JP2018526428A5 - - Google Patents
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- JP2018526428A5 JP2018526428A5 JP2018513549A JP2018513549A JP2018526428A5 JP 2018526428 A5 JP2018526428 A5 JP 2018526428A5 JP 2018513549 A JP2018513549 A JP 2018513549A JP 2018513549 A JP2018513549 A JP 2018513549A JP 2018526428 A5 JP2018526428 A5 JP 2018526428A5
- Authority
- JP
- Japan
- Prior art keywords
- lymphocytes
- effector
- patient
- virus
- oncolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 244000309459 oncolytic virus Species 0.000 claims 35
- 210000003162 effector t lymphocyte Anatomy 0.000 claims 29
- 201000011510 cancer Diseases 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 230000001419 dependent effect Effects 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 230000002519 immonomodulatory effect Effects 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000004936 stimulating effect Effects 0.000 claims 5
- 238000002255 vaccination Methods 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 230000002927 anti-mitotic effect Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 210000003563 lymphoid tissue Anatomy 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241001372913 Maraba virus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000710960 Sindbis virus Species 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 201000000220 brain stem cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 239000003145 cytotoxic factor Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 108010072285 growth inhibitory proteins Proteins 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000000568 immunological adjuvant Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 230000002101 lytic effect Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000003226 mitogen Substances 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000022983 regulation of cell cycle Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021147640A JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2023176751A JP2023176003A (ja) | 2015-09-09 | 2023-10-12 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216046P | 2015-09-09 | 2015-09-09 | |
| US201562216062P | 2015-09-09 | 2015-09-09 | |
| US62/216,046 | 2015-09-09 | ||
| US62/216,062 | 2015-09-09 | ||
| US201562255294P | 2015-11-13 | 2015-11-13 | |
| US62/255,294 | 2015-11-13 | ||
| US201662323065P | 2016-04-15 | 2016-04-15 | |
| US62/323,065 | 2016-04-15 | ||
| PCT/US2016/050994 WO2017044780A1 (en) | 2015-09-09 | 2016-09-09 | Methods for combining adoptive t cell therapy with oncolytic virus adjunct therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147640A Division JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018526428A JP2018526428A (ja) | 2018-09-13 |
| JP2018526428A5 true JP2018526428A5 (https=) | 2019-10-24 |
Family
ID=58240173
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513549A Withdrawn JP2018526428A (ja) | 2015-09-09 | 2016-09-09 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2021147640A Pending JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2023176751A Pending JP2023176003A (ja) | 2015-09-09 | 2023-10-12 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147640A Pending JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2023176751A Pending JP2023176003A (ja) | 2015-09-09 | 2023-10-12 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20190038727A1 (https=) |
| EP (1) | EP3347473A4 (https=) |
| JP (3) | JP2018526428A (https=) |
| WO (1) | WO2017044780A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2097517B1 (en) | 2006-10-16 | 2014-06-04 | Genelux Corporation | Recombinant Lister strain vaccinia virus encoding an anti-VEGF single chain antibody |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| CN115300622A (zh) | 2015-02-25 | 2022-11-08 | 纪念斯隆-凯特琳癌症中心 | 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合 |
| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| EP3347473A4 (en) * | 2015-09-09 | 2019-04-10 | Tvax Biomedical I, LLC | METHOD FOR COMBINING ADOPTIVE T CELL THERAPY WITH ONCOLYTIC VIRUS ATTACHMENT THERAPY |
| IL261321B2 (en) | 2016-02-25 | 2023-12-01 | Memorial Sloan Kettering Cancer Center | Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors |
| KR20180133395A (ko) | 2016-02-25 | 2018-12-14 | 메모리얼 슬로안 케터링 캔서 센터 | 암 면역요법을 위한, 인간 flt3l 또는 gm-csf의 발현이 있거나 없으며 티미딘 키나제가 결실된 복제 가능 약독화 백시니아 바이러스 |
| SG11201811408PA (en) | 2016-06-24 | 2019-01-30 | Univ Mcmaster | Adoptive cell transfer and oncolytic virus combination therapy |
| JP7724601B2 (ja) | 2017-02-03 | 2025-08-18 | ユニバーシティ オブ ピッツバーグ －オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 腫瘍溶解性ウイルス療法 |
| WO2018209315A1 (en) | 2017-05-12 | 2018-11-15 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| BR112020014727A2 (pt) * | 2018-01-19 | 2020-12-08 | Kolon Life Science, Inc. | Vírus vaccinia recombinante e composição farmacêutica compreendendo o mesmo |
| MX2021003013A (es) | 2018-09-15 | 2021-08-11 | Memorial Sloan Kettering Cancer Center | Poxvirus recombinantes para inmunoterapia contra cáncer. |
| EP3897846A1 (en) * | 2018-12-21 | 2021-10-27 | GlaxoSmithKline Biologicals SA | Methods of inducing an immune response |
| CA3133971A1 (en) * | 2019-03-20 | 2020-09-24 | Turnstone Biologics Inc. | Sequential heterologous boost oncolytic viral mmunotherapy |
| WO2020247547A1 (en) * | 2019-06-03 | 2020-12-10 | Geovax, Inc. | Cancer vaccine compositions and methods for use thereof |
| JP7629872B2 (ja) * | 2019-06-05 | 2025-02-14 | レイトラム，エル．エル．シー． | 滑らかに直径を減少する自動スタッキング式スパイラルベルトコンベヤ |
| CN110540960A (zh) * | 2019-09-11 | 2019-12-06 | 苏州大学 | 结合有免疫检查点阻断剂的t淋巴细胞及其在制备抗肿瘤药物中的应用 |
| TWI894357B (zh) * | 2020-09-18 | 2025-08-21 | 大陸商成都美杰賽爾生物科技有限公司 | 溶瘤病毒與經改造的免疫細胞聯合治療腫瘤 |
| EP4052716A1 (en) * | 2021-03-04 | 2022-09-07 | Deutsches Krebsforschungszentrum - Stiftung des öffentlichen Rechts / Universität Heidelberg | Cancer therapy involving car-engineered t-cells and parvovirus h-1 |
| WO2024054293A1 (en) * | 2022-09-08 | 2024-03-14 | Research Institute At Nationwide Children's Hospital | Oncolytic virus combination to maximize oncolytic activity |
| WO2024124190A1 (en) | 2022-12-09 | 2024-06-13 | Microbial Machines, Inc. | Engineered microorganisms for delivery of therapeutic agents |
| EP4727562A1 (en) * | 2023-06-16 | 2026-04-22 | Elias Animal Health | Use of cd200ar-l for enhancing adoptive t-cell therapy |
| WO2024263805A1 (en) | 2023-06-21 | 2024-12-26 | Microbial Machines, Inc. | Genetically engineered microorganisms for detection of diseased cells |
| CN118045162A (zh) * | 2024-02-28 | 2024-05-17 | 北京景达生物科技有限公司 | 核心蛋白聚糖联合nk细胞在治疗实体瘤中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406699B1 (en) * | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
| US20120052003A9 (en) | 2008-05-16 | 2012-03-01 | Szalay Aladar A | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
| EP2406387A4 (en) | 2009-03-09 | 2013-04-17 | Tvax Biomedical I Llc | CELL IMMUNOTHERAPY FOR INFECTION DISEASES |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| DK2986311T3 (en) | 2013-04-18 | 2019-02-25 | Tilt Biotherapeutics Oy | IMPROVED ADOPTIVE CELL THERAPY |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| EP3347473A4 (en) * | 2015-09-09 | 2019-04-10 | Tvax Biomedical I, LLC | METHOD FOR COMBINING ADOPTIVE T CELL THERAPY WITH ONCOLYTIC VIRUS ATTACHMENT THERAPY |
-
2016
- 2016-09-09 EP EP16845141.7A patent/EP3347473A4/en active Pending
- 2016-09-09 JP JP2018513549A patent/JP2018526428A/ja not_active Withdrawn
- 2016-09-09 WO PCT/US2016/050994 patent/WO2017044780A1/en not_active Ceased
- 2016-09-09 US US15/757,687 patent/US20190038727A1/en not_active Abandoned
-
2020
- 2020-07-27 US US16/939,266 patent/US11633442B2/en active Active
-
2021
- 2021-09-10 JP JP2021147640A patent/JP2022003043A/ja active Pending
-
2023
- 2023-04-05 US US18/295,994 patent/US12419924B2/en active Active
- 2023-10-12 JP JP2023176751A patent/JP2023176003A/ja active Pending
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