JP2018527392A5 - - Google Patents
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- Publication number
- JP2018527392A5 JP2018527392A5 JP2018514876A JP2018514876A JP2018527392A5 JP 2018527392 A5 JP2018527392 A5 JP 2018527392A5 JP 2018514876 A JP2018514876 A JP 2018514876A JP 2018514876 A JP2018514876 A JP 2018514876A JP 2018527392 A5 JP2018527392 A5 JP 2018527392A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- oral dosage
- lysine
- enteric coated
- zoledronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006186 oral dosage form Substances 0.000 claims 22
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 17
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 14
- 229960004276 zoledronic acid Drugs 0.000 claims 14
- 239000004472 Lysine Substances 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 229960003646 lysine Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 159000000000 sodium salts Chemical group 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- HZRUTVAFDWTKGD-UHFFFAOYSA-N 2,6-diaminohexanoic acid;hydrate Chemical group O.NCCCCC(N)C(O)=O HZRUTVAFDWTKGD-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000002702 enteric coating Substances 0.000 claims 2
- 238000009505 enteric coating Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- -1 disodium zoledronic acid tetrahydrate Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229940002005 zometa Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220404P | 2015-09-18 | 2015-09-18 | |
| US62/220,404 | 2015-09-18 | ||
| PCT/US2016/052492 WO2017049294A1 (en) | 2015-09-18 | 2016-09-19 | Crystallization method and bioavailability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018527392A JP2018527392A (ja) | 2018-09-20 |
| JP2018527392A5 true JP2018527392A5 (enExample) | 2019-10-31 |
Family
ID=58289727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514876A Pending JP2018527392A (ja) | 2015-09-18 | 2016-09-19 | 結晶化法及びバイオアベイラビリティ |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20190083407A1 (enExample) |
| EP (1) | EP3362071A4 (enExample) |
| JP (1) | JP2018527392A (enExample) |
| KR (1) | KR20180053384A (enExample) |
| CN (1) | CN108601791A (enExample) |
| AU (1) | AU2016324482A1 (enExample) |
| CA (1) | CA2997378A1 (enExample) |
| CL (1) | CL2018000705A1 (enExample) |
| CO (1) | CO2018003558A2 (enExample) |
| MX (1) | MX2018002627A (enExample) |
| PE (1) | PE20180931A1 (enExample) |
| WO (1) | WO2017049294A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| KR101813728B1 (ko) | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| KR20200110317A (ko) | 2017-12-05 | 2020-09-23 | 선오비온 파마슈티컬스 인코포레이티드 | 결정형 및 이의 제조 방법 |
| CN118593482A (zh) | 2017-12-05 | 2024-09-06 | 赛诺维信制药公司 | 非外消旋混合物及其用途 |
| CN108440449B (zh) * | 2018-04-17 | 2021-05-07 | 中国海洋大学 | 一种氢氯噻嗪与脯氨酸的共晶及其制备方法 |
| CN108558791B (zh) * | 2018-06-08 | 2021-05-07 | 中国海洋大学 | 一种乙酰唑胺与脯氨酸的共晶及其制备方法 |
| CN108570051B (zh) * | 2018-07-20 | 2021-02-02 | 中国科学院上海药物研究所 | 呋塞米-氨苯蝶啶盐、晶型i及其制备方法和应用 |
| CN108794418A (zh) * | 2018-09-18 | 2018-11-13 | 中国药科大学 | 一种缬沙坦烟酰胺共无定形物 |
| CN109568284B (zh) * | 2018-12-29 | 2020-04-24 | 广东中润药物研发有限公司 | 一种替诺福韦艾拉酚胺肠溶片及其制备方法 |
| CN109776430B (zh) * | 2019-02-01 | 2022-05-13 | 福建农林大学 | 一种磺胺二甲嘧啶共晶及其制备方法 |
| AU2020286441A1 (en) | 2019-06-04 | 2022-01-06 | Sunovion Pharmaceuticals Inc. | Modified release formulations and uses thereof |
| CN110372575A (zh) * | 2019-07-10 | 2019-10-25 | 复旦大学 | 一种二氢吡啶钙拮抗剂共晶体及其制备方法和应用 |
| CN111053755B (zh) * | 2019-12-31 | 2022-03-29 | 金日制药（中国）有限公司 | 一种高渗透性的头孢克肟胶囊制剂制备方法 |
| WO2022162604A1 (ko) * | 2021-01-28 | 2022-08-04 | (주)아이엠디팜 | 카모스타트 및 니클로사마이드를 포함하는 공결정, 이를 포함하는 약학 조성물 및 이의 제조 방법 |
| CN113181179A (zh) * | 2021-04-08 | 2021-07-30 | 深圳市泰力生物医药有限公司 | 一种二氢吡啶类钙拮抗剂盐组合物及其制备方法和应用 |
| KR102544543B1 (ko) * | 2021-04-29 | 2023-06-16 | 대봉엘에스 주식회사 | L,d-엘도스테인의 개별적 공결정화물 |
| WO2024151838A1 (en) * | 2023-01-11 | 2024-07-18 | Board Of Regents, The University Of Texas System | Co-crystals with thin-film freeze-drying process to enhance delivery |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040220264A1 (en) * | 2003-03-17 | 2004-11-04 | Yu Ruey J | Bioavailability and improved delivery of acidic pharmaceutical drugs |
| US20050054616A1 (en) * | 2003-07-03 | 2005-03-10 | Judith Aronhime | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation |
| TWI480286B (zh) * | 2009-02-25 | 2015-04-11 | Merrion Res Iii Ltd | 雙膦酸鹽類組合物及藥物遞送 |
| KR101813728B1 (ko) * | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| WO2011014781A1 (en) * | 2009-07-31 | 2011-02-03 | Thar Pharmaceuticals, Inc. | Novel oral forms of a phosphonic acid derivative |
| EP2531200B1 (en) * | 2010-02-06 | 2017-07-12 | Grünenthal GmbH | Crystallization method and bioavailability |
| KR20120105738A (ko) * | 2011-03-16 | 2012-09-26 | 현대약품 주식회사 | 장용코팅된 경구용 제제 |
| US8802658B2 (en) * | 2012-05-14 | 2014-08-12 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| CA2987470A1 (en) * | 2012-05-14 | 2013-11-21 | Antecip Bioventures Ii Llc | Compositions comprising zoledronic acid or related compounds for relieving inflammatory pain and related conditions |
| US20140349974A1 (en) * | 2014-08-12 | 2014-11-27 | Antecip Bioventures Ii Llc | Zoledronic acid dosage forms for the treatment of pain |
| US20140348916A1 (en) * | 2014-08-11 | 2014-11-27 | Antecip Bioventures Ii Llc | Treatment of Pain with Oral Dosage Forms Comprising Zoledronic Acid and An Enhancer |
-
2016
- 2016-09-19 CN CN201680067559.3A patent/CN108601791A/zh active Pending
- 2016-09-19 CA CA2997378A patent/CA2997378A1/en not_active Abandoned
- 2016-09-19 EP EP16847548.1A patent/EP3362071A4/en not_active Withdrawn
- 2016-09-19 PE PE2018000403A patent/PE20180931A1/es unknown
- 2016-09-19 MX MX2018002627A patent/MX2018002627A/es unknown
- 2016-09-19 AU AU2016324482A patent/AU2016324482A1/en not_active Abandoned
- 2016-09-19 KR KR1020187010719A patent/KR20180053384A/ko not_active Withdrawn
- 2016-09-19 WO PCT/US2016/052492 patent/WO2017049294A1/en not_active Ceased
- 2016-09-19 JP JP2018514876A patent/JP2018527392A/ja active Pending
-
2018
- 2018-03-15 US US15/922,278 patent/US20190083407A1/en not_active Abandoned
- 2018-03-16 CL CL2018000705A patent/CL2018000705A1/es unknown
- 2018-04-04 CO CONC2018/0003558A patent/CO2018003558A2/es unknown