JP2018526428A - 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 - Google Patents

養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 Download PDF

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JP2018526428A
JP2018526428A JP2018513549A JP2018513549A JP2018526428A JP 2018526428 A JP2018526428 A JP 2018526428A JP 2018513549 A JP2018513549 A JP 2018513549A JP 2018513549 A JP2018513549 A JP 2018513549A JP 2018526428 A JP2018526428 A JP 2018526428A
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cancer
patient
virus
lymphocytes
oncolytic virus
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ウッド ギャリー
ウッド ギャリー
ハラルド ストリッツカー ジョッケン
ハラルド ストリッツカー ジョッケン
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ティーブイエーエックス バイオメディカル アイ，リミティド ライアビリティ カンパニー
ティーブイエーエックス バイオメディカル アイ，リミティド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/55—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/56—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018513549A 2015-09-09 2016-09-09 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 Withdrawn JP2018526428A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021147640A JP2022003043A (ja) 2015-09-09 2021-09-10 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2023176751A JP2023176003A (ja) 2015-09-09 2023-10-12 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562216046P 2015-09-09 2015-09-09
US201562216062P 2015-09-09 2015-09-09
US62/216,046 2015-09-09
US62/216,062 2015-09-09
US201562255294P 2015-11-13 2015-11-13
US62/255,294 2015-11-13
US201662323065P 2016-04-15 2016-04-15
US62/323,065 2016-04-15
PCT/US2016/050994 WO2017044780A1 (en) 2015-09-09 2016-09-09 Methods for combining adoptive t cell therapy with oncolytic virus adjunct therapy

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JP2021147640A Division JP2022003043A (ja) 2015-09-09 2021-09-10 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法

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JP2018526428A true JP2018526428A (ja) 2018-09-13
JP2018526428A5 JP2018526428A5 (https=) 2019-10-24

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JP2018513549A Withdrawn JP2018526428A (ja) 2015-09-09 2016-09-09 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2021147640A Pending JP2022003043A (ja) 2015-09-09 2021-09-10 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2023176751A Pending JP2023176003A (ja) 2015-09-09 2023-10-12 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法

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JP2023176751A Pending JP2023176003A (ja) 2015-09-09 2023-10-12 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法

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US (3) US20190038727A1 (https=)
EP (1) EP3347473A4 (https=)
JP (3) JP2018526428A (https=)
WO (1) WO2017044780A1 (https=)

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JP2022003043A (ja) * 2015-09-09 2022-01-11 ティーブイエーエックス バイオメディカル アイ，リミティド ライアビリティ カンパニー 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2024519428A (ja) * 2021-03-04 2024-05-14 ドイッチェス・クレープスフォルシュングスツェントルム Ｃａｒ操作ｔ細胞及びパルボウイルスｈ－１を含む癌療法

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EP2097517B1 (en) 2006-10-16 2014-06-04 Genelux Corporation Recombinant Lister strain vaccinia virus encoding an anti-VEGF single chain antibody
ES2733211T3 (es) 2011-04-15 2019-11-28 Genelux Corp Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas
CN115300622A (zh) 2015-02-25 2022-11-08 纪念斯隆-凯特琳癌症中心 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合
CN107847534B (zh) 2015-04-17 2022-10-04 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
IL261321B2 (en) 2016-02-25 2023-12-01 Memorial Sloan Kettering Cancer Center Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
KR20180133395A (ko) 2016-02-25 2018-12-14 메모리얼 슬로안 케터링 캔서 센터 암 면역요법을 위한, 인간 flt3l 또는 gm-csf의 발현이 있거나 없으며 티미딘 키나제가 결실된 복제 가능 약독화 백시니아 바이러스
SG11201811408PA (en) 2016-06-24 2019-01-30 Univ Mcmaster Adoptive cell transfer and oncolytic virus combination therapy
JP7724601B2 (ja) 2017-02-03 2025-08-18 ユニバーシティ オブ ピッツバーグ －オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 腫瘍溶解性ウイルス療法
WO2018209315A1 (en) 2017-05-12 2018-11-15 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
BR112020014727A2 (pt) * 2018-01-19 2020-12-08 Kolon Life Science, Inc. Vírus vaccinia recombinante e composição farmacêutica compreendendo o mesmo
MX2021003013A (es) 2018-09-15 2021-08-11 Memorial Sloan Kettering Cancer Center Poxvirus recombinantes para inmunoterapia contra cáncer.
EP3897846A1 (en) * 2018-12-21 2021-10-27 GlaxoSmithKline Biologicals SA Methods of inducing an immune response
CA3133971A1 (en) * 2019-03-20 2020-09-24 Turnstone Biologics Inc. Sequential heterologous boost oncolytic viral mmunotherapy
WO2020247547A1 (en) * 2019-06-03 2020-12-10 Geovax, Inc. Cancer vaccine compositions and methods for use thereof
JP7629872B2 (ja) * 2019-06-05 2025-02-14 レイトラム，エル．エル．シー． 滑らかに直径を減少する自動スタッキング式スパイラルベルトコンベヤ
CN110540960A (zh) * 2019-09-11 2019-12-06 苏州大学 结合有免疫检查点阻断剂的t淋巴细胞及其在制备抗肿瘤药物中的应用
TWI894357B (zh) * 2020-09-18 2025-08-21 大陸商成都美杰賽爾生物科技有限公司 溶瘤病毒與經改造的免疫細胞聯合治療腫瘤
WO2024054293A1 (en) * 2022-09-08 2024-03-14 Research Institute At Nationwide Children's Hospital Oncolytic virus combination to maximize oncolytic activity
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CN118045162A (zh) * 2024-02-28 2024-05-17 北京景达生物科技有限公司 核心蛋白聚糖联合nk细胞在治疗实体瘤中的应用

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Cited By (3)

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JP2022003043A (ja) * 2015-09-09 2022-01-11 ティーブイエーエックス バイオメディカル アイ，リミティド ライアビリティ カンパニー 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2023176003A (ja) * 2015-09-09 2023-12-12 ティーブイエーエックス バイオメディカル アイ，リミティド ライアビリティ カンパニー 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2024519428A (ja) * 2021-03-04 2024-05-14 ドイッチェス・クレープスフォルシュングスツェントルム Ｃａｒ操作ｔ細胞及びパルボウイルスｈ－１を含む癌療法

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WO2017044780A1 (en) 2017-03-16
EP3347473A4 (en) 2019-04-10
JP2022003043A (ja) 2022-01-11
US12419924B2 (en) 2025-09-23
JP2023176003A (ja) 2023-12-12
US20200353002A1 (en) 2020-11-12
EP3347473A1 (en) 2018-07-18
US20230233631A1 (en) 2023-07-27
US20190038727A1 (en) 2019-02-07
US11633442B2 (en) 2023-04-25

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