JP2018525371A - アリール置換された二環式ヘテロアリール化合物 - Google Patents

アリール置換された二環式ヘテロアリール化合物 Download PDF

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Publication number
JP2018525371A
JP2018525371A JP2018504757A JP2018504757A JP2018525371A JP 2018525371 A JP2018525371 A JP 2018525371A JP 2018504757 A JP2018504757 A JP 2018504757A JP 2018504757 A JP2018504757 A JP 2018504757A JP 2018525371 A JP2018525371 A JP 2018525371A
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alkyl
aryl
alkoxy
alkylene
fluoroalkyl
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JP2018525371A5 (enExample
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シャオジュン・ジャン
シャオファン・ジェン
ルイーズ・エス・チュパック
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018504757A 2015-07-30 2016-07-28 アリール置換された二環式ヘテロアリール化合物 Ceased JP2018525371A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562198706P 2015-07-30 2015-07-30
US62/198,706 2015-07-30
PCT/US2016/044388 WO2017019828A1 (en) 2015-07-30 2016-07-28 Aryl substituted bicyclic heteroaryl compounds

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JP2018525371A true JP2018525371A (ja) 2018-09-06
JP2018525371A5 JP2018525371A5 (enExample) 2019-08-15

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JP2018504757A Ceased JP2018525371A (ja) 2015-07-30 2016-07-28 アリール置換された二環式ヘテロアリール化合物

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US (1) US10517870B2 (enExample)
EP (1) EP3328839A1 (enExample)
JP (1) JP2018525371A (enExample)
KR (1) KR20180030913A (enExample)
CN (1) CN108137514A (enExample)
WO (1) WO2017019828A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10730868B2 (en) 2016-07-14 2020-08-04 Bristol-Myers Squibb Company Bicyclic heteroaryl substituted compounds
CN109689642B (zh) 2016-07-14 2022-04-12 百时美施贵宝公司 经单环杂芳基取代的化合物
EP3484894B1 (en) * 2016-07-14 2020-08-19 Bristol-Myers Squibb Company Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors
ES2823180T3 (es) 2016-07-14 2021-05-06 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos con heteroarilo
WO2019113312A1 (en) * 2017-12-08 2019-06-13 Innocrin Pharmaceuticals, Inc. Anticancer compound process
CN111440161B (zh) * 2020-05-15 2023-04-14 中国药科大学 一种具有par4拮抗活性的二环杂芳基类化合物及其应用
CN111440146B (zh) * 2020-05-15 2022-10-21 中国药科大学 一种具有par4拮抗活性的苯并三嗪类化合物及其应用
CN116041341B (zh) * 2022-11-24 2025-02-28 中国药科大学 一种喹唑啉类par4拮抗剂及其医药应用

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JPH06503093A (ja) * 1990-11-26 1994-04-07 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 置換された縮合複素環式除草剤
JP2009023986A (ja) * 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
JP2011520941A (ja) * 2008-05-23 2011-07-21 ノバルティス アーゲー キノキサリン−およびキノリン−カルボキシアミド誘導体
WO2011156610A2 (en) * 2010-06-09 2011-12-15 Gilead Sciences, Inc. Inhibitors of hepatitis c virus
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EP2514749A1 (en) * 2009-12-15 2012-10-24 Shionogi & Co., Ltd. Oxadiazole derivative having endothelial lipase inhibitory activity
JP2013503824A (ja) * 2009-09-04 2013-02-04 バイエル・ファルマ・アクチェンゲゼルシャフト チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン

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TW279162B (enExample) 1991-09-26 1996-06-21 Mitsubishi Chem Corp
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BR9815785A (pt) 1998-03-31 2000-12-05 Warner Lambert Co Quinoxalinonas como inibidores de protease de serina tal como fator xa e trombina
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JP2009023986A (ja) * 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
JP2011520941A (ja) * 2008-05-23 2011-07-21 ノバルティス アーゲー キノキサリン−およびキノリン−カルボキシアミド誘導体
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
JP2012522741A (ja) * 2009-04-02 2012-09-27 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング キノキサリン誘導体並びに良性の及び悪性の腫瘍疾患の治療のためのその使用
JP2013503824A (ja) * 2009-09-04 2013-02-04 バイエル・ファルマ・アクチェンゲゼルシャフト チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン
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Also Published As

Publication number Publication date
CN108137514A (zh) 2018-06-08
WO2017019828A1 (en) 2017-02-02
EP3328839A1 (en) 2018-06-06
KR20180030913A (ko) 2018-03-26
US20180214445A1 (en) 2018-08-02
US10517870B2 (en) 2019-12-31

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