|
US4099012A
(en)
|
1975-08-28 |
1978-07-04 |
Ciba-Geigy Corporation |
2-pyrazolyl-benzophenones
|
|
US4481142A
(en)
|
1979-02-07 |
1984-11-06 |
Hoffmann-La Roche Inc. |
Pyrimido-2-benzazepines
|
|
CA1138863A
(en)
|
1979-02-07 |
1983-01-04 |
Norman W. Gilman |
Benzazepine-derivatives
|
|
US4469633A
(en)
|
1980-05-16 |
1984-09-04 |
Hoffmann-La Roche Inc. |
N-oxides of 5-oxo-1-phenyl-2-benzazepines
|
|
EP0273697A3
(en)
|
1986-12-30 |
1989-11-29 |
Merck & Co. Inc. |
2-benzazepines with 5- and 6- membered heterocyclic rings
|
|
US5166151A
(en)
|
1988-03-25 |
1992-11-24 |
Merck & Co., Inc. |
2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
|
|
US5210082A
(en)
|
1991-05-16 |
1993-05-11 |
Merck & Co., Inc. |
2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
KR19990087585A
(ko)
|
1996-03-08 |
1999-12-27 |
돈 리사 로얄 |
신경학적 활성제로서의 아졸로벤즈아제핀 유도체
|
|
US6057329A
(en)
|
1996-12-23 |
2000-05-02 |
Celltech Therapeutics Limited |
Fused polycyclic 2-aminopyrimidine derivatives
|
|
GB9713087D0
(en)
|
1997-06-20 |
1997-08-27 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
DK1026167T3
(da)
|
1997-09-29 |
2003-05-26 |
Meiji Seika Kaisha |
Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler
|
|
US6277844B1
(en)
|
1998-09-14 |
2001-08-21 |
Sydney Spector |
Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
|
|
US6417207B1
(en)
|
1999-05-12 |
2002-07-09 |
Nitromed, Inc. |
Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
|
|
NZ526472A
(en)
|
2000-12-21 |
2004-04-30 |
Vertex Pharma |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6686352B2
(en)
|
2001-05-18 |
2004-02-03 |
Hoffmann-La Roche Inc. |
Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
|
|
JP4364637B2
(ja)
|
2001-08-09 |
2009-11-18 |
アクテリオン ファーマシューティカルズ リミテッド |
新規なベンゾ縮合へテロ環化合物
|
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
GB0226583D0
(en)
|
2002-11-14 |
2002-12-18 |
Cyclacel Ltd |
Compounds
|
|
ES2290529T3
(es)
|
2002-12-24 |
2008-02-16 |
Astrazeneca Ab |
Derivados de fosfonooxiquinazolina y su uso farmaceutico.
|
|
BRPI0407544A
(pt)
|
2003-02-17 |
2006-02-14 |
Pharmacia Italia Spa |
derivados de pirazol tetracìclicos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas que os compreendem
|
|
TWI372050B
(en)
|
2003-07-03 |
2012-09-11 |
Astex Therapeutics Ltd |
(morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
|
|
GB0315657D0
(en)
|
2003-07-03 |
2003-08-13 |
Astex Technology Ltd |
Pharmaceutical compounds
|
|
US7141568B2
(en)
|
2003-07-09 |
2006-11-28 |
Pfizer Italia S.R.L. |
Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
WO2005013996A2
(en)
|
2003-08-07 |
2005-02-17 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds and uses as anti-proliferative agents
|
|
CN1897950A
(zh)
|
2003-10-14 |
2007-01-17 |
惠氏公司 |
稠合芳基和杂芳基衍生物及其使用方法
|
|
ES2540987T3
(es)
|
2004-05-14 |
2015-07-15 |
Millennium Pharmaceuticals, Inc. |
Métodos para preparar inhibidores de la aurora cinasa
|
|
EP1763514A2
(en)
|
2004-05-18 |
2007-03-21 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
JP2008505167A
(ja)
|
2004-07-05 |
2008-02-21 |
アステックス、セラピューティックス、リミテッド |
医薬組成物
|
|
EP1768984B1
(en)
|
2004-07-16 |
2010-10-20 |
Sunesis Pharmaceuticals, Inc. |
Thienopyrimidines useful as aurora kinase inhibitors
|
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
ATE421996T1
(de)
|
2004-11-15 |
2009-02-15 |
Rigel Pharmaceuticals Inc |
Verfahren zur herstellung optisch aktiver n- carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase
|
|
JP2008520713A
(ja)
|
2004-11-17 |
2008-06-19 |
ミイカナ セラピューティクス インコーポレイテッド |
キナーゼ阻害剤
|
|
US20100160324A1
(en)
|
2004-12-30 |
2010-06-24 |
Astex Therapeutics Limited |
Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
|
|
EP1833819A1
(en)
|
2004-12-30 |
2007-09-19 |
Astex Therapeutics Limited |
Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases
|
|
WO2006070192A1
(en)
|
2004-12-30 |
2006-07-06 |
Astex Therapeutics Limited |
Thiazole and isothiazole derivatives that modulate the acivity of cdk, gsk and aurora kynases
|
|
WO2006070202A1
(en)
|
2004-12-30 |
2006-07-06 |
Astex Therapeutics Limited |
Pyrazole derivatives having kinase modulating activity
|
|
US7485661B2
(en)
|
2005-01-18 |
2009-02-03 |
Pfizer Italia S.R.L. |
Heterobicyclic pyrazole derivatives as kinase inhibitors
|
|
CA2622352C
(en)
|
2005-09-30 |
2014-05-27 |
Miikana Therapeutics, Inc. |
Substituted pyrazole compounds
|
|
EP1954277B1
(en)
|
2005-11-03 |
2017-01-18 |
Vertex Pharmaceuticals Incorporated |
Aminopyrimidines useful as kinase inhibitors
|
|
SI1962830T1
(sl)
|
2005-12-23 |
2013-07-31 |
Glaxosmithkline Llc |
Azaindolni inhibitorji kinaz Aurora
|
|
TW200808311A
(en)
|
2006-03-30 |
2008-02-16 |
Nerviano Medical Sciences Srl |
Use of a kinase inhibitor for the treatment of particular resistant tumors
|
|
WO2007129062A1
(en)
|
2006-05-08 |
2007-11-15 |
Astex Therapeutics Limited |
Pharmaceutical combinations of diazole derivatives for cancer treatment
|
|
WO2007132221A1
(en)
|
2006-05-12 |
2007-11-22 |
Cyclacel Limited |
Combined anticancer pyrimidine-thiazole aurora kinase inhibitors
|
|
GB0609530D0
(en)
|
2006-05-12 |
2006-06-21 |
Cyclacel Ltd |
Combination
|
|
WO2007132220A1
(en)
|
2006-05-12 |
2007-11-22 |
Cyclacel Limited |
Combination of a 2-substituted-4-heter0aryl-pyrimidine amine with a cytotoxic drug and use thereof in the treatment of a proliferative disorder
|
|
US7718648B2
(en)
|
2006-08-09 |
2010-05-18 |
Millennium Pharmaceuticals, Inc. |
Pyridobenzazepine compounds and methods for inhibiting mitotic progression
|
|
CL2007003244A1
(es)
|
2006-11-16 |
2008-04-04 |
Millennium Pharm Inc |
Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
|
|
WO2009114703A2
(en)
|
2008-03-12 |
2009-09-17 |
Fox Chase Cancer Center |
Combination therapy for the treatment of cancer
|
|
JO3635B1
(ar)
|
2009-05-18 |
2020-08-27 |
Millennium Pharm Inc |
مركبات صيدلانية صلبة وطرق لانتاجها
|
|
JO3434B1
(ar)
|
2009-07-31 |
2019-10-20 |
Millennium Pharm Inc |
مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
|
|
CA2788774A1
(en)
|
2010-02-19 |
2011-08-25 |
Millennium Pharmaceuticals, Inc. |
Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate
|
|
AR086656A1
(es)
*
|
2011-06-03 |
2014-01-15 |
Millennium Pharm Inc |
Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
|
|
JP2018524292A
(ja)
|
2015-07-21 |
2018-08-30 |
ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. |
オーロラキナーゼインヒビターと化学療法剤の投与
|