JP2018524349A5 - - Google Patents
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- JP2018524349A5 JP2018524349A5 JP2017568261A JP2017568261A JP2018524349A5 JP 2018524349 A5 JP2018524349 A5 JP 2018524349A5 JP 2017568261 A JP2017568261 A JP 2017568261A JP 2017568261 A JP2017568261 A JP 2017568261A JP 2018524349 A5 JP2018524349 A5 JP 2018524349A5
- Authority
- JP
- Japan
- Prior art keywords
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- amino acid
- acid sequence
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- sequence set
- Prior art date
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- 0 COc(cc(c(NC[C@](C1)N2c3c1cccc3)c1)C2=O)c1OCc1cc(COc(cc(c2c3)C(*)=C=C(*)[C@](Cc4ccccc44)N4C2=O)c3OC)cc(**SS)c1 Chemical compound COc(cc(c(NC[C@](C1)N2c3c1cccc3)c1)C2=O)c1OCc1cc(COc(cc(c2c3)C(*)=C=C(*)[C@](Cc4ccccc44)N4C2=O)c3OC)cc(**SS)c1 0.000 description 12
- SZVNORTXUATKNF-HWKANZROSA-N C/C=N/NC(C)=O Chemical compound C/C=N/NC(C)=O SZVNORTXUATKNF-HWKANZROSA-N 0.000 description 1
- YCKRVGKVZGBWHU-UHFFFAOYSA-N CC(CC(N1CC(CC2)CCC2C(C)=O)=O)C1=O Chemical compound CC(CC(N1CC(CC2)CCC2C(C)=O)=O)C1=O YCKRVGKVZGBWHU-UHFFFAOYSA-N 0.000 description 1
- UIWVQFSAXYWENY-UHFFFAOYSA-N CCNNC(C)=O Chemical compound CCNNC(C)=O UIWVQFSAXYWENY-UHFFFAOYSA-N 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022209445A JP7611218B2 (ja) | 2015-06-29 | 2022-12-27 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2024226350A JP2025041791A (ja) | 2015-06-29 | 2024-12-23 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2026024247A JP2026086801A (ja) | 2015-06-29 | 2026-02-18 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562186161P | 2015-06-29 | 2015-06-29 | |
| US62/186,161 | 2015-06-29 | ||
| US201662338203P | 2016-05-18 | 2016-05-18 | |
| US62/338,203 | 2016-05-18 | ||
| US201662346730P | 2016-06-07 | 2016-06-07 | |
| US62/346,730 | 2016-06-07 | ||
| PCT/US2016/039797 WO2017004026A1 (en) | 2015-06-29 | 2016-06-28 | Anti-cd 123 antibodies and conjugates and derivatives thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022209445A Division JP7611218B2 (ja) | 2015-06-29 | 2022-12-27 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524349A JP2018524349A (ja) | 2018-08-30 |
| JP2018524349A5 true JP2018524349A5 (enExample) | 2019-08-08 |
| JP7203497B2 JP7203497B2 (ja) | 2023-01-13 |
Family
ID=56373176
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568261A Active JP7203497B2 (ja) | 2015-06-29 | 2016-06-28 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2022209445A Active JP7611218B2 (ja) | 2015-06-29 | 2022-12-27 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2024226350A Pending JP2025041791A (ja) | 2015-06-29 | 2024-12-23 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2026024247A Pending JP2026086801A (ja) | 2015-06-29 | 2026-02-18 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022209445A Active JP7611218B2 (ja) | 2015-06-29 | 2022-12-27 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2024226350A Pending JP2025041791A (ja) | 2015-06-29 | 2024-12-23 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
| JP2026024247A Pending JP2026086801A (ja) | 2015-06-29 | 2026-02-18 | 抗ｃｄ１２３抗体、ならびにその複合体及び誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US10077313B2 (enExample) |
| EP (2) | EP3313884B9 (enExample) |
| JP (4) | JP7203497B2 (enExample) |
| KR (3) | KR20260039810A (enExample) |
| CN (4) | CN114671951A (enExample) |
| AR (1) | AR105194A1 (enExample) |
| AU (3) | AU2016285552B2 (enExample) |
| CA (1) | CA2989321A1 (enExample) |
| CY (1) | CY1123884T1 (enExample) |
| DK (1) | DK3313884T3 (enExample) |
| ES (1) | ES2887273T3 (enExample) |
| HR (1) | HRP20210263T1 (enExample) |
| HU (1) | HUE053619T2 (enExample) |
| IL (2) | IL256271B (enExample) |
| LT (1) | LT3313884T (enExample) |
| MD (1) | MD3313884T2 (enExample) |
| PL (1) | PL3313884T3 (enExample) |
| PT (1) | PT3313884T (enExample) |
| RS (1) | RS61452B9 (enExample) |
| RU (1) | RU2739612C2 (enExample) |
| SG (1) | SG10202005144TA (enExample) |
| SI (1) | SI3313884T1 (enExample) |
| SM (1) | SMT202100092T1 (enExample) |
| TW (3) | TW202423981A (enExample) |
| WO (1) | WO2017004026A1 (enExample) |
| ZA (1) | ZA202007918B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6957035B2 (ja) | 2015-04-10 | 2021-11-02 | トーマス・ジェファーソン・ユニバーシティ | 対象への移植用の免疫原性拡散チャンバおよびその調製方法 |
| SMT202100092T1 (it) * | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| SI3313845T1 (sl) | 2015-06-29 | 2021-01-29 | Immunogen, Inc. | Konjugati spremenjenih protiteles cisteina |
| RS65120B1 (sr) * | 2015-11-25 | 2024-02-29 | Immunogen Inc | Farmaceutske formulacije i postupci za njihovu upotrebu |
| EP3544983A2 (en) | 2016-11-23 | 2019-10-02 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
| TW201825515A (zh) * | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Ｍｅｔ抗體以及其免疫結合物及用途 |
| HRP20230002T1 (hr) * | 2017-01-25 | 2023-02-17 | Immunogen, Inc. | Postupci pripreme citotoksičnih derivata benzodiazepina |
| IL298414B2 (en) | 2017-02-28 | 2024-12-01 | Immunogen Inc | Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof |
| TWI826393B (zh) * | 2017-09-22 | 2023-12-21 | 美商免疫遺傳股份有限公司 | 使用陽離子交換層析法分離三輕鏈抗體 |
| CN111372610B (zh) | 2017-09-22 | 2023-05-30 | 伊缪诺金公司 | 防止免疫结合物中的甲硫氨酸氧化的方法 |
| CA3177215C (en) | 2017-09-29 | 2026-06-09 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
| WO2019082020A1 (en) * | 2017-10-27 | 2019-05-02 | Pfizer Inc. | ANTIBODIES AND CONJUGATES CD123-SPECIFIC ANTIBODIES AND USES THEREOF |
| AU2018374283B2 (en) | 2017-11-29 | 2025-09-18 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD5+ cells |
| US12201154B2 (en) | 2018-01-03 | 2025-01-21 | Cqens Technologies Inc. | Heat-not-burn device and method |
| AU2019206587A1 (en) | 2018-01-12 | 2020-08-06 | Immunogen, Inc. | Methods for antibody drug conjugation, purification, and formulation |
| CN116425874A (zh) * | 2018-06-15 | 2023-07-14 | 康源博创生物科技(北京)有限公司 | 抗cd123抗体及其制备方法和应用 |
| WO2020092533A2 (en) * | 2018-10-30 | 2020-05-07 | Immunogen, Inc. | Methods of treatment using anti-cd123 immunoconjugates |
| US20210393791A1 (en) * | 2018-10-31 | 2021-12-23 | Health Research, Inc. | Combination treatment with anti-cd123 antibody drug conjugate and parp inhibitor |
| AU2019381628A1 (en) * | 2018-11-12 | 2021-05-27 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN112996792B (zh) * | 2018-11-12 | 2024-04-26 | 伊缪诺金公司 | 制备细胞毒性苯并二氮杂卓衍生物的方法 |
| JP2022518150A (ja) * | 2019-01-07 | 2022-03-14 | マジェンタ セラピューティクス インコーポレイテッド | 細胞療法での抗ｃｄ４５抗体－薬物結合体（ａｄｃ）の使用経験 |
| AU2020240310A1 (en) | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| US20230094471A1 (en) | 2019-03-29 | 2023-03-30 | Immunogen, Inc. | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases |
| JP7585231B2 (ja) * | 2019-04-29 | 2024-11-18 | イミュノジェン， インコーポレイテッド | 抗ｃｄ１２３免疫複合体を含む治療的組み合わせ |
| US20220306751A1 (en) * | 2019-09-13 | 2022-09-29 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| CN112646033B (zh) * | 2020-12-16 | 2022-04-12 | 北京艺妙神州医药科技有限公司 | 靶向cd123的嵌合抗原受体及其用途 |
| EP4410307A4 (en) | 2021-09-30 | 2026-05-06 | Jiangsu Hengrui Pharmaceuticals Co Ltd | PYRROLO BENZODIAZEPINE DERIVATIVE AND CONJUGATE, PROCESS FOR THEIR PREPARATION AND USE |
| CN120957754A (zh) * | 2023-05-12 | 2025-11-14 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和用途 |
| KR20260048598A (ko) | 2023-07-31 | 2026-04-10 | 아스트라제네카 아베 | Cd123 항체-약물 접합체 및 이의 사용 방법 |
| US20250345449A1 (en) | 2024-05-10 | 2025-11-13 | Immunogen, Inc. | Anti-cd123 immunoconjugates for the treatment of blastic plasmacytoid cell neoplasm |
| WO2025235924A2 (en) | 2024-05-10 | 2025-11-13 | Immunogen, Inc. | Anti-cd123 immunoconjugates for the treatment of acute myeloid leukemia |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| DE3587814T2 (de) | 1985-03-30 | 1994-11-10 | Marc Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| DE3600905A1 (de) | 1986-01-15 | 1987-07-16 | Ant Nachrichtentech | Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen |
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2016842A1 (en) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
| EP0478627A4 (en) | 1989-05-16 | 1992-08-19 | William D. Huse | Co-expression of heteromeric receptors |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| WO1993011794A1 (en) | 1991-12-13 | 1993-06-24 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| US6828422B1 (en) | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| ATE482275T1 (de) | 1999-07-02 | 2010-10-15 | Morphosys Ag | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| DK1578446T3 (en) | 2002-11-07 | 2015-06-29 | Immunogen Inc | ANTI-CD33 ANTIBODIES AND PROCEDURES FOR TREATING ACUTE MYELOID LEUKEMIA BY USING IT |
| EP1725585A2 (en) | 2004-03-10 | 2006-11-29 | Lonza Ltd | Method for producing antibodies |
| US20080312425A1 (en) | 2004-08-30 | 2008-12-18 | Lonza Biologics Plc. | Ion Exchange Chromatography and Purification of Antibodies |
| SI1964852T1 (sl) * | 2005-12-20 | 2013-09-30 | Sbi Biotech Co. Ltd. | Proti-ilt7 protitelo |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| WO2008127735A1 (en) * | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
| US8093364B2 (en) | 2008-01-18 | 2012-01-10 | Bio-Rad Laboratories, Inc. | Enhanced purification of antibodies and antibody fragments by apatite chromatography |
| JP5470817B2 (ja) | 2008-03-10 | 2014-04-16 | 日産自動車株式会社 | 電池用電極およびこれを用いた電池、並びにその製造方法 |
| US20100209341A1 (en) | 2009-02-18 | 2010-08-19 | Csl Limited | Treatment of chronic inflammatory conditions |
| ES2550639T3 (es) * | 2009-04-27 | 2015-11-11 | Kyowa Hakko Kirin Co., Ltd. | Anticuerpo anti-IL-3Ralfa para su utilización en el tratamiento de un tumor de la sangre |
| CN102821815A (zh) * | 2010-02-18 | 2012-12-12 | Csl有限公司 | 慢性炎症状态的治疗 |
| CN105777907B (zh) | 2010-02-24 | 2020-03-17 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| CA3220104A1 (en) * | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| NZ604510A (en) * | 2010-08-17 | 2013-10-25 | Csl Ltd | Dilutable biocidal compositions and methods of use |
| SI2675480T1 (sl) | 2011-02-15 | 2019-05-31 | Immunogen, Inc. | Metode priprave konjugatov |
| JP6136279B2 (ja) | 2013-01-15 | 2017-05-31 | 株式会社ジェイテクト | 転がり軸受装置 |
| WO2014138805A1 (en) | 2013-03-14 | 2014-09-18 | Csl Limited | Anti il-3r alpha agents and uses thereof |
| TWI503850B (zh) | 2013-03-22 | 2015-10-11 | Polytronics Technology Corp | 過電流保護元件 |
| EP2839842A1 (en) * | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| US20160251440A1 (en) * | 2013-09-26 | 2016-09-01 | Ablynx N.V. | Bispecific nanobodies |
| TWI510996B (zh) | 2013-10-03 | 2015-12-01 | Acer Inc | 控制觸控面板的方法以及使用該方法的可攜式電腦 |
| MA39885A (fr) * | 2014-05-20 | 2015-11-26 | Immunogen Inc | Procédés de caractérisation et de traitement de la leucémie myéloïde aiguë |
| SG11201701565PA (en) * | 2014-09-03 | 2017-03-30 | Immunogen Inc | Conjugates comprising cell-binding agents and cytotoxic agents |
| CR20170111A (es) * | 2014-09-03 | 2017-05-23 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| DK3189081T3 (da) * | 2014-09-05 | 2020-05-04 | Janssen Pharmaceutica Nv | Cd123-bindende midler og anvendelser deraf |
| SI3313845T1 (sl) | 2015-06-29 | 2021-01-29 | Immunogen, Inc. | Konjugati spremenjenih protiteles cisteina |
| SMT202100092T1 (it) * | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| RS65120B1 (sr) * | 2015-11-25 | 2024-02-29 | Immunogen Inc | Farmaceutske formulacije i postupci za njihovu upotrebu |
| US9816280B1 (en) | 2016-11-02 | 2017-11-14 | Matthew Reitnauer | Portable floor |
| EP3544983A2 (en) * | 2016-11-23 | 2019-10-02 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
| TWI826393B (zh) * | 2017-09-22 | 2023-12-21 | 美商免疫遺傳股份有限公司 | 使用陽離子交換層析法分離三輕鏈抗體 |
| CN111372610B (zh) * | 2017-09-22 | 2023-05-30 | 伊缪诺金公司 | 防止免疫结合物中的甲硫氨酸氧化的方法 |
| AU2019206587A1 (en) | 2018-01-12 | 2020-08-06 | Immunogen, Inc. | Methods for antibody drug conjugation, purification, and formulation |
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2016
- 2016-06-28 SM SM20210092T patent/SMT202100092T1/it unknown
- 2016-06-28 HR HRP20210263TT patent/HRP20210263T1/hr unknown
- 2016-06-28 EP EP16736718.4A patent/EP3313884B9/en active Active
- 2016-06-28 KR KR1020267007615A patent/KR20260039810A/ko active Pending
- 2016-06-28 PL PL16736718T patent/PL3313884T3/pl unknown
- 2016-06-28 KR KR1020247014500A patent/KR20240063203A/ko not_active Ceased
- 2016-06-28 RU RU2017146345A patent/RU2739612C2/ru active
- 2016-06-28 RS RS20210197A patent/RS61452B9/sr unknown
- 2016-06-28 DK DK16736718.4T patent/DK3313884T3/da active
- 2016-06-28 CN CN202210033457.7A patent/CN114671951A/zh active Pending
- 2016-06-28 WO PCT/US2016/039797 patent/WO2017004026A1/en not_active Ceased
- 2016-06-28 MD MDE20180449T patent/MD3313884T2/ro unknown
- 2016-06-28 PT PT167367184T patent/PT3313884T/pt unknown
- 2016-06-28 CA CA2989321A patent/CA2989321A1/en active Pending
- 2016-06-28 CN CN201680038058.2A patent/CN107889493B/zh active Active
- 2016-06-28 ES ES16736718T patent/ES2887273T3/es active Active
- 2016-06-28 AU AU2016285552A patent/AU2016285552B2/en active Active
- 2016-06-28 CN CN202510430627.9A patent/CN120248124A/zh active Pending
- 2016-06-28 HU HUE16736718A patent/HUE053619T2/hu unknown
- 2016-06-28 LT LTEP16736718.4T patent/LT3313884T/lt unknown
- 2016-06-28 US US15/195,401 patent/US10077313B2/en active Active
- 2016-06-28 KR KR1020187002732A patent/KR102663480B1/ko active Active
- 2016-06-28 SI SI201631099T patent/SI3313884T1/sl unknown
- 2016-06-28 SG SG10202005144TA patent/SG10202005144TA/en unknown
- 2016-06-28 EP EP20208057.8A patent/EP3842459A1/en active Pending
- 2016-06-28 JP JP2017568261A patent/JP7203497B2/ja active Active
- 2016-06-28 CN CN202210033558.4A patent/CN114672490A/zh active Pending
- 2016-06-29 TW TW112134213A patent/TW202423981A/zh unknown
- 2016-06-29 TW TW110114906A patent/TW202134284A/zh unknown
- 2016-06-29 TW TW105120515A patent/TWI727958B/zh active
- 2016-06-29 AR ARP160101974A patent/AR105194A1/es unknown
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2017
- 2017-08-03 US US15/667,697 patent/US10919969B2/en active Active
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2018
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2020
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2021
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2022
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2024
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2026
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