ステアリン酸イソセチル、オレイルアルコール、ラウリン酸イソプロピル、ラウリン酸ヘキシル、オレイン酸デシル、オクタデカン−2−オール、イソセチルアルコール、エイコサニルアルコール(eicosanyl alcohol)、ベヘニルアルコール、パルミチン酸セチル、ジメチルポリシロキサンなどのシリコーン油、セバシン酸ジ−n−ブチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、ステアリン酸イソプロピル、ステアリン酸ブチル、ポリエチレングリコール、トリエチレングリコール、ラノリン、ココアバター、コーン油、綿実油、オリーブ油、パーム核油、菜種油、紅花種子油、月見草油、大豆油、ヒマワリ種子油、アボガド油、ゴマ油、ココナツ油、ラッカセイ油、ヒマシ油、アセチル化ラノリンアルコール、ワセリン、鉱油、ミリスチン酸ブチル、イソステアリン酸、パルミチン酸、リノール酸イソプロピル、乳酸ラウリル、乳酸ミリスチル、オイレン酸デシル、ミリスチン酸ミリスチル;
溶媒、例えば、エチルアルコール、イソプロパノール、アセトン、エチレングリコールモノエチルエーテル、ジエチレングリコールモノブチルエーテル、ジエチレングリコールモノエチルエーテル;
有利には、上記で定義した皮膚コンディショニング剤以外の活性薬剤を組成物に添加することができる。これらの活性成分は、有利には、殺菌剤、ビタミン、抗アクネ活性物質;抗シワ、抗皮膚萎縮及び皮膚修復活性物質;皮膚バリア修復活性物質;非ステロイド系化粧用鎮静活性物質;人工日焼け剤及び促進剤;皮膚美白活性物質;日焼け止め活性物質;皮脂刺激剤;皮脂抑制剤;酸化防止剤;プロテアーゼ阻害剤;皮膚引き締め剤;かゆみ防止成分;育毛阻害剤;5−アルファレダクターゼ阻害剤;落屑酵素エンハンサー;抗糖化剤;又はそれらの混合物;等から選択することができる。
AMP(ソリアジン(psoriasin))の生成のための、本発明によるナイアシンアミドとピコリンアミドとの組合せを用いたインビトロ実験:
実験は以下のプロトコルを使用して行った:
ステップ1:ヒト新生児初代皮膚ケラチノサイト(NHEK)細胞をLonza(登録商標)から得た。実験は、3〜4回継代させた上記の細胞を用いて行った。次いで、Invitrogen(登録商標)から入手したケラチノサイト成長培地(KGM)を含む24ウェルプレートに細胞を播種した(35,000細胞/ウェル)。次いで、プレートを37±2℃でC02インキュベーターにおいて48時間インキュベートした。
ステップ4:上記処理の後、細胞を再び37±2℃でC02インキュベーターにおいて72時間インキュベートした。
上記の表から、本発明の範囲内にある組成物(実施例1〜3)は、対照実施例(実施例B〜E)よりもソリアジン(AMP)分泌においてはるかに優れた倍率変化をもたらすことが明らかである。実施例B(5mMナイアシンアミド)及び実施例E(10mMピコリンアミド)は、一緒に組み合わせた場合(実施例2)、AMP生成において相乗利益をもたらすことにも留意されたい。相乗効果は、実施例1(実施例Cと実施例Eの組合せ)及び実施例3(実施例Cと実施例Dの組合せ)に関しても観察される。
Claims (15)
- ナイアシンアミド対ピコリンアミドのモル比が1:20〜20:1である、ナイアシンアミドとピコリンアミドとを含む局所用組成物。
- ナイアシンアミド対ピコリンアミドのモル比が1:10〜10:1である、請求項1に記載の組成物。
- ナイアシンアミド対ピコリンアミドのモル比が1:2〜2:1である、請求項1に記載の組成物。
- 化粧品として許容される基剤をさらに含む、請求項1から3のいずれか一項に記載の組成物。
- 皮膚有益剤を含む、請求項1から4のいずれか一項に記載の組成物。
- リーブオン組成物の形態である、請求項1から5のいずれか一項に記載の組成物。
- 洗い流し組成物の形態である、請求項1から5のいずれか一項に記載の組成物。
- 前記リーブオン組成物が、ローション、クリーム、消臭剤、手指消毒剤及びボディスプレーを含む、請求項6に記載の組成物。
- 表面を消毒する方法であって、請求項1から8のいずれか一項に記載の組成物を前記表面に塗布するステップを含む方法。
- 前記組成物が洗い流し組成物の形態であり、前記組成物を少なくとも部分的に除去する追加のステップを含む、請求項9に記載の方法。
- 前記組成物を少なくとも部分的に除去するステップが、前記組成物を基体上に塗布するステップの後、5分未満で行われる、請求項10に記載の方法。
- 抗菌利益のための、請求項1から7のいずれか一項に記載の組成物の使用。
- 抗菌利益改善のための、ナイアシンアミドとピコリンアミドとを含む組成物の使用。
- 人体の外面に塗布された場合に抗菌ペプチド(AMP)の分泌を誘導するための、ナイアシンアミドとピコリンアミドとを含む組成物の使用。
- ケラチノサイトからの抗菌ペプチド(AMP)の分泌を誘導するための、請求項14に記載のナイアシンアミドとピコリンアミドとを含む組成物の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15188360 | 2015-10-05 | ||
EP15188360.0 | 2015-10-05 | ||
PCT/EP2016/073626 WO2017060213A1 (en) | 2015-10-05 | 2016-10-04 | Composition comprising niacinamide and picolinamide |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018529735A true JP2018529735A (ja) | 2018-10-11 |
JP6907196B2 JP6907196B2 (ja) | 2021-07-21 |
Family
ID=54256684
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018517293A Active JP6907196B2 (ja) | 2015-10-05 | 2016-10-04 | ナイアシンアミドとピコリンアミドとを含む組成物 |
JP2018517350A Active JP6880011B2 (ja) | 2015-10-05 | 2016-10-04 | 皮膚美白組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018517350A Active JP6880011B2 (ja) | 2015-10-05 | 2016-10-04 | 皮膚美白組成物 |
Country Status (13)
Country | Link |
---|---|
US (3) | US10952952B2 (ja) |
EP (2) | EP3359124B1 (ja) |
JP (2) | JP6907196B2 (ja) |
KR (1) | KR102643373B1 (ja) |
CN (2) | CN108135824B (ja) |
AR (1) | AR106261A1 (ja) |
BR (1) | BR112018005742B1 (ja) |
CA (2) | CA3000296A1 (ja) |
EA (2) | EA035440B1 (ja) |
MX (2) | MX2018004143A (ja) |
PH (1) | PH12018500619B1 (ja) |
WO (2) | WO2017060211A1 (ja) |
ZA (2) | ZA201802005B (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10952952B2 (en) | 2015-10-05 | 2021-03-23 | Conopco, Inc. | Skin lightening composition |
WO2019121529A1 (en) | 2017-12-18 | 2019-06-27 | Unilever N.V. | A topical composition |
WO2021008824A1 (en) * | 2019-07-12 | 2021-01-21 | Unilever Plc | Bioenergetic combinations and methods of using same |
WO2021249760A1 (en) * | 2020-06-10 | 2021-12-16 | Unilever Ip Holdings B.V. | A cosmetic composition comprising 6-methyl-picolinamide |
US11696889B2 (en) | 2020-08-07 | 2023-07-11 | David Levy | Botanical antimicrobial composition |
WO2023175061A1 (en) * | 2022-03-18 | 2023-09-21 | Unilever Ip Holdings B.V. | A skin brightening composition |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003267817A (ja) * | 2002-03-18 | 2003-09-25 | Pias Arise Kk | 皮膚分配浸透性組成物、並びにその組成物を配合した皮膚外用剤及び化粧料 |
JP2004123554A (ja) * | 2002-09-30 | 2004-04-22 | Pias Arise Kk | 皮膚バリア機能改善物質、皮膚のしわ改善物質、および該物質を含む皮膚外用剤、化粧料および医薬部外品 |
JP2005537238A (ja) * | 2002-06-20 | 2005-12-08 | アスティオン デルマトロジー エイ/エス | ポリヒドロキシアルカンの脂肪酸エステルおよびピリジンカルボキシ誘導体の新規複合体 |
EP2742942A1 (en) * | 2012-12-14 | 2014-06-18 | Unilever N.V. | Niacinamide for inducing generation of antimicrobial peptides |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1370236A (en) * | 1972-01-11 | 1974-10-16 | Unilever Ltd | Skin composition |
GB1533119A (en) * | 1975-04-10 | 1978-11-22 | Unilever Ltd | Skin lightening compositions |
GB8910366D0 (en) * | 1989-05-05 | 1989-06-21 | Unilever Plc | Skin composition |
TW233264B (ja) | 1992-02-03 | 1994-11-01 | Otsuka Pharma Co Ltd | |
US5411741A (en) * | 1993-07-29 | 1995-05-02 | Zaias; Nardo | Method and composition for skin depigmentation |
CN1292699A (zh) | 1998-03-16 | 2001-04-25 | 宝洁公司 | 皮肤刺激的处理方法 |
US20010036924A1 (en) | 2000-03-21 | 2001-11-01 | Weidner Morten Sloth | Chemical complex comprising a substituted pyridine carboxy derivative and a glucosaminoglycan |
US20030105034A1 (en) | 2001-07-05 | 2003-06-05 | Astion Deveopment A/S | Pyridine carboxy derivatives and an aminosugar |
FR2827763B1 (fr) | 2001-07-24 | 2005-09-23 | Cs | Substance alkyloside inhibant la fixation de microorganismes, utilisation topique et composition contenant au moins une telle substance |
US20090105188A1 (en) | 2007-10-17 | 2009-04-23 | Nationwide Children's Hospital, Inc. | Compositions and Methods for Treating Necrotizing Enterocolitis |
US20090317341A1 (en) | 2008-06-18 | 2009-12-24 | Conopco, Inc., D/B/A Unilever | Compositions for Lightening Skin Color |
WO2010002586A2 (en) | 2008-06-30 | 2010-01-07 | Elc Management Llc | Topical compositions comprising isonicotinamide |
EP2362866B1 (en) * | 2008-11-11 | 2015-07-08 | Signum Biosciences, Inc. | Isoprenyl compounds and methods thereof |
US20130052162A1 (en) | 2010-04-20 | 2013-02-28 | Cedars-Sinai Medical Center | Boosting immune defense by upregulating ccaat/enhancer binding protein epsilon |
EP2522331A1 (en) * | 2011-05-09 | 2012-11-14 | DSM IP Assets B.V. | Use of resveratrol and niacinamide |
WO2013030794A2 (en) * | 2011-08-31 | 2013-03-07 | Behrooz Kasraee | Use of substituted pyridines as skin depigmenting compounds |
US20140161750A1 (en) * | 2012-12-12 | 2014-06-12 | Thomas Christopher Balshi | Sunscreen composition with pigment correcting properties |
JP6507158B2 (ja) * | 2013-10-24 | 2019-04-24 | ザ プロクター アンド ギャンブル カンパニー | 皮膚を明るくする化粧組成物 |
EA031758B1 (ru) | 2014-05-12 | 2019-02-28 | Юнилевер Н.В. | Ниацинамид для стимуляции продуцирования антимикробных пептидов |
US10952952B2 (en) * | 2015-10-05 | 2021-03-23 | Conopco, Inc. | Skin lightening composition |
-
2016
- 2016-10-04 US US15/764,968 patent/US10952952B2/en active Active
- 2016-10-04 CA CA3000296A patent/CA3000296A1/en active Pending
- 2016-10-04 BR BR112018005742-8A patent/BR112018005742B1/pt active IP Right Grant
- 2016-10-04 MX MX2018004143A patent/MX2018004143A/es active IP Right Grant
- 2016-10-04 MX MX2018004144A patent/MX365369B/es active IP Right Grant
- 2016-10-04 JP JP2018517293A patent/JP6907196B2/ja active Active
- 2016-10-04 CA CA3000880A patent/CA3000880A1/en active Pending
- 2016-10-04 KR KR1020187008919A patent/KR102643373B1/ko active IP Right Grant
- 2016-10-04 JP JP2018517350A patent/JP6880011B2/ja active Active
- 2016-10-04 EP EP16775715.2A patent/EP3359124B1/en active Active
- 2016-10-04 CN CN201680058538.5A patent/CN108135824B/zh active Active
- 2016-10-04 WO PCT/EP2016/073617 patent/WO2017060211A1/en active Application Filing
- 2016-10-04 EA EA201890886A patent/EA035440B1/ru not_active IP Right Cessation
- 2016-10-04 CN CN201680058411.3A patent/CN108136232B/zh active Active
- 2016-10-04 EP EP16778325.7A patent/EP3359261B1/en active Active
- 2016-10-04 EA EA201890889A patent/EA035789B1/ru not_active IP Right Cessation
- 2016-10-04 US US15/765,015 patent/US10660840B2/en active Active
- 2016-10-04 WO PCT/EP2016/073626 patent/WO2017060213A1/en active Application Filing
- 2016-10-05 AR ARP160103044A patent/AR106261A1/es unknown
-
2018
- 2018-03-21 PH PH12018500619A patent/PH12018500619B1/en unknown
- 2018-03-26 ZA ZA2018/02005A patent/ZA201802005B/en unknown
- 2018-04-05 ZA ZA2018/02233A patent/ZA201802233B/en unknown
-
2020
- 2020-03-18 US US16/822,183 patent/US11298312B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003267817A (ja) * | 2002-03-18 | 2003-09-25 | Pias Arise Kk | 皮膚分配浸透性組成物、並びにその組成物を配合した皮膚外用剤及び化粧料 |
JP2005537238A (ja) * | 2002-06-20 | 2005-12-08 | アスティオン デルマトロジー エイ/エス | ポリヒドロキシアルカンの脂肪酸エステルおよびピリジンカルボキシ誘導体の新規複合体 |
JP2004123554A (ja) * | 2002-09-30 | 2004-04-22 | Pias Arise Kk | 皮膚バリア機能改善物質、皮膚のしわ改善物質、および該物質を含む皮膚外用剤、化粧料および医薬部外品 |
EP2742942A1 (en) * | 2012-12-14 | 2014-06-18 | Unilever N.V. | Niacinamide for inducing generation of antimicrobial peptides |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11298312B2 (en) | Composition comprising niacinamide and picolinamide | |
EP3727316B1 (en) | A topical composition based on niacinamide derivative | |
US20220087914A1 (en) | An antimicrobial composition | |
EP3442493B1 (en) | An antimicrobial composition comprising thymol, terpineol and a cationic phospholipid | |
EP3727315B1 (en) | A topical composition comprising n-cyclopropyl nicotinamide | |
BR112018072388B1 (pt) | Composiqao topica, metodo nao-terapeutico de desinfecqao de uma superficie e usos naoterapeuticos de uma composiqao | |
WO2019121319A1 (en) | An antimicrobial composition | |
EP3727300B1 (en) | An antimicrobial composition | |
EA036416B1 (ru) | Противомикробная композиция |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A529 | Written submission of copy of amendment under article 34 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A529 Effective date: 20180531 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190802 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200630 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200714 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201012 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210302 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210517 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210601 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210630 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6907196 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |