JP2018525447A5 - - Google Patents
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- JP2018525447A5 JP2018525447A5 JP2018530646A JP2018530646A JP2018525447A5 JP 2018525447 A5 JP2018525447 A5 JP 2018525447A5 JP 2018530646 A JP2018530646 A JP 2018530646A JP 2018530646 A JP2018530646 A JP 2018530646A JP 2018525447 A5 JP2018525447 A5 JP 2018525447A5
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- Prior art keywords
- compound
- halogenated
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- compound according
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 39
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 102100021257 Beta-secretase 1 Human genes 0.000 claims 7
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- -1 heteroaryl halide Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 230000001603 reducing effect Effects 0.000 claims 2
- 230000006999 cognitive decline Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 0 CN(C1=O)C(N)=NC1(c1ccc(*)c(*)c1)C1=C**C(*)=C1 Chemical compound CN(C1=O)C(N)=NC1(c1ccc(*)c(*)c1)C1=C**C(*)=C1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562210945P | 2015-08-27 | 2015-08-27 | |
| US62/210,945 | 2015-08-27 | ||
| PCT/US2016/049271 WO2017035529A1 (en) | 2015-08-27 | 2016-08-29 | Compositions for app-selective bace inhibition and uses therfor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020152650A Division JP2021001188A (ja) | 2015-08-27 | 2020-09-11 | Ａｐｐ選択的ｂａｃｅ阻害のための組成物およびそのための使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018525447A JP2018525447A (ja) | 2018-09-06 |
| JP2018525447A5 true JP2018525447A5 (enExample) | 2019-08-29 |
Family
ID=58101012
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530646A Pending JP2018525447A (ja) | 2015-08-27 | 2016-08-29 | Ａｐｐ選択的ｂａｃｅ阻害のための組成物およびそのための使用 |
| JP2020152650A Pending JP2021001188A (ja) | 2015-08-27 | 2020-09-11 | Ａｐｐ選択的ｂａｃｅ阻害のための組成物およびそのための使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020152650A Pending JP2021001188A (ja) | 2015-08-27 | 2020-09-11 | Ａｐｐ選択的ｂａｃｅ阻害のための組成物およびそのための使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11142505B2 (enExample) |
| EP (1) | EP3341362B1 (enExample) |
| JP (2) | JP2018525447A (enExample) |
| KR (1) | KR20180090778A (enExample) |
| CN (1) | CN108349905A (enExample) |
| AU (1) | AU2016311502B2 (enExample) |
| CA (2) | CA3096896A1 (enExample) |
| WO (1) | WO2017035529A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014127042A1 (en) * | 2013-02-12 | 2014-08-21 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| KR20180090778A (ko) * | 2015-08-27 | 2018-08-13 | 난트뉴로, 엘엘씨 | App-선택적 bace 억제를 위한 조성물 및 그의 용도 |
| EP3759079A4 (en) * | 2018-03-01 | 2021-11-17 | The Regents Of The University Of California | AMYLOID PROTEIN SELECTIVE BACE INHIBITORS (ASBIS) FOR ALZHEIMER'S DISEASE |
| US11926599B1 (en) | 2023-10-23 | 2024-03-12 | King Faisal University | 1-(2-chlorobenzylideneamino)-5,5-diphenylimidazolidine-2,4-dione as an antimicrobial compound |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991019810A1 (en) | 1990-06-15 | 1991-12-26 | California Biotechnology Inc. | Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease |
| CA2372251A1 (en) | 1991-01-21 | 1992-08-06 | Michael John Mullan | Test and model for alzheimer's disease |
| JPH07506720A (ja) | 1992-01-07 | 1995-07-27 | アテナ ニューロサイエンシーズ， インコーポレイテッド | アルツハイマー病のトランスジェニック動物モデル |
| US5604102A (en) | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| JPH09507746A (ja) | 1993-10-27 | 1997-08-12 | アテナ ニューロサイエンシズ，インコーポレイティド | Ｓｗｅｄｉｓｈ変異を有するＡＰＰ対立遺伝子を含有するトランスジェニック動物 |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| AU6383396A (en) | 1995-06-07 | 1996-12-30 | Athena Neurosciences, Inc. | Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition |
| US5744346A (en) | 1995-06-07 | 1998-04-28 | Athena Neurosciences, Inc. | β-secretase |
| WO2000003819A1 (en) | 1998-07-17 | 2000-01-27 | The Penn State Research Foundation | Full form roll finishing technique |
| KR20070013361A (ko) | 1998-09-24 | 2007-01-30 | 파마시아 앤드 업존 캄파니 엘엘씨 | 알츠하이머병 세크레타제 |
| ES2332659T3 (es) * | 2004-06-16 | 2010-02-10 | Wyeth | Derivados de amino-5,5-difenilimidazolona para la inhibicion de beta-secretasa. |
| TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| EP1896448A1 (en) | 2005-06-30 | 2008-03-12 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
| KR20080050430A (ko) * | 2005-09-26 | 2008-06-05 | 와이어쓰 | 베타-세크레타제 (ｂａｃｅ) 억제제로서아미노-5-[4-(디플루오로메톡시)페닐]-5-페닐이미다졸론화합물 |
| CN101360737A (zh) | 2005-12-19 | 2009-02-04 | 惠氏公司 | 2-氨基-5-哌啶咪唑酮化合物和其用于β分泌酶调节的用途 |
| CL2008000791A1 (es) * | 2007-03-23 | 2008-05-30 | Wyeth Corp | Compuestos derivados de 2-amino-5-(4-difluorometoxi-fenil)-5-fenil-imidazolidin-4-ona; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una enfermedad asociada con la actividad bace excesiva, tales como enferm |
| WO2014127042A1 (en) | 2013-02-12 | 2014-08-21 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| US9980769B2 (en) | 2014-04-08 | 2018-05-29 | Ethicon Llc | Methods and devices for controlling motorized surgical devices |
| KR20180090778A (ko) | 2015-08-27 | 2018-08-13 | 난트뉴로, 엘엘씨 | App-선택적 bace 억제를 위한 조성물 및 그의 용도 |
| US20200165225A1 (en) | 2017-06-28 | 2020-05-28 | Nantbio, Inc. | Bace1 inhibitors for treatment of alzheimer's disease |
| EP3759079A4 (en) | 2018-03-01 | 2021-11-17 | The Regents Of The University Of California | AMYLOID PROTEIN SELECTIVE BACE INHIBITORS (ASBIS) FOR ALZHEIMER'S DISEASE |
-
2016
- 2016-08-29 KR KR1020187008350A patent/KR20180090778A/ko not_active Ceased
- 2016-08-29 WO PCT/US2016/049271 patent/WO2017035529A1/en not_active Ceased
- 2016-08-29 CN CN201680053449.1A patent/CN108349905A/zh active Pending
- 2016-08-29 CA CA3096896A patent/CA3096896A1/en not_active Abandoned
- 2016-08-29 JP JP2018530646A patent/JP2018525447A/ja active Pending
- 2016-08-29 AU AU2016311502A patent/AU2016311502B2/en not_active Ceased
- 2016-08-29 EP EP16840254.3A patent/EP3341362B1/en active Active
- 2016-08-29 US US15/755,496 patent/US11142505B2/en active Active
- 2016-08-29 CA CA2996542A patent/CA2996542C/en active Active
-
2020
- 2020-09-11 JP JP2020152650A patent/JP2021001188A/ja active Pending