JP2018527912A5 - - Google Patents

Info

Publication number

JP2018527912A5

JP2018527912A5 JP2018506135A JP2018506135A JP2018527912A5 JP 2018527912 A5 JP2018527912 A5 JP 2018527912A5 JP 2018506135 A JP2018506135 A JP 2018506135A JP 2018506135 A JP2018506135 A JP 2018506135A JP 2018527912 A5 JP2018527912 A5 JP 2018527912A5

Authority

JP

Japan

Prior art keywords

antigen

binding fragment

antibody

chain variable

variable region

Prior art date

2016-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims description 114
• 102000036639 antigens Human genes 0.000 claims description 114
• 108091007433 antigens Proteins 0.000 claims description 114
• 239000012634 fragment Substances 0.000 claims description 113
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 61
• 210000004027 cell Anatomy 0.000 claims description 31
• 239000000203 mixture Substances 0.000 claims description 22
• 102000018682 Interleukin Receptor Common gamma Subunit Human genes 0.000 claims description 19
• 108010066719 Interleukin Receptor Common gamma Subunit Proteins 0.000 claims description 19
• 238000000034 method Methods 0.000 claims description 16
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 10
• 238000000338 in vitro Methods 0.000 claims description 10
• 208000035473 Communicable disease Diseases 0.000 claims description 9
• 206010028980 Neoplasm Diseases 0.000 claims description 9
• 201000011510 cancer Diseases 0.000 claims description 9
• 210000000822 natural killer cell Anatomy 0.000 claims description 9
• 239000003814 drug Substances 0.000 claims description 5
• 230000015572 biosynthetic process Effects 0.000 claims description 4
• 102000039446 nucleic acids Human genes 0.000 claims description 3
• 108020004707 nucleic acids Proteins 0.000 claims description 3
• 150000007523 nucleic acids Chemical class 0.000 claims description 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
• 229940079593 drug Drugs 0.000 claims description 2
• 238000013160 medical therapy Methods 0.000 claims description 2
• 238000002560 therapeutic procedure Methods 0.000 claims description 2
• 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 1
• 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 1
• 230000004064 dysfunction Effects 0.000 claims 1
• 239000000018 receptor agonist Substances 0.000 claims 1
• 229940044601 receptor agonist Drugs 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 description 11
• 108090000765 processed proteins & peptides Proteins 0.000 description 11
• 102000004196 processed proteins & peptides Human genes 0.000 description 11
• 125000003275 alpha amino acid group Chemical group 0.000 description 10
• 208000015181 infectious disease Diseases 0.000 description 8
• 102000025171 antigen binding proteins Human genes 0.000 description 6
• 108091000831 antigen binding proteins Proteins 0.000 description 6
• 150000001413 amino acids Chemical class 0.000 description 4
• 238000012217 deletion Methods 0.000 description 4
• 230000037430 deletion Effects 0.000 description 4
• 238000003780 insertion Methods 0.000 description 4
• 230000037431 insertion Effects 0.000 description 4
• 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 4
• 238000006467 substitution reaction Methods 0.000 description 4
• 238000001727 in vivo Methods 0.000 description 3
• 238000004519 manufacturing process Methods 0.000 description 3
• 108010002350 Interleukin-2 Proteins 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 235000004879 dioscorea Nutrition 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1